BRPI0514537A - compostos de aminoeteroarila substituìdo com pirazol como inibidores de proteìna quinase - Google Patents

compostos de aminoeteroarila substituìdo com pirazol como inibidores de proteìna quinase

Info

Publication number
BRPI0514537A
BRPI0514537A BRPI0514537-6A BRPI0514537A BRPI0514537A BR PI0514537 A BRPI0514537 A BR PI0514537A BR PI0514537 A BRPI0514537 A BR PI0514537A BR PI0514537 A BRPI0514537 A BR PI0514537A
Authority
BR
Brazil
Prior art keywords
compounds
protein kinase
kinase inhibitors
aminoetheroyl
pyrazol
Prior art date
Application number
BRPI0514537-6A
Other languages
English (en)
Inventor
Jingrong Jean Cui
Lee Andrew Funk
Lei Jia
Pei-Pei Kung
Jerry Jialun Meng
Mitchell David Nambu
Mason Alan Pairish
Hong Shen
Michelle Bich Tran-Dube
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35677463&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0514537(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of BRPI0514537A publication Critical patent/BRPI0514537A/pt
Publication of BRPI0514537B1 publication Critical patent/BRPI0514537B1/pt
Publication of BRPI0514537B8 publication Critical patent/BRPI0514537B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

COMPOSTOS DE ANINOETEROARILA SUBSTITUìDOS COM PIRAZOL COMO INIBIDORES DE PROTEìNA QUINASE São fornecidos compostos de Fórmula I, assim como métodos para sua síntese e uso. Os compostos preferidos são potentes inibidores de c-Met proteína quinase, e são úteis no tratamento de distúrbios de crescimento anormal da célula, tais como cânceres.
BRPI0514537A 2004-08-26 2005-08-15 compostos de aminoeteroarila substituídos com pirazol e composição farmacêutica que os compreende BRPI0514537B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US60524404P 2004-08-26 2004-08-26
US60/605,244 2004-08-26
US69080305P 2005-06-14 2005-06-14
US60/690,803 2005-06-14
PCT/IB2005/002695 WO2006021881A2 (en) 2004-08-26 2005-08-15 Pyrazole-substituted aminoheteroaryl compounds as protein kinase inhibitors

Publications (3)

Publication Number Publication Date
BRPI0514537A true BRPI0514537A (pt) 2008-06-17
BRPI0514537B1 BRPI0514537B1 (pt) 2020-05-12
BRPI0514537B8 BRPI0514537B8 (pt) 2021-05-25

Family

ID=35677463

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0514537A BRPI0514537B8 (pt) 2004-08-26 2005-08-15 compostos de aminoeteroarila substituídos com pirazol e composição farmacêutica que os compreende

Country Status (44)

Country Link
US (1) US20060128724A1 (pt)
EP (1) EP1784396B8 (pt)
JP (1) JP4167295B2 (pt)
KR (1) KR100869393B1 (pt)
CN (1) CN101018780B (pt)
AP (1) AP2332A (pt)
AR (1) AR050529A1 (pt)
AT (1) ATE492544T1 (pt)
AU (1) AU2005276132B2 (pt)
BR (1) BRPI0514537B8 (pt)
CA (1) CA2577937C (pt)
CR (2) CR8938A (pt)
CY (1) CY1111138T1 (pt)
DE (1) DE602005025499D1 (pt)
DK (1) DK1784396T3 (pt)
EA (1) EA011725B1 (pt)
EC (1) ECSP077278A (pt)
ES (1) ES2355923T3 (pt)
GE (1) GEP20094845B (pt)
GT (1) GT200500226A (pt)
HK (1) HK1105415A1 (pt)
HN (1) HN2005000477A (pt)
HR (1) HRP20110116T1 (pt)
IL (1) IL181045A0 (pt)
MA (1) MA28827B1 (pt)
ME (1) ME01309B (pt)
MX (1) MX2007002310A (pt)
MY (1) MY139942A (pt)
NI (1) NI200700058A (pt)
NL (1) NL1029809C2 (pt)
NO (1) NO338656B1 (pt)
NZ (1) NZ552946A (pt)
PA (1) PA8643201A1 (pt)
PE (1) PE20060651A1 (pt)
PL (1) PL1784396T3 (pt)
PT (1) PT1784396E (pt)
RS (1) RS51601B (pt)
SI (1) SI1784396T1 (pt)
SV (1) SV2006002208A (pt)
TN (1) TNSN07071A1 (pt)
TW (1) TWI300411B (pt)
UY (1) UY29080A1 (pt)
WO (1) WO2006021881A2 (pt)
ZA (1) ZA200701281B (pt)

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