BRPI9909860B8 - polipeptídeo multifuncional de cadeia simples, polinucleotídeo, vetor, célula procariótica, de levedura ou unicelular, composição, usos de polipeptídeo e polinucleotídeo e métodos para preparo do referido polipeptídeo e para identificação de ativadores ou inibidores de ativação ou estimulação das células t - Google Patents
polipeptídeo multifuncional de cadeia simples, polinucleotídeo, vetor, célula procariótica, de levedura ou unicelular, composição, usos de polipeptídeo e polinucleotídeo e métodos para preparo do referido polipeptídeo e para identificação de ativadores ou inibidores de ativação ou estimulação das células tInfo
- Publication number
- BRPI9909860B8 BRPI9909860B8 BRPI9909860A BR9909860A BRPI9909860B8 BR PI9909860 B8 BRPI9909860 B8 BR PI9909860B8 BR PI9909860 A BRPI9909860 A BR PI9909860A BR 9909860 A BR9909860 A BR 9909860A BR PI9909860 B8 BRPI9909860 B8 BR PI9909860B8
- Authority
- BR
- Brazil
- Prior art keywords
- polypeptide
- polynucleotide
- polypeptides
- prokaryotic
- yeast
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 11
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 11
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 11
- 102000040430 polynucleotide Human genes 0.000 title abstract 6
- 108091033319 polynucleotide Proteins 0.000 title abstract 6
- 239000002157 polynucleotide Substances 0.000 title abstract 6
- 239000013598 vector Substances 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 title 1
- 210000001744 T-lymphocyte Anatomy 0.000 title 1
- 230000004913 activation Effects 0.000 title 1
- 239000012190 activator Substances 0.000 title 1
- 210000004027 cell Anatomy 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000000638 stimulation Effects 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 238000009169 immunotherapy Methods 0.000 abstract 1
- 230000036210 malignancy Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000009870 specific binding Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98107269 | 1998-04-21 | ||
PCT/EP1999/002693 WO1999054440A1 (en) | 1998-04-21 | 1999-04-21 | CD19xCD3 SPECIFIC POLYPEPTIDES AND USES THEREOF |
Publications (3)
Publication Number | Publication Date |
---|---|
BR9909860A BR9909860A (pt) | 2000-12-19 |
BRPI9909860B1 BRPI9909860B1 (pt) | 2016-05-31 |
BRPI9909860B8 true BRPI9909860B8 (pt) | 2021-05-25 |
Family
ID=8231795
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI9909860A BRPI9909860B8 (pt) | 1998-04-21 | 1999-04-21 | polipeptídeo multifuncional de cadeia simples, polinucleotídeo, vetor, célula procariótica, de levedura ou unicelular, composição, usos de polipeptídeo e polinucleotídeo e métodos para preparo do referido polipeptídeo e para identificação de ativadores ou inibidores de ativação ou estimulação das células t |
Country Status (29)
Country | Link |
---|---|
US (2) | US7112324B1 (pt) |
EP (2) | EP1071752B1 (pt) |
JP (1) | JP4169478B2 (pt) |
KR (1) | KR100508289B1 (pt) |
CN (1) | CN1302103C (pt) |
AT (1) | ATE244758T1 (pt) |
AU (1) | AU761587B2 (pt) |
BR (1) | BRPI9909860B8 (pt) |
CA (1) | CA2326389C (pt) |
CU (1) | CU23252B7 (pt) |
CZ (1) | CZ302070B6 (pt) |
DE (1) | DE69909459T2 (pt) |
DK (1) | DK1071752T3 (pt) |
ES (1) | ES2203141T3 (pt) |
HK (1) | HK1037674A1 (pt) |
HR (1) | HRP20000714B1 (pt) |
HU (1) | HU229039B1 (pt) |
ID (1) | ID27512A (pt) |
IL (2) | IL138857A0 (pt) |
NO (1) | NO326523B1 (pt) |
NZ (1) | NZ507381A (pt) |
PL (1) | PL199747B1 (pt) |
PT (1) | PT1071752E (pt) |
RU (1) | RU2228202C2 (pt) |
SI (1) | SI1071752T1 (pt) |
SK (1) | SK286683B6 (pt) |
TR (1) | TR200003087T2 (pt) |
WO (1) | WO1999054440A1 (pt) |
ZA (1) | ZA200005866B (pt) |
Families Citing this family (406)
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ES2331644T3 (es) | 1999-06-09 | 2010-01-12 | Immunomedics, Inc. | Inmunoterapia de trastornos autoinmunes usando anticuerpos cuya diana son celulas b. |
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DE19962583A1 (de) * | 1999-12-23 | 2001-06-28 | Mueller Hermelink Hans Konrad | Antikörper gegen Plasmazellen |
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