TR200001880T2 - İtrakonazolün bir oral preparasyonunun bileşiği ve yöntemi. - Google Patents

İtrakonazolün bir oral preparasyonunun bileşiği ve yöntemi.

Info

Publication number
TR200001880T2
TR200001880T2 TR2000/01880T TR200001880T TR200001880T2 TR 200001880 T2 TR200001880 T2 TR 200001880T2 TR 2000/01880 T TR2000/01880 T TR 2000/01880T TR 200001880 T TR200001880 T TR 200001880T TR 200001880 T2 TR200001880 T2 TR 200001880T2
Authority
TR
Turkey
Prior art keywords
preparation
itraconazole
oral
compound
oral preparation
Prior art date
Application number
TR2000/01880T
Other languages
English (en)
Inventor
Young Jung Jae
Hyun Kim Kye
Heo Lee Sang
Woong Hong Ji
Woo Park Jong
Hyun Lee Kyu
Original Assignee
Choongwae Pharma Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1019980027730A external-priority patent/KR100288890B1/ko
Application filed by Choongwae Pharma Corporation filed Critical Choongwae Pharma Corporation
Publication of TR200001880T2 publication Critical patent/TR200001880T2/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Abstract

Mevcut bulus, mantar karsiti mükemmel bir azol ilaci olan agizdan bir itrakonazol preparasyonuna yönelik bir metot ve kompozisyonla ilgilidir. Daha özel olarak bu , gelismis biyo saglanabilirlige sahip agizdan bir itrakonazol preperasyonu ile ilgilidir; bu preperasyon, asagidaki asamalar ile hazirlanir: i) itrakonazol ve hidrofilik çözücü ile çözündürülmesi, ii) adi geçen karisimin spreyle kurutulmasi, ve iii) agizdan preparasyon için kati yayilimlar hazirlanmasi. Bu bulus dahilinde hazirlanan kati yayilimlar; tabletler, granüler ve diger agizdan dozaj formlarinin hazirlanmasinda faydali olabilir.
TR2000/01880T 1997-12-31 1998-12-17 İtrakonazolün bir oral preparasyonunun bileşiği ve yöntemi. TR200001880T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR19970081947 1997-12-31
KR1019980027730A KR100288890B1 (ko) 1997-12-31 1998-07-10 이트라코나졸 경구용 제제 및 그의 제조방법

Publications (1)

Publication Number Publication Date
TR200001880T2 true TR200001880T2 (tr) 2000-11-21

Family

ID=26633347

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/01880T TR200001880T2 (tr) 1997-12-31 1998-12-17 İtrakonazolün bir oral preparasyonunun bileşiği ve yöntemi.

Country Status (14)

Country Link
US (1) US6485743B1 (tr)
EP (1) EP1039909B1 (tr)
JP (1) JP3696087B2 (tr)
CN (1) CN1153570C (tr)
AU (1) AU1511399A (tr)
BR (1) BR9814729A (tr)
CA (1) CA2317106C (tr)
DE (1) DE69808670T2 (tr)
ES (1) ES2185238T3 (tr)
HK (1) HK1034906A1 (tr)
PL (1) PL191181B1 (tr)
PT (1) PT1039909E (tr)
TR (1) TR200001880T2 (tr)
WO (1) WO1999033467A1 (tr)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100694667B1 (ko) * 1999-12-08 2007-03-14 동아제약주식회사 생체내이용률 향상과 개인간 및 개인내 흡수 편차를감소시킨 이트라코나졸 함유 항진균성 제제
PT1239831E (pt) * 1999-12-23 2013-01-23 Mayne Pharma International Pty Ltd Composições farmacêuticas melhoradas para fármacos fracamente solúveis
FR2803748A1 (fr) * 2000-01-14 2001-07-20 Ethypharm Lab Prod Ethiques Composition d'itraconazole et procede de preparation
KR20010097244A (ko) * 2000-04-21 2001-11-08 유충식 위산도 비의존성 고용해도를 갖는 이트라코나졸 함유약학적 조성물 및 그 제조방법
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
ATE319432T1 (de) * 2000-12-22 2006-03-15 Baxter Int Verfahren zur herstellung von submikropartikel- suspensionen pharmazeutischer substanzen
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
AU2002317063A (en) * 2001-06-12 2002-12-23 Smartrix Technologies Inc Itraconazole granulations: pharmaceutical formulations for oral administration and method of preparing same
KR100425755B1 (ko) * 2001-08-27 2004-04-03 주식회사 원진신약 이트라코나졸을 함유하는 조성물 및 그 제조방법
US20060003012A9 (en) 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
EP1429749A2 (en) 2001-09-26 2004-06-23 Baxter International Inc. Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal
FR2841138B1 (fr) * 2002-06-25 2005-02-25 Cll Pharma Composition pharmaceutique solide contenant un principe actif lipophile, son procede de preparation
EP1521571A1 (en) * 2002-07-04 2005-04-13 Janssen Pharmaceutica N.V. Solid dispersion comprising two different polymer matrixes
US20040086567A1 (en) * 2002-10-30 2004-05-06 Pawan Seth Bioequivalent composition of itraconazole and a hydrophilic polymer
DE60312636T3 (de) * 2003-01-14 2014-12-24 Acino Pharma Ag Bioaequivalente Zusammensetzung in der Form einer festen Dispersion enthaltend Itraconazol und ein hydrophiles Polymer
JP4342426B2 (ja) * 2004-11-24 2009-10-14 科研製薬株式会社 イトラコナゾール経口投与用製剤
ES2403006T3 (es) 2005-08-22 2013-05-13 The Johns Hopkins University Antagonistas de la vía Hedgehog para tratar enfermedades
GB0607105D0 (en) * 2006-04-10 2006-05-17 Leuven K U Res & Dev Enhancing solubility and dissolution rate of poorly soluble drugs
US8309129B2 (en) 2007-05-03 2012-11-13 Bend Research, Inc. Nanoparticles comprising a drug, ethylcellulose, and a bile salt
WO2008135855A2 (en) 2007-05-03 2008-11-13 Pfizer Products Inc. Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and a nonionizable polymer
US8974827B2 (en) 2007-06-04 2015-03-10 Bend Research, Inc. Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer
WO2008149230A2 (en) 2007-06-04 2008-12-11 Pfizer Products Inc. Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glycol succinate
WO2009073215A1 (en) 2007-12-06 2009-06-11 Bend Research, Inc. Pharmaceutical compositions comprising nanoparticles and a resuspending material
US9233078B2 (en) 2007-12-06 2016-01-12 Bend Research, Inc. Nanoparticles comprising a non-ionizable polymer and an Amine-functionalized methacrylate copolymer
WO2013093823A2 (en) 2011-12-20 2013-06-27 Vyome Biosciences Pvt Ltd Topical oil composition for the treatment of fungal infections
KR20220093389A (ko) 2012-06-04 2022-07-05 파마싸이클릭스 엘엘씨 브루톤 타이로신 키나아제 저해제의 결정 형태
US8921374B2 (en) 2012-06-21 2014-12-30 Mayne Pharma International Pty Ltd Itraconazole compositions and dosage forms, and methods of using the same
WO2014167554A2 (en) * 2013-04-12 2014-10-16 Vyome Biosciences Pvt. Ltd. Composition and formulation of antimicrobial agents, processes thereof and methods for treating microbial infections
MX2016002502A (es) * 2013-08-27 2017-02-28 Voudouris Vasilios Composiciones farmaceuticas de bendamustina.
US10016500B2 (en) * 2014-03-05 2018-07-10 Professional Compounding Centers Of America Poloxamer-based pharmaceutical compositions for treating wounds
KR20170033358A (ko) * 2014-08-07 2017-03-24 파마싸이클릭스 엘엘씨 브루톤 티로신 키나아제 저해제의 신규한 제제
CN104688536B (zh) * 2015-02-03 2016-06-08 常州制药厂有限公司 一种伊曲康唑制剂的制备方法
DK3265084T3 (da) 2015-03-03 2024-02-12 Pharmacyclics Llc Farmaceutiske formuleringer af Bruton's tyrosinkinase-hæmmer
CN106511265A (zh) * 2016-11-16 2017-03-22 北京万全德众医药生物技术有限公司 一种含有伊曲康唑的口服溶液及其制备工艺
WO2019043427A1 (en) 2017-09-01 2019-03-07 Jordan Sweden Medical And Sterilization Company FAST SELF-DISPERSION DOSAGE FORMS OF DEFERASIROX
CN109172532A (zh) * 2018-10-24 2019-01-11 北京哈三联科技有限责任公司 一种伊曲康唑分散片及其制备方法和应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4218458A (en) 1978-06-23 1980-08-19 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-aryloxy-methyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
JPS57171428A (en) 1981-04-13 1982-10-22 Sankyo Co Ltd Preparation of coated solid preparation
DE3346123A1 (de) 1983-12-21 1985-06-27 Janssen Pharmaceutica, N.V., Beerse Pharmazeutische praeparate von in wasser schwerloeslichen oder instabilen arzneistoffen und verfahren zu ihrer herstellung
GB8506792D0 (en) 1985-03-15 1985-04-17 Janssen Pharmaceutica Nv Derivatives of y-cyclodextrin
JPS63188621A (ja) * 1987-01-30 1988-08-04 Taisho Pharmaceut Co Ltd 矯味経口製剤
JPH0774151B2 (ja) * 1987-10-12 1995-08-09 三井東圧化学株式会社 薬物の好ましくない官能的性質を隠蔽した散剤の製造方法
GB8908250D0 (en) 1989-04-12 1989-05-24 Fisons Plc Formulations
JP3034592B2 (ja) * 1990-11-20 2000-04-17 わかもと製薬株式会社 経口用固形製剤及びその製造法
ATE138561T1 (de) 1992-02-12 1996-06-15 Janssen Cilag S P A Liposomale itraconazol formulierungen
PH30929A (en) * 1992-09-03 1997-12-23 Janssen Pharmaceutica Nv Beads having a core coated with an antifungal and a polymer.
TW438601B (en) 1994-05-18 2001-06-07 Janssen Pharmaceutica Nv New mucoadhesive emulsion compositions and a process for the preparation thereof
FR2722984B1 (fr) 1994-07-26 1996-10-18 Effik Lab Procede de preparation de formes pharmaceutiques seches et les compositions pharmaceutiques ainsi realisees
US5750147A (en) * 1995-06-07 1998-05-12 Emisphere Technologies, Inc. Method of solubilizing and encapsulating itraconazole
DE69726729T2 (de) * 1996-05-20 2004-12-02 Janssen Pharmaceutica N.V. Fungizide mittel mit verbesserter bioverfügbarkeit

Also Published As

Publication number Publication date
DE69808670T2 (de) 2003-07-03
US6485743B1 (en) 2002-11-26
PL341566A1 (en) 2001-04-23
CN1285746A (zh) 2001-02-28
CN1153570C (zh) 2004-06-16
WO1999033467A1 (en) 1999-07-08
JP2001527044A (ja) 2001-12-25
DE69808670D1 (de) 2002-11-14
BR9814729A (pt) 2002-01-08
ES2185238T3 (es) 2003-04-16
JP3696087B2 (ja) 2005-09-14
EP1039909B1 (en) 2002-10-09
AU1511399A (en) 1999-07-19
CA2317106C (en) 2004-11-23
PL191181B1 (pl) 2006-03-31
EP1039909A1 (en) 2000-10-04
CA2317106A1 (en) 1999-07-08
HK1034906A1 (en) 2001-11-09
PT1039909E (pt) 2003-02-28

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