CL2014000181A1 - Anticuerpo monoclonal capaz de inhibir la dimerización de receptor para el factor del crecimiento de hepatocitos (c-met); acido nucleico aislado que lo codifica; vector y célula huesped que lo comprenden; proceso para la produccion del anticuerpo; uso del anticuerpo para tratar cancer (divisional de la solicitud 1296-11). - Google Patents
Anticuerpo monoclonal capaz de inhibir la dimerización de receptor para el factor del crecimiento de hepatocitos (c-met); acido nucleico aislado que lo codifica; vector y célula huesped que lo comprenden; proceso para la produccion del anticuerpo; uso del anticuerpo para tratar cancer (divisional de la solicitud 1296-11).Info
- Publication number
- CL2014000181A1 CL2014000181A1 CL2014000181A CL2014000181A CL2014000181A1 CL 2014000181 A1 CL2014000181 A1 CL 2014000181A1 CL 2014000181 A CL2014000181 A CL 2014000181A CL 2014000181 A CL2014000181 A CL 2014000181A CL 2014000181 A1 CL2014000181 A1 CL 2014000181A1
- Authority
- CL
- Chile
- Prior art keywords
- antibody
- divisional
- met
- vector
- nucleic acid
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IB2008/055663 WO2010064089A1 (en) | 2008-12-02 | 2008-12-02 | Novel anti-cmet antibody |
US18450209P | 2009-06-05 | 2009-06-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2014000181A1 true CL2014000181A1 (es) | 2014-07-25 |
Family
ID=41693124
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2011001296A CL2011001296A1 (es) | 2008-12-02 | 2011-06-01 | Anticuerpo monoclonal capaz de inhibir la dimerizacion de cmet; acido nucleico, vector y celula huesped que comprenden las secuencias que codifican el anticuerpo; composicion que comprende el anticuerpo; uso del anticuerpo para inhibir el crecimiento y/o proliferacion de celulas tumorales. |
CL2014000181A CL2014000181A1 (es) | 2008-12-02 | 2014-01-24 | Anticuerpo monoclonal capaz de inhibir la dimerización de receptor para el factor del crecimiento de hepatocitos (c-met); acido nucleico aislado que lo codifica; vector y célula huesped que lo comprenden; proceso para la produccion del anticuerpo; uso del anticuerpo para tratar cancer (divisional de la solicitud 1296-11). |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2011001296A CL2011001296A1 (es) | 2008-12-02 | 2011-06-01 | Anticuerpo monoclonal capaz de inhibir la dimerizacion de cmet; acido nucleico, vector y celula huesped que comprenden las secuencias que codifican el anticuerpo; composicion que comprende el anticuerpo; uso del anticuerpo para inhibir el crecimiento y/o proliferacion de celulas tumorales. |
Country Status (39)
Country | Link |
---|---|
US (4) | US8741290B2 (es) |
EP (4) | EP2370468B1 (es) |
JP (3) | JP5863458B2 (es) |
KR (1) | KR101838299B1 (es) |
CN (2) | CN102227446B (es) |
AR (1) | AR074439A1 (es) |
AU (3) | AU2009328318C1 (es) |
BR (2) | BRPI0923231B8 (es) |
CA (1) | CA2743433C (es) |
CL (2) | CL2011001296A1 (es) |
CO (1) | CO6382139A2 (es) |
CR (1) | CR20110324A (es) |
CY (2) | CY1119172T1 (es) |
DK (2) | DK3135691T3 (es) |
EC (1) | ECSP11011127A (es) |
ES (3) | ES2629855T3 (es) |
GE (2) | GEP20135930B (es) |
HK (2) | HK1162536A1 (es) |
HR (2) | HRP20171011T8 (es) |
HU (3) | HUE035047T2 (es) |
IL (2) | IL213273A0 (es) |
LT (2) | LT3135691T (es) |
MA (1) | MA32892B1 (es) |
MX (2) | MX2011005677A (es) |
MY (2) | MY192567A (es) |
NZ (1) | NZ593853A (es) |
PE (1) | PE20120343A1 (es) |
PH (1) | PH12015501515A1 (es) |
PL (3) | PL3135691T3 (es) |
PT (3) | PT2370468T (es) |
RS (2) | RS56204B1 (es) |
RU (2) | RU2015127471A (es) |
SA (2) | SA109300720B1 (es) |
SG (2) | SG187518A1 (es) |
SI (3) | SI2370468T1 (es) |
TN (1) | TN2011000216A1 (es) |
TW (2) | TWI523866B (es) |
WO (1) | WO2010069765A1 (es) |
ZA (1) | ZA201105164B (es) |
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EP2014681A1 (en) | 2007-07-12 | 2009-01-14 | Pierre Fabre Medicament | Novel antibodies inhibiting c-met dimerization, and uses thereof |
US8545839B2 (en) * | 2008-12-02 | 2013-10-01 | Pierre Fabre Medicament | Anti-c-Met antibody |
EP2287197A1 (en) * | 2009-08-21 | 2011-02-23 | Pierre Fabre Medicament | Anti-cMET antibody and its use for the detection and the diagnosis of cancer |
CN103003307B (zh) | 2010-03-10 | 2017-08-11 | 根马布股份公司 | 抗c‑MEt的单克隆抗体 |
CN103415619B (zh) | 2010-09-03 | 2015-10-14 | 中央研究院 | 抗-c-met抗体及其使用方法 |
BR122014027420A2 (pt) | 2010-11-03 | 2019-08-20 | Argenx Bvba | Anticorpos anti c-met |
CN103842383B (zh) | 2011-05-16 | 2017-11-03 | 健能隆医药技术(上海)有限公司 | 多特异性fab融合蛋白及其使用方法 |
KR101865223B1 (ko) | 2011-10-05 | 2018-06-08 | 삼성전자주식회사 | 항 c-Met 인간화 항체 및 그의 용도 |
KR20130036993A (ko) * | 2011-10-05 | 2013-04-15 | 삼성전자주식회사 | c-Met의 SEMA 도메인 내의 에피토프에 특이적으로 결합하는 항체 |
US9926364B2 (en) | 2011-11-03 | 2018-03-27 | Argen-X N.V. | Chimeric human-llama antigens and methods of use |
KR101463098B1 (ko) | 2011-11-28 | 2014-11-27 | 한국생명공학연구원 | c-Met에 대한 인간항체에 약물이 접합된 약물 복합체 및 이의 용도 |
KR101910601B1 (ko) | 2011-12-22 | 2018-10-23 | 삼성전자주식회사 | 면역원성이 제거된 항 c-Met 인간화 항체 및 그의 용도 |
US10377827B2 (en) | 2012-06-21 | 2019-08-13 | Sorrento Therapeutics, Inc. | Antigen binding proteins that bind c-met |
EP2708556B1 (en) | 2012-09-12 | 2018-11-07 | Samsung Electronics Co., Ltd | Pharmaceutical composition for the use in a combination therapy for prevention or treatment of c-met or angiogenesis factor induced diseases |
HUE045435T2 (hu) | 2012-10-12 | 2019-12-30 | Medimmune Ltd | Pirrolobenzodiazepinek és konjugátumaik |
CA2905181C (en) | 2013-03-13 | 2020-06-02 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof for providing targeted therapy |
KR102049990B1 (ko) * | 2013-03-28 | 2019-12-03 | 삼성전자주식회사 | c-Met 항체 및 VEGF 결합 단편이 연결된 융합 단백질 |
EP2992019B1 (en) | 2013-04-30 | 2019-03-06 | Agency For Science, Technology And Research | Mab 2 anti-met antibody |
US9567641B2 (en) * | 2013-07-03 | 2017-02-14 | Samsung Electronics Co., Ltd. | Combination therapy for the treatment of cancer using an anti-C-met antibody |
US9717715B2 (en) | 2013-11-15 | 2017-08-01 | Samsung Electronics Co., Ltd. | Method of combination therapy using an anti-C-Met antibody |
WO2015094330A1 (en) * | 2013-12-20 | 2015-06-25 | Development Center For Biotechnology | Alpha-enolase specific antibodies and methods of uses in cancer therapy |
US10188746B2 (en) | 2014-09-10 | 2019-01-29 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
US20180057595A1 (en) * | 2015-03-16 | 2018-03-01 | Celldex Therapeutics, Inc. | Anti-MET Antibodies and Methods of Use Thereof |
US10927177B2 (en) | 2016-02-05 | 2021-02-23 | Helixmith Co., Ltd | Methods of treatment using anti-c-met antibodies |
EP3430058A4 (en) | 2016-03-15 | 2019-10-23 | Generon (Shanghai) Corporation Ltd. | MULTISPECIFIC FAB FUSION PROTEINS AND USES THEREOF |
KR20230028574A (ko) | 2016-05-17 | 2023-02-28 | 애브비 바이오테라퓨틱스 인크. | 항-cMet 항체 약물 컨쥬게이트 및 그들의 이용 방법 |
US10457726B2 (en) | 2016-06-30 | 2019-10-29 | University Of Connecticut | Antibody and antigen-binding fragment compositions targeting cell surface antigens in tumors and methods of use thereof |
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TWI782930B (zh) | 2016-11-16 | 2022-11-11 | 美商再生元醫藥公司 | 抗met抗體,結合met之雙特異性抗原結合分子及其使用方法 |
TW201825515A (zh) * | 2017-01-04 | 2018-07-16 | 美商伊繆諾金公司 | Met抗體以及其免疫結合物及用途 |
CN109771642B (zh) * | 2017-11-13 | 2022-09-20 | 同济大学苏州研究院 | c-MET激动型抗体及其用途 |
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CN109541221B (zh) * | 2018-10-24 | 2022-03-22 | 益善生物技术股份有限公司 | 一种c-Met特异性抗体、组合物及试剂盒 |
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2009
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