ES2185238T3 - Preparado oral de itraconazol y su procedimiento de preparacion. - Google Patents

Preparado oral de itraconazol y su procedimiento de preparacion.

Info

Publication number
ES2185238T3
ES2185238T3 ES98959284T ES98959284T ES2185238T3 ES 2185238 T3 ES2185238 T3 ES 2185238T3 ES 98959284 T ES98959284 T ES 98959284T ES 98959284 T ES98959284 T ES 98959284T ES 2185238 T3 ES2185238 T3 ES 2185238T3
Authority
ES
Spain
Prior art keywords
preparation
oral preparation
weight
itraconazole
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98959284T
Other languages
English (en)
Inventor
Jae Young Jung
Kye Hyun Kim
Sang Heon Lee
Ji Woong Hong
Jong Woo Park
Kyu Hyun Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Choongwae Pharmaceutical Co Ltd
Original Assignee
Choongwae Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1019980027730A external-priority patent/KR100288890B1/ko
Application filed by Choongwae Pharmaceutical Co Ltd filed Critical Choongwae Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2185238T3 publication Critical patent/ES2185238T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Abstract

Preparado oral de itraconazol de biodisponibilidad mejorada, que puede obtenerse según los siguientes pasos: i) disolver 1 parte en peso de itraconazol y 0, 5-5, 0 partes en peso de polímero hidrofílico inerte subordinado al pH, que es al menos un polímero seleccionado a partir del grupo compuesto de dietilamino-acetato de polivinil-acetal y un copolímero de metacrilato de amino-alquilo, con al menos un disolvente seleccionado a partir del grupo compuesto de cloruro de metileno, cloroformo, etanol y metanol, ii) someter la solución resultante obtenida después de la disolución, a un proceso de dispersión y secado por pulverización para preparar una solución sólida, y iii) proporcionar dicha solución sólida preparada para la fabricación del preparado oral.
ES98959284T 1997-12-31 1998-12-17 Preparado oral de itraconazol y su procedimiento de preparacion. Expired - Lifetime ES2185238T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR19970081947 1997-12-31
KR1019980027730A KR100288890B1 (ko) 1997-12-31 1998-07-10 이트라코나졸 경구용 제제 및 그의 제조방법

Publications (1)

Publication Number Publication Date
ES2185238T3 true ES2185238T3 (es) 2003-04-16

Family

ID=26633347

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98959284T Expired - Lifetime ES2185238T3 (es) 1997-12-31 1998-12-17 Preparado oral de itraconazol y su procedimiento de preparacion.

Country Status (14)

Country Link
US (1) US6485743B1 (es)
EP (1) EP1039909B1 (es)
JP (1) JP3696087B2 (es)
CN (1) CN1153570C (es)
AU (1) AU1511399A (es)
BR (1) BR9814729A (es)
CA (1) CA2317106C (es)
DE (1) DE69808670T2 (es)
ES (1) ES2185238T3 (es)
HK (1) HK1034906A1 (es)
PL (1) PL191181B1 (es)
PT (1) PT1039909E (es)
TR (1) TR200001880T2 (es)
WO (1) WO1999033467A1 (es)

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EP2415462A1 (en) * 1999-12-23 2012-02-08 Mayne Pharma International Pty Ltd. Improved pharmaceutical compositions for poorly soluble drugs
FR2803748A1 (fr) * 2000-01-14 2001-07-20 Ethypharm Lab Prod Ethiques Composition d'itraconazole et procede de preparation
KR20010097244A (ko) * 2000-04-21 2001-11-08 유충식 위산도 비의존성 고용해도를 갖는 이트라코나졸 함유약학적 조성물 및 그 제조방법
DK1347747T3 (da) * 2000-12-22 2006-04-10 Baxter Int Fremgangsmåde til behandling af submikropartikelsuspensioner af farmaceutiske midler
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
WO2002100407A1 (en) * 2001-06-12 2002-12-19 Smartrix Technologies Inc. Itraconazole granulations: pharmaceutical formulations for oral administration and method of preparing same
KR100425755B1 (ko) * 2001-08-27 2004-04-03 주식회사 원진신약 이트라코나졸을 함유하는 조성물 및 그 제조방법
US20060003012A9 (en) 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
CA2461349C (en) 2001-09-26 2011-11-29 Baxter International Inc. Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal
FR2841138B1 (fr) * 2002-06-25 2005-02-25 Cll Pharma Composition pharmaceutique solide contenant un principe actif lipophile, son procede de preparation
CN1318019C (zh) * 2002-07-04 2007-05-30 詹森药业有限公司 包含两种不同聚合物骨架的固体分散体
US20040086567A1 (en) * 2002-10-30 2004-05-06 Pawan Seth Bioequivalent composition of itraconazole and a hydrophilic polymer
DE60312636T3 (de) * 2003-01-14 2014-12-24 Acino Pharma Ag Bioaequivalente Zusammensetzung in der Form einer festen Dispersion enthaltend Itraconazol und ein hydrophiles Polymer
JP4342426B2 (ja) * 2004-11-24 2009-10-14 科研製薬株式会社 イトラコナゾール経口投与用製剤
EP2404602A1 (en) 2005-08-22 2012-01-11 The Johns Hopkins University Hedgehog pathway antagonists to treat cancer
GB0607105D0 (en) * 2006-04-10 2006-05-17 Leuven K U Res & Dev Enhancing solubility and dissolution rate of poorly soluble drugs
WO2008135828A2 (en) 2007-05-03 2008-11-13 Pfizer Products Inc. Nanoparticles comprising a drug, ethylcellulose, and a bile salt
WO2008135855A2 (en) 2007-05-03 2008-11-13 Pfizer Products Inc. Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and a nonionizable polymer
US8974827B2 (en) 2007-06-04 2015-03-10 Bend Research, Inc. Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer
US9545384B2 (en) 2007-06-04 2017-01-17 Bend Research, Inc. Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glocol succinate
US9233078B2 (en) 2007-12-06 2016-01-12 Bend Research, Inc. Nanoparticles comprising a non-ionizable polymer and an Amine-functionalized methacrylate copolymer
WO2009073215A1 (en) 2007-12-06 2009-06-11 Bend Research, Inc. Pharmaceutical compositions comprising nanoparticles and a resuspending material
CN110075310A (zh) 2011-12-20 2019-08-02 维奥姆治疗有限公司 用于治疗真菌感染的局部油组合物
NZ702548A (en) 2012-06-04 2015-11-27 Pharmacyclics Llc Crystalline forms of a bruton’s tyrosine kinase inhibitor
EP2863911A4 (en) 2012-06-21 2016-07-13 Mayne Pharma Int Pty Ltd ITRACONAZOLE COMPOSITIONS AND METHOD OF DOSING AND METHOD OF USE THEREOF
WO2014167554A2 (en) * 2013-04-12 2014-10-16 Vyome Biosciences Pvt. Ltd. Composition and formulation of antimicrobial agents, processes thereof and methods for treating microbial infections
CN105491886B (zh) * 2013-08-27 2019-01-29 V·沃道里斯 苯达莫司汀医药组合物
US10016500B2 (en) * 2014-03-05 2018-07-10 Professional Compounding Centers Of America Poloxamer-based pharmaceutical compositions for treating wounds
JP2017523206A (ja) * 2014-08-07 2017-08-17 ファーマサイクリックス エルエルシー ブルトン型チロシンキナーゼ阻害剤の新規製剤
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CN106511265A (zh) * 2016-11-16 2017-03-22 北京万全德众医药生物技术有限公司 一种含有伊曲康唑的口服溶液及其制备工艺
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Also Published As

Publication number Publication date
TR200001880T2 (tr) 2000-11-21
CA2317106C (en) 2004-11-23
PL191181B1 (pl) 2006-03-31
DE69808670D1 (de) 2002-11-14
EP1039909A1 (en) 2000-10-04
DE69808670T2 (de) 2003-07-03
PL341566A1 (en) 2001-04-23
BR9814729A (pt) 2002-01-08
PT1039909E (pt) 2003-02-28
CN1153570C (zh) 2004-06-16
AU1511399A (en) 1999-07-19
HK1034906A1 (en) 2001-11-09
JP3696087B2 (ja) 2005-09-14
CN1285746A (zh) 2001-02-28
US6485743B1 (en) 2002-11-26
WO1999033467A1 (en) 1999-07-08
JP2001527044A (ja) 2001-12-25
EP1039909B1 (en) 2002-10-09
CA2317106A1 (en) 1999-07-08

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