PE20020676A1 - Compuestos de mutilina como antibacterianos - Google Patents

Compuestos de mutilina como antibacterianos

Info

Publication number
PE20020676A1
PE20020676A1 PE2001000905A PE2001000905A PE20020676A1 PE 20020676 A1 PE20020676 A1 PE 20020676A1 PE 2001000905 A PE2001000905 A PE 2001000905A PE 2001000905 A PE2001000905 A PE 2001000905A PE 20020676 A1 PE20020676 A1 PE 20020676A1
Authority
PE
Peru
Prior art keywords
compounds
mutilin
amino
alkyl
antibacterial
Prior art date
Application number
PE2001000905A
Other languages
English (en)
Inventor
Gerd Ascher
Heinz Berner
Johannes Hildebrandt
Original Assignee
Biochemie Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0022439A external-priority patent/GB0022439D0/en
Priority claimed from GB0022440A external-priority patent/GB0022440D0/en
Priority claimed from GB0024674A external-priority patent/GB0024674D0/en
Application filed by Biochemie Gmbh filed Critical Biochemie Gmbh
Publication of PE20020676A1 publication Critical patent/PE20020676A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/54—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms

Abstract

SE REFIERE A COMPUESTOS DE MUTILINA DE FORMULA I DONDE R Y R2 JUNTO CON N FORMAN PIRROLIDINILO, PIPERIDINILO; R1 ES C(=X)(R9); R3 Y R3' SON H, DEUTERIO, HALOGENO; R4, R5, R10 SON H, ALQUILO; R6, R7, R8 SON H, DEUTERIO; R9 ES AMINO, ALQUILO, ARILO, HETEROCICLILO, MERCAPTO; SI X ES O; R9 ES H; X ES S, O, NR10, N+(R10')2; R10' ES ALQUILO; Y ES S, O; m ES 0-2; CUANDO R Y R2 JUNTO A N FORMAN PIPERIDINILO; m ES O, Y ES S; Y ESTA UNIDO EN A LA POSICION 3 DEL ANILLO DE PIPERIDINA. SON COMPUESTOS PREFERIDOS 14-O-[(N)-(3-METIL-2-AMINO-BUTIRIL-PIPERIDIN-3-IL)SULFANIL)-ACETIL]MUTILINA, 14-O-[(N-(3-METIL-2-AMINO-BUTIRIL-PIPERIDIN-4-IL)SULFANIL)-ACETIL]MUTILINA, ENTRE OTROS. LOS COMPUESTOS PUEDEN SER UTILES COMO AGENTES ANTIBACTERIANOS
PE2001000905A 2000-09-13 2001-09-10 Compuestos de mutilina como antibacterianos PE20020676A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0022439A GB0022439D0 (en) 2000-09-13 2000-09-13 Organic compounds
GB0022440A GB0022440D0 (en) 2000-09-13 2000-09-13 Organic Compounds
GB0024674A GB0024674D0 (en) 2000-10-09 2000-10-09 Organic compounds

Publications (1)

Publication Number Publication Date
PE20020676A1 true PE20020676A1 (es) 2002-08-27

Family

ID=27255885

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001000905A PE20020676A1 (es) 2000-09-13 2001-09-10 Compuestos de mutilina como antibacterianos

Country Status (17)

Country Link
US (3) US7169804B2 (es)
EP (1) EP1320525B1 (es)
JP (1) JP5134181B2 (es)
CN (1) CN1288134C (es)
AR (1) AR030651A1 (es)
AT (1) ATE264843T1 (es)
AU (1) AU2001291854A1 (es)
BR (1) BRPI0113837B8 (es)
CA (1) CA2418538C (es)
DE (1) DE60102936T2 (es)
ES (1) ES2220809T3 (es)
HK (1) HK1079506A1 (es)
MY (1) MY133930A (es)
PE (1) PE20020676A1 (es)
PT (1) PT1320525E (es)
TW (1) TWI306852B (es)
WO (1) WO2002022580A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9918037D0 (en) * 1999-07-30 1999-09-29 Biochemie Gmbh Organic compounds
GB0207495D0 (en) * 2002-03-28 2002-05-08 Biochemie Gmbh Organic compounds
GB0209262D0 (en) 2002-04-23 2002-06-05 Biochemie Gmbh Organic compounds
CN100355729C (zh) * 2002-07-24 2007-12-19 桑多斯股份公司 截短侧耳素
GB0308114D0 (en) * 2003-04-08 2003-05-14 Glaxo Group Ltd Novel compounds
US7544963B2 (en) * 2005-04-29 2009-06-09 Cree, Inc. Binary group III-nitride based high electron mobility transistors
GB0513058D0 (en) * 2005-06-27 2005-08-03 Sandoz Ag Organic compounds
WO2007037518A1 (ja) * 2005-09-29 2007-04-05 Dainippon Sumitomo Pharma Co., Ltd. ムチリン誘導体及びそれを含有する医薬組成物
EP1808431A1 (en) * 2006-01-16 2007-07-18 Nabriva Therapeutics Forschungs GmbH Mutilin derivatives and their use as pharmaceutical
JP2009539866A (ja) * 2006-06-05 2009-11-19 オースペックス・ファーマシューティカルズ・インコーポレイテッド 置換エリスロマイシンアナログの調製および有用性
EP1908750A1 (en) * 2006-10-05 2008-04-09 Nabriva Therapeutics Forschungs GmbH Process for the preparation of pleuromutilins
EP2149571A4 (en) 2007-05-24 2010-09-01 Kyorin Seiyaku Kk MUTILINE DERIVATIVE WITH A RINGED, HETEROCYCLIC AND AROMATIC CARBOXYLIC ACID STRUCTURE IN A SUBSTITUTE AT POSITION 14
WO2010056855A1 (en) * 2008-11-13 2010-05-20 Teva Pharmaceutical Industries Ltd. Preparation of retapamulin via its pleuromutilin-thiol precursor
CN103709115A (zh) * 2012-10-09 2014-04-09 山东亨利医药科技有限责任公司 截短侧耳素类抗生素衍生物
TWI762573B (zh) 2017-02-10 2022-05-01 奧地利商納畢瓦治療有限責任公司 截短側耳素之純化

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE789629A (fr) * 1971-10-05 1973-04-03 Sandoz Sa Nouveaux derives de la pleuromutiline, leur preparation et leurapplication en therapeutique
DE2811314A1 (de) 1978-03-16 1979-09-27 Sandoz Ag Kokzidiostatisches kombinationspraeparat
DE2966635D1 (en) 1979-01-12 1984-03-08 Sandoz Ag New pleuromutilin derivatives, their production and pharmaceutical compositions containing them
ZA80175B (en) * 1979-01-12 1981-08-26 Sandoz Ltd New pleuromutilin derivatives, their production and use
EP0153277B1 (de) * 1984-02-17 1987-08-26 Sandoz Ag Neue Pleuromutilinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung
JP3054875B2 (ja) * 1995-02-13 2000-06-19 株式会社小松製作所 プラズマトーチ
BR9612426A (pt) * 1996-01-03 1999-07-13 Smithkline Beecham Plc Derivados carbomoilóxi e sua aplicação como antibacterianos
UY25225A1 (es) * 1997-10-29 2000-12-29 Smithkline Beecham Plc Derivados de pleuromutilina utiles como agentes antimicrobianos
WO2000027790A1 (en) * 1998-11-11 2000-05-18 Smithkline Beecham P.L.C. Mutilin compounds
AU3036200A (en) * 1998-12-18 2000-07-12 Smithkline Beecham Plc Mutilin 14-ester derivatives having antibacterial activity
GB9918037D0 (en) * 1999-07-30 1999-09-29 Biochemie Gmbh Organic compounds
GB0207495D0 (en) * 2002-03-28 2002-05-08 Biochemie Gmbh Organic compounds
CN100355729C (zh) * 2002-07-24 2007-12-19 桑多斯股份公司 截短侧耳素

Also Published As

Publication number Publication date
BRPI0113837B8 (pt) 2021-05-25
US20040102482A1 (en) 2004-05-27
AU2001291854A1 (en) 2002-03-26
DE60102936D1 (de) 2004-05-27
US20090209584A1 (en) 2009-08-20
CN1288134C (zh) 2006-12-06
EP1320525A1 (en) 2003-06-25
CA2418538C (en) 2009-12-22
TWI306852B (en) 2009-03-01
DE60102936T2 (de) 2005-03-24
US7569587B2 (en) 2009-08-04
ATE264843T1 (de) 2004-05-15
HK1079506A1 (en) 2006-04-07
ES2220809T3 (es) 2004-12-16
US7169804B2 (en) 2007-01-30
JP2004509107A (ja) 2004-03-25
EP1320525B1 (en) 2004-04-21
JP5134181B2 (ja) 2013-01-30
CA2418538A1 (en) 2002-03-21
BR0113837A (pt) 2003-06-03
US20070135483A1 (en) 2007-06-14
AR030651A1 (es) 2003-08-27
CN1633415A (zh) 2005-06-29
PT1320525E (pt) 2004-09-30
WO2002022580A1 (en) 2002-03-21
MY133930A (en) 2007-11-30
BRPI0113837B1 (pt) 2019-01-29

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