MX2014000130A - Procedimientos y composiciones para la inhibicion de resorcion osea. - Google Patents

Procedimientos y composiciones para la inhibicion de resorcion osea.

Info

Publication number
MX2014000130A
MX2014000130A MX2014000130A MX2014000130A MX2014000130A MX 2014000130 A MX2014000130 A MX 2014000130A MX 2014000130 A MX2014000130 A MX 2014000130A MX 2014000130 A MX2014000130 A MX 2014000130A MX 2014000130 A MX2014000130 A MX 2014000130A
Authority
MX
Mexico
Prior art keywords
methods
inhibition
compounds
disclosed
btk
Prior art date
Application number
MX2014000130A
Other languages
English (en)
Inventor
Joseph J Buggy
Betty Y Chang
Original Assignee
Pharmacyclics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacyclics Inc filed Critical Pharmacyclics Inc
Publication of MX2014000130A publication Critical patent/MX2014000130A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0031—Rectum, anus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

En el presente documento se desvelan procedimientos y compuestos para inhibir resorción ósea y/o de cartílago en un individuo. Los procedimientos comprenden administrar al individuo una composición que comprende una cantidad terapéuticamente eficaz de un compuesto que es un inhibidor irreversible de una tirosina cinasa de Bruton (BTK), o una sal farmacéuticamente aceptable de la misma. También se describen inhibidores irreversibles de Btk y procedimientos para la preparación de los compuestos. También se desvelan composiciones farmacéuticas que incluyen los compuestos. Procedimientos de uso de los inhibidores de Btk se desvelan, solos o en combinación con otros agentes terapéuticos, para la inhibición de metástasis de cáncer, y para inhibición de la resorción ósea o de cartílago en pacientes con cáncer.
MX2014000130A 2011-06-28 2012-06-28 Procedimientos y composiciones para la inhibicion de resorcion osea. MX2014000130A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161502271P 2011-06-28 2011-06-28
PCT/US2012/044708 WO2013003629A2 (en) 2011-06-28 2012-06-28 Methods and compositions for inhibition of bone resorption

Publications (1)

Publication Number Publication Date
MX2014000130A true MX2014000130A (es) 2014-05-01

Family

ID=47424803

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014000130A MX2014000130A (es) 2011-06-28 2012-06-28 Procedimientos y composiciones para la inhibicion de resorcion osea.

Country Status (7)

Country Link
US (1) US20130178483A1 (es)
EP (1) EP2726077A4 (es)
AU (1) AU2012275275A1 (es)
BR (1) BR112013033534A2 (es)
CA (1) CA2840413A1 (es)
MX (1) MX2014000130A (es)
WO (1) WO2013003629A2 (es)

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US8957080B2 (en) 2013-04-09 2015-02-17 Principia Biopharma Inc. Tyrosine kinase inhibitors
WO2014187319A1 (en) 2013-05-21 2014-11-27 Jiangsu Medolution Ltd Substituted pyrazolopyrimidines as kinases inhibitors
JP6800750B2 (ja) * 2013-08-02 2020-12-16 ファーマサイクリックス エルエルシー 固形腫瘍の処置方法
BR112016006978A2 (pt) 2013-09-30 2017-08-01 Pharmacyclics Llc inibidores de tirosina quinase de bruton
EP3060218A4 (en) 2013-10-25 2017-07-19 Pharmacyclics LLC Methods of treating and preventing graft versus host disease
US20150141438A1 (en) * 2013-11-15 2015-05-21 Pharmacyclics, Inc. Methods for delaying or preventing the onset of type 1 diabetes
CN103626774B (zh) * 2013-11-20 2015-11-04 苏州明锐医药科技有限公司 伊鲁替尼的制备方法
US9512084B2 (en) 2013-11-29 2016-12-06 Novartis Ag Amino pyrimidine derivatives
WO2015083008A1 (en) 2013-12-05 2015-06-11 Acerta Pharma B.V. Therapeutic combination of a pi3k inhibitor and a btk inhibitor
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CN105481862B (zh) * 2015-01-21 2018-08-21 中国科学院合肥物质科学研究院 Flt3激酶的新型抑制剂及其用途
CN104557946A (zh) * 2015-02-04 2015-04-29 王立强 一种依鲁替尼的制备方法
CN106188062A (zh) * 2015-05-08 2016-12-07 苏州鹏旭医药科技有限公司 依鲁替尼的制备方法、依鲁替尼的中间体及中间体的制备方法
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CN106083860A (zh) * 2016-06-23 2016-11-09 艾美科健（中国）生物医药有限公司 一种依鲁替尼中间体的合成与纯化工艺
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Also Published As

Publication number Publication date
CA2840413A1 (en) 2013-01-03
AU2012275275A1 (en) 2014-01-23
WO2013003629A3 (en) 2013-04-11
EP2726077A2 (en) 2014-05-07
WO2013003629A2 (en) 2013-01-03
EP2726077A4 (en) 2014-12-10
BR112013033534A2 (pt) 2017-02-07
US20130178483A1 (en) 2013-07-11

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