KR20050004292A - 여성의 위축 억제 또는 위축관련 증상 치료 또는 예방 방법 - Google Patents
여성의 위축 억제 또는 위축관련 증상 치료 또는 예방 방법 Download PDFInfo
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- KR20050004292A KR20050004292A KR10-2004-7019843A KR20047019843A KR20050004292A KR 20050004292 A KR20050004292 A KR 20050004292A KR 20047019843 A KR20047019843 A KR 20047019843A KR 20050004292 A KR20050004292 A KR 20050004292A
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- atrophy
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Gynecology & Obstetrics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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- Orthopedics, Nursing, And Contraception (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
화합물 및 약량 | MI 1 평균 | MI 1 Sd | MI 3 평균 | MI 3 Sd |
오스페미핀,30 mg,(n=21) | -40 | 42 | +12.4 | 13.6 |
오스페미핀,60 mg,(n=20) | -26 | 39 | +5.5 | 13.4 |
오스페미핀,90 mg,(n=22) | -48 | 44 | +12.5 | 14.0 |
라록시펜,60 mg,(n=19) | -2 | 34 | -0.3 | 4.1 |
Claims (22)
- 여성의 피부 위축, 또는 상피 또는 점막 위축 억제 방법에 있어서, 여성에게 효과적인 양의 식(I)(I)화합물, 이들의 기하학적 이성질체, 입체 이성질체, 약물학적으로 수용가능한 염, 에스테르 또는 이들의 대사물질을 투여하는 것을 포함하는 방법.
- 제 1 항에 있어서, 화합물(I)이 오스페미핀인 방법.
- 제 1 항 또는 제 2 항에 있어서, 위축이 비뇨생식기 위축인 방법.
- 여성의 피부 위축, 또는 상피 또는 점막 위축에 관련된 증상을 치료 또는 억제하는 방법에 있어서, 여성에게 효과적인 양의 식(I)(I)화합물, 이들의 기하학적 이성질체, 입체 이성질체, 약물학적으로 수용가능한 염, 에스테르 또는 이들의 대사물질을 투여하는 것을 포함하는 방법.
- 제 4 항에 있어서, 화합물(I)이 오스페미핀인 방법.
- 제 1 항에 있어서, 위축이 비뇨생식기계 위축인 방법.
- 제 6 항에 있어서, 증상이 비뇨기계 증상인 방법.
- 제 7 항에 있어서, 상기 비뇨기 증상은 믹튜레이션(micturation) 질병, 배뇨곤란, 혈뇨, 잦은 오줌, 긴급 인식(sensation of urgency), 요로감염, 요로염증, 야뇨증, 요실금, 절박성 요실금, 및 비자발성 배뇨인 방법.
- 제 6 항에 있어서, 상기 증상은 질 증상인 방법.
- 제 9 항에 있어서, 상기 질 증상은 따가움, 가려움, 달아오름, 말라도로스 배출(maladorous discharge), 감염, 백대하, 외음소양증, 압력 감지, 및 성교후 출혈인 방법.
- 제 1 항 또는 제 4 항에 있어서, 화합물(I), 그 이성질체, 염, 또는 에스테르가 경구적으로, 경피적으로, 도포적으로, 질내로 또는 피하적으로 투여되는 방법.
- 여성의 피부 위축, 또는 상피 또는 점막 위축 억제용 약물학적 조성물의 제조를 위한 식(I)(I)화합물, 이들의 기하학적 이성질체, 입체 이성질체, 약물학적으로 수용가능한 염, 에스테르 또는 이들의 대사물질의 용법.
- 제 12 항에 있어서, 화합물(I)이 오스페미핀인 용법.
- 제 12 항 또는 제 13 항에 있어서, 위축이 비뇨생식기 위축인 용법.
- 여성의 피부 위축, 또는 상피 또는 점막 위축에 관련된 증상을 치료 또는 억제하기 위한 약물학적 조성물의 제조를 위한 식(I)(I)화합물, 이들의 기하학적 이성질체, 입체 이성질체, 약물학적으로 수용가능한 염, 에스테르 또는 이들의 대사물질의 용법.
- 제 15 항에 있어서, 화합물(I)이 오스페미핀인 용법.
- 제 12 항에 있어서, 위축이 비뇨생식기 위축인 용법.
- 제 17 항에 있어서, 상기 증상은 비뇨기 증상인 용법.
- 제 18 항에 있어서, 상기 비뇨기 증상이 믹튜레이션(micturation) 질병, 배뇨곤란, 혈뇨, 잦은 오줌, 긴급 인식(sensation of urgency), 요로감염, 요로염증, 야뇨증, 요실금, 절박성 요실금, 및 비자발성 배뇨인 용법.
- 제 17 항에 있어서, 상기 증상이 질 증상인 용법.
- 제 20 항에 있어서, 상기 질 증상이 따가움, 가려움, 달아오름, 말라도로스 배출(maladorous discharge), 감염, 백대하, 외음소양증, 압력 감지, 및 성교후 출혈인 용법.
- 제 12 또는 15 항에 있어서, 화합물(I), 그 이성체, 염 또는 에스테르를 경구, 도포, 경피, 질내, 또는 피하로 투여하는 용법.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38590402P | 2002-06-06 | 2002-06-06 | |
US60/385,904 | 2002-06-06 | ||
PCT/FI2003/000369 WO2003103649A1 (en) | 2002-06-06 | 2003-05-14 | Method for the inhibition of atrophy or for treatment or prevention of atrophy-related symptoms in women |
Publications (2)
Publication Number | Publication Date |
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KR20050004292A true KR20050004292A (ko) | 2005-01-12 |
KR100991157B1 KR100991157B1 (ko) | 2010-11-02 |
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Application Number | Title | Priority Date | Filing Date |
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KR1020047019843A KR100991157B1 (ko) | 2002-06-06 | 2003-05-14 | 여성의 위축 억제 또는 위축관련 증상 치료 또는 예방 방법 |
Country Status (24)
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EP (1) | EP1509215B1 (ko) |
JP (1) | JP4362442B2 (ko) |
KR (1) | KR100991157B1 (ko) |
CN (2) | CN101406464A (ko) |
AT (1) | ATE344025T1 (ko) |
AU (1) | AU2003227790B2 (ko) |
BR (1) | BR0311613A (ko) |
CA (1) | CA2484542C (ko) |
CY (1) | CY1105787T1 (ko) |
DE (1) | DE60309465T2 (ko) |
DK (1) | DK1509215T3 (ko) |
ES (1) | ES2270025T3 (ko) |
HR (1) | HRP20041150B1 (ko) |
IL (1) | IL164528A (ko) |
MX (1) | MXPA04012220A (ko) |
NO (3) | NO334090B1 (ko) |
NZ (1) | NZ536118A (ko) |
PL (1) | PL214242B1 (ko) |
PT (1) | PT1509215E (ko) |
RU (1) | RU2317816C2 (ko) |
SI (1) | SI1509215T1 (ko) |
UA (1) | UA79797C2 (ko) |
WO (1) | WO2003103649A1 (ko) |
ZA (1) | ZA200408321B (ko) |
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US8236861B2 (en) * | 2004-02-13 | 2012-08-07 | Hormos Medical Corporation | Method for enhancing the bioavailablity of ospemifene |
US8642079B2 (en) | 2004-02-23 | 2014-02-04 | Hormos Medical Corporation | Solid formulations of ospemifene |
CN1950071A (zh) | 2004-05-04 | 2007-04-18 | 霍尔莫斯医疗有限公司 | ospemifene的新口服制剂 |
US8758821B2 (en) | 2004-05-04 | 2014-06-24 | Hormos Medical Ltd. | Oral formulations of ospemifene |
JP5193196B2 (ja) | 2006-06-02 | 2013-05-08 | ペア ツリー ウーマンズ ヘルス ケア | 萎縮性膣炎の治療の方法 |
SI2121553T1 (sl) | 2007-02-14 | 2012-11-30 | Hormos Medical Ltd | Postopek za pripravo terapevtsko uporabnih trifenilbutenskih derivatov |
WO2008099060A2 (en) | 2007-02-14 | 2008-08-21 | Hormos Medical Ltd | Methods for the preparation of fispemifene from ospemifene |
US9321712B2 (en) | 2012-10-19 | 2016-04-26 | Fermion Oy | Process for the preparation of ospemifene |
KR102052133B1 (ko) | 2017-08-10 | 2019-12-05 | 고려대학교 산학협력단 | 당 부가된 오스페미펜, 이의 제조방법 및 이를 유효성분으로 함유하는 약학적 조성물 |
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US5352699A (en) * | 1992-04-30 | 1994-10-04 | University Of Massachusetts Medical Center | Use of retinioc acid to treat vaginal atrophy |
US5461064A (en) * | 1993-12-21 | 1995-10-24 | Eli Lilly And Company | Methods of inhibiting atrophy of the skin and vagina |
US5747059A (en) * | 1996-01-11 | 1998-05-05 | Novo Nordisk A/S | Atrophy of skin/mucous membrane |
RU2342145C2 (ru) * | 2000-01-28 | 2008-12-27 | Андорешерш, Инк. | Селективные модуляторы рецептора эстрогена в комбинации с эстрогенами |
US20010034340A1 (en) * | 2000-03-20 | 2001-10-25 | American Home Products Corporation | Hormone replacement therapy |
US6245819B1 (en) * | 2000-07-21 | 2001-06-12 | Hormos Medical Oy, Ltd. | Method for the treatment of vaginal dryness and sexual dysfunction in women during or after the menopause |
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