EA201190301A1 - ПРОИЗВОДНЫЕ 1,2,4-ТРИАЗОЛО[4,3-а]ПИРИДИНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ПОЛОЖИТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2 - Google Patents

ПРОИЗВОДНЫЕ 1,2,4-ТРИАЗОЛО[4,3-а]ПИРИДИНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ПОЛОЖИТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2

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Publication number
EA201190301A1
EA201190301A1 EA201190301A EA201190301A EA201190301A1 EA 201190301 A1 EA201190301 A1 EA 201190301A1 EA 201190301 A EA201190301 A EA 201190301A EA 201190301 A EA201190301 A EA 201190301A EA 201190301 A1 EA201190301 A1 EA 201190301A1
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EA
Eurasian Patent Office
Prior art keywords
compounds
triazolo
mglur2
positive allosteric
allosteric modulators
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EA201190301A
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English (en)
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EA020671B1 (ru
Inventor
Хосе Мария Сид-Нуньес
Ана Изабель Де Лукас Оливарес
Андрес Авелино Трабанко-Суарес
Грегор Джеймс Макдональд
Original Assignee
Янссен Фармасьютикалз, Инк.
Аддекс Фарма С.А.
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Application filed by Янссен Фармасьютикалз, Инк., Аддекс Фарма С.А. filed Critical Янссен Фармасьютикалз, Инк.
Publication of EA201190301A1 publication Critical patent/EA201190301A1/ru
Publication of EA020671B1 publication Critical patent/EA020671B1/ru

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Abstract

Настоящее изобретение относится к новым производным триазоло[4,3-а]пиридина формулы (I), где все радикалы являются такими, как они определены в формуле изобретения. Соединения по изобретению являются позитивными аллостерическими модуляторами метаботропного глутаматного рецептора субтипа 2 ("mGluR2"), которые полезны для лечения или предупреждения неврологических и психиатрических расстройств, ассоциированных с глутаматной дисфункцией, и заболеваний, в которые вовлечен mGluR2 субтип метаботропных рецепторов. Изобретение также относится к фармацевтическим композициям, содержащим такие соединения, к способам получения таких соединений и композиций и к применению таких соединений для предупреждения или лечения неврологических и психиатрических расстройств и заболеваний, в которые вовлечен mGluR2.
EA201190301A 2009-05-12 2010-05-11 ПРОИЗВОДНЫЕ 1,2,4-ТРИАЗОЛО[4,3-a]ПИРИДИНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ПОЛОЖИТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2 EA020671B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09160067 2009-05-12
PCT/EP2010/002908 WO2010130422A1 (en) 2009-05-12 2010-05-11 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors

Publications (2)

Publication Number Publication Date
EA201190301A1 true EA201190301A1 (ru) 2012-06-29
EA020671B1 EA020671B1 (ru) 2014-12-30

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EA201190301A EA020671B1 (ru) 2009-05-12 2010-05-11 ПРОИЗВОДНЫЕ 1,2,4-ТРИАЗОЛО[4,3-a]ПИРИДИНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ПОЛОЖИТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2

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US (1) US8946205B2 (ru)
EP (1) EP2430031B1 (ru)
JP (1) JP5707390B2 (ru)
KR (1) KR20120035158A (ru)
CN (1) CN102439015B (ru)
AR (1) AR076859A1 (ru)
AU (1) AU2010246607B2 (ru)
BR (1) BRPI1010831A2 (ru)
CA (1) CA2760259C (ru)
CL (1) CL2011002837A1 (ru)
EA (1) EA020671B1 (ru)
ES (1) ES2409006T3 (ru)
IL (1) IL215910A (ru)
MX (1) MX2011011962A (ru)
MY (1) MY153912A (ru)
NZ (1) NZ596053A (ru)
SG (1) SG176018A1 (ru)
TW (1) TW201100417A (ru)
WO (1) WO2010130422A1 (ru)
ZA (1) ZA201107836B (ru)

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