CO2018000668A2 - Nuevos compuestos bicíclicos como inhibidores duales de atx/ca - Google Patents

Nuevos compuestos bicíclicos como inhibidores duales de atx/ca

Info

Publication number
CO2018000668A2
CO2018000668A2 CONC2018/0000668A CO2018000668A CO2018000668A2 CO 2018000668 A2 CO2018000668 A2 CO 2018000668A2 CO 2018000668 A CO2018000668 A CO 2018000668A CO 2018000668 A2 CO2018000668 A2 CO 2018000668A2
Authority
CO
Colombia
Prior art keywords
inhibitors
bicyclic compounds
new bicyclic
compounds
atx
Prior art date
Application number
CONC2018/0000668A
Other languages
English (en)
Inventor
Daniel Hunziker
Jérôme Hert
Patrizio Mattei
Markus Rudolph
Petra Schmitz
Christoph Ullmer
Giorgio Patrick Di
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CO2018000668A2 publication Critical patent/CO2018000668A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

La invención proporciona nuevos compuestos que tienen la fórmula general (I), en la que R1, R2, Y, W, m, n, p y q tienen los significados aquí definidos, composiciones que contienen los compuestos y métodos de uso de dichos compuestos.
CONC2018/0000668A 2015-09-24 2018-01-24 Nuevos compuestos bicíclicos como inhibidores duales de atx/ca CO2018000668A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15186633 2015-09-24
PCT/EP2016/072347 WO2017050791A1 (en) 2015-09-24 2016-09-21 New bicyclic compounds as dual atx/ca inhibitors

Publications (1)

Publication Number Publication Date
CO2018000668A2 true CO2018000668A2 (es) 2018-05-10

Family

ID=54199035

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2018/0000668A CO2018000668A2 (es) 2015-09-24 2018-01-24 Nuevos compuestos bicíclicos como inhibidores duales de atx/ca

Country Status (21)

Country Link
US (2) US10647719B2 (es)
EP (1) EP3353178B1 (es)
JP (1) JP6877413B2 (es)
KR (1) KR20180054634A (es)
CN (1) CN107922415B (es)
AR (1) AR106099A1 (es)
AU (1) AU2016328436B2 (es)
BR (1) BR112018006080A2 (es)
CA (1) CA2991612A1 (es)
CL (1) CL2018000685A1 (es)
CO (1) CO2018000668A2 (es)
CR (1) CR20180057A (es)
HK (1) HK1252995A1 (es)
IL (1) IL256724A (es)
MA (1) MA42923A (es)
MX (1) MX2018001430A (es)
PE (1) PE20180552A1 (es)
RU (1) RU2724899C2 (es)
TW (1) TW201720823A (es)
WO (1) WO2017050791A1 (es)
ZA (1) ZA201800480B (es)

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