AR095079A1 - Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo - Google Patents

Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo

Info

Publication number
AR095079A1
AR095079A1 ARP140100780A ARP140100780A AR095079A1 AR 095079 A1 AR095079 A1 AR 095079A1 AR P140100780 A ARP140100780 A AR P140100780A AR P140100780 A ARP140100780 A AR P140100780A AR 095079 A1 AR095079 A1 AR 095079A1
Authority
AR
Argentina
Prior art keywords
substituted
alkoxy
alkyl
cycloalkyl
pyridinyl
Prior art date
Application number
ARP140100780A
Other languages
English (en)
Inventor
Mattei Patrizio
Mauser Harald
Tang Guozhi
Wang Lisha
Hert Jrme
Hunziker Daniel
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR095079A1 publication Critical patent/AR095079A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Reivindicación 1: Compuestos de la fórmula (1) en la que: R¹ es cicloalquilo sustituido, cicloalquilalquilo sustituido, fenilo sustituido, fenilalquilo sustituido, fenoxialquilo sustituido, fenilcicloalquilo sustituido, fenilalquenilo sustituido, fenilalquinilo sustituido, naftilo sustituido, naftilalquilo sustituido, naftiloxialquilo sustituido, naftilalquenilo sustituido, piridinilo sustituido, piridinil-alquilo sustituido, piridinilalquenilo sustituido, piridinil-alquinilo sustituido, tiofenilo sustituido, tiofenilalquilo sustituido, tiofenilalquenilo sustituido, tiofenilalquinilo sustituido, indolilo sustituido, quinolilo sustituido, iso-quinolilo sustituido, 2,3-dihidro-1H-isoindol-2-ilo sustituido, 1H-indol-2-ilo sustituido o benzofuran-2-ilo sustituido, dichos cicloalquilo sustituido, cicloalquil-alquilo sustituido, fenilo sustituido, fenilalquilo sustituido, fenoxialquilo sustituido, fenilcicloalquilo sustituido, fenilalquenilo sustituido, fenilalquinilo sustituido, naftilo sustituido, naftilalquilo sustituido, naftiloxialquilo sustituido, naftilalquenilo sustituido, piridinilo sustituido, piridinilalquilo sustituido, piridinilalquenilo sustituido, piridinilalquinilo sustituido, tiofenilo sustituido, tiofenilalquilo sustituido, tiofenil-alquenilo sustituido, tiofenilalquinilo sustituido, indolilo sustituido, quinolilo sustituido, isoquinolilo sustituido, 2,3-dihidro-1H-isoindol-2-ilo sustituido, 1H-indol-2-ilo sustituido y benzofuran-2-ilo sustituido están sustituidos por R⁷, R⁸ y R⁹; R² es fenilo sustituido, piridinilo sustituido, pirrolilo sustituido, oxodihidropiridinilo o tiofenilo sustituido, dichos fenilo sustituido, piridinilo sustituido, pirrolilo sustituido y tiofenilo sustituido están sustituidos por R¹⁰, R¹¹ y R¹²; Y es -OC(O)-, -NR⁵C(O)-, -C(O)-, -S(O)₂-, un resto de fórmula (2) ó un resto de fórmula (3); A es -N- o CH-; W es -O-, -S-, -NR⁶-, -C(O)-, -S(O)₂-, o -CR³R⁴-; R³ y R⁴ se eligen con independencia entre H, halógeno, alquilo y cicloalquilo; R⁵ y R⁶ se eligen con independencia entre H, alquilo y cicloalquilo; R⁷, R⁸ y R⁹ se eligen con independencia entre H, alquilo, hidroxialquilo, haloalquilo, hidroxihaloalquilo, cicloalquilo, cicloalquilalquilo, cicloalquilalcoxi, cicloalcoxi, cicloalcoxialquilo, cicloalquilalcoxialquilo, alcoxi, alcoxi-alquilo, haloalcoxi, alcoxihaloalquilo, alcoxialcoxi, alcoxi-alcoxialquilo, fenilo, fenilo sustituido, piridinilo, piridinilo sustituido, halógeno, hidroxi, ciano, alquil-sulfanilo, haloalquilsulfanilo, cicloalquilsulfanilo, alquilsulfinilo, haloalquilsulfinilo, cicloalquilsulfinilo, alquilsulfonilo, haloalquilsulfonilo, cicloalquilsulfonilo, aminosulfonilo sustituido, amino sustituido y aminoalquilo sustituido, dichos aminosulfonilo sustituido, amino sustituido y aminoalquilo sustituido están sustituidos en el átomo de nitrógeno por uno o dos sustituyentes elegidos con independencia entre H, alquilo, cicloalquilo, cicloalquil-alquilo, hidroxialquilo, alcoxialquilo, alquilcarbonilo y cicloalquilcarbonilo, y dichos fenilo sustituido y piridinilo sustituido están opcionalmente sustituidos de una a tres veces por sustituyentes elegidos con independencia entre alquilo, halógeno, haloalquilo, alcoxi y haloalcoxi, y por lo menos uno de R⁷, R⁸ y R⁹ no es H; R¹⁰ es aminosulfonilo sustituido, alcoxicarbonilo, alquil-carbonilamino, alquilsulfonilamino, amino sustituido, carboxi, ciano, hidroxi o tetrazolilo, dicho amino sustituido está sustituido en el átomo de nitrógeno por uno o dos sustituyentes elegidos con independencia entre H, alquilo, cicloalquilo, cicloalquilalquilo, hidroxialquilo y alcoxialquilo; R¹¹ y R¹² se eligen con independencia entre H, alquilo, cicloalquilo, alcoxi, halógeno y haloalquilo; m, n, p y q se eligen con independencia entre 1 y 2; o las sales farmacéuticamente aceptables.
ARP140100780A 2013-03-12 2014-03-10 Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo AR095079A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP13158724 2013-03-12

Publications (1)

Publication Number Publication Date
AR095079A1 true AR095079A1 (es) 2015-09-16

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ID=47843184

Family Applications (1)

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ARP140100780A AR095079A1 (es) 2013-03-12 2014-03-10 Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo

Country Status (33)

Country Link
US (2) US20150376194A1 (es)
EP (1) EP2970256B1 (es)
JP (2) JP6483034B2 (es)
KR (1) KR20150126036A (es)
CN (1) CN105073748B (es)
AR (1) AR095079A1 (es)
AU (1) AU2014230943B8 (es)
BR (1) BR112015022804A2 (es)
CA (1) CA2901047A1 (es)
CL (1) CL2015002386A1 (es)
CR (1) CR20150436A (es)
DK (1) DK2970256T3 (es)
EA (1) EA035015B1 (es)
ES (1) ES2763417T3 (es)
HK (1) HK1211935A1 (es)
HR (1) HRP20192274T1 (es)
HU (1) HUE046776T2 (es)
IL (1) IL240796B (es)
LT (1) LT2970256T (es)
MA (1) MA38432B1 (es)
MX (1) MX2015011311A (es)
MY (1) MY177574A (es)
PE (1) PE20151605A1 (es)
PH (1) PH12015501934A1 (es)
PL (1) PL2970256T3 (es)
PT (1) PT2970256T (es)
RS (1) RS59682B1 (es)
SG (1) SG11201507396YA (es)
SI (1) SI2970256T1 (es)
TW (1) TWI678368B (es)
UA (1) UA115354C2 (es)
WO (1) WO2014139978A1 (es)
ZA (1) ZA201505944B (es)

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