CO5660084A1 - Nuevos derivados de fenilheteroalquilamina, proceso para su prepraracion, composiciones farmaceuticas que comprenden dichos derivados novedosos y su uso en terapia - Google Patents

Nuevos derivados de fenilheteroalquilamina, proceso para su prepraracion, composiciones farmaceuticas que comprenden dichos derivados novedosos y su uso en terapia

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Publication number
CO5660084A1
CO5660084A1 CO01013435A CO01013435A CO5660084A1 CO 5660084 A1 CO5660084 A1 CO 5660084A1 CO 01013435 A CO01013435 A CO 01013435A CO 01013435 A CO01013435 A CO 01013435A CO 5660084 A1 CO5660084 A1 CO 5660084A1
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Colombia
Prior art keywords
therapy
new
sup
preparation
phenylhetero
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CO01013435A
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English (en)
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David Cheshire
Stephen Connolly
Ian David Millichip
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Astrazeneca Ab
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Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CO5660084A1 publication Critical patent/CO5660084A1/es

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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
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Abstract

El uso de un compuesto de la fórmula (I)<EMI FILE="01013435_1" ID="1" IMF=JPEG HE=50 WI=50 >En donde: X y Y independientemente representan alquil C1 a 4, alcoxi C1 a 4, halógeno, CF3, OCF3, CN, C=CH, S(O)mCH3, S(O)pCF3, NO2 o NHCHO,m y p independientemente representan un entero 0, 1 o 2;Z representa H o fluoro;V representa O, S(O)n o NR3; o W representa fenil o un anillo heterociclico aromático de cinco o seis miembros que contiene 1 a 3 heterátomos independientemente seleccionados entre O, S y N; dicho fenil o anillo heterocíclico aromático siendo opcionalmente substituido por uno o más substituyentes seleccionados independientemente entre halógeno, alquil C1 a 4, alcoxi C1 a 4, OH, CN, NO2 o NR4R5; dicho grupo alquil o alcoxi siendo además opcionalmente substituido por uno o más átomos de flúor; R1 y R2 independientemente representan H, alquil C1 a 4 o cicloalquil C3 a 6; dicho grupo alquil siendo opcionalmente substituido por alcoxi C1 a 4, halógeno, hidroxi, NR6R7, fenil o un anillo heterocíclico saturado o aromático de cinco o seis miembros que contiene 1 a 3 heteroátomos independientemente seleccionados entre O, S y N; dicho fenil o anillo heterocíclico aromático siendo además opcionalmente substituido por halógeno, alquil C1 a 4, alcoxi C1 a 4, CF3, OCF3, CN o NO2;o el grupo NR1R2 junto representa un anillo azacíclico saturado de 4 a 8 miembros que incorpora opcionalmente un heteroátomo adicional seleccionado entre O, S o NR8; dicho anillo siendo opcionalmente substituido por alquil C1 a 4, alcoxi C1 a 4 o OH; dicho grupo alquil siendo opcionalmente substituido por alcoxi C1 a 4, OH o NR9R10; R3 representa H o alquil C1 a 4;R4, R5, R6, R7, R9 y R10 independiente representan H o alquil C1 a 4;R8 representa H o alquil C1 a 6; dicho grupo alquil siendo opcionalmente substituido por alcoxi C1 a 4, OH, NR11R12, fenil o un anillo heterocíclico saturado o aromático de cinco o seis miembros que contiene 1 a 3 heteroátomos independientemente seleccionados entre O, S y N; dicho fenil o anillo heterocíclico aromático siendo además opcionalmente substituido por halógeno, alquil C1 a 4, alcoxi C1 a 4, CF3, OCF3, CN o NO2; ...
CO01013435A 2000-02-23 2001-02-20 Nuevos derivados de fenilheteroalquilamina, proceso para su prepraracion, composiciones farmaceuticas que comprenden dichos derivados novedosos y su uso en terapia CO5660084A1 (es)

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CO5660084A1 true CO5660084A1 (es) 2006-07-31

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US (1) US6953797B2 (es)
EP (1) EP1263718B1 (es)
JP (1) JP2003523995A (es)
KR (1) KR100721087B1 (es)
CN (1) CN1210270C (es)
AT (1) ATE265428T1 (es)
AU (1) AU780781B2 (es)
BR (1) BR0108539A (es)
CA (1) CA2396960A1 (es)
CO (1) CO5660084A1 (es)
DE (1) DE60103035T2 (es)
GB (1) GB0004151D0 (es)
IL (1) IL150640A0 (es)
MX (1) MXPA02008204A (es)
NO (1) NO20024013L (es)
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GB0004152D0 (en) 2000-02-23 2000-04-12 Astrazeneca Uk Ltd Novel compounds
AR035700A1 (es) * 2001-05-08 2004-06-23 Astrazeneca Ab Derivados de arilheteroalquilamina, composicion farmaceutica, usos de estos derivados para la fabricacion de medicamentos, metodos de tratamiento, y proceso para la preparacion de estos derivados
WO2002100848A1 (en) * 2001-06-12 2002-12-19 Sk Corporation Novel phenylalkyl diamine and amide analogs
SE0102640D0 (sv) 2001-07-31 2001-07-31 Astrazeneca Ab Novel compounds
SE0203304D0 (sv) * 2002-11-07 2002-11-07 Astrazeneca Ab Novel Coumpounds

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US466910A (en) * 1892-01-12 Machine for covering wire
GB765849A (en) 1953-09-21 1957-01-16 Univ Leeds Improvements in or relating to new aminoalkyl phenyl ethers
GB922600A (en) 1960-05-06 1963-04-03 Crookes Lab Ltd Ortho-tertiary-butyl phenolethers
US3205136A (en) 1962-12-24 1965-09-07 Smith Kline French Lab Antidepressant phenyloxyalkylamines
JPS52941B1 (es) * 1969-12-09 1977-01-11
JPS5144934B1 (es) * 1969-12-09 1976-12-01
US4314081A (en) 1974-01-10 1982-02-02 Eli Lilly And Company Arloxyphenylpropylamines
JPS52941A (en) 1975-06-24 1977-01-06 Hitachi Chem Co Ltd Polyurethane insulating coating composition
FR2432500A1 (fr) 1978-02-24 1980-02-29 Roussel Uclaf Nouveaux derives de la benzene propanamine et leurs sels, procede de preparation et application a titre de medicaments
GB2060621A (en) 1979-09-14 1981-05-07 Wyeth John & Brother Ltd 3-Aryl-3-aryloxypropylamines
GB2060622B (en) 1979-09-14 1983-05-25 Wyeth John & Brother Ltd 3-aryl-3-aryloxyalkylamines
GB2060620B (en) 1979-09-14 1983-05-25 Wyeth John & Brother Ltd 3-aryl-3-aryloxypropylamines
DE3138550A1 (de) 1981-09-28 1983-04-07 Boehringer Ingelheim KG, 6507 Ingelheim Substituierte 2-phenyl-2-(pyridyloxy)-ethylamine und isostere verbindungen, verfahren zu ihrer herstellung und verwendung
KR880007433A (ko) 1986-12-22 1988-08-27 메리 앤 터커 3-아릴옥시-3-치환된 프로판아민
DK630987D0 (da) 1987-12-01 1987-12-01 Ferrosan As Aryloxyphenylpropylaminer, deres fremstilling og anvendelse
US4902710A (en) * 1988-12-14 1990-02-20 Eli Lilly And Company Serotonin and norepinephrine uptake inhibitors
DK258389D0 (da) 1989-05-26 1989-05-26 Ferrosan As Aryloxyphenylpropylaminer, deres fremstilling og anvendelse
US5320825A (en) 1991-05-01 1994-06-14 Trustees Of The University Of Pennsylvania Serotonin reuptake inhibitors for S.P.E.C.T. imaging
FR2676054B1 (fr) 1991-05-03 1993-09-03 Sanofi Elf Nouveaux composes n-alkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
EP0571685A1 (en) 1992-05-27 1993-12-01 Novo Nordisk A/S Aryloxyheteroarylpropylamines, their preparation and use
EP0576766A1 (en) 1992-06-29 1994-01-05 Novo Nordisk A/S Propanolamine derivatives, their preparation and use
EP0661266A1 (en) 1993-12-27 1995-07-05 Toa Eiyo Ltd. Substituted cyclic amine compounds as 5HT2 antagonists
PT707007E (pt) 1994-10-14 2002-06-28 Merck Patent Gmbh Derivados amino(tio)eter como agentes activos no snc
HN1998000118A (es) 1997-08-27 1999-02-09 Pfizer Prod Inc 2 - aminopiridinas que contienen sustituyentes de anillos condensados.
HN1998000125A (es) * 1997-08-28 1999-02-09 Pfizer Prod Inc 2-aminopiridinas con sustituyentes alcoxi ramificados
CA2319781A1 (en) 1998-02-02 1999-08-05 Liping Wang Cyclic amine modulators of chemokine receptor activity
CN1303379A (zh) 1998-06-03 2001-07-11 辉瑞产品公司 作为氧化氮合酶抑制剂的含稠环取代基的2－氨基吡啶
SE9803773D0 (sv) 1998-11-05 1998-11-05 Astra Pharma Prod Compounds
KR20010108394A (ko) 1999-03-26 2001-12-07 다비드 에 질레스 신규 화합물
GB0004149D0 (en) 2000-02-23 2000-04-12 Astrazeneca Uk Ltd Novel compounds
GB0021670D0 (en) 2000-09-04 2000-10-18 Astrazeneca Ab Chemical compounds
WO2002030899A1 (en) 2000-10-09 2002-04-18 Novartis Ag N-(4-aryloxypiperidin-1-ylalkyl) cinnamic amides as ccr3 receptor antagonists
AU2002366210A1 (en) * 2001-11-21 2003-06-10 Danmarks Farmaceutiske Hojskole Use of glycosides of mono- and diacylglycerol as anti-inflammatory agents

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MXPA02008204A (es) 2002-11-29
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GB0004151D0 (en) 2000-04-12
CA2396960A1 (en) 2001-08-30
AU780781B2 (en) 2005-04-14
WO2001062721A1 (en) 2001-08-30
DE60103035T2 (de) 2005-03-24
BR0108539A (pt) 2002-10-22
ATE265428T1 (de) 2004-05-15
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US20030073685A1 (en) 2003-04-17
ZA200205801B (en) 2003-10-20

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