DE60005545D1 - Pyridyl enthaltende spirocyclische verbindungen als inhibitoren der fibrinogen-abhängigen blutplättchen aggregation - Google Patents
Pyridyl enthaltende spirocyclische verbindungen als inhibitoren der fibrinogen-abhängigen blutplättchen aggregationInfo
- Publication number
- DE60005545D1 DE60005545D1 DE60005545T DE60005545T DE60005545D1 DE 60005545 D1 DE60005545 D1 DE 60005545D1 DE 60005545 T DE60005545 T DE 60005545T DE 60005545 T DE60005545 T DE 60005545T DE 60005545 D1 DE60005545 D1 DE 60005545D1
- Authority
- DE
- Germany
- Prior art keywords
- fibrinogen
- pyridyl
- inhibitors
- spirocyclic compounds
- blood plate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16182599P | 1999-10-27 | 1999-10-27 | |
| PCT/US2000/029804 WO2001030780A2 (en) | 1999-10-27 | 2000-10-27 | Pyridyl-containing spirocyclic compounds as inhibitors of fibrinogen-dependent platelet aggregation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60005545D1 true DE60005545D1 (de) | 2003-10-30 |
Family
ID=22582914
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60005545T Expired - Lifetime DE60005545D1 (de) | 1999-10-27 | 2000-10-27 | Pyridyl enthaltende spirocyclische verbindungen als inhibitoren der fibrinogen-abhängigen blutplättchen aggregation |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20030055244A1 (de) |
| EP (1) | EP1224186B1 (de) |
| JP (1) | JP2003514777A (de) |
| AT (1) | ATE250604T1 (de) |
| AU (1) | AU1244001A (de) |
| CA (1) | CA2389034A1 (de) |
| DE (1) | DE60005545D1 (de) |
| WO (1) | WO2001030780A2 (de) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US6818787B2 (en) | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| NZ537214A (en) | 2002-07-05 | 2007-08-31 | Targacept Inc | N-Aryl diazaspiracyclic compounds capable of affecting nicotinic cholinergic receptors and methods of preparation and use thereof |
| SE0202133D0 (sv) | 2002-07-08 | 2002-07-08 | Astrazeneca Ab | Novel compounds |
| EP1776362A1 (de) * | 2003-07-18 | 2007-04-25 | Virochem Pharma Inc. | Spiroverbindungen und verfahren zur modulation der aktivität des chemokinrezeptors |
| CA2579608A1 (en) | 2003-09-10 | 2005-03-17 | Virochem Pharma Inc. | Spiro compounds and methods for the modulation of chemokine receptor activity |
| SE0303090D0 (sv) | 2003-11-20 | 2003-11-20 | Astrazeneca Ab | Novel compounds |
| SE0303541D0 (sv) | 2003-12-22 | 2003-12-22 | Astrazeneca Ab | New compounds |
| JO2676B1 (en) | 2004-04-06 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Derivatives of second-aza-spiro- (5,4) -dikan and their use as antihistamines |
| TWI350168B (en) | 2004-05-07 | 2011-10-11 | Incyte Corp | Amido compounds and their use as pharmaceuticals |
| US7687665B2 (en) | 2004-06-24 | 2010-03-30 | Incyte Corporation | 2-methylprop anamides and their use as pharmaceuticals |
| WO2006000096A1 (en) * | 2004-06-25 | 2006-01-05 | Virochem Pharma Inc. | Spirohydantoin compounds and methods for the modulation of chemokine receptor activity |
| JP2008510711A (ja) * | 2004-08-20 | 2008-04-10 | ターガセプト，インコーポレイテッド | 嗜癖治療におけるｎ−アリールジアザスピラ環状化合物の使用 |
| WO2006115833A1 (en) | 2005-04-20 | 2006-11-02 | Merck & Co., Inc. | Benzothiophene hydroxamic acid derivatives with carbamate, urea, amide and sulfonamide substitutions |
| US7834034B2 (en) | 2005-04-20 | 2010-11-16 | Merck Sharp & Dohme Corp. | Benzothiophene derivatives |
| AU2006240248A1 (en) | 2005-04-20 | 2006-11-02 | Merck Sharp & Dohme Corp. | Benzothiophene hydroxamic acid derivatives |
| JP2008546793A (ja) | 2005-06-24 | 2008-12-25 | メルク エンド カムパニー インコーポレーテッド | 修飾マロン酸誘導体 |
| AR057579A1 (es) | 2005-11-23 | 2007-12-05 | Merck & Co Inc | Compuestos espirociclicos como inhibidores de histona de acetilasa (hdac) |
| KR101415861B1 (ko) * | 2005-12-05 | 2014-07-04 | 인사이트 코포레이션 | 락탐 화합물 및 이를 사용하는 방법 |
| WO2007100657A2 (en) | 2006-02-28 | 2007-09-07 | Merck & Co., Inc. | Inhibitors of histone deacetylase |
| US8119685B2 (en) | 2006-04-26 | 2012-02-21 | Merck Sharp & Dohme Corp. | Disubstituted aniline compounds |
| US8119652B2 (en) | 2006-05-18 | 2012-02-21 | Merck Sharp & Dohme Corp. | Aryl-fused spirocyclic compounds |
| EP2049124A4 (de) | 2006-07-20 | 2010-02-10 | Merck & Co Inc | Phosphorderivate als histondeacetylasehemmer |
| US20100210633A1 (en) * | 2006-10-12 | 2010-08-19 | Epix Delaware, Inc. | Carboxamide compounds and their use |
| CL2008001839A1 (es) | 2007-06-21 | 2009-01-16 | Incyte Holdings Corp | Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades. |
| US8389553B2 (en) | 2007-06-27 | 2013-03-05 | Merck Sharp & Dohme Corp. | 4-carboxybenzylamino derivatives as histone deacetylase inhibitors |
| CA2692153A1 (en) | 2007-06-27 | 2009-01-08 | Richard W. Heidebrecht, Jr. | Pyridyl and pyrimidinyl derivatives as histone deacetylase inhibitors |
| US8569282B2 (en) | 2007-12-11 | 2013-10-29 | Cytopathfinder, Inc. | Carboxamide compounds and their use |
| JP2012136439A (ja) * | 2009-04-24 | 2012-07-19 | Nippon Chemiphar Co Ltd | ジアザスピロアルカン誘導体 |
| JP2013542960A (ja) * | 2010-11-08 | 2013-11-28 | グラクソスミスクライン、インテレクチュアル、プロパティー、ナンバー２、リミテッド | 脂肪酸シンターゼ阻害剤 |
| JP5964426B2 (ja) * | 2011-08-19 | 2016-08-03 | グラクソスミスクライン、インテレクチュアル、プロパティー、ナンバー２、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｎｏ．２ Ｌｉｍｉｔｅｄ | 脂肪酸シンターゼ阻害剤 |
| MA37756B1 (fr) | 2012-06-13 | 2018-09-28 | Hoffmann La Roche | Nouveaux composés diazaspirocycloalcane et azaspirocycloalcane |
| EP3590940B1 (de) | 2012-09-25 | 2021-06-09 | F. Hoffmann-La Roche AG | Hexahydropyrrolo[3,4-c]pyrrol-derivate und verwandte verbindungen als autotaxin (atx) inhibitoren und als inhibitoren der lysophosphatinsäure (lpa) produktion zur behandlung von z.b. nierenerkrankungen |
| CN105073111A (zh) | 2012-10-11 | 2015-11-18 | 默沙东公司 | 用作gpr120激动剂的取代的螺哌啶基化合物 |
| AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
| US9346802B2 (en) | 2013-03-15 | 2016-05-24 | Epizyme, Inc. | CARM1 inhibitors and uses thereof |
| WO2014144455A1 (en) | 2013-03-15 | 2014-09-18 | Epizyme, Inc. | 1 -phenoxy-3-(alkylamino)-propan-2-ol derivatives as carm1 inhibitors and uses thereof |
| US9738651B2 (en) | 2013-03-15 | 2017-08-22 | Epizyme, Inc. | CARM1 inhibitors and uses thereof |
| MA38982A1 (fr) | 2013-11-26 | 2017-09-29 | Hoffmann La Roche | Nouvel octahydro-cyclobuta [1,2-c; 3,4-c'] dipyrrol-2-yl |
| US20160318897A1 (en) | 2013-12-18 | 2016-11-03 | Basf Se | Azole compounds carrying an imine-derived substituent |
| CN106103446B (zh) | 2014-03-26 | 2019-07-30 | 豪夫迈·罗氏有限公司 | 作为自分泌运动因子(atx)和溶血磷脂酸(lpa)生产抑制剂的二环化合物 |
| MX2016010675A (es) | 2014-03-26 | 2016-11-10 | Hoffmann La Roche | Compuestos condensados de [1,4]diazepina como inhibidores de produccion de la autotaxina (atx) y acido lisofosfatidico (lpa). |
| US20170298073A1 (en) * | 2014-09-17 | 2017-10-19 | Epizyme, Inc | Salts, co-crystals, amorphous forms, and crystalline forms of a co-activator-associated arginine methyltransferase 1 (carm1) inhibitor |
| CN104628625A (zh) * | 2014-12-23 | 2015-05-20 | 安徽德信佳生物医药有限公司 | 一种N-boc-4-羟基哌啶合成方法 |
| MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
| CN108026077B (zh) | 2015-09-04 | 2021-11-05 | 豪夫迈·罗氏有限公司 | 苯氧基甲基衍生物 |
| WO2017050792A1 (en) | 2015-09-24 | 2017-03-30 | F. Hoffmann-La Roche Ag | Bicyclic compounds as atx inhibitors |
| MA42923A (fr) | 2015-09-24 | 2021-04-28 | Hoffmann La Roche | Composés bicycliques comme inhibiteurs mixtes de atx/ca |
| MA42918A (fr) | 2015-09-24 | 2018-08-01 | Hoffmann La Roche | Composés bicycliques utilisés en tant qu'inhibiteurs d'atx |
| JP6845230B2 (ja) | 2015-09-24 | 2021-03-17 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | デュアルａｔｘ／ｃａ阻害剤としての新規な二環式化合物 |
| MA49879A (fr) | 2017-03-16 | 2020-06-24 | Hoffmann La Roche | Composés hétérocycliques utiles en tant qu'inhibiteurs doubles d'atx/ca |
| CN110382484B (zh) | 2017-03-16 | 2022-12-06 | 豪夫迈·罗氏有限公司 | 新的作为atx抑制剂的二环化合物 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU713235B2 (en) * | 1995-09-29 | 1999-11-25 | Cor Therapeutics, Inc. | Spiro compounds as inhibitors of fibrinogen-dependent platelet aggregation |
-
2000
- 2000-10-27 AU AU12440/01A patent/AU1244001A/en not_active Abandoned
- 2000-10-27 EP EP00974002A patent/EP1224186B1/de not_active Expired - Lifetime
- 2000-10-27 CA CA002389034A patent/CA2389034A1/en not_active Abandoned
- 2000-10-27 WO PCT/US2000/029804 patent/WO2001030780A2/en active IP Right Grant
- 2000-10-27 AT AT00974002T patent/ATE250604T1/de not_active IP Right Cessation
- 2000-10-27 DE DE60005545T patent/DE60005545D1/de not_active Expired - Lifetime
- 2000-10-27 JP JP2001533133A patent/JP2003514777A/ja active Pending
-
2002
- 2002-04-26 US US10/134,658 patent/US20030055244A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20030055244A1 (en) | 2003-03-20 |
| WO2001030780A3 (en) | 2001-11-29 |
| EP1224186A2 (de) | 2002-07-24 |
| JP2003514777A (ja) | 2003-04-22 |
| WO2001030780A2 (en) | 2001-05-03 |
| EP1224186B1 (de) | 2003-09-24 |
| ATE250604T1 (de) | 2003-10-15 |
| CA2389034A1 (en) | 2001-05-03 |
| AU1244001A (en) | 2001-05-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de |