HUE032969T2 - Rákellenes hatású kinoli-8-szulfonamid-származékok - Google Patents

Rákellenes hatású kinoli-8-szulfonamid-származékok Download PDF

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HUE032969T2
HUE032969T2 HUE10794668A HUE10794668A HUE032969T2 HU E032969 T2 HUE032969 T2 HU E032969T2 HU E10794668 A HUE10794668 A HU E10794668A HU E10794668 A HUE10794668 A HU E10794668A HU E032969 T2 HUE032969 T2 HU E032969T2
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compound
nmr
mhz
quinoline
piperazine
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HUE10794668A
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Jeffrey O Saunders
Francesco G Salituro
Shunqi Yan
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Agios Pharmaceuticals Inc
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Claims (19)

  1. RtkellÉté* í * I. (Il):
    kèplelû vegyülMvagy valamely gyógvászsttiag elfogadható sója, ahol: W, X. Y és Z mkdegyike egymástól ffcggetienöi CH vagy N közül válásától: D és Ds egymásáéi függetlenül egy kötés vagy HR" kőztüs választott; L egy köles, ~€(ΟΚ -iCtCRV, -0C(O}-, -CCrR%rOC(Ok -(ClCRVCfÖk •NR^CCSK vagy ««))- csoport; R: atkil, cikloalkil, asf yhefóromil, ës heierodkllcsopokközt; választott; melyek mindegyike Ö-5 R” csoporttal sxubszrituáiv; mindegyik R* egymástól: fdggeilMtd hsiogéaaíöm., halogénül kik alktiplndt'oxll és •OiC csoportok közül választót!; mindegyik Rs egytsásüi fiiggeílenüi aiktk aeit hldí-oilhlkil es iisiogémtiMlesepos'í: közli váiasHöRi mindegyik Rl> e^^ÄÄp«tImpWdp§gÄi«iS alkileaöport közül választott; mindegyik Rs egymástól függetleníti hidrogénatom, hálogénaíom, alkll alkosí és lategénalkojilesoporf közül választolt vagy kél IC a hozzál uk kapcsolódó szénatommal együk egy adod cselben sz.uhs/.üíuálí eikloaikiknoportot alkot; mhldegylk IC egymástól függetlenül haKyçéaalom, haiogénalkik halogénalkoxí, aíkü, alkinik nitrín elarn hidroxlk -C{0)R\ -OC(0)R:!f -CíOlOtC, -SR\ -NRsRiJ és -OR" csoport közül választott vagy két Ri! á hozamok kapcsolódó szénatommal együtt egy adod ekéiben szubsztítnáit heterocíkhlesepottOt alkot ; π értéke Ö, I ? vagy 2; te értéke C 2 vagy 3; It cooks ilgés g értéke I. 2.. Á2 i, igénypont szerinti vegyűlet, ahol W, Xs Y és Z jelentése C'H «söpört. 3, A 2, igénypont szóróm vegyűlet ahol D jelentése N!lb és D'$ egy kötés. 4. A 3. igénypont szerinti vegyűlet, ahol Bejelentése H, meril vagy etBesopork
  2. 5.. Az 1 -4. igénypontok bánnetyike szerinti vegyűlet, ahol L egy kötés, *(CRv8c^. 441143(0)-, ACR'7l%-€(0)~, -C(ö;h, -{CR^%-0'QO}- vagy .«CXCO}~ csoport, t>. Az 5, Igénypont szerinti vegyűlet álról L egy -.<CRftRe)««·· esoport, 7. A 6. igénypont szerinti vegyitíet ahol R: Ö-$ R;> csoporttal sznbsztitnáll eikloaikil aril, hetemen 1, vagy hetereeikUlesoport.
  3. 8. Á b, igénypont szerinti vegyűlet ahol R* hidrogénatom. 9. A 6-8. igénypontok bánnelyike szerinti vegyűlet, ahol n értéke 0. 10. A 6-8. igénypontok bármelyike szerűül vegyűlet, ahol n értéke l és RJ CHj, CHjCH*. ΟΩΒ, OCH3CH.5, OH, P, Cl, vagy CP* csoport
  4. 11. Az 1. Igénypont szerinti vegyűlet vagy valamely gyogyászatiiag elfogadható sója. ahol a vegytUet; -gy:
    képle!0 vegyűlet
  5. 12. Az 1. igénypont szerinti vegyűlet ahol a vegyűlet:
    vagy valamely gyógyáxzatUag eSfopdhstó sója közöl választott ! 3. Az I. igénypont szert fitt vegyül&amp;í, ahol a vegyűteí:
    •vagy valamely gyogyásssatífeg elfogadható sója kősói! választott.
  6. 14. Az 1, igénypont szefíaii vegyüiet,. ahol a vegyülök
    cs
    vagy valamely gyógyászai;!lag. elfogadható sála közöl választott.
  7. 15. Az Î. igénypont szerinti vegyidet vagy valamely gyógyászati lag elfogadható sója. mely: képlet«.
  8. 16. Áz 1. igénypont szerinti vegyidet vagy valamely gyógyászati lag elfogadható sója, mely: képietil.
  9. 17. Az 1. Igénypont szerinti vegyidet vagy valamely gyógyászáiilag elfogadható sója, mely: képtefü.
  10. 18. Az 1, igénypont szerinti vegyidet vagy valamely gyógyósAöHag elfogadható sója, mely:
    IP. Az 1. Igénypont szetmd vegyülét vagy valamely gyógyászatllag elfogadható sója. mely: képleté.
    20; .¾ 1 igénypoîvtszefmti vegyidet vagy valamely gyógyászati lag eSÍPgadb&amp;tó sois, tsoly: képiek,
  11. 21. Az l. igénypont saerkti vegyütet vagy valamely gyógyAszatllag elfogadhâtô sója, mely: képlet«.
  12. 22. Az i. Igénypont asenntl vegyidet vagy vaíámö'íy: gyógyászatilag elfogadható sála, mely: képleté:
  13. 23. Az I. igénypont szeri«« vegyúlei vagy valamely gyógyáazatilagelfögatllsáto §ójh,.-mely: képleté:
    2A Az I. igénypont szerié« vegyidet vagy valamely gyégYászatifag elfogadható apja. mely; képkiíü,
    .25, Az ?.. igénypont szerinti vegyidet vagy valamely gyógyászaíiiag eifegadbató séfa, mely; képlet«.
    M. Az I. igénypont szerinti vegyidet vagy vsfamély gyegyászstUag elfogadható sója, mely: képlet«,
  14. 27, Az 1. igénypont szerinti vegyidet vagy valamely gyógylszatiiag elfogadható sója.,, mely; képlet«,
  15. 28, Az 1, igénypont szerinti vegyüíel vagy valamely gyögyász&amp;tilag elfogadható .-soja, mely: képlet«,
  16. 29, Az 1, igénypont szerinti vegyidet vagy valamely gyógyászati lag elfögádhaíó sóim mely: K cp Ici Ui.
    < eHViöUK&amp;íxíó sója. mely 3Ö< fei, vegpíkt vágy vaiawíy gÿ^4' 4' - ^ képiem.
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    képieífi. 34.fe.|, spijypppts^íispi vegyüleí vagy vsiapveiy gyógyi$aatikg ellepett# sója, mélyí Mpletíl
    IS.: 1 < igénypert szerinti vegyiig? vagy valamely gyógyászati kg elikgaóhatő $ójm mély; képktü,
  17. 36. Az 1. igénypont szerinti vegyük! vagy valamely gyógyászati sag ¢) fogadható sója, moly: kégiktn,
    3:7; Az :J, igénypsmt: szénák vegyük? vagy mlamely gyógyászakjsg gjfogááfeaté §6JSk ít&amp;'Jy- képlet ü.
  18. 38, Qyogyás zat! készítmény, .mély agy í>3 ?. igénypontok: tkSMeiyiks szét iittt vagy 8 let®?· vagy tat»? mely gvógyaszaíHag eltögadimó sóját tartalma/.
  19. 39, Az 1-38. igénypontok bármelyike szerinti vegyük? vagy gyógyászati készítmény gyógyszerkén? történő alkalmazásra. 4;ü, Ml*M, igéítypontökbármelyiik« sMdstk veipiéí vagy :gyégyásmtt*80* '«-iaftÿto· FkMz akt! vitassál ősszstngg® *ák 'fcezetéséfeën Ätiß&amp; alkalmazásra.
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