MA26659A1 - Dérivés de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procédé pour leur préparation. - Google Patents

Dérivés de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procédé pour leur préparation.

Info

Publication number
MA26659A1
MA26659A1 MA25646A MA25646A MA26659A1 MA 26659 A1 MA26659 A1 MA 26659A1 MA 25646 A MA25646 A MA 25646A MA 25646 A MA25646 A MA 25646A MA 26659 A1 MA26659 A1 MA 26659A1
Authority
MA
Morocco
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
benzimidazole derivatives
novel benzimidazole
Prior art date
Application number
MA25646A
Other languages
English (en)
Inventor
Ito Fumitaka
Kondo Hiroshi
Noguchi Hirohide
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MA26659A1 publication Critical patent/MA26659A1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56Nitrogen atoms
    • C07D211/58Nitrogen atoms attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
MA25646A 1998-08-06 1999-06-25 Dérivés de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procédé pour leur préparation. MA26659A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IBPCT/IB98/01206 1998-08-06

Publications (1)

Publication Number Publication Date
MA26659A1 true MA26659A1 (fr) 2004-12-20

Family

ID=11004738

Family Applications (1)

Application Number Title Priority Date Filing Date
MA25646A MA26659A1 (fr) 1998-08-06 1999-06-25 Dérivés de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procédé pour leur préparation.

Country Status (44)

Country Link
US (1) US6172067B1 (fr)
EP (1) EP1102762B1 (fr)
JP (1) JP3367945B2 (fr)
CN (1) CN1317968A (fr)
AP (1) AP2001002063A0 (fr)
AR (1) AR018686A1 (fr)
AT (1) ATE227716T1 (fr)
AU (1) AU749166B2 (fr)
BG (1) BG105301A (fr)
BR (1) BR9912778A (fr)
CA (1) CA2339621C (fr)
CZ (1) CZ2001397A3 (fr)
DE (1) DE69903953T2 (fr)
DK (1) DK1102762T3 (fr)
EA (1) EA200100104A1 (fr)
EE (1) EE200100075A (fr)
ES (1) ES2185357T3 (fr)
GE (1) GEP20033000B (fr)
GT (1) GT199900125A (fr)
HK (1) HK1040188A1 (fr)
HN (1) HN1999000105A (fr)
HR (1) HRP20010089B1 (fr)
HU (1) HUP0103567A3 (fr)
ID (1) ID27212A (fr)
IL (1) IL141029A0 (fr)
IS (1) IS5812A (fr)
MA (1) MA26659A1 (fr)
NO (1) NO20010603L (fr)
NZ (1) NZ509299A (fr)
OA (1) OA11590A (fr)
PA (1) PA8477701A1 (fr)
PE (1) PE20000868A1 (fr)
PL (1) PL346211A1 (fr)
PT (1) PT1102762E (fr)
SI (1) SI1102762T1 (fr)
SK (1) SK1602001A3 (fr)
SV (1) SV1999000099A (fr)
TN (1) TNSN99142A1 (fr)
TR (1) TR200100403T2 (fr)
TW (1) TW513424B (fr)
UY (1) UY25659A1 (fr)
WO (1) WO2000008013A2 (fr)
YU (1) YU8201A (fr)
ZA (1) ZA200100900B (fr)

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SE9902987D0 (sv) 1999-08-24 1999-08-24 Astra Pharma Prod Novel compounds
SE9903544D0 (sv) 1999-10-01 1999-10-01 Astra Pharma Prod Novel compounds
ES2249237T3 (es) 2000-01-05 2006-04-01 Pfizer Inc. Compuestos de bencimidazol como antagonistas del receptor orl1.
GB2359081A (en) 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active thiazolopyrimidines
GB2359078A (en) 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
GB2359551A (en) 2000-02-23 2001-08-29 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
GB0005642D0 (en) 2000-03-10 2000-05-03 Astrazeneca Uk Ltd Chemical compounds
SE0003828D0 (sv) 2000-10-20 2000-10-20 Astrazeneca Ab Novel compounds
AU2403802A (en) 2000-11-15 2002-05-27 Banyu Pharma Co Ltd Benzimidazole derivatives
GB0104050D0 (en) 2001-02-19 2001-04-04 Astrazeneca Ab Chemical compounds
GB0107228D0 (en) 2001-03-22 2001-05-16 Astrazeneca Ab Chemical compounds
SE0101322D0 (sv) 2001-04-12 2001-04-12 Astrazeneca Ab Novel compounds
DK1385515T3 (da) 2001-04-18 2008-10-27 Euro Celtique Sa Spiropyrazole forbindelser
DE60228072D1 (de) * 2001-04-18 2008-09-18 Euro Celtique Sa Benzimidazolon-verbindungen
ES2316559T3 (es) 2001-04-18 2009-04-16 Euro-Celtique S.A. Compuestos espiroindeno y espiroindano.
HUP0402510A3 (en) * 2001-04-18 2012-08-28 Euro Celtique Sa Nociceptin analogs and pharmaceutical compositions containing them
AU2002307416B2 (en) * 2001-04-18 2005-08-11 Euro-Celtique S.A. Nociceptin analogs
JP2005502619A (ja) * 2001-07-02 2005-01-27 オメロス コーポレイション オピオイドレセプター様レセプター1アゴニストと交替でオピオイドレセプターアゴニストを投与することを含む、痛覚脱失を生成するための方法
US20030040479A1 (en) * 2001-07-02 2003-02-27 Omeros Corporation Rotational intrathecal analgesia method and device
SE0102716D0 (sv) * 2001-08-14 2001-08-14 Astrazeneca Ab Novel compounds
SE0103818D0 (sv) 2001-11-15 2001-11-15 Astrazeneca Ab Chemical compounds
WO2003049736A1 (fr) * 2001-12-11 2003-06-19 Sepracor, Inc. Piperidines 4-substitues, et methodes d'utilisation
US7566728B2 (en) 2002-03-29 2009-07-28 Mitsubishi Tanabe Pharma Corporation Remedy for sleep disturbance
GB0221828D0 (en) 2002-09-20 2002-10-30 Astrazeneca Ab Novel compound
GB0221829D0 (en) * 2002-09-20 2002-10-30 Astrazeneca Ab Novel compound
DE10252666A1 (de) * 2002-11-11 2004-08-05 Grünenthal GmbH N-Piperidyl-cyclohexan-Derivate
DE10252665A1 (de) 2002-11-11 2004-06-03 Grünenthal GmbH 4-Aminomethyl-1-aryl-cyclohexylamin-Derivate
GB0315203D0 (en) * 2003-06-28 2003-08-06 Celltech R&D Ltd Chemical compounds
SA04250305B1 (ar) 2003-09-25 2008-06-02 سولفاي فارماسوتيكالز بي . في مشتقات بنزيميدازولون cenzimidazolone وكينازولينون quinazolinone كمساعادات على مستقبلات ORL1 البشرية
GB0328243D0 (en) * 2003-12-05 2004-01-07 Astrazeneca Ab Methods
US20050228023A1 (en) * 2003-12-19 2005-10-13 Sri International Agonist and antagonist ligands of the nociceptin receptor
JPWO2006038738A1 (ja) * 2004-10-08 2008-05-15 武田薬品工業株式会社 受容体機能調節剤
DE602006018255D1 (de) 2005-01-11 2010-12-30 Neurosearch As Neue 2-amino-benzimidazolderivate und ihre verwendung als modulatoren calciumaktivierter kaliumkanäle mit geringer leitfähigkeit
JP2009541454A (ja) * 2006-07-03 2009-11-26 ノイロサーチ アクティーゼルスカブ モノアミン再摂取阻害剤及びカリウムチャネル活性剤の併用
EP2397477B1 (fr) * 2007-01-16 2014-03-05 Purdue Pharma LP Composés de pipéridine hétérocycliques substitués et leurs utilisations
EP2433935A1 (fr) * 2007-08-31 2012-03-28 Purdue Pharma LP Composés de pipéridine de type quinoxaline substituée et leurs utilisations
US8119661B2 (en) * 2007-09-11 2012-02-21 Astrazeneca Ab Piperidine derivatives and their use as muscarinic receptor modulators
PE20140102A1 (es) 2008-07-21 2014-02-06 Purdue Pharma Lp Compuestos de piperidina puenteada tipo quinoxalina sustituida con actividad sobre el receptor orl-1
WO2012018668A1 (fr) 2010-08-05 2012-02-09 Amgen Inc. Composés benzimidazole et azabenzimidazole qui inhibent la kinase des lymphomes anaplasiques
WO2013103598A2 (fr) 2012-01-06 2013-07-11 Novus International Inc. Agents tensio-actifs à base de sulfoxyde
PL2812372T3 (pl) 2012-02-09 2018-12-31 Novus International Inc. Cykliczne dimery zawierające heteroatom
JO3300B1 (ar) 2012-06-06 2018-09-16 Novartis Ag مركبات وتركيبات لتعديل نشاط egfr
CN107753462B (zh) 2012-07-12 2021-01-08 诺华丝国际股份有限公司 用于保护生物活性剂的基质和层组合物
US9085561B2 (en) * 2012-07-30 2015-07-21 Purdue Pharma L.P. Cyclic urea- or lactam-substituted quinoxaline-type piperidines as ORL-1 modulators
WO2014102594A2 (fr) * 2012-12-27 2014-07-03 Purdue Pharma L.P. Composés de pipéridine de type benzimidazole substitué et leurs utilisations
WO2014153529A1 (fr) 2013-03-22 2014-09-25 The Scripps Research Institute Benzimidazoles substitués en tant que modulateurs d'un récepteur de nociceptine
TWI683813B (zh) 2014-03-20 2020-02-01 美商卡佩拉醫療公司 苯并咪唑衍生物及其醫藥組合物及使用方法
CN112707851A (zh) 2015-11-12 2021-04-27 诺华丝国际股份有限公司 作为溶剂的含硫化合物
US10584306B2 (en) 2017-08-11 2020-03-10 Board Of Regents Of The University Of Oklahoma Surfactant microemulsions

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WO1997007208A1 (fr) 1995-08-15 1997-02-27 Universite Libre De Bruxelles Molecules d'acide nucleique codant des peptides presentant des proprietes pronociceptives
US5866346A (en) 1995-09-27 1999-02-02 Indiana Unversity Foundation Methods of using dynorphins as ligands for XOR1 receptor
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US5929035A (en) 1998-04-14 1999-07-27 Regents Of The University Of Michigan Methods of treating intestinal disorders
ID29137A (id) 1998-07-27 2001-08-02 Schering Corp Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1

Also Published As

Publication number Publication date
BG105301A (en) 2001-12-29
CA2339621C (fr) 2005-04-05
DE69903953T2 (de) 2003-03-27
TW513424B (en) 2002-12-11
IS5812A (is) 2001-01-16
EP1102762B1 (fr) 2002-11-13
JP3367945B2 (ja) 2003-01-20
HRP20010089A2 (en) 2002-02-28
HUP0103567A3 (en) 2003-01-28
SK1602001A3 (en) 2002-09-10
ATE227716T1 (de) 2002-11-15
BR9912778A (pt) 2001-09-25
EA200100104A1 (ru) 2001-08-27
AU749166B2 (en) 2002-06-20
CZ2001397A3 (cs) 2002-05-15
ZA200100900B (en) 2002-08-28
DE69903953D1 (de) 2002-12-19
HN1999000105A (es) 2000-11-11
IL141029A0 (en) 2002-02-10
PL346211A1 (en) 2002-01-28
HRP20010089B1 (en) 2003-04-30
EE200100075A (et) 2002-06-17
AP2001002063A0 (en) 2001-03-31
OA11590A (en) 2004-08-18
SI1102762T1 (en) 2003-04-30
CA2339621A1 (fr) 2000-02-17
PE20000868A1 (es) 2000-08-31
DK1102762T3 (da) 2002-12-16
WO2000008013A2 (fr) 2000-02-17
SV1999000099A (es) 2000-09-05
TNSN99142A1 (fr) 2005-11-10
YU8201A (sh) 2003-07-07
AU4385999A (en) 2000-02-28
GT199900125A (es) 2001-01-27
GEP20033000B (en) 2003-06-25
ID27212A (id) 2001-03-08
NO20010603L (no) 2001-04-05
US6172067B1 (en) 2001-01-09
HK1040188A1 (zh) 2002-05-31
NZ509299A (en) 2003-05-30
NO20010603D0 (no) 2001-02-05
PA8477701A1 (es) 2000-09-29
UY25659A1 (es) 2000-02-23
WO2000008013A3 (fr) 2000-03-23
EP1102762A2 (fr) 2001-05-30
AR018686A1 (es) 2001-11-28
JP2002522431A (ja) 2002-07-23
TR200100403T2 (tr) 2001-07-23
ES2185357T3 (es) 2003-04-16
CN1317968A (zh) 2001-10-17
HUP0103567A2 (hu) 2002-02-28
PT1102762E (pt) 2003-02-28

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