HRP20041150B1 - Method for the inhibition of atrophy or for treatment or prevention of atrophy-related symptoms in women - Google Patents

Method for the inhibition of atrophy or for treatment or prevention of atrophy-related symptoms in women

Info

Publication number: HRP20041150B1
Authority: HR; Croatia
Prior art keywords: toremifene; tore; urgency; atrophy; urinary
Prior art date: 2002-06-06

Application number

HR20041150A

Other languages

English (en)

Croatian (hr)

Inventor

Blom Taru

Gr�nroos Paula

Halonen Kaija

H�rk�nen Pirkko

Original Assignee

Hormos Medical Corporation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-06-06

Filing date

2004-12-02

Publication date

2007-06-30

2004-12-02 Application filed by Hormos Medical Corporation filed Critical Hormos Medical Corporation

2006-03-31 Publication of HRP20041150A2 publication Critical patent/HRP20041150A2/xx

2007-06-30 Publication of HRP20041150B1 publication Critical patent/HRP20041150B1/xx

Links

208000024891 symptom Diseases 0.000 title abstract 3
206010003694 Atrophy Diseases 0.000 title 2
230000037444 atrophy Effects 0.000 title 2
230000005764 inhibitory process Effects 0.000 title 1
230000002265 prevention Effects 0.000 title 1
XFCLJVABOIYOMF-QPLCGJKRSA-N toremifene Chemical compound C1=CC(OCCN(C)C)=CC=C1C(\C=1C=CC=CC=1)=C(\CCCl)C1=CC=CC=C1 XFCLJVABOIYOMF-QPLCGJKRSA-N 0.000 abstract 4
229960005026 toremifene Drugs 0.000 abstract 4
208000003251 Pruritus Diseases 0.000 abstract 2
206010046543 Urinary incontinence Diseases 0.000 abstract 2
206010071018 Urogenital atrophy Diseases 0.000 abstract 2
206010011985 Decubitus ulcer Diseases 0.000 abstract 1
208000032843 Hemorrhage Diseases 0.000 abstract 1
206010021639 Incontinence Diseases 0.000 abstract 1
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
208000004210 Pressure Ulcer Diseases 0.000 abstract 1
206010064921 Urinary tract inflammation Diseases 0.000 abstract 1
208000034158 bleeding Diseases 0.000 abstract 1
230000000740 bleeding effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
208000028659 discharge Diseases 0.000 abstract 1
206010013990 dysuria Diseases 0.000 abstract 1
208000006750 hematuria Diseases 0.000 abstract 1
208000015181 infectious disease Diseases 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
230000007794 irritation Effects 0.000 abstract 1
230000007803 itching Effects 0.000 abstract 1
201000005630 leukorrhea Diseases 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000002207 metabolite Substances 0.000 abstract 1
230000027939 micturition Effects 0.000 abstract 1
206010029446 nocturia Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000001568 sexual effect Effects 0.000 abstract 1
230000002485 urinary effect Effects 0.000 abstract 1
208000019206 urinary tract infection Diseases 0.000 abstract 1
206010046901 vaginal discharge Diseases 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Gynecology & Obstetrics (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Orthopedics, Nursing, And Contraception (AREA)
Medicinal Preparation (AREA)

HR20041150A 2002-06-06 2004-12-02 Method for the inhibition of atrophy or for treatment or prevention of atrophy-related symptoms in women HRP20041150B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US38590402P	2002-06-06	2002-06-06
PCT/FI2003/000369 WO2003103649A1 (en)	2002-06-06	2003-05-14	Method for the inhibition of atrophy or for treatment or prevention of atrophy-related symptoms in women

Publications (2)

Publication Number	Publication Date
HRP20041150A2 HRP20041150A2 (en)	2006-03-31
HRP20041150B1 true HRP20041150B1 (en)	2007-06-30

Family

ID=29736123

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20041150A HRP20041150B1 (en)	2002-06-06	2004-12-02	Method for the inhibition of atrophy or for treatment or prevention of atrophy-related symptoms in women

Country Status (24)

Country	Link
EP (1)	EP1509215B1 (zh)
JP (1)	JP4362442B2 (zh)
KR (1)	KR100991157B1 (zh)
CN (2)	CN101406464A (zh)
AT (1)	ATE344025T1 (zh)
AU (1)	AU2003227790B2 (zh)
BR (1)	BR0311613A (zh)
CA (1)	CA2484542C (zh)
CY (1)	CY1105787T1 (zh)
DE (1)	DE60309465T2 (zh)
DK (1)	DK1509215T3 (zh)
ES (1)	ES2270025T3 (zh)
HR (1)	HRP20041150B1 (zh)
IL (1)	IL164528A (zh)
MX (1)	MXPA04012220A (zh)
NO (3)	NO334090B1 (zh)
NZ (1)	NZ536118A (zh)
PL (1)	PL214242B1 (zh)
PT (1)	PT1509215E (zh)
RU (1)	RU2317816C2 (zh)
SI (1)	SI1509215T1 (zh)
UA (1)	UA79797C2 (zh)
WO (1)	WO2003103649A1 (zh)
ZA (1)	ZA200408321B (zh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8236861B2 (en) *	2004-02-13	2012-08-07	Hormos Medical Corporation	Method for enhancing the bioavailablity of ospemifene
US8642079B2 (en)	2004-02-23	2014-02-04	Hormos Medical Corporation	Solid formulations of ospemifene
CN1950071A (zh)	2004-05-04	2007-04-18	霍尔莫斯医疗有限公司	ospemifene的新口服制剂
US8758821B2 (en)	2004-05-04	2014-06-24	Hormos Medical Ltd.	Oral formulations of ospemifene
JP5193196B2 (ja)	2006-06-02	2013-05-08	ペアツリーウーマンズヘルスケア	萎縮性膣炎の治療の方法
SI2121553T1 (sl)	2007-02-14	2012-11-30	Hormos Medical Ltd	Postopek za pripravo terapevtsko uporabnih trifenilbutenskih derivatov
WO2008099060A2 (en)	2007-02-14	2008-08-21	Hormos Medical Ltd	Methods for the preparation of fispemifene from ospemifene
US9321712B2 (en)	2012-10-19	2016-04-26	Fermion Oy	Process for the preparation of ospemifene
KR102052133B1 (ko)	2017-08-10	2019-12-05	고려대학교 산학협력단	당 부가된 오스페미펜, 이의 제조방법 및 이를 유효성분으로 함유하는 약학적 조성물

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5352699A (en) *	1992-04-30	1994-10-04	University Of Massachusetts Medical Center	Use of retinioc acid to treat vaginal atrophy
US5461064A (en) *	1993-12-21	1995-10-24	Eli Lilly And Company	Methods of inhibiting atrophy of the skin and vagina
US5747059A (en) *	1996-01-11	1998-05-05	Novo Nordisk A/S	Atrophy of skin/mucous membrane
RU2342145C2 (ru) *	2000-01-28	2008-12-27	Андорешерш, Инк.	Селективные модуляторы рецептора эстрогена в комбинации с эстрогенами
US20010034340A1 (en) *	2000-03-20	2001-10-25	American Home Products Corporation	Hormone replacement therapy
US6245819B1 (en) *	2000-07-21	2001-06-12	Hormos Medical Oy, Ltd.	Method for the treatment of vaginal dryness and sexual dysfunction in women during or after the menopause

2003
- 2003-05-14 CA CA2484542A patent/CA2484542C/en not_active Expired - Lifetime
- 2003-05-14 UA UAA200500144A patent/UA79797C2/uk unknown
- 2003-05-14 PL PL372758A patent/PL214242B1/pl unknown
- 2003-05-14 EP EP03725238A patent/EP1509215B1/en not_active Expired - Lifetime
- 2003-05-14 DK DK03725238T patent/DK1509215T3/da active
- 2003-05-14 NZ NZ536118A patent/NZ536118A/en not_active IP Right Cessation
- 2003-05-14 SI SI200330601T patent/SI1509215T1/sl unknown
- 2003-05-14 DE DE60309465T patent/DE60309465T2/de not_active Expired - Lifetime
- 2003-05-14 WO PCT/FI2003/000369 patent/WO2003103649A1/en active IP Right Grant
- 2003-05-14 PT PT03725238T patent/PT1509215E/pt unknown
- 2003-05-14 AU AU2003227790A patent/AU2003227790B2/en not_active Expired
- 2003-05-14 CN CNA2008101733358A patent/CN101406464A/zh active Pending
- 2003-05-14 MX MXPA04012220A patent/MXPA04012220A/es active IP Right Grant
- 2003-05-14 ES ES03725238T patent/ES2270025T3/es not_active Expired - Lifetime
- 2003-05-14 AT AT03725238T patent/ATE344025T1/de active
- 2003-05-14 RU RU2004138571/14A patent/RU2317816C2/ru active
- 2003-05-14 BR BR0311613-1A patent/BR0311613A/pt not_active Application Discontinuation
- 2003-05-14 KR KR1020047019843A patent/KR100991157B1/ko active IP Right Grant
- 2003-05-14 CN CNB038128780A patent/CN100448437C/zh not_active Expired - Lifetime
- 2003-05-14 JP JP2004510768A patent/JP4362442B2/ja not_active Expired - Lifetime
2004
- 2004-10-12 IL IL164528A patent/IL164528A/en active IP Right Grant
- 2004-10-14 ZA ZA200408321A patent/ZA200408321B/en unknown
- 2004-10-22 NO NO20044568A patent/NO334090B1/no not_active IP Right Cessation
- 2004-12-02 HR HR20041150A patent/HRP20041150B1/xx not_active IP Right Cessation
2006
- 2006-11-15 CY CY20061101664T patent/CY1105787T1/el unknown
2013
- 2013-09-04 NO NO20131189A patent/NO336612B1/no not_active IP Right Cessation
2015
- 2015-04-22 NO NO20150487A patent/NO339194B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
IL164528A (en)	2010-06-30
RU2317816C2 (ru)	2008-02-27
CN100448437C (zh)	2009-01-07
NO336612B1 (no)	2015-10-12
HRP20041150A2 (en)	2006-03-31
AU2003227790B2 (en)	2007-11-29
BR0311613A (pt)	2005-03-08
RU2004138571A (ru)	2005-06-10
KR20050004292A (ko)	2005-01-12
DE60309465T2 (de)	2007-08-30
JP2005532353A (ja)	2005-10-27
MXPA04012220A (es)	2005-04-08
ZA200408321B (en)	2006-07-26
PL214242B1 (pl)	2013-07-31
CN1658851A (zh)	2005-08-24
NZ536118A (en)	2007-08-31
CA2484542C (en)	2010-11-02
WO2003103649A1 (en)	2003-12-18
KR100991157B1 (ko)	2010-11-02
JP4362442B2 (ja)	2009-11-11
CN101406464A (zh)	2009-04-15
NO339194B1 (no)	2016-11-14
AU2003227790A1 (en)	2003-12-22
NO20044568L (no)	2004-12-22
CY1105787T1 (el)	2011-02-02
EP1509215A1 (en)	2005-03-02
IL164528A0 (en)	2005-12-18
EP1509215B1 (en)	2006-11-02
CA2484542A1 (en)	2003-12-18
DE60309465D1 (de)	2006-12-14
ATE344025T1 (de)	2006-11-15
NO20150487L (no)	2004-12-22
SI1509215T1 (sl)	2007-02-28
NO20131189L (no)	2004-12-22
DK1509215T3 (da)	2007-03-12
NO334090B1 (no)	2013-12-09
PL372758A1 (en)	2005-08-08
UA79797C2 (en)	2007-07-25
ES2270025T3 (es)	2007-04-01
PT1509215E (pt)	2007-01-31

Legal Events

Date	Code	Title	Description
2006-03-31	A1OB	Publication of a patent application
2006-09-27	ARAI	Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
2007-06-30	B1PR	Patent granted
2019-05-31	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20190507 Year of fee payment: 17
2020-05-29	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20200505 Year of fee payment: 18
2021-05-28	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20210505 Year of fee payment: 19
2022-06-24	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20220506 Year of fee payment: 20
2023-05-15	PB20	Patent expired after termination of 20 years	Effective date: 20230514

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