PE20061155A1 - Derivados de indolinona como agentes para el tratamiento o la prevencion de enfermedades fibroticas - Google Patents

Derivados de indolinona como agentes para el tratamiento o la prevencion de enfermedades fibroticas

Info

Publication number
PE20061155A1
PE20061155A1 PE2005001477A PE2005001477A PE20061155A1 PE 20061155 A1 PE20061155 A1 PE 20061155A1 PE 2005001477 A PE2005001477 A PE 2005001477A PE 2005001477 A PE2005001477 A PE 2005001477A PE 20061155 A1 PE20061155 A1 PE 20061155A1
Authority
PE
Peru
Prior art keywords
phenyl
indolinone
treatment
fibrotic diseases
carboxyethyl
Prior art date
Application number
PE2005001477A
Other languages
English (en)
Inventor
John Edward Park
Nveed Chaudhary
Armin Heckel
Jorg Kley
Thorsten Lehmann-Lintz
Gerald Jurgen Roth
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of PE20061155A1 publication Critical patent/PE20061155A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

REFERIDA A UN COMPUESTO DERIVADO DE INDOLINONA DE FORMULA (I), DONDE X ES O; R1 ES H; R2 ES F, Cl, Br O CN; R3 ES FENILO OPCIONALMENTE MONOSUSTITUIDO CON F, Cl, Br, I O ALCOXI C1-C3, PUDIENDO DICHO FENILO ESTAR SUSTITUIDO EN LA POSICION 3 O 4 CON CN, ALCOXI C1-C3, CARBOXIALQUILO C1-C3, ENTRE OTROS; R4 ES FENILO O FENILO SUSTITUIDO CON AMINO, GUANIDINO, MONO O DI(ALQUIL C1-C2)AMINO, ENTRE OTROS; R5 Y R6 SON H. SON COMPUESTOS PREFERIDOS: 3-Z-[1-(4-DIMETILAMINOMETILANILINO)-1-(3-(2-CARBOXIETIL)FENIL)METILEN]-6-CLORO-2-INDOLINONA, 3-Z-[1-(4-DIMETILAMINOMETILANILINO)-1-(4-(2-CARBOXIETIL)FENIL)METILEN]-6-FLUORO-2-INDOLINONA, 3-Z-[1-(4-(N-(4-METILPIPERAZIN-1-ILMETILCARBONIL)-N-METILAMINO)ANILINO)-1-(4-(2-CARBOXIETIL)FENIL)METILEN]-6-FLUORO-2-INDOLINONA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES FIBROTICAS TALES COMO FIBROSIS PULMONAR, FIBROSIS QUISTICA, GRANULOMATOSIS, ENTRE OTRAS
PE2005001477A 2004-12-24 2005-12-16 Derivados de indolinona como agentes para el tratamiento o la prevencion de enfermedades fibroticas PE20061155A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04030769 2004-12-24

Publications (1)

Publication Number Publication Date
PE20061155A1 true PE20061155A1 (es) 2006-12-16

Family

ID=35717457

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005001477A PE20061155A1 (es) 2004-12-24 2005-12-16 Derivados de indolinona como agentes para el tratamiento o la prevencion de enfermedades fibroticas

Country Status (26)

Country Link
US (3) US20060148883A1 (es)
EP (1) EP1835907B1 (es)
JP (1) JP5748386B2 (es)
KR (1) KR20070092305A (es)
CN (1) CN101087604B (es)
AR (1) AR052439A1 (es)
AT (1) ATE429222T1 (es)
AU (1) AU2005318136B2 (es)
BR (1) BRPI0519351A2 (es)
CA (1) CA2591089C (es)
DE (1) DE602005014145D1 (es)
DK (1) DK1835907T3 (es)
EA (1) EA200701181A1 (es)
ES (1) ES2326277T3 (es)
HR (1) HRP20090312T1 (es)
IL (1) IL184124A0 (es)
MX (1) MX2007007676A (es)
NO (1) NO20073830L (es)
PE (1) PE20061155A1 (es)
PL (1) PL1835907T3 (es)
PT (1) PT1835907E (es)
RS (1) RS50833B (es)
SI (1) SI1835907T1 (es)
TW (1) TW200637544A (es)
WO (1) WO2006067175A1 (es)
ZA (1) ZA200703600B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7514468B2 (en) * 2002-07-23 2009-04-07 Boehringer Ingelheim Pharma Gmbh & Co. Kg Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions
US7169936B2 (en) * 2002-07-23 2007-01-30 Boehringer Ingelheim Pharma Gmbh & Co. Kg Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments
PE20060777A1 (es) 2004-12-24 2006-10-06 Boehringer Ingelheim Int Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
WO2007057399A2 (en) * 2005-11-15 2007-05-24 Boehringer Ingelheim International Gmbh Treatment of cancer with indole derivatives
EP2116367B1 (en) * 2007-03-02 2018-04-04 Mitsui Chemicals, Inc. Layered nonwoven fabric
JP5524852B2 (ja) * 2007-11-15 2014-06-18 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 置換アミド、それらの製造及び医薬品としての使用
US20090131359A1 (en) * 2007-11-19 2009-05-21 Atamas Sergei P Antifibrotic therapy
RU2010135198A (ru) * 2008-01-25 2012-02-27 Бёрингер Ингельхайм Интернациональ Гмбх (De) Солевые формы производного 6-фтор-1,2-дигидро-2-оксо-3н-индол-3-илидена, способ их получения и содержащие их фармацевтические композиции
US8759010B2 (en) 2008-09-26 2014-06-24 Inserm (Institut National De La Sante Et De La Recherche Medicale) Host cell kinases as targets for antiviral therapies against HCV infection
US20140050728A1 (en) * 2011-01-28 2014-02-20 Board Of Regents Of The University Of Nebraska Methods and compositions for inhibiting cyclophilin d for the treatment and prevention of obesity and kidney indications
US10450295B2 (en) 2013-08-09 2019-10-22 Acclaim BioMed USA LLC Method of using an indolinone molecule and derivatives for inhibiting liver fibrosis and hepatitis
LT3691620T (lt) 2017-10-05 2022-09-26 Fulcrum Therapeutics, Inc. P38 kinazės inhibitoriai, sumažinantys dux4 ir pasrovinių genų raišką, skirti fshd gydymui
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU21301A (sh) * 1998-09-25 2003-04-30 Boehringer Ingelheim Pharama Gmbh. & Co. Kg. Novi supstituisani indolinoni sa inhibitorskim efektom za različite kinaze i komplekse ciklin/cdk
US6762180B1 (en) * 1999-10-13 2004-07-13 Boehringer Ingelheim Pharma Kg Substituted indolines which inhibit receptor tyrosine kinases
DE10117204A1 (de) * 2001-04-06 2002-10-10 Boehringer Ingelheim Pharma In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
PE20040701A1 (es) * 2002-07-23 2004-11-30 Boehringer Ingelheim Pharma Derivados de indolinona sustituidos en posicion 6 y su preparacion como medicamentos
US7169936B2 (en) * 2002-07-23 2007-01-30 Boehringer Ingelheim Pharma Gmbh & Co. Kg Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments

Also Published As

Publication number Publication date
DK1835907T3 (da) 2009-08-03
ATE429222T1 (de) 2009-05-15
US20120004202A1 (en) 2012-01-05
JP5748386B2 (ja) 2015-07-15
DE602005014145D1 (de) 2009-06-04
KR20070092305A (ko) 2007-09-12
RS50833B (sr) 2010-08-31
TW200637544A (en) 2006-11-01
CN101087604A (zh) 2007-12-12
WO2006067175A1 (en) 2006-06-29
PL1835907T3 (pl) 2009-08-31
EP1835907A1 (en) 2007-09-26
US20140128409A1 (en) 2014-05-08
SI1835907T1 (sl) 2009-10-31
JP2008525374A (ja) 2008-07-17
EA200701181A1 (ru) 2008-02-28
US20060148883A1 (en) 2006-07-06
EP1835907B1 (en) 2009-04-22
CA2591089C (en) 2014-02-11
CN101087604B (zh) 2010-10-13
AU2005318136B2 (en) 2012-02-09
HRP20090312T1 (en) 2009-07-31
AR052439A1 (es) 2007-03-21
BRPI0519351A2 (pt) 2009-01-20
PT1835907E (pt) 2009-06-16
CA2591089A1 (en) 2006-06-29
ZA200703600B (en) 2008-07-30
NO20073830L (no) 2007-07-23
AU2005318136A1 (en) 2006-06-29
IL184124A0 (en) 2007-10-31
ES2326277T3 (es) 2009-10-06
MX2007007676A (es) 2007-08-14

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