MA41898A - Dérivés de quinazolinone bicyclique - Google Patents
Dérivés de quinazolinone bicycliqueInfo
- Publication number
- MA41898A MA41898A MA041898A MA41898A MA41898A MA 41898 A MA41898 A MA 41898A MA 041898 A MA041898 A MA 041898A MA 41898 A MA41898 A MA 41898A MA 41898 A MA41898 A MA 41898A
- Authority
- MA
- Morocco
- Prior art keywords
- bicyclic
- quinazolinone derivatives
- quinazolinone
- derivatives
- bicyclic quinazolinone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15163133 | 2015-04-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA41898A true MA41898A (fr) | 2018-02-13 |
Family
ID=52824124
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA041898A MA41898A (fr) | 2015-04-10 | 2016-04-06 | Dérivés de quinazolinone bicyclique |
Country Status (23)
Country | Link |
---|---|
US (2) | US10676446B2 (fr) |
EP (1) | EP3280707B1 (fr) |
JP (1) | JP6774960B2 (fr) |
KR (1) | KR20170132766A (fr) |
CN (1) | CN107428754B (fr) |
AR (1) | AR104208A1 (fr) |
AU (1) | AU2016245914B2 (fr) |
BR (1) | BR112017021803A2 (fr) |
CA (1) | CA2975664A1 (fr) |
CL (1) | CL2017002452A1 (fr) |
CO (1) | CO2017007635A2 (fr) |
CR (1) | CR20170455A (fr) |
HK (1) | HK1245249A1 (fr) |
IL (1) | IL253588B (fr) |
MA (1) | MA41898A (fr) |
MX (1) | MX2017013036A (fr) |
PE (1) | PE20171737A1 (fr) |
PH (1) | PH12017501825A1 (fr) |
RU (1) | RU2017135520A (fr) |
SG (2) | SG11201706457RA (fr) |
TW (1) | TW201710247A (fr) |
UA (1) | UA121133C2 (fr) |
WO (1) | WO2016162390A1 (fr) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6258928B2 (ja) | 2012-06-13 | 2018-01-10 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 新規ジアザスピロシクロアルカンおよびアザスピロシクロアルカン |
PT2900669T (pt) | 2012-09-25 | 2019-10-29 | Hoffmann La Roche | Derivados de hexahidropirrolo[3,4−c]pirrol e compostos relacionados enquanto inibidores da autotaxina (atx) e enquanto inibidores da produção de ácido lisofosfatídico (lpa) para o tratamento de, por exemplo, doenças renais |
AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
WO2015078803A1 (fr) | 2013-11-26 | 2015-06-04 | F. Hoffmann-La Roche Ag | Nouvel octahydro-cyclobuta [1,2-c; 3,4-c'] dipyrrol-2-yl |
CN106029667B (zh) | 2014-03-26 | 2019-08-23 | 豪夫迈·罗氏有限公司 | 作为自分泌运动因子(atx)和溶血磷脂酸(lpa)生产抑制剂的稠合[1,4]二氮杂*化合物 |
SI3122750T1 (sl) | 2014-03-26 | 2019-12-31 | F. Hoffmann-La Roche Ag | Biciklične spojine kot zaviralci proizvodnje avtotaksina (ATX) in lizofosfatidne kisline (LPA) |
MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
WO2016169906A1 (fr) | 2015-04-21 | 2016-10-27 | Glaxosmithkline Intellectual Property Development Limited | Dérivés de 2,4-dioxo-1,2-dihydropyrido[3,4-d]pyrimidine |
UA123362C2 (uk) | 2015-09-04 | 2021-03-24 | Ф. Хоффманн-Ля Рош Аг | Феноксиметильні похідні |
MA42918A (fr) | 2015-09-24 | 2018-08-01 | Hoffmann La Roche | Composés bicycliques utilisés en tant qu'inhibiteurs d'atx |
MX2017015034A (es) | 2015-09-24 | 2018-04-13 | Hoffmann La Roche | Nuevos compuestos biciclicos como inhibidores duales de autotaxina (atx)/anhidrasa carbonica (ca). |
CN107922415B (zh) | 2015-09-24 | 2022-04-15 | 豪夫迈·罗氏有限公司 | 新的作为双重atx/ca抑制剂的二环化合物 |
JP6876685B2 (ja) | 2015-09-24 | 2021-05-26 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Atx阻害剤としての二環式化合物 |
CN110382484B (zh) | 2017-03-16 | 2022-12-06 | 豪夫迈·罗氏有限公司 | 新的作为atx抑制剂的二环化合物 |
CA3053329A1 (fr) | 2017-03-16 | 2018-09-20 | F. Hoffmann-La Roche Ag | Composes heterocycliques utiles en tant qu'inhibiteurs doubles d'atx/ca |
US20230167093A1 (en) * | 2020-04-08 | 2023-06-01 | Remix Therapeutics Inc. | Compounds and methods for modulating splicing |
CN116323619A (zh) * | 2021-05-26 | 2023-06-23 | 因诺库尔治疗公司 | 哌啶二酮衍生物 |
Family Cites Families (129)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1252898B (de) | 1965-06-12 | 1967-10-26 | Bayer Ag | Verfahren zur Herstellung von Copolymerisaten des Trioxans |
US5240928A (en) | 1989-07-03 | 1993-08-31 | Merck & Co., Inc. | Substituted quinazolinones as angiotensin II antagonists |
DE3930262A1 (de) | 1989-09-11 | 1991-03-21 | Thomae Gmbh Dr K | Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
CA2037630C (fr) | 1990-03-07 | 2001-07-03 | Akira Morimoto | Composes heterocycliques renfermant de l'azote, methode de production et applications correspondantes |
US5470975A (en) | 1990-10-16 | 1995-11-28 | E.R. Squibb & Sons, Inc. | Dihydropyrimidine derivatives |
US5290780A (en) | 1991-01-30 | 1994-03-01 | American Cyanamid Co. | Angiotensin II receptor blocking 2,3,6 substituted quinazolinones |
US5238942A (en) | 1991-05-10 | 1993-08-24 | Merck & Co., Inc. | Substituted quinazolinones bearing acidic functional groups as angiotensin ii antagonists |
US5202322A (en) | 1991-09-25 | 1993-04-13 | Merck & Co., Inc. | Quinazolinone and pyridopyrimidine a-II antagonists |
US5532243A (en) | 1992-02-14 | 1996-07-02 | The Dupont Merck Pharmaceutical Company | Antipsychotic nitrogen-containing bicyclic compounds |
US5358951A (en) | 1993-04-23 | 1994-10-25 | American Cyanamid Company | Angiotensin II receptor blocking 2, 3, 6 substituted quinazolinones |
DE4407047A1 (de) | 1994-03-03 | 1995-09-07 | Merck Patent Gmbh | Acetamide |
US20010016657A1 (en) | 1997-03-18 | 2001-08-23 | Smithkline Beecham P.L.C. | Substituted isoquinoline derivatives and their use as anticonvulsants |
CN1290251A (zh) | 1998-02-04 | 2001-04-04 | 万有制药株式会社 | N-酰基环胺衍生物 |
JP2001039950A (ja) | 1999-07-30 | 2001-02-13 | Banyu Pharmaceut Co Ltd | N−アシル環状アミン誘導体 |
ATE250604T1 (de) | 1999-10-27 | 2003-10-15 | Millennium Pharm Inc | Pyridyl enthaltende spirocyclische verbindungen als inhibitoren der fibrinogen-abhängigen blutplättchen aggregation |
MXPA03008109A (es) | 2001-03-07 | 2003-12-12 | Pfizer Prod Inc | Moduladores de la actividad de receptores de quimiocinas. |
AU2003223510B2 (en) | 2002-04-12 | 2008-05-08 | Merck Sharp & Dohme Corp. | Bicyclic amides |
GB0303852D0 (en) | 2003-02-19 | 2003-03-26 | Pfizer Ltd | Triazole compounds useful in therapy |
WO2005023762A1 (fr) | 2003-09-04 | 2005-03-17 | Abbott Laboratories | Derives de pyrrolidine-2-carbonitrile et leur utilisation comme inhibiteurs de la dipeptidyle peptidase-iv (dpp-iv) |
SE0302811D0 (sv) | 2003-10-23 | 2003-10-23 | Astrazeneca Ab | Novel compounds |
GB0324790D0 (en) | 2003-10-24 | 2003-11-26 | Astrazeneca Ab | Amide derivatives |
US7226951B2 (en) | 2003-12-17 | 2007-06-05 | Allergan, Inc. | Compounds having selective cytochrome P450RAI-1 or selective cytochrome P450RAI-2 inhibitory activity and methods of obtaining the same |
KR100610731B1 (ko) | 2004-02-24 | 2006-08-09 | 한국과학기술연구원 | T-형 칼슘 채널 차단제로서 유용한 3,4-디히드로퀴나졸린유도체 및 그의 제조 방법 |
JP4845873B2 (ja) | 2004-03-03 | 2011-12-28 | ケモセントリックス インコーポレーティッド | 二環式および架橋した窒素複素環 |
CN101001860A (zh) | 2004-06-09 | 2007-07-18 | 霍夫曼-拉罗奇有限公司 | 杂环抗病毒化合物 |
CN101035773B (zh) | 2004-08-10 | 2012-06-06 | 詹森药业有限公司 | 抑制hiv的1,2,4-三嗪-6-酮衍生物 |
US7410949B2 (en) * | 2005-01-18 | 2008-08-12 | Hoffmann-La Roche Inc. | Neuropeptide-2 receptor (Y-2R) agonists and uses thereof |
GB0504019D0 (en) | 2005-02-26 | 2005-04-06 | Astrazeneca Ab | Amide derivatives |
BRPI0610433A2 (pt) | 2005-04-28 | 2010-11-23 | Wyeth Corp | forma polimórfica ii de tanaproget, processos para preparar a mesma, e para preparar forma micronizada de um composto, composição farmacêutica, método de preparação de uma composição farmacêutica, e, uso da forma polimórfica ii de tanaproget ou da forma micronizada |
US7737279B2 (en) | 2005-05-10 | 2010-06-15 | Bristol-Myers Squibb Company | 1,6-dihydro-1,3,5,6-tetraaza-as-indacene based tricyclic compounds and pharmaceutical compositions comprising same |
TW200800999A (en) | 2005-09-06 | 2008-01-01 | Astrazeneca Ab | Novel compounds |
EP1942108B1 (fr) | 2005-10-28 | 2013-09-04 | Ono Pharmaceutical Co., Ltd. | Compose contenant un groupe basique et son utilisation |
DK1961744T3 (da) | 2005-11-18 | 2013-07-15 | Ono Pharmaceutical Co | Forbindelse indeholdende basiske grupper samt anvendelse deraf |
WO2007065808A2 (fr) * | 2005-12-07 | 2007-06-14 | F. Hoffmann-La Roche Ag | Agonistes du récepteur du neuropeptide-2 |
JP2007176809A (ja) | 2005-12-27 | 2007-07-12 | Hideaki Natsukari | 複素環置換アミド化合物、その製造法および医薬組成物 |
WO2007103719A2 (fr) | 2006-03-03 | 2007-09-13 | Incyte Corporation | MODULATEURS DE LA 11-β-HYDROXYSTÉROÏDE DÉSHYDROGÉNASE DE TYPE 1, LEURS COMPOSITIONS PHARMACEUTIQUES ET LEURS PROCÉDÉS D'UTILISATION |
JP2008031064A (ja) | 2006-07-27 | 2008-02-14 | Astellas Pharma Inc | ジアシルピペラジン誘導体 |
US7632814B2 (en) | 2006-09-07 | 2009-12-15 | University Of South Florida | HYD1 peptides as anti-cancer agents |
WO2008033764A2 (fr) | 2006-09-11 | 2008-03-20 | N.V. Organon | Dérivés d'acétamide de quinazolinone et d'isoqiinolinone |
AR062790A1 (es) | 2006-09-15 | 2008-12-03 | Schering Corp | Derivados de azetidina utiles en el tratamiento del dolor, diabetes y trastornos del metabolismo de los lipidos |
US8735411B2 (en) | 2006-10-02 | 2014-05-27 | Abbvie Inc. | Macrocyclic benzofused pyrimidine derivatives |
ATE523497T1 (de) | 2006-11-15 | 2011-09-15 | High Point Pharmaceuticals Llc | Neue 2-(2-hydroxyphenyl)benzimidazole, die sich für die behandlung von obesitas und diabetes eignen |
TW200831085A (en) | 2006-12-13 | 2008-08-01 | Merck & Co Inc | Non-nucleoside reverse transcriptase inhibitors |
MX2009009920A (es) | 2007-03-29 | 2009-10-19 | Hoffmann La Roche | Inhibidores no nucleosidos de transcriptasa inversa. |
CL2008001002A1 (es) | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana. |
AU2008248996A1 (en) | 2007-04-27 | 2008-11-13 | Sanofi-Aventis | 2 -heteroaryl- pyrrolo [3, 4-C] pyrrole derivatives and their use as SCD inhibitors |
DE102007047737A1 (de) | 2007-10-05 | 2009-04-30 | Merck Patent Gmbh | Piperidin- und Piperazinderivate |
AR069126A1 (es) | 2007-10-31 | 2009-12-30 | Janssen Pharmaceutica Nv | Diaminas en puente o fusionadas sustituidas con arilo como moduladores de leucotrieno a4 hidrolasa |
JP2009161449A (ja) | 2007-12-28 | 2009-07-23 | Lion Corp | Ppar活性促進剤並びに美容用飲食品、皮膚外用剤及び医薬 |
WO2009154132A1 (fr) | 2008-06-19 | 2009-12-23 | 萬有製薬株式会社 | Dérivé de spirodiamine-diarylcétoxime |
US8673917B2 (en) | 2008-09-09 | 2014-03-18 | Sanofi | 2-heteroaryl-pyrrolo [3,4-C]pyrrole derivatives, and use thereof as SCD inhibitors |
US8299023B2 (en) | 2008-09-17 | 2012-10-30 | Hoffmann-La Roche Inc. | Neuropeptide-2 receptor (Y-2R) agonists |
TW201020247A (en) | 2008-11-06 | 2010-06-01 | Gruenenthal Gmbh | Substituierte disulfonamide |
US8188090B2 (en) | 2008-11-17 | 2012-05-29 | Hoffman-La Roche Inc. | Naphthylacetic acids |
DE102008059578A1 (de) | 2008-11-28 | 2010-06-10 | Merck Patent Gmbh | Benzo-Naphtyridin Verbindungen |
EA201100879A1 (ru) | 2008-12-01 | 2012-01-30 | Мерк Патент Гмбх | Производные пиридопиримидина в качестве ингибиторов аутотаксина |
TW201035102A (en) | 2009-03-04 | 2010-10-01 | Gruenethal Gmbh | Sulfonylated tetrahydroazolopyrazines and their use as medicinal products |
TW201038572A (en) | 2009-03-25 | 2010-11-01 | Gruenenthal Gmbh | Substituted spiro-amide compounds |
EA201101396A1 (ru) | 2009-04-02 | 2012-09-28 | Мерк Патент Гмбх | Ингибиторы аутотаксина |
EP2414330B1 (fr) | 2009-04-02 | 2013-05-01 | Merck Patent GmbH | Dérivés de pipéridine et de pyrazine comme inhibiteurs de l'autotaxine |
US8841324B2 (en) | 2009-04-02 | 2014-09-23 | Merck Patent Gmbh | Heterocyclic compounds as autotaxin inhibitors |
FR2945534B1 (fr) | 2009-05-12 | 2012-11-16 | Sanofi Aventis | DERIVES DE CYCLOPENTAL[c]PYRROLE-2-CARBOXYLATES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
AU2010249790A1 (en) | 2009-05-22 | 2011-12-08 | Exelixis, Inc. | Benzoxazepines based P13K/mT0R inhibitors against proliferative diseases |
US20120083476A1 (en) | 2009-06-05 | 2012-04-05 | Janssen Pharmaceutica Nv | Heteroaryl-substituted spirocyclic diamine urea modulators of fatty acid amide hydrolase |
DE102009033392A1 (de) | 2009-07-16 | 2011-01-20 | Merck Patent Gmbh | Heterocyclische Verbindungen als Autotaxin-Inhibitoren II |
US8592402B2 (en) | 2009-08-04 | 2013-11-26 | Amira Pharmaceuticals, Inc. | Compounds as lysophosphatidic acid receptor antagonists |
UA107360C2 (en) | 2009-08-05 | 2014-12-25 | Biogen Idec Inc | Bicyclic aryl sphingosine 1-phosphate analogs |
CN102596228A (zh) * | 2009-10-13 | 2012-07-18 | 霍夫曼-拉罗奇有限公司 | 神经肽-2受体(y-2r)激动剂 |
AR079022A1 (es) | 2009-11-02 | 2011-12-21 | Sanofi Aventis | Derivados de acido carboxilico ciclico sustituidos con acilamino, su uso como productos farmaceuticos, composicion farmaceutica y metodo de preparacion |
AU2011204323B2 (en) | 2010-01-07 | 2013-12-12 | E. I. Du Pont De Nemours And Company | Fungicidal heterocyclic compounds |
WO2011115813A1 (fr) | 2010-03-18 | 2011-09-22 | Abbott Laboratories | Acétamides de lactame en tant que bloqueurs des canaux calciques |
RS54383B1 (en) | 2010-03-19 | 2016-04-28 | Pfizer Inc. | 2,3-DIHYDRO-1H-INDEN-1-IL-2,7-DIAZASPIRO DERIVATIVES [3.6] NONANES AND THEIR USE AS ANTAGONISTS OR INVERNING AGELISTS OF GRELIN RECEPTORS |
AU2011232058B2 (en) | 2010-03-26 | 2016-09-08 | Merck Patent Gmbh | Benzonaphthyridinamines as autotaxin inhibitors |
GB201008005D0 (en) | 2010-05-13 | 2010-06-30 | Sentinel Oncology Ltd | Pharmaceutical compounds |
EP2575794A2 (fr) | 2010-06-04 | 2013-04-10 | B.S.R.C. "Alexander Fleming" | Modulation de la voie autotaxine et utilisations correspondantes |
AR082590A1 (es) | 2010-08-12 | 2012-12-19 | Hoffmann La Roche | Inhibidores de la tirosina-quinasa de bruton |
JP2013536200A (ja) | 2010-08-20 | 2013-09-19 | アミラ ファーマシューティカルス,インコーポレーテッド | オートタキシン阻害剤およびその使用 |
EP2611808B1 (fr) | 2010-09-02 | 2014-11-12 | Merck Patent GmbH | Dérivés de pyrazolopyridinone en tant qu'antagonistes de récepteur de lpa |
CN104906103B (zh) | 2010-12-14 | 2018-05-18 | 电泳有限公司 | 酪蛋白激酶1δ(CK1δ)抑制剂 |
CN103282054A (zh) * | 2011-01-03 | 2013-09-04 | 弗·哈夫曼-拉罗切有限公司 | 抗dig抗体和与肽缀合的地高辛配基的复合物的药物组合物 |
WO2012166415A1 (fr) | 2011-05-27 | 2012-12-06 | Amira Pharmaceuticals, Inc. | Inhibiteurs hétérocycliques d'autotaxine et leurs utilisations |
EP2751118B1 (fr) | 2011-08-29 | 2016-10-12 | Bristol-Myers Squibb Company | Dérivés spiraniques de diamine bicyclique utilisés en tant qu'inhibiteurs de la fixation du vih |
JP2013065847A (ja) | 2011-09-01 | 2013-04-11 | Fujifilm Corp | 絶縁反射基板およびledパッケージ |
WO2013054185A1 (fr) | 2011-10-13 | 2013-04-18 | Pfizer, Inc. | Dérivés de pyrimidine et de pyridine utiles en thérapie |
JPWO2013065712A1 (ja) | 2011-10-31 | 2015-04-02 | 東レ株式会社 | ジアザスピロウレア誘導体及びその医薬用途 |
US8809552B2 (en) | 2011-11-01 | 2014-08-19 | Hoffmann-La Roche Inc. | Azetidine compounds, compositions and methods of use |
WO2013079223A1 (fr) | 2011-12-02 | 2013-06-06 | Phenex Pharmaceuticals Ag | Pyrrolocarboxamides en tant que modulateurs de l'activité d'un récepteur orphelin gamma (rorϒ, nr1f3) apparenté au récepteur nucléaire orphelin rar et destinés au traitement de maladies inflammatoires chroniques et auto-immunes |
TWI638802B (zh) | 2012-05-24 | 2018-10-21 | 芬蘭商奧利安公司 | 兒茶酚o-甲基轉移酶活性抑制化合物 |
JP6258928B2 (ja) | 2012-06-13 | 2018-01-10 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 新規ジアザスピロシクロアルカンおよびアザスピロシクロアルカン |
IL289834B1 (en) | 2012-06-13 | 2024-03-01 | Incyte Holdings Corp | Conversion of tricyclic compounds as FGFR inhibitors |
JP6391571B2 (ja) | 2012-07-27 | 2018-09-19 | バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. | Atx調節剤 |
JP6324380B2 (ja) | 2012-07-27 | 2018-05-16 | バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. | S1p調節剤および/またはatx調節剤である化合物 |
PL2900269T3 (pl) | 2012-09-25 | 2019-02-28 | Bayer Pharma Aktiengesellschaft | Połączenie regorafenibu i kwasu acetylosalicylowego do leczenia raka jelita grubego |
PT2900669T (pt) | 2012-09-25 | 2019-10-29 | Hoffmann La Roche | Derivados de hexahidropirrolo[3,4−c]pirrol e compostos relacionados enquanto inibidores da autotaxina (atx) e enquanto inibidores da produção de ácido lisofosfatídico (lpa) para o tratamento de, por exemplo, doenças renais |
AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
PL2912019T3 (pl) | 2012-10-25 | 2021-11-02 | Tetra Discovery Partners Llc | Heteroarylowe inhibitory pde4 |
WO2014133112A1 (fr) | 2013-03-01 | 2014-09-04 | 国立大学法人東京大学 | Dérivé imidazopyrimidinone substitué en position 8 présentant une activité inhibitrice de l'autotaxine |
AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
EP3539962A1 (fr) | 2013-03-12 | 2019-09-18 | AbbVie Inc. | Inhibiteurs de bromodomaine tétracycliques |
TWI593692B (zh) | 2013-03-12 | 2017-08-01 | 美國禮來大藥廠 | 四氫吡咯并噻嗪化合物 |
JP2016512528A (ja) | 2013-03-12 | 2016-04-28 | アクセラ インコーポレイテッド | 眼疾患及び眼障害を治療するための置換された3−フェニルプロピルアミン誘導体 |
US20160039825A1 (en) | 2013-03-15 | 2016-02-11 | Biogen Ma Inc. | S1p and/or atx modulating agents |
AU2014291711B2 (en) | 2013-07-18 | 2017-02-02 | Novartis Ag | Autotaxin inhibitors comprising a heteroaromatic ring-benzyl-amide-cycle core |
LT3057959T (lt) | 2013-10-17 | 2018-06-11 | Vertex Pharmaceuticals Incorporated | Dnr-pk inhibitoriai |
SI3071561T1 (sl) | 2013-11-22 | 2021-11-30 | Sabre Therapeutics Llc | Spojine, ki inhibirajo avtotaksin |
WO2015078803A1 (fr) | 2013-11-26 | 2015-06-04 | F. Hoffmann-La Roche Ag | Nouvel octahydro-cyclobuta [1,2-c; 3,4-c'] dipyrrol-2-yl |
JO3512B1 (ar) | 2014-03-26 | 2020-07-05 | Astex Therapeutics Ltd | مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز |
CN106029667B (zh) | 2014-03-26 | 2019-08-23 | 豪夫迈·罗氏有限公司 | 作为自分泌运动因子(atx)和溶血磷脂酸(lpa)生产抑制剂的稠合[1,4]二氮杂*化合物 |
SI3122750T1 (sl) | 2014-03-26 | 2019-12-31 | F. Hoffmann-La Roche Ag | Biciklične spojine kot zaviralci proizvodnje avtotaksina (ATX) in lizofosfatidne kisline (LPA) |
ES2671452T3 (es) | 2014-03-26 | 2018-06-06 | Basf Se | Compuestos de [1,2,4]triazol e imidazol sustituidos como fungicidas |
KR20160133004A (ko) | 2014-04-04 | 2016-11-21 | 엑스-알엑스, 인크. | 오토탁신의 치환된 스피로시클릭 억제제 |
EP3187492A4 (fr) | 2014-08-29 | 2018-05-09 | The University of Tokyo | Dérivé de pyrimidone ayant une activité inhibitrice de l'autotaxine |
PT3207043T (pt) | 2014-10-14 | 2019-03-25 | Vitae Pharmaceuticals Llc | Inibidores de di-hidropirrolopiridina de ror-gama |
CR20170367A (es) | 2015-02-15 | 2017-09-12 | Hoffmann La Roche | Derivados de 1-(het)arilsulfonil-(pirrolidin o piperidin)-2-carboxamida y su uso como antagonistas de trpa1 |
MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
CN104927727B (zh) | 2015-07-06 | 2017-01-11 | 香山红叶建设有限公司 | 一种玻璃幕墙用结构密封胶及其制备方法 |
UA123362C2 (uk) | 2015-09-04 | 2021-03-24 | Ф. Хоффманн-Ля Рош Аг | Феноксиметильні похідні |
PL415078A1 (pl) | 2015-09-04 | 2017-03-13 | Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością | Podstawione aminotriazole przydatne jako inhibitory kwaśnej chitynazy ssaków |
CN107922415B (zh) | 2015-09-24 | 2022-04-15 | 豪夫迈·罗氏有限公司 | 新的作为双重atx/ca抑制剂的二环化合物 |
TW201723176A (zh) | 2015-09-24 | 2017-07-01 | Ionis製藥公司 | Kras表現之調節劑 |
MX2017015034A (es) | 2015-09-24 | 2018-04-13 | Hoffmann La Roche | Nuevos compuestos biciclicos como inhibidores duales de autotaxina (atx)/anhidrasa carbonica (ca). |
MA42918A (fr) | 2015-09-24 | 2018-08-01 | Hoffmann La Roche | Composés bicycliques utilisés en tant qu'inhibiteurs d'atx |
JP6876685B2 (ja) | 2015-09-24 | 2021-05-26 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Atx阻害剤としての二環式化合物 |
RU2742035C2 (ru) | 2015-11-25 | 2021-02-01 | Дана-Фарбер Кэнсер Инститьют, Инк. | Бивалентные ингибиторы бромодоменов и пути их применения |
KR102070746B1 (ko) | 2015-12-01 | 2020-01-29 | 니혼노야쿠가부시키가이샤 | 3h-피롤로피리딘 화합물 또는 그의 n-옥사이드, 또는 그들의 염류 및 상기 화합물을 함유하는 농원예용 살충제 및 그의 사용 방법 |
WO2017139978A1 (fr) | 2016-02-19 | 2017-08-24 | 吴伟东 | Procédé et système d'actualisation d'application de téléphone mobile |
CN110382484B (zh) | 2017-03-16 | 2022-12-06 | 豪夫迈·罗氏有限公司 | 新的作为atx抑制剂的二环化合物 |
CA3053329A1 (fr) | 2017-03-16 | 2018-09-20 | F. Hoffmann-La Roche Ag | Composes heterocycliques utiles en tant qu'inhibiteurs doubles d'atx/ca |
BR112018075312A2 (pt) | 2017-03-20 | 2019-10-01 | Forma Therapeutics Inc | composições de pirrolopirrol como ativadores da piruvato quinase (pkr) |
-
2016
- 2016-04-06 MA MA041898A patent/MA41898A/fr unknown
- 2016-04-07 CN CN201680016801.4A patent/CN107428754B/zh active Active
- 2016-04-07 WO PCT/EP2016/057549 patent/WO2016162390A1/fr active Application Filing
- 2016-04-07 CR CR20170455A patent/CR20170455A/es unknown
- 2016-04-07 AU AU2016245914A patent/AU2016245914B2/en not_active Ceased
- 2016-04-07 SG SG11201706457RA patent/SG11201706457RA/en unknown
- 2016-04-07 EP EP16714899.8A patent/EP3280707B1/fr active Active
- 2016-04-07 MX MX2017013036A patent/MX2017013036A/es unknown
- 2016-04-07 UA UAA201710791A patent/UA121133C2/uk unknown
- 2016-04-07 RU RU2017135520A patent/RU2017135520A/ru not_active Application Discontinuation
- 2016-04-07 SG SG10201909485Y patent/SG10201909485YA/en unknown
- 2016-04-07 KR KR1020177027393A patent/KR20170132766A/ko unknown
- 2016-04-07 CA CA2975664A patent/CA2975664A1/fr not_active Abandoned
- 2016-04-07 PE PE2017001540A patent/PE20171737A1/es unknown
- 2016-04-07 JP JP2017553149A patent/JP6774960B2/ja active Active
- 2016-04-07 BR BR112017021803-8A patent/BR112017021803A2/pt not_active Application Discontinuation
- 2016-04-08 TW TW105111141A patent/TW201710247A/zh unknown
- 2016-04-08 AR ARP160100947A patent/AR104208A1/es unknown
-
2017
- 2017-07-19 IL IL253588A patent/IL253588B/en active IP Right Grant
- 2017-07-27 CO CONC2017/0007635A patent/CO2017007635A2/es unknown
- 2017-09-28 CL CL2017002452A patent/CL2017002452A1/es unknown
- 2017-10-05 PH PH12017501825A patent/PH12017501825A1/en unknown
- 2017-10-10 US US15/728,894 patent/US10676446B2/en active Active
-
2018
- 2018-04-03 HK HK18104426.6A patent/HK1245249A1/zh unknown
-
2020
- 2020-02-18 US US16/793,178 patent/US20200317624A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA41898A (fr) | Dérivés de quinazolinone bicyclique | |
DK3360864T3 (da) | Pyrimidinforbindelse | |
DK3319956T3 (da) | Substituerede oxopyridinderivater | |
MA54254A (fr) | Dérivés de benzodiazépine cytotoxique | |
BR112018000297A2 (pt) | polimorfo de macrociclo de diarila | |
DK3286188T3 (da) | Isoxazolyl-substituerede imidazopyridiner | |
CL2016002461A1 (es) | Derivados macrocíclicos de pirimidina | |
MA54568A (fr) | Substitutions de nucléotides prédéterminées | |
CL2016002165A1 (es) | Compuestos de aminocarbonilcarbamato | |
DK3183242T3 (da) | Substituerede bicykliske forbindelser | |
MA41790A (fr) | Dérivé de morphinane | |
DK3597189T3 (da) | Krystallinske forbindelser | |
DK3372589T3 (da) | Pyrimidinderivat | |
FR3023290B1 (fr) | Derives de flavaglines | |
DK3795591T3 (da) | Cys80-konjugerede immunoglobuliner | |
ES1150811Y (es) | Torniquete sanitario | |
MA49708A (fr) | Dérivés de dihétérocycle liés à cycloalkyle | |
ES2789757T8 (es) | Herramienta de conformado | |
MA50130A (fr) | Détecteur de position | |
MA44018A (fr) | Dérivés de tétrahydroisoquinoline | |
MA41641A (fr) | Dérivés de tétrahydropyranylbenzamide | |
DK3081855T3 (da) | Projektør | |
FR3019594B1 (fr) | Section additionnelle de poussee | |
DK3484852T3 (da) | Benzo-n-hydroxyamidforbindelser med antitumor-aktivitet | |
FR3039391B1 (fr) | Orthese de contention |