AU2001268154A1 - Indolinone derivatives as protein kinase/phosphatase inhibitors - Google Patents
Indolinone derivatives as protein kinase/phosphatase inhibitorsInfo
- Publication number
- AU2001268154A1 AU2001268154A1 AU2001268154A AU6815401A AU2001268154A1 AU 2001268154 A1 AU2001268154 A1 AU 2001268154A1 AU 2001268154 A AU2001268154 A AU 2001268154A AU 6815401 A AU6815401 A AU 6815401A AU 2001268154 A1 AU2001268154 A1 AU 2001268154A1
- Authority
- AU
- Australia
- Prior art keywords
- protein kinase
- phosphatase inhibitors
- indolinone derivatives
- indolinone
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 102000045595 Phosphoprotein Phosphatases Human genes 0.000 title 1
- 108700019535 Phosphoprotein Phosphatases Proteins 0.000 title 1
- 102000001253 Protein Kinase Human genes 0.000 title 1
- JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical class C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 108060006633 protein kinase Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20916200P | 2000-06-02 | 2000-06-02 | |
US60/209,162 | 2000-06-02 | ||
PCT/US2001/017961 WO2001094312A2 (en) | 2000-06-02 | 2001-06-04 | Indolinone derivatives as protein kinase/phosphatase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001268154A1 true AU2001268154A1 (en) | 2001-12-17 |
Family
ID=22777614
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001268154A Abandoned AU2001268154A1 (en) | 2000-06-02 | 2001-06-04 | Indolinone derivatives as protein kinase/phosphatase inhibitors |
Country Status (6)
Country | Link |
---|---|
US (2) | US6706709B2 (de) |
EP (1) | EP1294688A2 (de) |
JP (1) | JP2003535847A (de) |
AU (1) | AU2001268154A1 (de) |
CA (1) | CA2410509A1 (de) |
WO (1) | WO2001094312A2 (de) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR035721A1 (es) | 2000-12-20 | 2004-07-07 | Sugen Inc | Indolinonas 4-aril sustituidas; sus composiciones farmaceuticas y metodo para modular la actividad catalitica de una proteina quinasa |
US6797825B2 (en) | 2001-12-13 | 2004-09-28 | Abbott Laboratories | Protein kinase inhibitors |
US20030187026A1 (en) | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
WO2004050681A2 (en) | 2002-11-15 | 2004-06-17 | Exelixis, Inc. | Kinase modulators |
WO2004048366A1 (ja) * | 2002-11-22 | 2004-06-10 | Yamanouchi Pharmaceutical Co., Ltd. | 2−オキソインドリン誘導体 |
US20040266843A1 (en) * | 2003-03-07 | 2004-12-30 | Sugen, Inc. | Sulfonamide substituted indolinones as inhibitors of DNA dependent protein kinase (DNA-PK) |
US7157577B2 (en) * | 2003-03-07 | 2007-01-02 | Sugen Inc. | 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors |
US7801585B1 (en) | 2003-06-02 | 2010-09-21 | Newlife Sciences Llc | System for analyzing and treating abnormality of human and animal tissues |
US7640052B2 (en) | 2004-05-28 | 2009-12-29 | Ippp, Llc | Method of integrated proton beam and therapeutic magnetic resonance therapy |
CA2534990A1 (en) * | 2003-07-25 | 2005-02-10 | Novartis Ag | P-38 kinase inhibitors |
GT200500321A (es) * | 2004-11-09 | 2006-09-04 | Compuestos y composiciones como inhibidores de proteina kinase. | |
US8108047B2 (en) * | 2005-11-08 | 2012-01-31 | Newlife Sciences Llc | Device and method for the treatment of pain with electrical energy |
PT1973910E (pt) | 2006-01-27 | 2013-09-06 | Shanghai Hengrui Pharm Co Ltd | Inibidores de pirrolo [3,2-c] piridina-4-ona 2-indolinona proteína cinase |
CN101007815B (zh) * | 2006-01-27 | 2010-06-23 | 江苏恒瑞医药股份有限公司 | 吡咯并六元杂环化合物及其在医药上的用途 |
EP1985093A1 (de) * | 2006-02-15 | 2008-10-29 | France Télécom | Verfahren und vorrichtung zur verwaltung mindestens einer benutzergruppe und entsprechendes computerprogramm |
WO2008011513A2 (en) * | 2006-07-19 | 2008-01-24 | The Cleveland Clinic Foundation | Compounds and methods of modulating angiogenesis |
US8080252B2 (en) * | 2006-07-19 | 2011-12-20 | The Cleveland Clinic Foundation | Compounds and methods of modulating angiogenesis |
US8329686B2 (en) * | 2006-08-29 | 2012-12-11 | Washington University | Isatin analogues and uses therefor |
US20080109049A1 (en) * | 2006-11-08 | 2008-05-08 | Schumann Daniel H | Device & method for relieving pain |
WO2008138232A1 (fr) * | 2007-05-14 | 2008-11-20 | Shanghai Hengrui Pharmaceutical Co., Ltd. | Dérivés pyrrolo-azotés hétérocycliques, leur préparation et leur utilisation pharmaceutique |
WO2008138184A1 (fr) | 2007-05-14 | 2008-11-20 | Shanghai Hengrui Pharmaceutical Co.Ltd. | Dérivés de pyrrolo-azacycles, leur procédé de fabrication et leur utilisation en tant qu'inhibiteurs de protéine kinases |
CN101367801B (zh) * | 2007-08-15 | 2011-01-12 | 上海恒瑞医药有限公司 | 吡咯并六元n杂环羟基***啉类衍生物的制备方法及其在医药上的应用 |
CA2736177A1 (en) * | 2007-09-06 | 2009-03-12 | Boston Biomedical, Inc. | Compositions of kinase inhibitors and their use for treatment of cancer and other diseases related to kinases |
US20090149732A1 (en) * | 2007-12-08 | 2009-06-11 | Weinstock Ronald J | System for use of electrical resonant frequencies in analyzing and treating abnormality of human and animal tissues |
US20100324627A1 (en) * | 2008-07-28 | 2010-12-23 | Newlife Sciences, Llc | Method and apparatus for resistivity measurement, detection and treatment in living tissue |
ES2465971T3 (es) | 2009-04-06 | 2014-06-09 | University Health Network | Inhibidores de quinasa y método para tratar cáncer con los mismos |
EP2377850A1 (de) * | 2010-03-30 | 2011-10-19 | Pharmeste S.r.l. | TRPV1-Vanilloidrezeptorantagonisten mit einem bizyklischen Teil |
DK2556071T3 (en) | 2010-04-06 | 2016-12-12 | Univ Health Network | Kinase inhibitors AND THEIR USE FOR THE TREATMENT OF CANCER |
CA2797694A1 (en) | 2010-04-29 | 2011-11-03 | The United States Of America, As Represented By The Secretary, Departmen T Of Health And Human Services | Activators of human pyruvate kinase |
US10085670B2 (en) | 2010-11-30 | 2018-10-02 | Newlife Sciences Llc | Apparatus and method for treatment of pain with body impedance analyzer |
WO2014201587A1 (zh) * | 2013-06-20 | 2014-12-24 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | 具有酪氨酸激酶抑制活性的物质、其制备方法及用途 |
ES2908200T3 (es) | 2013-10-18 | 2022-04-28 | Univ Health Network | Tratamiento para el cáncer de páncreas |
FR3030516B1 (fr) * | 2014-12-19 | 2019-12-27 | Galderma Research & Development | Derives sulfonamides bicycles en tant qu'agonistes inverses du recepteur gamma orphelin associe aux retinoides ror gamma (t) |
US20170057948A1 (en) * | 2015-08-27 | 2017-03-02 | Tallinn University Of Technology | Indole-like trk receptor antagonists |
WO2020252406A1 (en) | 2019-06-12 | 2020-12-17 | Truerelief, Llc | System and method for delivering pulsed electric current to living tissue |
WO2021260722A1 (en) * | 2020-06-21 | 2021-12-30 | Translational Health Science And Technology Institute | Design, synthesis of novel oxyindole inhibitors of denv rna dependent rna polymerase |
US11911605B2 (en) | 2021-03-05 | 2024-02-27 | Truerelief Llc | Method and apparatus for injury treatment |
Family Cites Families (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL104796C (de) | 1957-08-19 | |||
BE553661A (de) | 1955-12-23 | |||
BE558210A (de) | 1956-06-08 | |||
FR1398224A (fr) | 1964-05-06 | 1965-05-07 | Ici Ltd | Procédé de teinture de matières textiles de polyacrylonitrile |
FR1599772A (de) | 1968-09-17 | 1970-07-20 | ||
DE2159360A1 (de) | 1971-11-30 | 1973-06-14 | Bayer Ag | Nitrofuranderivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
DE2159361A1 (de) | 1971-11-30 | 1973-06-14 | Bayer Ag | Nitrofuranderivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
DE2159363A1 (de) | 1971-11-30 | 1973-06-14 | Bayer Ag | Antimikrobielle mittel |
DE2159362A1 (de) | 1971-11-30 | 1973-06-14 | Bayer Ag | Nitrofuranderivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
GB1384599A (en) | 1972-05-04 | 1975-02-19 | Colgate Palmolive Co | Coloured detergent compositions |
US4002749A (en) | 1975-08-12 | 1977-01-11 | E. R. Squibb & Sons, Inc. | Substituted indolinones |
US4053613A (en) | 1975-09-17 | 1977-10-11 | E. R. Squibb & Sons, Inc. | 1,3,thiazolinyl and 1,3 thiazinyl substituted indolinones |
DE3310891A1 (de) | 1983-03-25 | 1984-09-27 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue indolinon-(2)-derivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und zwischenprodukte |
DE3426419A1 (de) | 1984-07-18 | 1986-01-23 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue oxindol-derivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und zwischenprodukte |
JPS6229570A (ja) | 1985-07-29 | 1987-02-07 | Kanegafuchi Chem Ind Co Ltd | 3,5−ジイソプロピルベンジリデン複素環式化合物 |
JPS6239564A (ja) | 1985-08-13 | 1987-02-20 | Kanegafuchi Chem Ind Co Ltd | α−ベンジリデン−γ−ブチロラクトンまたはγ−ブチロラクタム誘導体 |
WO1993012786A1 (en) | 1986-07-10 | 1993-07-08 | Howard Harry R Jr | Indolinone derivatives |
JPS63141955A (ja) | 1986-12-03 | 1988-06-14 | Kanegafuchi Chem Ind Co Ltd | トリベンジルアミン誘導体 |
GB8816944D0 (en) | 1988-07-15 | 1988-08-17 | Sobio Lab | Compounds |
GB9004483D0 (en) | 1990-02-28 | 1990-04-25 | Erba Carlo Spa | New aryl-and heteroarylethenylene derivatives and process for their preparation |
CA2012634A1 (en) | 1990-03-20 | 1991-09-20 | Hassan Salari | Tyrphostins for treatment of allergic, inflammatory and cardiovascular diseases |
US5196446A (en) | 1990-04-16 | 1993-03-23 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Certain indole compounds which inhibit EGF receptor tyrosine kinase |
US5302606A (en) | 1990-04-16 | 1994-04-12 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Styryl-substituted pyridyl compounds which inhibit EGF receptor tyrosine kinase |
WO1992007830A2 (en) | 1990-10-29 | 1992-05-14 | Pfizer Inc. | Oxindole peptide antagonists |
DK0584222T3 (da) | 1991-05-10 | 1998-02-23 | Rhone Poulenc Rorer Int | Bis-mono- og bicycliske aryl- og heteroarylforbindelser, som inhiberer EGF- og/eller PDGF-receptor-tyrosinkinase |
GB9115160D0 (en) | 1991-07-12 | 1991-08-28 | Erba Carlo Spa | Methylen-oxindole derivatives and process for their preparation |
US5124347A (en) | 1991-07-31 | 1992-06-23 | Warner-Lambert Co. | 3-5-ditertiarybutylphenyl-4-hydroxymethylidene derivatives of 1,3-dihydro-2H-indole-2-ones as antiinflammatory agents |
JPH0558894A (ja) | 1991-08-27 | 1993-03-09 | Kanegafuchi Chem Ind Co Ltd | 抗腫瘍剤 |
US5389661A (en) | 1991-12-05 | 1995-02-14 | Warner-Lambert Company | Imidazole and 1,2,4-triazole derivatives with angiotensin II antagonist properties |
US5322950A (en) | 1991-12-05 | 1994-06-21 | Warner-Lambert Company | Imidazole with angiotensin II antagonist properties |
FR2689397A1 (fr) | 1992-04-01 | 1993-10-08 | Adir | Utilisation des dérivés de la 3-(3,5-Ditert-Butyl-4-Hydroxybenzylidenyl) Indoline-2-one pour l'obtention de médicaments. |
FR2694004B1 (fr) | 1992-07-21 | 1994-08-26 | Adir | Nouvelles 3-(Hydroxybenzylidényl)-indoline-2-ones et 3-(hydroxybenzylidényl)-indoline-2-thiones, leurs procédés de préparation, et les compositions pharmaceutiques qui les contiennent. |
GB9226855D0 (en) | 1992-12-23 | 1993-02-17 | Erba Carlo Spa | Vinylene-azaindole derivatives and process for their preparation |
EP0632102B1 (de) | 1993-06-28 | 1997-04-02 | Bayer Ag | Massefärben von Kunststoffen |
GB9313638D0 (en) | 1993-07-01 | 1993-08-18 | Erba Carlo Spa | Arylidene and heteroarylidene oxindole derivatives and process for their preparation |
GB9326136D0 (en) | 1993-12-22 | 1994-02-23 | Erba Carlo Spa | Biologically active 3-substituted oxindole derivatives useful as anti-angiogenic agents |
GB9412719D0 (en) | 1994-06-24 | 1994-08-17 | Erba Carlo Spa | Substituted azaindolylidene compounds and process for their preparation |
GB9423997D0 (en) | 1994-11-28 | 1995-01-11 | Erba Carlo Spa | Substituted 3-arylidene-7-azaoxindole compounds and process for their preparation |
GB9501567D0 (en) | 1995-01-26 | 1995-03-15 | Pharmacia Spa | Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors |
GB9507298D0 (en) | 1995-04-07 | 1995-05-31 | Pharmacia Spa | Substituted indolylmethylene-oxindale analogues as tyrosine kinase inhibitors |
US5880141A (en) | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
ATE243034T1 (de) | 1996-01-17 | 2003-07-15 | Taiho Pharmaceutical Co Ltd | Intimale verdickungsinhibitoren |
EP0788890A1 (de) | 1996-02-06 | 1997-08-13 | Agfa-Gevaert N.V. | Farbstoffe und Farbstoffdonorelemente zur thermischen Farbstoffübertragungsaufzeichnung |
AU4155697A (en) | 1996-08-23 | 1998-03-06 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
WO1998024432A2 (en) | 1996-12-05 | 1998-06-11 | Sugen, Inc. | Use of indolinone compounds as modulators of protein kinases |
CO4940469A1 (es) | 1997-03-05 | 2000-07-24 | Sugen Inc | Composicion oral de estabilidad mejorada que comprende un derivado de indolinona y una mezcla de gliceridos o esteres de polietilenglicol |
ES2239393T3 (es) * | 1997-05-07 | 2005-09-16 | Sugen, Inc. | Derivados de 2-indolinona utilizados como moduladores de la actividad de la proteina-quinasa. |
US6987113B2 (en) * | 1997-06-11 | 2006-01-17 | Sugen, Inc. | Tyrosine kinase inhibitors |
GB9716557D0 (en) | 1997-08-06 | 1997-10-08 | Glaxo Group Ltd | Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity |
US6133305A (en) | 1997-09-26 | 2000-10-17 | Sugen, Inc. | 3-(substituted)-2-indolinones compounds and use thereof as inhibitors of protein kinase activity |
US6531502B1 (en) * | 1998-01-21 | 2003-03-11 | Sugen, Inc. | 3-Methylidenyl-2-indolinone modulators of protein kinase |
DE19816624A1 (de) | 1998-04-15 | 1999-10-21 | Boehringer Ingelheim Pharma | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
US6395734B1 (en) | 1998-05-29 | 2002-05-28 | Sugen, Inc. | Pyrrole substituted 2-indolinone protein kinase inhibitors |
DE19826940A1 (de) | 1998-06-17 | 1999-12-23 | Bayer Ag | Substituierte N-Aryl-O-alkyl-carbamate |
AU5468499A (en) | 1998-08-04 | 2000-02-28 | Sugen, Inc. | 3-methylidenyl-2-indolinone modulators of protein kinase |
AU760039B2 (en) | 1998-12-17 | 2003-05-08 | F. Hoffmann-La Roche Ag | 4-aryloxindoles as inhibitors of JNK protein kinases |
AU770375B2 (en) | 1998-12-17 | 2004-02-19 | F. Hoffmann-La Roche Ag | 4-alkenyl (and alkynyl) oxindoles as inhibitors of cyclin-dependent kinases, in particular CDK2 |
TR200101747T2 (tr) | 1998-12-17 | 2001-11-21 | F.Hoffmann-La Roche Ag | 4- ve 5-alkinil oksindoller ve 4- ve 5-alkeniloksindoller. |
IL143920A0 (en) | 1998-12-31 | 2002-04-21 | Sugen Inc | 3-heteroarylidenyl-2-indolinone derivatives and pharmaceutical compositions containing the same |
JP2002540096A (ja) | 1999-03-24 | 2002-11-26 | スージェン・インコーポレーテッド | キナーゼ阻害剤としてのインドリノン化合物 |
US6689806B1 (en) * | 1999-03-24 | 2004-02-10 | Sugen, Inc. | Indolinone compounds as kinase inhibitors |
WO2001060814A2 (en) | 2000-02-15 | 2001-08-23 | Sugen, Inc. | Pyrrole substituted 2-indolinone protein kinase inhibitors |
MY128450A (en) * | 2000-05-24 | 2007-02-28 | Upjohn Co | 1-(pyrrolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives |
JP2004502686A (ja) * | 2000-06-30 | 2004-01-29 | スージェン・インコーポレーテッド | 4−ヘテロアリール−3−ヘテロアリーリデニル−2−インドリノンおよび蛋白質キナーゼ阻害剤としてのその使用 |
AR035721A1 (es) * | 2000-12-20 | 2004-07-07 | Sugen Inc | Indolinonas 4-aril sustituidas; sus composiciones farmaceuticas y metodo para modular la actividad catalitica de una proteina quinasa |
US6797825B2 (en) * | 2001-12-13 | 2004-09-28 | Abbott Laboratories | Protein kinase inhibitors |
US7157577B2 (en) * | 2003-03-07 | 2007-01-02 | Sugen Inc. | 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors |
-
2001
- 2001-06-04 CA CA002410509A patent/CA2410509A1/en not_active Abandoned
- 2001-06-04 AU AU2001268154A patent/AU2001268154A1/en not_active Abandoned
- 2001-06-04 EP EP01946059A patent/EP1294688A2/de not_active Withdrawn
- 2001-06-04 WO PCT/US2001/017961 patent/WO2001094312A2/en not_active Application Discontinuation
- 2001-06-04 JP JP2002501862A patent/JP2003535847A/ja not_active Withdrawn
- 2001-06-04 US US09/871,700 patent/US6706709B2/en not_active Expired - Fee Related
-
2003
- 2003-12-02 US US10/725,277 patent/US7071332B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6706709B2 (en) | 2004-03-16 |
US20040147586A1 (en) | 2004-07-29 |
EP1294688A2 (de) | 2003-03-26 |
JP2003535847A (ja) | 2003-12-02 |
WO2001094312A3 (en) | 2002-08-08 |
US7071332B2 (en) | 2006-07-04 |
US20020052369A1 (en) | 2002-05-02 |
WO2001094312A2 (en) | 2001-12-13 |
CA2410509A1 (en) | 2001-12-13 |
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