CO2020005417A2 - Inhibidores de la quinasa p38 que reducen la expresión de dux4 y de los genes corriente abajo para el tratamiento de fshd - Google Patents

Inhibidores de la quinasa p38 que reducen la expresión de dux4 y de los genes corriente abajo para el tratamiento de fshd

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Publication number
CO2020005417A2
CO2020005417A2 CONC2020/0005417A CO2020005417A CO2020005417A2 CO 2020005417 A2 CO2020005417 A2 CO 2020005417A2 CO 2020005417 A CO2020005417 A CO 2020005417A CO 2020005417 A2 CO2020005417 A2 CO 2020005417A2
Authority
CO
Colombia
Prior art keywords
dux4
downstream genes
fshd
treatment
kinase inhibitors
Prior art date
Application number
CONC2020/0005417A
Other languages
English (en)
Inventor
Angela Marie Cacace
Soto Luis Gustavo Alejandro Rojas
Lorin A Thompson Iii
Owen Brendan Wallace
Lucienne V Ronco
Ning Shen
Aaron Nakwon Chang
Alan Scott Robertson
Original Assignee
Fulcrum Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fulcrum Therapeutics Inc filed Critical Fulcrum Therapeutics Inc
Publication of CO2020005417A2 publication Critical patent/CO2020005417A2/es

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    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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Abstract

La invención se refiere a métodos y composiciones que incluyen agentes e inhibidores de la quinasa p38 que regulan la expresión de DUX4 y de los genes corriente abajo que incluyen, mas no se limitan a, ZSCAN4, LEUTX, PRAMEF2, TRIM43, MBD3L2, KHDC1L, RFPL2, CCNA1, SLC34A2, TPRX1, PRAMEF20, TRIM49, PRAMEF4, PRAME6, PRAMEF15, o ZNF280A. Se divulgan métodos útiles para tratar una enfermedad asociada con la expresión anormal de DUX4 y de los genes corriente abajo (por ejemplo, distrofia muscular facioescapulohumeral).
CONC2020/0005417A 2017-10-05 2020-04-30 Inhibidores de la quinasa p38 que reducen la expresión de dux4 y de los genes corriente abajo para el tratamiento de fshd CO2020005417A2 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762568673P 2017-10-05 2017-10-05
US201762568754P 2017-10-05 2017-10-05
US201862682565P 2018-06-08 2018-06-08
US201862682563P 2018-06-08 2018-06-08
PCT/US2018/054642 WO2019071147A1 (en) 2017-10-05 2018-10-05 INHIBITORS OF KINASE P38 REDUCING EXPRESSION OF DUX4 GENE AND DOWNSTREAM GENES FOR THE TREATMENT OF FSHD

Publications (1)

Publication Number Publication Date
CO2020005417A2 true CO2020005417A2 (es) 2020-07-31

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Application Number Title Priority Date Filing Date
CONC2020/0005351A CO2020005351A2 (es) 2017-10-05 2020-04-29 Uso de inhibidores de p38 para reducir la expresión de dux4
CONC2020/0005417A CO2020005417A2 (es) 2017-10-05 2020-04-30 Inhibidores de la quinasa p38 que reducen la expresión de dux4 y de los genes corriente abajo para el tratamiento de fshd

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CONC2020/0005351A CO2020005351A2 (es) 2017-10-05 2020-04-29 Uso de inhibidores de p38 para reducir la expresión de dux4

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