DE602004024417D1 - Neues verfahren zur herstellung von pleuromutilinderivaten - Google Patents

Neues verfahren zur herstellung von pleuromutilinderivaten

Info

Publication number
DE602004024417D1
DE602004024417D1 DE602004024417T DE602004024417T DE602004024417D1 DE 602004024417 D1 DE602004024417 D1 DE 602004024417D1 DE 602004024417 T DE602004024417 T DE 602004024417T DE 602004024417 T DE602004024417 T DE 602004024417T DE 602004024417 D1 DE602004024417 D1 DE 602004024417D1
Authority
DE
Germany
Prior art keywords
production
new method
mutilin
ylsulfanyl
azabicyclo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602004024417T
Other languages
English (en)
Inventor
Gary Francis Breen
Michael Anthony Forth
Susan Shumei Kopelman
Francis Xavier Muller
Francis Dominic Sanderson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of DE602004024417D1 publication Critical patent/DE602004024417D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
DE602004024417T 2003-09-03 2004-08-30 Neues verfahren zur herstellung von pleuromutilinderivaten Active DE602004024417D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49978103P 2003-09-03 2003-09-03
PCT/US2004/028159 WO2005023257A1 (en) 2003-09-03 2004-08-30 Novel process, salts, compositions and use

Publications (1)

Publication Number Publication Date
DE602004024417D1 true DE602004024417D1 (de) 2010-01-14

Family

ID=34272868

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004024417T Active DE602004024417D1 (de) 2003-09-03 2004-08-30 Neues verfahren zur herstellung von pleuromutilinderivaten

Country Status (7)

Country Link
US (2) US7875630B2 (de)
EP (2) EP2181995A3 (de)
JP (4) JP5460947B2 (de)
AT (1) ATE450535T1 (de)
DE (1) DE602004024417D1 (de)
ES (1) ES2335284T3 (de)
WO (1) WO2005023257A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY25225A1 (es) 1997-10-29 2000-12-29 Smithkline Beecham Plc Derivados de pleuromutilina utiles como agentes antimicrobianos
ATE450535T1 (de) * 2003-09-03 2009-12-15 Glaxo Group Ltd Neues verfahren zur herstellung von pleuromutilinderivaten
GB0504314D0 (en) * 2005-03-02 2005-04-06 Glaxo Group Ltd Novel polymorph
WO2006104667A2 (en) * 2005-03-10 2006-10-05 Smithkline Beecham Corporation Novel method
GB0513058D0 (en) * 2005-06-27 2005-08-03 Sandoz Ag Organic compounds
EA016843B1 (ru) * 2006-12-14 2012-07-30 Тева Фармасьютикал Индастриз, Лтд. Таннат разагилина
EA016820B1 (ru) * 2006-12-14 2012-07-30 Тева Фармасьютикал Индастриз, Лтд. Кристаллическое твердое основание разагилина
EP2149571A4 (de) 2007-05-24 2010-09-01 Kyorin Seiyaku Kk Mutilin-derivat mit einer ringförmigen, heterozyklischen und aromatischen carboxylsäurestruktur in einem substituenten an position 14
TW200936582A (en) * 2007-11-26 2009-09-01 Teva Pharma Amorphous retapamulin and processes for preparation thereof
WO2009075776A1 (en) * 2007-12-05 2009-06-18 Teva Pharmaceutical Industries Ltd. Process for the preparation of retapamulin and its intermediates
WO2009095634A1 (en) * 2008-02-01 2009-08-06 Pliva Hrvatska D.O.O. Amorphous forms of retapamulin
WO2010056855A1 (en) * 2008-11-13 2010-05-20 Teva Pharmaceutical Industries Ltd. Preparation of retapamulin via its pleuromutilin-thiol precursor
EP2399904A1 (de) * 2010-05-26 2011-12-28 Nabriva Therapeutics AG Verfahren zur Herstellung von Pleuromutilinen
JP2013538868A (ja) * 2010-10-08 2013-10-17 ヘルパービー セラピューティクス リミテッド 新規な組成物
CN102267992B (zh) * 2011-06-17 2012-10-31 华南农业大学 一种截短侧耳素类抗生素的制备方法
CN105198873B (zh) * 2014-06-11 2017-08-04 上海医药工业研究院 一种制备瑞他莫林的方法
CA2991099A1 (en) 2015-07-02 2017-01-05 Horizon Orphan Llc Ado-resistant cysteamine analogs and uses thereof
TWI762573B (zh) 2017-02-10 2022-05-01 奧地利商納畢瓦治療有限責任公司 截短側耳素之純化
CN107324998B (zh) * 2017-07-31 2020-07-14 重庆华邦胜凯制药有限公司 一种制备外用抗生素类药物瑞他莫林的方法
CN114096231A (zh) * 2019-08-01 2022-02-25 联合利华知识产权控股有限公司 一种抗头皮屑组合物

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE789629A (fr) * 1971-10-05 1973-04-03 Sandoz Sa Nouveaux derives de la pleuromutiline, leur preparation et leurapplication en therapeutique
US4130709A (en) 1977-12-08 1978-12-19 Eli Lilly And Company Pleuromutilin glycoside derivatives
JPS54160358A (en) * 1978-06-06 1979-12-19 Sandoz Ag Improvement for organic compound
DE2966635D1 (en) * 1979-01-12 1984-03-08 Sandoz Ag New pleuromutilin derivatives, their production and pharmaceutical compositions containing them
JPH0613528B2 (ja) * 1985-08-20 1994-02-23 塩野義製薬株式会社 セフエム化合物のメトキシ化法
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
AT397654B (de) * 1992-05-04 1994-06-27 Biochemie Gmbh Neue pleuromutilinderivate, ihre verwendung und verfahren zu ihrer herstellung
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
GB9713730D0 (en) * 1997-06-30 1997-09-03 Ciba Geigy Ag Organic compounds
UY25225A1 (es) * 1997-10-29 2000-12-29 Smithkline Beecham Plc Derivados de pleuromutilina utiles como agentes antimicrobianos
CN1331674A (zh) * 1998-12-22 2002-01-16 霍夫曼-拉罗奇有限公司 磺酰胺异羟肟酸酯
GB9918037D0 (en) * 1999-07-30 1999-09-29 Biochemie Gmbh Organic compounds
TWI260220B (en) * 1999-11-22 2006-08-21 Novartis Ag A pharmaceutical composition for the transdermal treatment of bacterial infections in animals
US20040089753A1 (en) 2000-06-28 2004-05-13 Holland Simon Joseph Wet milling process
CA2437215A1 (en) * 2001-02-02 2002-08-15 Mitsubishi Pharma Corporation Dihydropyrazolopyridine compounds and pharmaceutical use thereof
GB0207495D0 (en) * 2002-03-28 2002-05-08 Biochemie Gmbh Organic compounds
CN100355729C (zh) * 2002-07-24 2007-12-19 桑多斯股份公司 截短侧耳素
ATE450535T1 (de) 2003-09-03 2009-12-15 Glaxo Group Ltd Neues verfahren zur herstellung von pleuromutilinderivaten
GB0504314D0 (en) 2005-03-02 2005-04-06 Glaxo Group Ltd Novel polymorph
WO2006104667A2 (en) 2005-03-10 2006-10-05 Smithkline Beecham Corporation Novel method

Also Published As

Publication number Publication date
ES2335284T3 (es) 2010-03-24
WO2005023257A1 (en) 2005-03-17
JP5719331B2 (ja) 2015-05-20
JP2007504231A (ja) 2007-03-01
EP2181995A3 (de) 2010-06-16
EP1663220A4 (de) 2007-04-18
EP1663220B1 (de) 2009-12-02
ATE450535T1 (de) 2009-12-15
US7875630B2 (en) 2011-01-25
JP5460947B2 (ja) 2014-04-02
US20060276503A1 (en) 2006-12-07
JP2012020998A (ja) 2012-02-02
JP5685156B2 (ja) 2015-03-18
JP2012236850A (ja) 2012-12-06
EP1663220A1 (de) 2006-06-07
US8207191B2 (en) 2012-06-26
US20110144151A1 (en) 2011-06-16
EP2181995A2 (de) 2010-05-05
JP2015013882A (ja) 2015-01-22

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