BR112018006080A2 - novos compostos bicíclicos como inibidores de dupla ação de atx/ca - Google Patents

novos compostos bicíclicos como inibidores de dupla ação de atx/ca

Info

Publication number
BR112018006080A2
BR112018006080A2 BR112018006080-1A BR112018006080A BR112018006080A2 BR 112018006080 A2 BR112018006080 A2 BR 112018006080A2 BR 112018006080 A BR112018006080 A BR 112018006080A BR 112018006080 A2 BR112018006080 A2 BR 112018006080A2
Authority
BR
Brazil
Prior art keywords
atx
dual action
bicyclic compounds
new bicyclic
action inhibitors
Prior art date
Application number
BR112018006080-1A
Other languages
English (en)
Inventor
Di Giorgio Patrick
Hert Jérôme
Hunziker Daniel
Mattei Patrizio
Rudolph Markus
Schmitz Petra
Ullmer Christoph
Original Assignee
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag
Publication of BR112018006080A2 publication Critical patent/BR112018006080A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

a invenção proporciona novos compostos que são dotados da fórmula geral (i) em que r1, r2, y, w, m, n, p e q são tais como se encontram definidos no presente caso, composições que incluem os compostos e métodos de utilização dos compostos.
BR112018006080-1A 2015-09-24 2016-09-21 novos compostos bicíclicos como inibidores de dupla ação de atx/ca BR112018006080A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15186633 2015-09-24
EP15186633.2 2015-09-24
PCT/EP2016/072347 WO2017050791A1 (en) 2015-09-24 2016-09-21 New bicyclic compounds as dual atx/ca inhibitors

Publications (1)

Publication Number Publication Date
BR112018006080A2 true BR112018006080A2 (pt) 2018-10-09

Family

ID=54199035

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018006080-1A BR112018006080A2 (pt) 2015-09-24 2016-09-21 novos compostos bicíclicos como inibidores de dupla ação de atx/ca

Country Status (21)

Country Link
US (2) US10647719B2 (pt)
EP (1) EP3353178B1 (pt)
JP (1) JP6877413B2 (pt)
KR (1) KR20180054634A (pt)
CN (1) CN107922415B (pt)
AR (1) AR106099A1 (pt)
AU (1) AU2016328436B2 (pt)
BR (1) BR112018006080A2 (pt)
CA (1) CA2991612A1 (pt)
CL (1) CL2018000685A1 (pt)
CO (1) CO2018000668A2 (pt)
CR (1) CR20180057A (pt)
HK (1) HK1252995A1 (pt)
IL (1) IL256724A (pt)
MA (1) MA42923A (pt)
MX (1) MX2018001430A (pt)
PE (1) PE20180552A1 (pt)
RU (1) RU2724899C2 (pt)
TW (1) TW201720823A (pt)
WO (1) WO2017050791A1 (pt)
ZA (1) ZA201800480B (pt)

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