DZ2634A1 - Dérivés de pleuromutiline nouveaux procédé pour leur préparation et compositions pharmaceutiques lescontenant. - Google Patents

Dérivés de pleuromutiline nouveaux procédé pour leur préparation et compositions pharmaceutiques lescontenant.

Info

Publication number: DZ2634A1
Authority: DZ; Algeria
Prior art keywords: preparation; pharmaceutical compositions; compositions containing; pleuromutilin derivatives; new pleuromutilin
Prior art date: 1997-10-29

Application number

DZ980244A

Other languages

English (en)

Inventor

Valerie Berry

Gary Woodnutt

Steven Dabbs

Colin Ian Frydrych

Eric Hunt

Francis Dominic Sanderson

Original Assignee

Smithkline Beecham Corp

Smithklne Beecham P L C

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-29

Filing date

1998-10-28

Publication date

2003-03-08

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26312507&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DZ2634(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-10-29 Priority claimed from GBGB9722817.5A external-priority patent/GB9722817D0/en

1998-06-25 Priority claimed from GBGB9813689.8A external-priority patent/GB9813689D0/en

1998-10-28 Application filed by Smithkline Beecham Corp, Smithklne Beecham P L C filed Critical Smithkline Beecham Corp

2003-03-08 Application granted granted Critical

2003-03-08 Publication of DZ2634A1 publication Critical patent/DZ2634A1/fr

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/32—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C271/36—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of rings other than six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/54—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems

DZ980244A 1997-10-29 1998-10-28 Dérivés de pleuromutiline nouveaux procédé pour leur préparation et compositions pharmaceutiques lescontenant. DZ2634A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9722817.5A GB9722817D0 (en)	1997-10-29	1997-10-29	Novel compounds
GBGB9813689.8A GB9813689D0 (en)	1998-06-25	1998-06-25	Novel compounds

Publications (1)

Publication Number	Publication Date
DZ2634A1 true DZ2634A1 (fr)	2003-03-08

Family

ID=26312507

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DZ980244A DZ2634A1 (fr)	1997-10-29	1998-10-28	Dérivés de pleuromutiline nouveaux procédé pour leur préparation et compositions pharmaceutiques lescontenant.

Country Status (36)

Country	Link
US (3)	USRE39128E1 (fr)
EP (3)	EP1452534A1 (fr)
JP (2)	JP4227729B2 (fr)
KR (1)	KR100538721B1 (fr)
CN (1)	CN1205211C (fr)
AR (1)	AR015987A1 (fr)
AT (2)	ATE277925T1 (fr)
AU (1)	AU742167C (fr)
BR (1)	BR9814747B1 (fr)
CA (1)	CA2307551C (fr)
CO (1)	CO5021129A1 (fr)
CY (2)	CY2007028I2 (fr)
CZ (1)	CZ298543B6 (fr)
DE (2)	DE122007000076I2 (fr)
DK (2)	DK1028961T5 (fr)
DZ (1)	DZ2634A1 (fr)
EG (1)	EG24177A (fr)
ES (2)	ES2371205T3 (fr)
FR (1)	FR07C0057I2 (fr)
HK (1)	HK1031376A1 (fr)
HU (2)	HU229792B1 (fr)
IL (2)	IL135811A0 (fr)
LU (1)	LU91372I2 (fr)
MY (1)	MY130665A (fr)
NL (1)	NL300304I2 (fr)
NO (3)	NO327392B1 (fr)
NZ (1)	NZ504203A (fr)
PE (1)	PE123299A1 (fr)
PL (2)	PL197672B1 (fr)
PT (2)	PT1930330E (fr)
SI (2)	SI1930330T1 (fr)
TR (1)	TR200001203T2 (fr)
TW (1)	TWI232861B (fr)
UY (1)	UY25225A1 (fr)
WO (1)	WO1999021855A1 (fr)
ZA (1)	ZA989767B (fr)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UY25225A1 (es) *	1997-10-29	2000-12-29	Smithkline Beecham Plc	Derivados de pleuromutilina utiles como agentes antimicrobianos
WO2000027790A1 (fr) *	1998-11-11	2000-05-18	Smithkline Beecham P.L.C.	Composes a base de mutiline
GB9912657D0 (en) *	1999-06-01	1999-07-28	Smithkline Beecham Plc	Novel compounds
GB9918037D0 (en) *	1999-07-30	1999-09-29	Biochemie Gmbh	Organic compounds
GB9919839D0 (en) *	1999-08-20	1999-10-27	Smithkline Beecham Plc	Novel compounds
CA2405132A1 (fr) *	2000-04-04	2001-10-11	Smithkline Beecham Plc	Derives de 2-(s)-hydroxymutiline carbamate pour utilisation antibacterienne
GB0017073D0 (en) *	2000-07-11	2000-08-30	Univ London	Microorganism
GB0017031D0 (en)	2000-07-11	2000-08-30	Biochemie Gmbh	Antimicrobials
PE20020676A1 (es) *	2000-09-13	2002-08-27	Biochemie Gmbh	Compuestos de mutilina como antibacterianos
GB0024811D0 (en) *	2000-10-10	2000-11-22	Smithkline Beecham Plc	Novel compounds
GB0027705D0 (en)	2000-11-11	2000-12-27	S P A	Novel compounds
FR2835186B1 (fr) *	2002-01-28	2006-10-20	Aventis Pharma Sa	Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
GB0207495D0 (en) *	2002-03-28	2002-05-08	Biochemie Gmbh	Organic compounds
CN100355729C (zh) *	2002-07-24	2007-12-19	桑多斯股份公司	截短侧耳素
GB0218578D0 (en) *	2002-08-09	2002-09-18	Glaxo Group Ltd	Novel method
GB0308114D0 (en) *	2003-04-08	2003-05-14	Glaxo Group Ltd	Novel compounds
DE602004024417D1 (de) *	2003-09-03	2010-01-14	Glaxo Group Ltd	Neues verfahren zur herstellung von pleuromutilinderivaten
EP1747219A4 (fr) *	2004-05-13	2010-05-26	Glaxo Group Ltd	Domaine de l'invention antagonistes récepteurs d'acétyle choline muscarinique
GB0504314D0 (en) *	2005-03-02	2005-04-06	Glaxo Group Ltd	Novel polymorph
EP1860943A4 (fr) *	2005-03-10	2008-06-18	Smithkline Beecham Corp	Nouveau procede
GB0513058D0 (en) *	2005-06-27	2005-08-03	Sandoz Ag	Organic compounds
TW200730488A (en) *	2005-06-27	2007-08-16	Nabriva Therapeutics Forschungs Gmbh	Organic compounds
WO2007037518A1 (fr) *	2005-09-29	2007-04-05	Dainippon Sumitomo Pharma Co., Ltd.	Derive de mutiline et composition pharmaceutique la contenant
WO2007079173A2 (fr) *	2005-12-30	2007-07-12	Emergent Biosolutions Inc.	Nouveaux dérivés de 2-hétéroaryloxyphénol au titre d'agents antibactériens
WO2008096870A1 (fr)	2007-02-09	2008-08-14	Astellas Pharma Inc.	Composé à cycle à pont aza
WO2008117796A1 (fr) *	2007-03-28	2008-10-02	Dainippon Sumitomo Pharma Co., Ltd.	Nouveaux dérivés de mutiline
EP2149571A4 (fr)	2007-05-24	2010-09-01	Kyorin Seiyaku Kk	Dérivé de la mutiline ayant une structure d'acide carboxylique à noyau aromatique hétérocyclique en substituant à la position 14
US20090076071A1 (en) *	2007-09-13	2009-03-19	Protia, Llc	Deuterium-enriched retapamulin
WO2009070307A1 (fr) *	2007-11-26	2009-06-04	Teva Pharmaceutical Industries Ltd.	Rétapamuline amorphe et ses procédés de préparation
WO2009075776A1 (fr) *	2007-12-05	2009-06-18	Teva Pharmaceutical Industries Ltd.	Procédé pour préparer de la rétapamuline et ses intermédiaires
US8278313B2 (en)	2008-03-11	2012-10-02	Abbott Laboratories	Macrocyclic spiro pyrimidine derivatives
US8436005B2 (en)	2008-04-03	2013-05-07	Abbott Laboratories	Macrocyclic pyrimidine derivatives
WO2010056855A1 (fr) *	2008-11-13	2010-05-20	Teva Pharmaceutical Industries Ltd.	Préparation de rétapamuline par l'intermédiaire de son précurseur pleuromutiline-thiol
JP5422821B2 (ja) *	2009-03-03	2014-02-19	独立行政法人放射線医学総合研究所	コリンエステラーゼ活性測定用試薬
NZ597613A (en)	2009-07-14	2014-01-31	Albany Molecular Res Inc	5-ht3 receptor modulators, methods of making, and use thereof
CN102344397B (zh) *	2011-08-23	2013-09-04	浙江升华拜克生物股份有限公司	一种伐奈莫林盐酸盐的提纯方法
CN103626693B (zh) *	2012-08-28	2016-09-14	中国科学院上海药物研究所	一类截短侧耳素衍生物、其药物组合物及其合成方法与用途
CN103709093B (zh) *	2012-09-28	2016-06-08	山东亨利医药科技有限责任公司	含有并环的截短侧耳素类抗生素
EP3171752B1 (fr)	2014-07-21	2019-12-11	EndoChoice, Inc.	Systèmes d'endoscope à foyers multiples et à caméra multiples
WO2017151489A1 (fr)	2016-03-02	2017-09-08	Anacor Pharmaceuticals, Inc.	Petites molécules contenant du bore
US10874679B2 (en)	2016-03-02	2020-12-29	Bill & Melinda Gates Foundation	Boron-containing small molecules
US10611781B2 (en)	2016-03-02	2020-04-07	Bill And Melinda Gates Foundation	Boron-containing small molecules
CN106496085B (zh) *	2016-09-21	2018-01-26	盐城市舜宝化工有限公司	合成盐酸沃尼妙林的中间体化合物以及盐酸沃尼妙林的制备方法
TWI762573B (zh)	2017-02-10	2022-05-01	奧地利商納畢瓦治療有限責任公司	截短側耳素之純化
CN111574395B (zh) *	2020-06-18	2021-07-02	华南农业大学	一种具有酰胺侧链的截短侧耳素衍生物及制备与应用
AT523646B1 (de)	2020-07-21	2021-10-15	Gerd Dr Ascher	Pharmazeutische Verbindungen, ihre Anwendung alleine oder in Kombination, zur Prophylaxe und lokalen Initial-Therapie bei bakteriellen und viralen Infektionen, insbesondere Coronaviren
US11155514B1 (en) *	2020-12-19	2021-10-26	Shaanxi University Of Science And Technology	Pleuromulin acitretin ester with antibacterial activity and a method of preparing the same
US11332430B1 (en) *	2021-01-25	2022-05-17	Xi'an Taikomed Pharmaceutical Technology Co., Ltd.	Pleuromulin lauric acid ester with antibacterial activity and a method of preparing the same
CN112919463B (zh) *	2021-04-09	2021-10-26	南京理工大学	一种利用泰妙菌素废盐制备的活性炭及其制备方法
CN113121355B (zh) *	2021-04-13	2023-05-09	西安康诺化工有限公司	一种截短侧耳素大黄酸酯及其制备方法和应用
CN114736194A (zh) *	2022-03-29	2022-07-12	中牧实业股份有限公司	一种具有抗病原微生物活性的含吡啶季铵盐侧链的截短侧耳素衍生物及其制备方法与应用

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4060542A (en)	1969-07-25	1977-11-29	Biochemie Gesellschaft M.B.H.	14-Desoxy-14 thiocyanato-acetoxy-mutilin
US3919290A (en)	1972-10-03	1975-11-11	Sandoz Ltd	Substituted 14-desoxy-mutilins
US4032530A (en)	1971-10-05	1977-06-28	Sandoz Ltd.	Certain pleuromutilins
US4208326A (en)	1971-10-05	1980-06-17	Sandoz Ltd.	Pleuromutilin esters
CH575375A5 (fr)	1972-05-25	1976-05-14	Sandoz Ag
BE789629A (fr)	1971-10-05	1973-04-03	Sandoz Sa	Nouveaux derives de la pleuromutiline, leur preparation et leurapplication en therapeutique
CH593912A5 (en)	1972-07-07	1977-12-30	Sandoz Ag	Pleuromutilin derivs. - prepd. by acylating derivs. contg. a (4)-hydroxyalkyl-(1)-piperazinyl gp.
DE2404046C3 (de)	1974-01-29	1984-07-26	Henkel KGaA, 4000 Düsseldorf	Verwendung von Carboxyl- bzw. Carboxylat- und Hydroxylgruppen aufweisenden Polymeren als Hautfeuchthaltemittel
US3987194A (en)	1975-05-12	1976-10-19	E. R. Squibb & Sons, Inc.	Use of pleuromutilin derivatives for the treatment of swine dysentery
CH619450A5 (fr)	1976-01-15	1980-09-30	Sandoz Ag
US4130709A (en)	1977-12-08	1978-12-19	Eli Lilly And Company	Pleuromutilin glycoside derivatives
GB2025930B (en) *	1978-06-01	1983-02-09	Sandoz Ltd	Process for the production of pleuromutilin derivatives
JPS5594359A (en) *	1979-01-12	1980-07-17	Sandoz Ag	Novel pleuromutilin derivatives*their manufacture and use
DE2966635D1 (en)	1979-01-12	1984-03-08	Sandoz Ag	New pleuromutilin derivatives, their production and pharmaceutical compositions containing them
FR2502951B1 (fr)	1981-04-06	1985-12-06	Sandoz Sa	Compositions pharmaceutiques topiques sous forme d'une micro-emulsion
EP0153277B1 (fr) *	1984-02-17	1987-08-26	Sandoz Ag	Dérivés de pleuromutiline, leur procédé de préparation et leur application
DE3405632A1 (de) *	1984-02-17	1985-08-22	Sandoz-Patent-GmbH, 7850 Lörrach	Neue pleuromutilinderivate, verfahren zu ihrer herstellung und ihre verwendung
AT400674B (de)	1991-07-24	1996-02-26	Biochemie Gmbh	Pharmazeutische pleuromutilin-zubereitung
GB9201751D0 (en)	1992-01-28	1992-03-11	Smithkline Beecham Plc	Compounds
AT397654B (de)	1992-05-04	1994-06-27	Biochemie Gmbh	Neue pleuromutilinderivate, ihre verwendung und verfahren zu ihrer herstellung
CA2207618A1 (fr)	1994-12-23	1996-07-04	Helmut Pieper	Derives de piperazine, medicaments contenant ces composes, leur utilisation et leur procede de preparation
KR19990076988A (ko)	1996-01-03	1999-10-25	피터 기딩스	머틸린의 카르바모일옥시 유도체 및 항균제로서의 이들의 용도
HUP0001741A3 (en)	1996-08-02	2000-11-28	Smithkline Beecham Plc	Azabicyclic carbamoyloxy mutilin derivatives for antibacterial use, process for preparing them, pharmaceuticals contg. them and their use
EP0939631A1 (fr)	1996-10-01	1999-09-08	Smithkline Beecham Corporation	Utilisation de la mupirocine dans la fabrication d'un medicament destine au traitement d'infections bacteriennes associees a la colonisation du rhino-pharynx par des organismes pathogenes
UY25225A1 (es) *	1997-10-29	2000-12-29	Smithkline Beecham Plc	Derivados de pleuromutilina utiles como agentes antimicrobianos
DE602004024417D1 (de)	2003-09-03	2010-01-14	Glaxo Group Ltd	Neues verfahren zur herstellung von pleuromutilinderivaten
GB0504314D0 (en)	2005-03-02	2005-04-06	Glaxo Group Ltd	Novel polymorph

1996
- 1996-05-07 UY UY25225A patent/UY25225A1/es not_active IP Right Cessation
1998
- 1998-10-27 SI SI9830932T patent/SI1930330T1/sl unknown
- 1998-10-27 SI SI9830709T patent/SI1028961T1/xx unknown
- 1998-10-27 US US10/631,707 patent/USRE39128E1/en not_active Ceased
- 1998-10-27 IL IL13581198A patent/IL135811A0/xx active IP Right Grant
- 1998-10-27 CZ CZ20001551A patent/CZ298543B6/cs not_active IP Right Cessation
- 1998-10-27 EP EP04076485A patent/EP1452534A1/fr not_active Withdrawn
- 1998-10-27 PL PL375435A patent/PL197672B1/pl unknown
- 1998-10-27 WO PCT/GB1998/003211 patent/WO1999021855A1/fr active IP Right Grant
- 1998-10-27 AU AU96361/98A patent/AU742167C/en not_active Expired
- 1998-10-27 PT PT08152170T patent/PT1930330E/pt unknown
- 1998-10-27 TR TR2000/01203T patent/TR200001203T2/xx unknown
- 1998-10-27 CN CNB988127318A patent/CN1205211C/zh not_active Expired - Lifetime
- 1998-10-27 AT AT98950202T patent/ATE277925T1/de active
- 1998-10-27 BR BRPI9814747-1A patent/BR9814747B1/pt not_active IP Right Cessation
- 1998-10-27 ES ES08152170T patent/ES2371205T3/es not_active Expired - Lifetime
- 1998-10-27 PT PT98950202T patent/PT1028961E/pt unknown
- 1998-10-27 KR KR10-2000-7004707A patent/KR100538721B1/ko not_active IP Right Cessation
- 1998-10-27 EP EP98950202A patent/EP1028961B3/fr not_active Expired - Lifetime
- 1998-10-27 DK DK98950202T patent/DK1028961T5/da active
- 1998-10-27 HU HU0004040A patent/HU229792B1/hu active Protection Beyond IP Right Term
- 1998-10-27 AT AT08152170T patent/ATE525373T1/de active
- 1998-10-27 US US09/530,446 patent/US6281226B1/en not_active Ceased
- 1998-10-27 US US13/102,156 patent/USRE43390E1/en not_active Expired - Lifetime
- 1998-10-27 ES ES98950202T patent/ES2229538T7/es active Active
- 1998-10-27 DE DE122007000076C patent/DE122007000076I2/de active Active
- 1998-10-27 NZ NZ504203A patent/NZ504203A/xx not_active IP Right Cessation
- 1998-10-27 CA CA002307551A patent/CA2307551C/fr not_active Expired - Lifetime
- 1998-10-27 EP EP08152170A patent/EP1930330B1/fr not_active Expired - Lifetime
- 1998-10-27 DE DE69826704T patent/DE69826704T3/de not_active Expired - Lifetime
- 1998-10-27 MY MYPI98004896A patent/MY130665A/en unknown
- 1998-10-27 ZA ZA9809767A patent/ZA989767B/xx unknown
- 1998-10-27 DK DK08152170.0T patent/DK1930330T3/da active
- 1998-10-27 JP JP2000517965A patent/JP4227729B2/ja not_active Expired - Lifetime
- 1998-10-27 AR ARP980105377A patent/AR015987A1/es active IP Right Grant
- 1998-10-27 PL PL340254A patent/PL191927B1/pl unknown
- 1998-10-28 DZ DZ980244A patent/DZ2634A1/fr active
- 1998-10-29 PE PE1998001018A patent/PE123299A1/es not_active Application Discontinuation
- 1998-10-29 CO CO98063556A patent/CO5021129A1/es unknown
- 1998-10-29 EG EG132598A patent/EG24177A/xx active
- 1998-11-24 TW TW087119420A patent/TWI232861B/zh not_active IP Right Cessation
2000
- 2000-04-24 IL IL135811A patent/IL135811A/en not_active IP Right Cessation
- 2000-04-27 NO NO20002173A patent/NO327392B1/no not_active IP Right Cessation
2001
- 2001-02-05 HK HK01100820A patent/HK1031376A1/xx not_active IP Right Cessation
2007
- 2007-10-24 LU LU91372C patent/LU91372I2/fr unknown
- 2007-11-06 NL NL300304C patent/NL300304I2/nl unknown
- 2007-11-09 FR FR07C0057C patent/FR07C0057I2/fr active Active
- 2007-11-12 CY CY200700028C patent/CY2007028I2/el unknown
2008
- 2008-08-25 JP JP2008215667A patent/JP2009040789A/ja active Pending
2009
- 2009-04-01 NO NO20091344A patent/NO20091344L/no not_active Application Discontinuation
- 2009-09-25 NO NO2009023C patent/NO2009023I2/no unknown
2011
- 2011-10-31 CY CY20111101037T patent/CY1112062T1/el unknown
2014
- 2014-12-18 HU HUS1400060C patent/HUS1400060I1/hu unknown

Also Published As

Publication number	Publication date
SI1930330T1 (sl)	2011-12-30
DK1930330T3 (da)	2011-12-12
HUS1400060I1 (hu)	2016-09-28
DE122007000076I2 (de)	2010-03-25
PL197672B1 (pl)	2008-04-30
DK1028961T3 (da)	2005-01-03
BR9814747A (pt)	2001-11-20
NL300304I1 (nl)	2008-01-02
USRE43390E1 (en)	2012-05-15
HU229792B1 (en)	2014-07-28
CN1205211C (zh)	2005-06-08
DE122007000076I1 (de)	2008-02-14
EG24177A (en)	2008-09-28
ES2229538T3 (es)	2005-04-16
JP2001521033A (ja)	2001-11-06
US6281226B1 (en)	2001-08-28
UY25225A1 (es)	2000-12-29
AU9636198A (en)	1999-05-17
MY130665A (en)	2007-07-31
NZ504203A (en)	2002-11-26
EP1930330A1 (fr)	2008-06-11
TWI232861B (en)	2005-05-21
NO20002173L (no)	2000-06-05
JP4227729B2 (ja)	2009-02-18
EP1028961A1 (fr)	2000-08-23
NO20002173D0 (no)	2000-04-27
PT1028961E (pt)	2005-01-31
HK1031376A1 (en)	2001-06-15
LU91372I2 (fr)	2007-12-24
DE69826704T2 (de)	2005-10-06
NO2009023I2 (no)	2012-12-03
KR20010031654A (ko)	2001-04-16
PT1930330E (pt)	2011-10-31
AU742167B2 (en)	2001-12-20
EP1930330B1 (fr)	2011-09-21
SI1028961T1 (en)	2005-02-28
HUP0004040A3 (en)	2001-08-28
DE69826704D1 (de)	2004-11-04
NO20091344L (no)	2000-06-05
DE69826704T3 (de)	2009-07-23
CY2007028I1 (el)	2009-11-04
WO1999021855A1 (fr)	1999-05-06
ATE277925T1 (de)	2004-10-15
ATE525373T1 (de)	2011-10-15
ES2371205T3 (es)	2011-12-28
PL340254A1 (en)	2001-01-29
HUP0004040A1 (hu)	2001-05-28
LU91372I9 (fr)	2019-01-02
KR100538721B1 (ko)	2005-12-26
IL135811A (en)	2006-12-31
DK1028961T5 (da)	2009-03-09
AR015987A1 (es)	2001-05-30
CY1112062T1 (el)	2015-11-04
USRE39128E1 (en)	2006-06-13
BR9814747B1 (pt)	2010-12-14
CZ20001551A3 (cs)	2001-01-17
PL191927B1 (pl)	2006-07-31
JP2009040789A (ja)	2009-02-26
CO5021129A1 (es)	2001-03-27
EP1028961B1 (fr)	2004-09-29
CZ298543B6 (cs)	2007-10-31
CN1283197A (zh)	2001-02-07
FR07C0057I2 (fr)	2008-05-16
NO2009023I1 (no)	2009-10-12
NO327392B1 (no)	2009-06-22
CA2307551C (fr)	2007-01-30
ZA989767B (en)	2000-04-28
CY2007028I2 (el)	2009-11-04
CA2307551A1 (fr)	1999-05-06
IL135811A0 (en)	2001-05-20
FR07C0057I1 (fr)	2007-12-14
TR200001203T2 (tr)	2000-08-21
AU742167C (en)	2003-08-07
EP1028961B3 (fr)	2008-12-03
ES2229538T7 (es)	2009-06-18
NL300304I2 (nl)	2008-03-03
EP1452534A1 (fr)	2004-09-01
PE123299A1 (es)	2000-02-05

Publication	Publication Date	Title
DZ2634A1 (fr)	2003-03-08	Dérivés de pleuromutiline nouveaux procédé pour leur préparation et compositions pharmaceutiques lescontenant.
DZ2197A1 (fr)	2002-12-02	Dérivés de 6-phénylpyridyl-2-amine, procédé pour leur préparation et compositions pharmaceutiques les contenant.
DZ2300A1 (fr)	2002-12-25	Dérivés 6,5-hétérobicycliques substitués, procédé pour leur préparation et compositions pharmaceutiques les contenant.
DZ2299A1 (fr)	2002-12-25	Dérivés 6,6-hétérobicycliques substitués, procédé pour leur préparation et compositions pharmaceutiques les contenant.
DZ1889A1 (fr)	2002-02-17	Dérivés de quinoléine nouveaux, procédé pour leur préparation et compositions pharmaceutiques les contenant.
DZ2963A1 (fr)	2004-03-15	Dérivés de bicycliques substituées nouveaux, procédé pour leur préparation et compositions pharmaceutiques les contenant.
DZ2891A1 (fr)	2003-12-15	Dérivés de tétrahydroquinoléines substués nouveaux, procédé pour leur préparation et compositions pharmaceutiques les contenant.
MA26659A1 (fr)	2004-12-20	Dérivés de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procédé pour leur préparation.
DZ1957A1 (fr)	2002-02-17	Dérivés de pipéridine nouveaux, procédé pour leur préparation et compositions pharmaceutiques les contenant.
DZ2128A1 (fr)	2002-10-26	Composés nouveaux, procédé pour leur préparation et compositions pharmaceutiques les contenant.
DZ3009A1 (fr)	2004-03-27	Dérivés de quinoléine-2-one à substituant hétéroaryle nouveaux, procédé pour leur préparation et compositions pharmaceutiques les contenant.
DZ3045A1 (fr)	2004-03-27	Dérivés de i 3-méthyl-érythromycine nouveaux, procédé pour leur préparation et compositions pharmaceutiques les contenant.
DZ2457A1 (fr)	2004-11-08	Derivés de nicotinamide nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant.
DZ2880A1 (fr)	2003-12-15	Dérivés de quinoléine-2-one à substituant alcynylenouveaux procédé pour leur préparation et composi tions pharmaceutiques les contenant.
DZ2198A1 (fr)	2002-12-02	Dérivés de lactames, procédé pour leur préparationet compositions pharmaceutiques les contenant.
DZ2758A1 (fr)	2003-09-15	Dérivés bicycliques d0acide hydroxamique nouveaux procédé pour leur préparation et compositions pharmaceutiques les contenant.
DZ2227A1 (fr)	2002-12-25	Dérivés d'indole nouveaux, procédé pour leur préparation et formulations pharmaceutiques les contenant.
DZ3042A1 (fr)	2004-03-27	Dérivés d'isothiazole nouveaux, procédé pour leur préparation et compositions pharmaceutiques les contenant.
DZ2407A1 (fr)	2003-01-04	Dérivés de sulfonylurée procédé pour leur préparation et compositions pharmaceutiques les contenant
DZ2777A1 (fr)	2003-12-01	Dérivés de quinazolinamines nouveaux procédé pour leur préparation et compositions pharmaceutiques les contenant.
DZ2188A1 (fr)	2002-12-02	Dérivés de quinoxalinedone, procédés et intermédiaires pour leur préparation et compositions pharmaceutiques les contenant.
DZ2414A1 (fr)	2003-01-04	2-amino-6-(2-substitué-4-phenoxy)substituté-pyridines procédé pour leur préparation et compositions pharmaceutiques les contenant.
DZ2550A1 (fr)	2003-02-08	Dérivés d'azétidinylpropylpipéridine procédé pour leur préparation et compositions pharmaceutiques les contenant.
DZ2498A1 (fr)	2003-01-25	Dérivés de quinoléine nouveaux procédé pour leur préparation et compositions pharmaceutiques les contenant.
DZ2751A1 (fr)	2003-09-15	Composés calciolytiques nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant.