UA94733C2 - Ингибиторы киназы и способы их использования - Google Patents

Ингибиторы киназы и способы их использования

Info

Publication number
UA94733C2
UA94733C2 UAA200810690A UAA200810690A UA94733C2 UA 94733 C2 UA94733 C2 UA 94733C2 UA A200810690 A UAA200810690 A UA A200810690A UA A200810690 A UAA200810690 A UA A200810690A UA 94733 C2 UA94733 C2 UA 94733C2
Authority
UA
Ukraine
Prior art keywords
methods
kinase inhibitors
kinases
prodrugs
prevention
Prior art date
Application number
UAA200810690A
Other languages
English (en)
Ukrainian (uk)
Inventor
Роберт Гронеберг
Лоренс Э. БУРГЕСС
Даренн Харвей
Эллен Лерд
Марк Мансон
Джеймс Риззи
Марта Родригес
Чарльз Тодд Эри
Даниэл Ватсон
Original Assignee
Эррей Биофарма Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эррей Биофарма Инк. filed Critical Эррей Биофарма Инк.
Publication of UA94733C2 publication Critical patent/UA94733C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C07D231/40—Acylated on said nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Соединение формулы IIили его фармацевтически приемлемые соли и пролекарства, которые полезны в лечении и предупреждении разных расстройств, опосредованных киназами.
UAA200810690A 2006-01-31 2007-01-26 Ингибиторы киназы и способы их использования UA94733C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US76371206P 2006-01-31 2006-01-31

Publications (1)

Publication Number Publication Date
UA94733C2 true UA94733C2 (ru) 2011-06-10

Family

ID=38037453

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200810690A UA94733C2 (ru) 2006-01-31 2007-01-26 Ингибиторы киназы и способы их использования

Country Status (27)

Country Link
US (2) US8044083B2 (ru)
EP (1) EP1981851B1 (ru)
JP (1) JP5131990B2 (ru)
KR (1) KR101357465B1 (ru)
CN (1) CN101415685B (ru)
AT (1) ATE542800T1 (ru)
AU (1) AU2007210073B2 (ru)
BR (1) BRPI0707401B8 (ru)
CA (1) CA2635813C (ru)
CY (1) CY1112770T1 (ru)
DK (1) DK1981851T3 (ru)
ES (1) ES2379656T3 (ru)
HK (1) HK1123548A1 (ru)
HR (1) HRP20120256T1 (ru)
IL (3) IL192949A (ru)
MY (1) MY151835A (ru)
NZ (1) NZ570846A (ru)
PL (1) PL1981851T3 (ru)
PT (1) PT1981851E (ru)
RS (1) RS52298B (ru)
RU (1) RU2442777C2 (ru)
SG (1) SG175599A1 (ru)
SI (1) SI1981851T1 (ru)
TW (1) TWI388557B (ru)
UA (1) UA94733C2 (ru)
WO (1) WO2007089646A1 (ru)
ZA (1) ZA200806507B (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7135575B2 (en) 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
RU2442777C2 (ru) 2006-01-31 2012-02-20 Эррэй Биофарма Инк. Ингибиторы киназ и способы их применения
US8202899B2 (en) * 2007-07-25 2012-06-19 Array Biopharma Inc. Pyrazole urea derivatives used as kinase inhibitors
EP2196461A1 (de) 2008-12-15 2010-06-16 Bayer CropScience AG 4-Amino-1,2,3-benzoxathiazin-Derivate als Pestizide
ME02583B (me) 2011-05-13 2017-06-20 Array Biopharma Inc Jedinjenja pirolidinil uree, pirolidinil tiouree i pirolidinil guanidina kao inhibitori trka kinaze
RU2627702C2 (ru) * 2012-03-01 2017-08-10 Эррэй Биофарма Инк. Кристаллические формы 1-(3-трет-бутил-1-п-толил-1н-пиразол-5-ил)-3-(5-фтор-2-(1-(2-гидроксиэтил)-1н-индазол-5-илокси)бензил) мочевины гидрохлорида
US9790206B2 (en) * 2013-02-27 2017-10-17 Array Biopharma Inc. Intermediates for use in the preparation of indazole derivatives and processes for the preparation thereof
CN114748622A (zh) 2017-10-05 2022-07-15 弗尔康医疗公司 P38激酶抑制剂降低dux4和下游基因表达以用于治疗fshd
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
WO2019114792A1 (zh) 2017-12-13 2019-06-20 劲方医药科技(上海)有限公司 一种TGF-βRI抑制剂的晶型、盐型及其制备方法
WO2023084459A1 (en) 2021-11-15 2023-05-19 Pfizer Inc. Methods of treating sars-cov-2

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3755332A (en) * 1971-07-01 1973-08-28 Ciba Geigy Corp Substituted 4 indazolaminoquinolines
JPS5998060A (ja) 1982-11-27 1984-06-06 Fujisawa Pharmaceut Co Ltd インダゾ−ル誘導体、その製造法および農薬
US4571255A (en) * 1983-12-29 1986-02-18 Ppg Industries, Inc. Subsituted phenoxybenzisoxazole herbicides
SU1545940A3 (ru) 1984-10-19 1990-02-23 Ай-Си-Ай Америказ Инк (Фирма) Способ получени гетероциклических кислот или их солей
US5234942A (en) * 1984-10-19 1993-08-10 Ici Americas Inc. Heterocyclic amides and leucotriene antagonistic use thereof
GB8524157D0 (en) * 1984-10-19 1985-11-06 Ici America Inc Heterocyclic amides
PL265549A1 (en) 1985-03-26 1988-09-01 The method of manufacture of new heterocyclic amides
JPS6368568A (ja) 1986-09-10 1988-03-28 Otsuka Pharmaceut Factory Inc ｐ−アミノフエノ−ル誘導体
NZ224714A (en) 1987-06-01 1990-03-27 Janssen Pharmaceutica Nv Substituted benzotriazole derivatives and pharmaceutical compositions
IE910278A1 (en) 1990-02-16 1991-08-28 Ici Plc Heterocyclic compounds
US6194439B1 (en) * 1991-05-29 2001-02-27 Pfizer Inc. Tricyclic polyhydroxylic tyrosine kinase inhibitors
RU2105005C1 (ru) * 1992-07-03 1998-02-20 Кумиай Кемикал Индастри Ко., Лтд. Конденсированное гетероциклическое производное, способ его получения и гербицидное средство
CA2150326A1 (en) * 1994-05-27 1995-11-28 Kimihiro Murakami Azolyl methyl phenyl derivatives having aromatase inhibitory activity
US6083949A (en) * 1995-10-06 2000-07-04 Merck & Co., Inc. Substituted imidazoles having anti-cancer and cytokine inhibitory activity
EE03681B1 (et) 1995-10-06 2002-04-15 Merck & Co., Inc. Asendatud imidasoolid, millel on vähivastane ja tsütokiine inhibeeriv toime
EA002113B1 (ru) 1996-09-04 2001-12-24 Пфайзер Инк. Производные индазола и их использование в качестве ингибиторов фосфодиэстеразы (фдэ) типа iv и продуцирования фактора некроза опухоли (фно)
KR100567649B1 (ko) 1996-09-25 2006-04-05 아스트라제네카 유케이 리미티드 혈관 내피 성장 인자와 같은 성장 인자의 효과를 억제하는 퀴놀린 유도체
US6218386B1 (en) * 1996-11-08 2001-04-17 Dupont Pharmaceuticals A1-(3-aminoindazol-5-yl)-3 butyl-cyclic urea useful as a HIV protease inhibitor
US5932570A (en) * 1996-11-08 1999-08-03 Dupont Pharmaceuticals Company 1-(3-aminoindazol-5-yl)-3-phenylmethyl-cyclic ureas useful as HIV protease inhibitors
KR20000053122A (ko) 1996-11-08 2000-08-25 블레어 큐. 퍼거슨 Ｈｉｖ 프로테아제 억제제로 유용한 1-(3-아미노인다졸-5-일)-3-페닐메틸-시클릭 우레아
US5945418A (en) * 1996-12-18 1999-08-31 Vertex Pharmaceuticals Incorporated Inhibitors of p38
UA73073C2 (ru) 1997-04-03 2005-06-15 Уайт Холдінгз Корпорейшн Замещенные 3-циан хинолины
IL132318A0 (en) * 1997-04-24 2001-03-19 Ortho Mcneil Pharm Inc Substituted imidazoles useful in the treatment of inflammatory diseases
CA2288787A1 (en) * 1997-05-22 1998-11-26 G.D. Searle And Co. Pyrazole derivatives as p38 kinase inhibitors
US6093742A (en) * 1997-06-27 2000-07-25 Vertex Pharmaceuticals, Inc. Inhibitors of p38
US6297239B1 (en) * 1997-10-08 2001-10-02 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
AU745579B2 (en) * 1997-10-20 2002-03-21 F. Hoffmann-La Roche Ag Bicyclic kinase inhibitors
WO1999023091A1 (en) * 1997-11-03 1999-05-14 Boehringer Ingelheim Pharmaceuticals, Inc. Aromatic heterocyclic compounds as anti-inflammatory agents
US6329412B1 (en) * 1997-11-04 2001-12-11 Pfizer Inc Bisamidine compounds as antiproliferative agents
KR20010031783A (ko) 1997-11-04 2001-04-16 데이비드 존 우드 Ｐｄｅ4 억제제 중 인다졸에 의한 카테콜의 생등입체성치환을 기재로 하는 치료상 활성인 화합물
US6391872B1 (en) 1997-11-04 2002-05-21 Pfizer Inc Indazole bioisostere replacement of catechol in therapeutically active compounds
US6589954B1 (en) * 1998-05-22 2003-07-08 Scios, Inc. Compounds and methods to treat cardiac failure and other disorders
GB9820767D0 (en) 1998-09-23 1998-11-18 Cerebrus Ltd Chemical compounds VIII
UA73492C2 (en) 1999-01-19 2005-08-15 Aromatic heterocyclic compounds as antiinflammatory agents
EP1157026A1 (en) * 1999-02-22 2001-11-28 Boehringer Ingelheim Pharmaceuticals Inc. Polycyclo heterocyclic derivatives as antiinflammatory agents
WO2000055152A1 (en) * 1999-03-12 2000-09-21 Boehringer Ingelheim Pharmaceuticals, Inc. Aromatic heterocyclic compounds as anti-inflammatory agents
RU2242474C2 (ru) * 1999-03-12 2004-12-20 Бёрингер Ингельхайм Фармасьютиклз, Инк. Соединения, пригодные в качестве противовоспалительных агентов
MXPA01009888A (es) * 1999-03-29 2003-07-21 Iaf Biochem Int Metodos para tratar leucemia.
AU4063600A (en) * 1999-04-05 2000-10-23 Merck & Co., Inc. A method of treating cancer
US6355636B1 (en) * 1999-04-21 2002-03-12 American Cyanamid Company Substituted 3-cyano-[1.7],[1.5], and [1.8] naphthyridine inhibitors of tyrosine kinases
KR20020002433A (ko) 1999-04-21 2002-01-09 윌리암 에이취 캘넌, 에곤 이 버그 티로신 키나제의 치환된 3-시아노-[1.7],[1.5] 및[1.8]-나프티리딘 억제제
CA2372567A1 (en) 1999-05-21 2000-11-30 Scios Inc. Indole-type derivatives as inhibitors of p38 kinase
PE20010306A1 (es) 1999-07-02 2001-03-29 Agouron Pharma Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
TWI262914B (en) * 1999-07-02 2006-10-01 Agouron Pharma Compounds and pharmaceutical compositions for inhibiting protein kinases
MXPA02000314A (es) * 1999-07-09 2004-06-22 Boehringer Ingelheim Pharma Proceso novedoso para la sintesis de compuestos de urea substituidos con heteroarilo.
US6743795B1 (en) * 1999-11-27 2004-06-01 Dong Wha Pharm. Ind. Co. Ltd. 3-nitropyridine derivaives and the pharmaceutical compositions containing said derivatives
AU1899501A (en) 1999-11-27 2001-06-04 Dong Wha Pharmaceutical Industrial Co., Ltd. Novel 3-nitropyridine derivatives and the pharmaceutical compositions containingsaid derivatives
WO2001078648A2 (en) 2000-04-17 2001-10-25 Dong Wha Pharm. Ind. Co., Ltd. 6-methylnicotinamide derivatives as antiviral agents
AU2002226911A1 (en) * 2000-11-20 2002-06-03 Scios Inc. Indol derivative and their use as inhibitors of p38 kinase
US7102009B2 (en) 2001-01-12 2006-09-05 Amgen Inc. Substituted amine derivatives and methods of use
US7105682B2 (en) 2001-01-12 2006-09-12 Amgen Inc. Substituted amine derivatives and methods of use
TW593278B (en) * 2001-01-23 2004-06-21 Wyeth Corp 1-aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands
JP4130774B2 (ja) 2001-03-09 2008-08-06 ファイザー・プロダクツ・インク 抗炎症薬としてのトリアゾロピリジン類
WO2002100833A1 (fr) 2001-06-12 2002-12-19 Sumitomo Pharmaceuticals Company, Limited Inhibiteurs de rho kinase
KR20040047869A (ko) 2001-09-26 2004-06-05 파마시아 이탈리아 에스.피.에이. 키나제 억제제로서 활성인 아미노인다졸 유도체, 이의제조방법 및 이를 함유하는 약제학적 조성물
EP1438048A1 (en) * 2001-10-18 2004-07-21 Boehringer Ingelheim Pharmaceuticals Inc. 1,4-disubstituted benzo-fused urea compounds as cytokine inhibitors
AU2002353186A1 (en) 2001-12-19 2003-06-30 Smithkline Beecham P.L.C. (1-h-indazol-3-yl) -amide derivatives as gsk-3 inhibitors
CA2473634C (en) * 2002-02-25 2011-11-29 Boehringer Ingelheim Pharmaceuticals, Inc. 1,4-disubstituted benzofused cycloalkyl urea compounds useful in treating cytokine mediated diseases
FR2836915B1 (fr) 2002-03-11 2008-01-11 Aventis Pharma Sa Derives d'aminoindazoles, procede de preparation et intermediaires de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant
FR2836914B1 (fr) * 2002-03-11 2008-03-14 Aventis Pharma Sa Indazoles substitues, compositions les contenant, procede de fabrication et utilisation
AU2003221184A1 (en) 2002-03-29 2003-10-27 Mochida Pharmaceutical Co., Ltd. Therapeutic agent for endothelial disorder
DE60325984D1 (de) 2002-07-19 2009-03-12 Memory Pharmaceutical Corp 4-aminobenzofuranverbindungen als phosphodiesterase-4-inhibitoren
CA2497351C (fr) 2002-09-05 2012-08-21 Aventis Pharma S.A. Nouveaux derives d'aminoindazoles a titre de medicaments et compositions pharmaceutiques les renfermant
CA2503445C (en) 2002-10-24 2012-07-31 Merck Patent Gesellschaft Mit Beschraenkter Haftung Methylene urea derivatives as raf-kinase inhibitors
CA2503646C (en) * 2002-10-28 2011-09-27 Bayer Healthcare Ag Heteroaryloxy-substituted phenylaminopyrimidines as rho-kinase inhibitors
US7196082B2 (en) * 2002-11-08 2007-03-27 Merck & Co. Inc. Ophthalmic compositions for treating ocular hypertension
AU2003293376A1 (en) 2002-12-10 2004-06-30 Imclone Systems Incorporated Anti-angiogenic compounds and their use in cancer treatment
US7135575B2 (en) * 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
RU2357957C2 (ru) 2003-03-03 2009-06-10 Эррэй Биофарма, Инк. Ингибиторы р38 и способы их применения
GB0320244D0 (en) 2003-05-06 2003-10-01 Aventis Pharma Inc Pyrazoles as inhibitors of tumour necrosis factor
US7129252B2 (en) 2003-06-16 2006-10-31 Guoqing P Chen Six membered amino-amide derivatives an angiogenisis inhibitors
SE0301906D0 (sv) 2003-06-26 2003-06-26 Astrazeneca Ab New compounds
WO2005004818A2 (en) 2003-07-09 2005-01-20 Imclone Systems Incorporated Heterocyclic compounds and their use as anticancer agents
BRPI0414313A (pt) 2003-09-11 2006-11-07 Kemia Inc inibidores de citocinas
JP2007514791A (ja) 2003-12-18 2007-06-07 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド Ｐ３８ｍａｐキナーゼインヒビターであるｂｉｒｂ７９６の多形
WO2005066164A1 (en) 2003-12-22 2005-07-21 Eli Lilly And Company Opioid receptor antagonists
TW200716561A (en) * 2005-05-11 2007-05-01 Array Biopharma Inc P38 inhibitors and methods of use thereof
RU2442777C2 (ru) 2006-01-31 2012-02-20 Эррэй Биофарма Инк. Ингибиторы киназ и способы их применения

Also Published As

Publication number Publication date
SG175599A1 (en) 2011-11-28
CY1112770T1 (el) 2016-02-10
WO2007089646A1 (en) 2007-08-09
BRPI0707401B1 (pt) 2020-09-15
IL219643A0 (en) 2012-06-28
CN101415685A (zh) 2009-04-22
PL1981851T3 (pl) 2012-07-31
MY151835A (en) 2014-07-14
HK1123548A1 (en) 2009-06-19
US20090023795A1 (en) 2009-01-22
IL192949A0 (en) 2009-02-11
IL192949A (en) 2012-12-31
EP1981851A1 (en) 2008-10-22
ZA200806507B (en) 2009-10-28
SI1981851T1 (sl) 2012-05-31
ATE542800T1 (de) 2012-02-15
JP5131990B2 (ja) 2013-01-30
CA2635813C (en) 2014-01-07
US20110124878A1 (en) 2011-05-26
AU2007210073A1 (en) 2007-08-09
US8044083B2 (en) 2011-10-25
US8039639B2 (en) 2011-10-18
RS52298B (en) 2012-12-31
TW200808774A (en) 2008-02-16
JP2009525330A (ja) 2009-07-09
IL219644A0 (en) 2012-06-28
AU2007210073B2 (en) 2011-10-06
IL219643A (en) 2013-11-28
ES2379656T3 (es) 2012-04-30
CA2635813A1 (en) 2007-08-09
KR20090003194A (ko) 2009-01-09
NZ570846A (en) 2011-08-26
DK1981851T3 (da) 2012-03-19
HRP20120256T1 (hr) 2012-04-30
BRPI0707401A2 (pt) 2011-05-03
BRPI0707401B8 (pt) 2022-12-20
KR101357465B1 (ko) 2014-02-03
IL219644A (en) 2014-08-31
RU2442777C2 (ru) 2012-02-20
RU2008135332A (ru) 2010-03-10
TWI388557B (zh) 2013-03-11
CN101415685B (zh) 2011-08-24
EP1981851B1 (en) 2012-01-25
PT1981851E (pt) 2012-04-13

Similar Documents

Publication Publication Date Title
IL219643A0 (en) Kinase inhibitors and methods of use thereof
MX2009006756A (es) Derivados de 1-amino-metil-l-fenil-ciclohexano como inhibidores de dpp-iv.
MX2010009739A (es) Inhibidores de cinasa pim y metodos para su uso.
MY148107A (en) Kinase inhibitor
NZ595572A (en) Inhibitors of pi3 kinase and / or mtor
PT1940839E (pt) Inibidores de piridopirimidinona pi3k alfa
MY153727A (en) Pyridazinone derivatives
MX2009003157A (es) Pirazoliltienopiridinas terapeuticas.
PL2120932T3 (pl) Indazolowe pochodne jako inhibitory kinazy do leczenia raka
MX2008011633A (es) Aminoquinolonas como inhibidores de gsk-3.
TNSN08178A1 (en) Triazolopyridine derivatives as inhibitors of lipases and phospholipases
MY155719A (en) 2-benzylpyridazinone derivatives as met kinase inhibitors
UA84929C2 (en) Prodrugs of pyrrolylpyrimidine erk protein kinase inhibitors
MX2009002842A (es) Inhibidores heterociclicos de c-met y usos de los mismos.
MX2011011764A (es) Compuestos de carboxamida y su uso como inhibidores de calpaina.
GEP20125389B (en) Substituted pyrazole and triazole compounds as ksp inhibitors
ZA201003352B (en) Heterocyclic derivatives as modulators of ion channels
HK1162502A1 (en) Cyanoaminoquinolones and tetrazoloaminoquinolones as gsk-3 inhibitors gsk-3
MX2010003563A (es) Inhibidores de proteina cinasa de c-met.
WO2007136741A3 (en) N-desmethyl-doxepin and methods of using the same to treat sleep disorders
UA109793C2 (ru) Арилсульфонамиды для лечения заболеваний центральной нервной системы (цнс)
MX2011012524A (es) Inhibidores de proteina cinasa c-met.
WO2009015000A8 (en) Pyrazole urea derivatives used as kinase inhibitors
MY145122A (en) Phenylacetic acid derivatives as cox-2 inhibitors