HRP20171924T1 - 6-o-supstituirani spojevi benzoksazola i benzotiazola te postupci inhibiranja signalizacije csf-1r - Google Patents
6-o-supstituirani spojevi benzoksazola i benzotiazola te postupci inhibiranja signalizacije csf-1r Download PDFInfo
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- HRP20171924T1 HRP20171924T1 HRP20171924TT HRP20171924T HRP20171924T1 HR P20171924 T1 HRP20171924 T1 HR P20171924T1 HR P20171924T T HRP20171924T T HR P20171924TT HR P20171924 T HRP20171924 T HR P20171924T HR P20171924 T1 HRP20171924 T1 HR P20171924T1
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- pharmaceutically acceptable
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- BCMCBBGGLRIHSE-UHFFFAOYSA-N 1,3-benzoxazole Chemical class C1=CC=C2OC=NC2=C1 BCMCBBGGLRIHSE-UHFFFAOYSA-N 0.000 title 1
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical class C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 230000011664 signaling Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 12
- 239000012453 solvate Substances 0.000 claims 12
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 206010005949 Bone cancer Diseases 0.000 claims 2
- 208000018084 Bone neoplasm Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims 2
- 206010014733 Endometrial cancer Diseases 0.000 claims 2
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 208000034578 Multiple myelomas Diseases 0.000 claims 2
- 208000001132 Osteoporosis Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 2
- 206010003246 arthritis Diseases 0.000 claims 2
- 201000010881 cervical cancer Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 2
- 208000014018 liver neoplasm Diseases 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 208000025113 myeloid leukemia Diseases 0.000 claims 2
- 208000003476 primary myelofibrosis Diseases 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 1
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
- 229940121369 angiogenesis inhibitor Drugs 0.000 claims 1
- 230000001028 anti-proliverative effect Effects 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 230000012820 cell cycle checkpoint Effects 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 239000000824 cytostatic agent Substances 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000002834 estrogen receptor modulator Substances 0.000 claims 1
- 239000004030 hiv protease inhibitor Substances 0.000 claims 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 102000027483 retinoid hormone receptors Human genes 0.000 claims 1
- 108091008679 retinoid hormone receptors Proteins 0.000 claims 1
- 239000003419 rna directed dna polymerase inhibitor Substances 0.000 claims 1
- 239000000849 selective androgen receptor modulator Substances 0.000 claims 1
- 230000007755 survival signaling Effects 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 239000003558 transferase inhibitor Substances 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Claims (12)
1. Spoj, naznačen time, da je odabran iz skupine koja se sastoji od sljedećih:
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ili njihov stereoizomer, tautomer, solvat, ili oksid, ili njihova farmaceutski prihvatljiva sol.
2. Spoj prema zahtjevu 1, naznačen time, da je to:
[image]
ili njegov solvat, oksid, ili njegova farmaceutski prihvatljiva sol.
3. Spoj prema zahtjevu 1, naznačen time, da je to:
[image]
ili njegov solvat, oksid, ili njegova farmaceutski prihvatljiva sol.
4. Spoj prema zahtjevu 1, naznačen time, da je to:
[image]
ili njegov solvat, oksid, ili njegova farmaceutski prihvatljiva sol.
5. Farmaceutski sastav, naznačen time, da obuhvaća spoj, njegov stereoizomer, tautomer, solvat ili oksid, ili njegovu farmaceutski prihvatljivu sol u skladu s bilo kojim od zahtjeva 1 do 4, zajedno s farmaceutski prihvatljivim nosačima.
6. Uporaba spoja, njegovog stereoizomera, tautomera, solvata ili oksida, ili njegove farmaceutski prihvatljive soli, u skladu s bilo kojim od zahtjeva 1 do 4, naznačena time, da je za proizvodnju lijeka za liječenje raka, osteoporoze, artritisa, ateroskleroze, mijelocitne leukemije, idiopatske mijelofibroze, raka dojke, raka cerviksa, raka jajnika, endometrijskog raka, raka prostate, hepatocelularnog raka, višestrukog mijeloma, raka pluća, raka kostiju, te reumatoidnog artritisa.
7. Spoj, njegov stereoizomer, tautomer, solvat ili oksid, ili njegova farmaceutski prihvatljiva sol, u skladu s bilo kojim od zahtjeva 1 do 4, naznačen/a time, da se daje pojedincu u djelotvornoj količini za smanjivanje ili sprečavanje rasta tumora, u kombinaciji s najmanje jednim dodatnim sredstvom za liječenje raka.
8. Spoj, njegov stereoizomer, tautomer, solvat ili oksid, ili njegova farmaceutski prihvatljiva sol, prema zahtjevu 7, naznačen/a time, da je dodatno sredstvo za liječenje raka odabrano od sljedećih: modulatori receptora estrogena, modulatori receptora androgena, modulatori receptora retinoida, citotoksična/citostatična sredstva, antiproliferativna sredstva, inhibitori transferaze prenilproteina, inhibitori reduktaze HMG-CoA i ostali inhibitori angiogeneze, inhibitori stanične proliferacije i signalizacije preživljavanja, sredstva za izazivanje apoptoze i sredstva koja interferiraju s kontrolnim točkama staničnog ciklusa, inhibitori proteaze HIV-a i inhibitori reverzibilne transkriptaze.
9. Spoj prema bilo kojem od zahtjeva 1 do 4, ili njegov stereoizomer, tautomer, solvat ili oksid, ili njegova farmaceutski prihvatljiva sol, naznačen/a time, da se upotrebljava u liječenju raka, osteoporoze, artritisa, ateroskleroze, mijelocitne leukemije, idiopatske mijelofibroze, raka dojke, raka cerviksa, raka jajnika, endometrijskog raka, raka prostate, hepatocelularnog raka, višestrukog mijeloma, raka pluća, raka kostiju, te reumatoidnog artritisa.
10. Spoj prema bilo kojem od zahtjeva 1 do 4, ili njegov stereoizomer, tautomer, solvat ili oksid, ili njegova farmaceutski prihvatljiva sol, naznačen/a time, da se upotrebljava u zajedničkoj primjeni s radijacijskom terapijom.
11. Kombinacija, naznačena time, da obuhvaća spoj, njegov stereoizomer, tautomer, solvat ili oksid, ili njegovu farmaceutski prihvatljivu sol, u skladu s bilo kojim od zahtjeva 1 do 4, te jedno ili više sredstava koja se upotrebljavaju u liječenju raka.
12. Spoj, njegov stereoizomer, tautomer, solvat ili oksid, ili njegova farmaceutski prihvatljiva sol, u skladu s bilo kojim od zahtjeva 1 do 4, te najmanje jedno dodatno terapeutsko sredstvo, naznačen/a/o time, da se upotrebljava u liječenju raka.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79351706P | 2006-04-19 | 2006-04-19 | |
US89385707P | 2007-03-08 | 2007-03-08 | |
PCT/US2007/066898 WO2007121484A2 (en) | 2006-04-19 | 2007-04-18 | 6-o-substituted benzoxazole and benzothiazole compounds and methods of inhibiting csf-1r signaling |
EP07797244.6A EP2010528B1 (en) | 2006-04-19 | 2007-04-18 | 6-o-substituted benzoxazole and benzothiazole compounds and methods of inhibiting csf-1r signaling |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20171924T1 true HRP20171924T1 (hr) | 2018-02-09 |
Family
ID=38610468
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20171924TT HRP20171924T1 (hr) | 2006-04-19 | 2017-12-12 | 6-o-supstituirani spojevi benzoksazola i benzotiazola te postupci inhibiranja signalizacije csf-1r |
Country Status (30)
Country | Link |
---|---|
US (3) | US7553854B2 (hr) |
EP (1) | EP2010528B1 (hr) |
JP (1) | JP5328640B2 (hr) |
KR (1) | KR101464385B1 (hr) |
AR (1) | AR060545A1 (hr) |
AU (1) | AU2007237904B2 (hr) |
BR (1) | BRPI0710540B1 (hr) |
CA (1) | CA2649288C (hr) |
CR (1) | CR10365A (hr) |
CY (1) | CY1119679T1 (hr) |
DK (1) | DK2010528T3 (hr) |
EA (1) | EA018917B1 (hr) |
EC (1) | ECSP088830A (hr) |
ES (1) | ES2654847T3 (hr) |
HR (1) | HRP20171924T1 (hr) |
HU (1) | HUE035654T2 (hr) |
IL (1) | IL194662A0 (hr) |
LT (1) | LT2010528T (hr) |
MA (1) | MA30407B1 (hr) |
MX (1) | MX2008013427A (hr) |
NO (1) | NO20084800L (hr) |
PE (1) | PE20080359A1 (hr) |
PL (1) | PL2010528T3 (hr) |
PT (1) | PT2010528T (hr) |
RS (1) | RS56600B1 (hr) |
SI (1) | SI2010528T1 (hr) |
SM (1) | SMP200800063B (hr) |
TN (1) | TNSN08406A1 (hr) |
TW (1) | TW200813039A (hr) |
WO (1) | WO2007121484A2 (hr) |
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