PE20070640A1 - Compuestos derivados de pirazol-isoquinolina urea como inhibidores de la cinasa p38 - Google Patents
Compuestos derivados de pirazol-isoquinolina urea como inhibidores de la cinasa p38Info
- Publication number
- PE20070640A1 PE20070640A1 PE2006001274A PE2006001274A PE20070640A1 PE 20070640 A1 PE20070640 A1 PE 20070640A1 PE 2006001274 A PE2006001274 A PE 2006001274A PE 2006001274 A PE2006001274 A PE 2006001274A PE 20070640 A1 PE20070640 A1 PE 20070640A1
- Authority
- PE
- Peru
- Prior art keywords
- urea
- pirazol
- methyl
- isoquinolin
- isoquinoline
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE PIRAZOL-ISOQUINOLINA UREA DE FORMULA (I) DONDE X ES UN COMPUESTO DE FORMULA (i) O (ii), DONDE R3 ES AMINO, ALQUILO(C1-C4), ALCOXI(C1-C4), ALQUILHALO(C1-C4), ENTRE OTROS; R1 ES ALQUILO(C1-C4), ALQUILHALO(C1-C4) O CICLOALQUILO(C3-C4) OPCIONALMENTE SUSTITUIDO CON ALCOXI(C1-C4), METILO O TRIFLUOROMETILO; R2 ES FENILO O PIRIDINILO OPCIONALMENTE SUSTITUIDOS CON ALQUILO(C1-C4). SON COMPUESTOS PREFERIDOS: MESILATO DE 1-{1-[4-(2,2-DIMETIL-PROPIONIL)-PIPERAZIN-1-IL]-ISOQUINOLIN-4-IL}-3-[5-(1-METIL-CICLOPROPIL)-2-p-TOLIL-2H-PIRAZOL-3-IL]-UREA, MESILATO DE 1-[5-TERC-BUTIL-2-(6-METIL-PIRIDIN-3-IL)-2H-PIRAZOL-3-IL]-{1-[1-(1-METIL-CICLOPROPANCARBONIL)-PIPERIDIN-4-ILOXI]-ISOQUINOLIN-4-IL}-UREA, MESILATO DE 1-{1-[1-(2-FLUORO-BENZOIL)-PIPERIDIN-4-ILOXI]-ISOQUINOLIN-4-IL}-3-[5-(1-METOXI-CICLOPROPIL)-2-p-TOLIL-2H-PIRAZOL-3-IL]-UREA. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA CINASA P38 SIENDO UTILES EN EL TRATAMIENTO DE ARTRITIS REUMATOIDE, OSTEOARTRITIS, ATEROESCLEROSIS, INSUFICIENCIA CARDIACA CRONICA
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05380240 | 2005-10-28 | ||
US75020005P | 2005-12-14 | 2005-12-14 | |
EP06380097 | 2006-04-26 | ||
US82196406P | 2006-08-10 | 2006-08-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20070640A1 true PE20070640A1 (es) | 2007-08-10 |
Family
ID=43298632
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2006001274A PE20070640A1 (es) | 2005-10-28 | 2006-10-20 | Compuestos derivados de pirazol-isoquinolina urea como inhibidores de la cinasa p38 |
Country Status (13)
Country | Link |
---|---|
US (1) | US7582638B2 (es) |
EP (1) | EP1943244A1 (es) |
JP (1) | JP2009513639A (es) |
KR (1) | KR101013303B1 (es) |
AR (1) | AR058128A1 (es) |
AU (1) | AU2006309174B2 (es) |
BR (1) | BRPI0617828A2 (es) |
CA (1) | CA2627670A1 (es) |
DO (1) | DOP2006000233A (es) |
EA (1) | EA015123B1 (es) |
PE (1) | PE20070640A1 (es) |
TW (1) | TW200800194A (es) |
WO (1) | WO2007053346A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008125014A1 (fr) * | 2007-04-13 | 2008-10-23 | Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. | Composés d'urée, leurs procédés de préparation et leurs utilisations pharmaceutiques |
EP2039676A1 (en) * | 2007-09-19 | 2009-03-25 | Huntsman International Llc | Process for the production of di-and polyamines of the diphenylmethane series |
PL2763984T3 (pl) | 2011-10-03 | 2016-10-31 | 1-pirazolilo-3-(4-((2-anilinopirymidyno-4-ilo)oksy)naftaleno-1-ilo)moczniki jako inhibitory kinazy p38 MAP | |
EP2578582A1 (en) | 2011-10-03 | 2013-04-10 | Respivert Limited | 1-Pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl)ureas as p38 MAP kinase inhibitors |
GB201214750D0 (en) | 2012-08-17 | 2012-10-03 | Respivert Ltd | Compounds |
EP2925742B1 (en) | 2012-11-16 | 2016-10-26 | Respivert Limited | Kinase inhibitors |
WO2014140582A1 (en) | 2013-03-14 | 2014-09-18 | Respivert Limited | Kinase inhibitors |
MX2019010302A (es) | 2017-03-30 | 2019-11-21 | Hoffmann La Roche | Isoquinolinas como inhibidores de hpk1. |
US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
LT3691620T (lt) | 2017-10-05 | 2022-09-26 | Fulcrum Therapeutics, Inc. | P38 kinazės inhibitoriai, sumažinantys dux4 ir pasrovinių genų raišką, skirti fshd gydymui |
US11612606B2 (en) | 2018-10-03 | 2023-03-28 | Genentech, Inc. | 8-aminoisoquinoline compounds and uses thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA73492C2 (en) | 1999-01-19 | 2005-08-15 | Aromatic heterocyclic compounds as antiinflammatory agents | |
US20060063782A1 (en) | 2002-07-03 | 2006-03-23 | Murray Christopher W | 3-Hetero arylmethoxy ! pyridines and their analogues as p38 map kinase inhibitors |
WO2006009741A1 (en) * | 2004-06-23 | 2006-01-26 | Eli Lilly And Company | Kinase inhibitors |
EP1609789A1 (en) | 2004-06-23 | 2005-12-28 | Eli Lilly And Company | Ureido-pyrazole derivatives and their use as kinase inhibitors |
-
2006
- 2006-10-20 PE PE2006001274A patent/PE20070640A1/es not_active Application Discontinuation
- 2006-10-20 AR ARP060104596A patent/AR058128A1/es unknown
- 2006-10-20 DO DO2006000233A patent/DOP2006000233A/es unknown
- 2006-10-20 TW TW095138681A patent/TW200800194A/zh unknown
- 2006-10-23 WO PCT/US2006/041266 patent/WO2007053346A1/en active Application Filing
- 2006-10-23 EA EA200801200A patent/EA015123B1/ru not_active IP Right Cessation
- 2006-10-23 CA CA002627670A patent/CA2627670A1/en not_active Abandoned
- 2006-10-23 AU AU2006309174A patent/AU2006309174B2/en not_active Expired - Fee Related
- 2006-10-23 US US12/089,420 patent/US7582638B2/en not_active Expired - Fee Related
- 2006-10-23 BR BRPI0617828-6A patent/BRPI0617828A2/pt not_active IP Right Cessation
- 2006-10-23 JP JP2008537837A patent/JP2009513639A/ja not_active Withdrawn
- 2006-10-23 KR KR1020087010067A patent/KR101013303B1/ko not_active IP Right Cessation
- 2006-10-23 EP EP06817284A patent/EP1943244A1/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
EP1943244A1 (en) | 2008-07-16 |
BRPI0617828A2 (pt) | 2011-08-09 |
WO2007053346A1 (en) | 2007-05-10 |
CA2627670A1 (en) | 2007-05-10 |
EA200801200A1 (ru) | 2008-08-29 |
TW200800194A (en) | 2008-01-01 |
DOP2006000233A (es) | 2007-06-15 |
EA015123B1 (ru) | 2011-06-30 |
AU2006309174A1 (en) | 2007-05-10 |
US20080275056A1 (en) | 2008-11-06 |
AR058128A1 (es) | 2008-01-23 |
AU2006309174B2 (en) | 2011-10-13 |
KR20080053514A (ko) | 2008-06-13 |
JP2009513639A (ja) | 2009-04-02 |
KR101013303B1 (ko) | 2011-02-09 |
US7582638B2 (en) | 2009-09-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration | ||
FD | Application declared void or lapsed |