BR112016002638A2 - novos aza-oxo-indóis para o tratamento e profilaxia de infecção pelo virus sincicial respiratório - Google Patents

novos aza-oxo-indóis para o tratamento e profilaxia de infecção pelo virus sincicial respiratório

Info

Publication number
BR112016002638A2
BR112016002638A2 BR112016002638A BR112016002638A BR112016002638A2 BR 112016002638 A2 BR112016002638 A2 BR 112016002638A2 BR 112016002638 A BR112016002638 A BR 112016002638A BR 112016002638 A BR112016002638 A BR 112016002638A BR 112016002638 A2 BR112016002638 A2 BR 112016002638A2
Authority
BR
Brazil
Prior art keywords
prophylaxis
treatment
virus infection
respiratory syncytial
syncytial virus
Prior art date
Application number
BR112016002638A
Other languages
English (en)
Inventor
Wang Baoxia
Liang Chungen
Yun Hongying
Guo Lei
Wang Lisha
Gao Lu
Zhang Weixing
Zheng Xiufang
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR112016002638A2 publication Critical patent/BR112016002638A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

a invenção proporciona novos compostos que são dotados da fórmula geral: em que r1, r2, r3, r4, w e x são tais como se encontram descritos neste contexto, composições que incluem os compostos e métodos de utilização dos compostos.
BR112016002638A 2013-08-12 2014-08-08 novos aza-oxo-indóis para o tratamento e profilaxia de infecção pelo virus sincicial respiratório BR112016002638A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2013081263 2013-08-12
PCT/EP2014/067046 WO2015022263A1 (en) 2013-08-12 2014-08-08 Novel aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection

Publications (1)

Publication Number Publication Date
BR112016002638A2 true BR112016002638A2 (pt) 2017-08-01

Family

ID=51298768

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016002638A BR112016002638A2 (pt) 2013-08-12 2014-08-08 novos aza-oxo-indóis para o tratamento e profilaxia de infecção pelo virus sincicial respiratório

Country Status (9)

Country Link
US (1) US9670211B2 (pt)
EP (1) EP3033341B1 (pt)
JP (1) JP6211195B2 (pt)
BR (1) BR112016002638A2 (pt)
CA (1) CA2914529A1 (pt)
HK (1) HK1222653A1 (pt)
MX (1) MX2016001855A (pt)
RU (1) RU2016105970A (pt)
WO (1) WO2015022263A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI630194B (zh) 2013-03-14 2018-07-21 凱立拉製藥公司 雙環止痛化合物
MX2016001858A (es) * 2013-08-15 2016-05-24 Hoffmann La Roche Aza-oxo-indoles novedosos para el tratamiento y profilaxis de la infeccion por el virus sincicial respiratorio.
US10189780B2 (en) 2013-12-12 2019-01-29 Zeno Royalties & Milestones, LLC Bicyclic alkyl compounds and synthesis
WO2015134710A1 (en) 2014-03-07 2015-09-11 Kalyra Pharmaceuticals, Inc. Propellane derivates and synthesis
GB201417707D0 (en) * 2014-10-07 2014-11-19 Viral Ltd Pharmaceutical compounds
WO2017160926A1 (en) * 2016-03-16 2017-09-21 Kalyra Pharmaceuticals, Inc. Analgesic compounds
GB201711704D0 (en) * 2017-07-20 2017-09-06 Reviral Ltd Pharmaceutical compounds
SG11202103313RA (en) 2018-09-06 2021-04-29 Cidara Therapeutics Inc Compositions and methods for the treatment of viral infections
CN114728937A (zh) * 2019-09-09 2022-07-08 奇达拉治疗公司 用于治疗呼吸道合胞病毒的组合物及方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI501967B (zh) * 2010-12-16 2015-10-01 Janssen R&D Ireland 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類
GB201119538D0 (en) * 2011-11-10 2011-12-21 Viral Ltd Pharmaceutical compounds
ME02835B (me) * 2012-10-16 2018-01-20 Janssen Sciences Ireland Uc Antivirusna rsv jedinjenja
CA2910508A1 (en) * 2013-05-14 2014-11-20 Song Feng Aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection

Also Published As

Publication number Publication date
US20160229853A1 (en) 2016-08-11
US9670211B2 (en) 2017-06-06
WO2015022263A1 (en) 2015-02-19
HK1222653A1 (zh) 2017-07-07
JP6211195B2 (ja) 2017-10-11
RU2016105970A (ru) 2017-09-19
EP3033341B1 (en) 2017-05-03
EP3033341A1 (en) 2016-06-22
MX2016001855A (es) 2016-05-24
JP2016530257A (ja) 2016-09-29
CA2914529A1 (en) 2015-02-19

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Legal Events

Date Code Title Description
B08F Application fees: dismissal - article 86 of industrial property law
B08K Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2474 DE 05-06-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.