AU2001249865A1 - Pyrazoles for inhibiting protein kinase - Google Patents
Pyrazoles for inhibiting protein kinaseInfo
- Publication number
- AU2001249865A1 AU2001249865A1 AU2001249865A AU4986501A AU2001249865A1 AU 2001249865 A1 AU2001249865 A1 AU 2001249865A1 AU 2001249865 A AU2001249865 A AU 2001249865A AU 4986501 A AU4986501 A AU 4986501A AU 2001249865 A1 AU2001249865 A1 AU 2001249865A1
- Authority
- AU
- Australia
- Prior art keywords
- pyrazoles
- protein kinase
- inhibiting protein
- inhibiting
- kinase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19786200P | 2000-04-18 | 2000-04-18 | |
| US60197862 | 2000-04-18 | ||
| PCT/US2001/010997 WO2001079198A1 (en) | 2000-04-18 | 2001-04-05 | Pyrazoles for inhibiting protein kinase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2001249865A1 true AU2001249865A1 (en) | 2001-10-30 |
Family
ID=22731040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2001249865A Abandoned AU2001249865A1 (en) | 2000-04-18 | 2001-04-05 | Pyrazoles for inhibiting protein kinase |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6462069B2 (en) |
| EP (1) | EP1274706A1 (en) |
| JP (1) | JP2004501083A (en) |
| AR (1) | AR030211A1 (en) |
| AU (1) | AU2001249865A1 (en) |
| BR (1) | BR0110302A (en) |
| CA (1) | CA2398446A1 (en) |
| GT (1) | GT200100061A (en) |
| MX (1) | MXPA02010222A (en) |
| PA (1) | PA8515701A1 (en) |
| PE (1) | PE20020226A1 (en) |
| SV (1) | SV2002000376A (en) |
| WO (1) | WO2001079198A1 (en) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020150921A1 (en) * | 1996-02-09 | 2002-10-17 | Francis Barany | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
| CA2699568C (en) | 1999-12-24 | 2013-03-12 | Aventis Pharma Limited | Azaindoles |
| CN1518543A (en) * | 2000-08-31 | 2004-08-04 | �Ʒ� | Pyrazole derivatives and their use as protein kinase inhibitors |
| IL154817A0 (en) | 2000-09-15 | 2003-10-31 | Vertex Pharma | Pyrazole derivatives and pharmaceutical compositions containing the same |
| US6660731B2 (en) | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| ES2272567T3 (en) | 2000-12-21 | 2007-05-01 | Vertex Pharmaceuticals Incorporated | PIRAZOL COMPOUNDS USED AS PROTEIN KINASE INHIBITORS. |
| US6756374B2 (en) | 2001-01-22 | 2004-06-29 | Hoffmann-La Roche Inc. | Diaminothiazoles having antiproliferative activity |
| GB0115109D0 (en) | 2001-06-21 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
| EA008770B1 (en) * | 2002-05-15 | 2007-08-31 | Янссен Фамацевтика Н.В. | N-substituted tricyclic 3-aminopyrazoles as pdgf receptor inhibitors |
| EP1739087A1 (en) * | 2002-08-02 | 2007-01-03 | Vertex Pharmaceuticals Incorporated | Pyrazole compositions useful as inhibitors of gsk-3 |
| WO2004013140A1 (en) * | 2002-08-02 | 2004-02-12 | Vertex Pharmaceuticals Incorporated | Pyrazole compositions useful as inhibitors of gsk-3 |
| US7157455B2 (en) | 2003-02-10 | 2007-01-02 | Hoffmann-La Roche Inc. | 4-Aminopyrimidine-5-one derivatives |
| BRPI0407618A (en) * | 2003-02-21 | 2006-02-21 | Pfizer | cycloalkyl-substituted amino thiazole derivatives containing n and pharmaceutical compositions for inhibiting cell proliferation and methods for their use |
| JP2006519234A (en) | 2003-02-27 | 2006-08-24 | スミスクライン ビーチャム コーポレーション | New compounds |
| FR2854159B1 (en) * | 2003-04-25 | 2008-01-11 | Aventis Pharma Sa | NOVEL INDOLE DERIVATIVES, THEIR PREPARATION AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND IN PARTICULAR AS KDR INHIBITORS |
| TWI372050B (en) | 2003-07-03 | 2012-09-11 | Astex Therapeutics Ltd | (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles |
| US20050032869A1 (en) * | 2003-07-08 | 2005-02-10 | Pharmacia Italia S.P.A. | Pyrazolyl-indole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
| PL1651612T3 (en) * | 2003-07-22 | 2012-09-28 | Astex Therapeutics Ltd | 3,4-disubstituted 1h-pyrazole compounds and their use as cyclin dependent kinases (cdk) and glycogen synthase kinase-3 (gsk-3) modulators |
| CA2532231A1 (en) * | 2003-07-25 | 2005-02-03 | Pfizer Inc. | Aminopyrazole compounds and use as chk1 inhibitors |
| WO2005049579A2 (en) * | 2003-11-13 | 2005-06-02 | Janssen Pharmaceutica N.V. | Immobilized n-substituted tricyclic 3-aminopyrazoles for the identification of biomolecular targets |
| GB0326601D0 (en) * | 2003-11-14 | 2003-12-17 | Novartis Ag | Organic compounds |
| GB2410947B (en) * | 2004-02-11 | 2008-09-17 | Cambridge Lab Ltd | Pharmaceutical compounds |
| US7211576B2 (en) | 2004-04-20 | 2007-05-01 | Hoffmann-La Roche Inc. | Diaminothiazoles |
| JP2007533717A (en) * | 2004-04-21 | 2007-11-22 | アストラゼネカ アクチボラグ | Compound |
| US20060035920A1 (en) * | 2004-05-28 | 2006-02-16 | Millennium Pharmaceuticals, Inc. | Chk-1 inhibitors |
| EP1761539A1 (en) * | 2004-06-02 | 2007-03-14 | Takeda Pharmaceutical Company Limited | Indole derivative and use for treatment of cancer |
| US7405220B2 (en) | 2004-06-09 | 2008-07-29 | Hoffmann-La Roche Inc. | Pyrazolopyrimidines |
| US7423053B2 (en) | 2004-07-15 | 2008-09-09 | Hoffmann-La Roche Inc. | 4-Aminothiazole derivatives |
| US7423051B2 (en) | 2004-07-15 | 2008-09-09 | Hoffmann-La Roche Inc. | 2,6-diaminopyridine derivatives |
| WO2006055831A2 (en) * | 2004-11-17 | 2006-05-26 | Miikana Therapeutics, Inc. | Kinase inhibitors |
| US20100160324A1 (en) * | 2004-12-30 | 2010-06-24 | Astex Therapeutics Limited | Pyrazole derivatives as that modulate the activity of cdk, gsk and aurora kinases |
| AU2005321091B2 (en) | 2004-12-30 | 2012-04-12 | Astex Therapeutics Limited | Pyrazole compounds that modulate the activity of CDK, GSK and Aurora kinases |
| WO2006101454A1 (en) * | 2005-03-21 | 2006-09-28 | S*Bio Pte Ltd | Benzothiophene derivatives: preparation and pharmaceutical applications |
| GB0514501D0 (en) * | 2005-07-14 | 2005-08-24 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
| GB0516168D0 (en) * | 2005-08-05 | 2005-09-14 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
| AU2006297120B2 (en) * | 2005-09-30 | 2011-05-19 | Miikana Therapeutics, Inc. | Substituted pyrazole compounds |
| US7705009B2 (en) | 2005-11-22 | 2010-04-27 | Hoffman-La Roche Inc. | 4-aminopyrimidine-5-thione derivatives |
| US8399442B2 (en) | 2005-12-30 | 2013-03-19 | Astex Therapeutics Limited | Pharmaceutical compounds |
| GB2450016B (en) * | 2006-02-03 | 2010-10-20 | Sumitomo Chemical Co | Process for producing aromatic compounds by transition metal complex-mediated ortho-alkenylation |
| WO2008001115A2 (en) | 2006-06-29 | 2008-01-03 | Astex Therapeutics Limited | Pharmaceutical combinations of 1-cyclopropyl-3- [3- (5-m0rphoolin-4-ylmethyl-1h-benzoimidazol-2-yl) -lh-1-pyrazol- 4-yl] -urea |
| AU2008262291A1 (en) * | 2007-06-11 | 2008-12-18 | Miikana Therapeutics, Inc. | Substituted pyrazole compounds |
| CL2009001152A1 (en) | 2008-05-13 | 2009-10-16 | Array Biopharma Inc | Compounds derived from n- (4- (nitrogen cycloalkyl-1-yl) -1h-pyrrolo [2,3-b] pyridin-3-yl) amide, kinase inhibitors; Preparation process; pharmaceutical composition; and its use for the treatment of a proliferative disease. |
| GB0810857D0 (en) * | 2008-06-13 | 2008-07-23 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
| US20110053866A1 (en) * | 2008-08-12 | 2011-03-03 | Biovail Laboratories International (Barbados) S.R.L. | Pharmaceutical compositions |
| GB2462611A (en) * | 2008-08-12 | 2010-02-17 | Cambridge Lab | Pharmaceutical composition comprising tetrabenazine |
| GB2463452A (en) * | 2008-09-08 | 2010-03-17 | Cambridge Lab | Desmethyl derivatives of tetrabenazine and pharmaceutical compositions thereof |
| GB2463451A (en) | 2008-09-08 | 2010-03-17 | Cambridge Lab | 3, 11b cis-dihydrotetrabenazine compounds for use in the treatment of dementia |
| GB2463283A (en) * | 2008-09-08 | 2010-03-10 | Cambridge Lab | 3,11b-cis-dihydrotetrabenazine for use in treating asthma |
| CN103408540B (en) * | 2013-08-22 | 2016-05-18 | 中国药科大学 | 2-azoles ring substituted thiophene class PLK1 inhibitor and uses thereof and uses thereof |
| CN108690006B (en) * | 2017-04-12 | 2022-02-18 | 中国药科大学 | Compound and application thereof in anti-AML (AML) drugs |
| CN111836801B (en) | 2018-02-07 | 2024-02-02 | 韩国化学硏究院 | Compounds for inhibiting TNIK and medical use thereof |
| CN110835334B (en) * | 2018-08-16 | 2022-10-18 | 中国药科大学 | Indole-substituted azole compound and application thereof |
| BR112023024571A2 (en) | 2021-05-27 | 2024-02-06 | Boundless Bio Inc | CHECKPOINT KINASE 1 (CHK1) INHIBITORS AND USES THEREOF |
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| DE273062C (en) | 1912-04-19 | 1914-04-20 | Deylen Sohn Firma | Device for setting plate ignition chips |
| CH575397A5 (en) | 1971-11-09 | 1976-05-14 | Basf Ag | |
| WO1986005779A1 (en) | 1985-04-03 | 1986-10-09 | Yamanouchi Pharmaceutical Co., Ltd. | Phenylene derivatives |
| JPH083564B2 (en) | 1986-07-25 | 1996-01-17 | 三菱化学株式会社 | Polarizing film |
| DD273062A1 (en) | 1988-06-14 | 1989-11-01 | Fahlberg List Veb | PROCESS FOR PREPARING HYDROXYBENZOESAEURE (CHINOXALIN-2-YLMETHYL) ETHANTS AND ETHERS |
| CA1330079C (en) * | 1988-10-13 | 1994-06-07 | Michihiko Tsujitani | Pyrrolo (3,2-e)pyrazolo(1,5-a)pyrimidine derivative and medicine comprising the same |
| ATE159009T1 (en) | 1991-05-10 | 1997-10-15 | Rhone Poulenc Rorer Int | BIS MONO- AND BICYCLIC ARYL AND HETEROARYL DERIVATIVES WITH AN INHIBITING EFFECT ON THE EGF AND/OR PDGF RECEPTOR TYROSINKINASE |
| AU670431B2 (en) | 1992-03-24 | 1996-07-18 | Merck Sharp & Dohme Limited | 3-ureido substituted benzodiazepin-2-ones having cholecystokinin and/or gastrin antagonistic activity and their use in therapy |
| US5612360A (en) | 1992-06-03 | 1997-03-18 | Eli Lilly And Company | Angiotensin II antagonists |
| AU5704594A (en) | 1992-12-18 | 1994-07-19 | Wellcome Foundation Limited, The | Pyrimidine, pyridine, pteridinone and indazole derivatives as enzyme inhibitors |
| US5625031A (en) | 1994-02-08 | 1997-04-29 | Bristol-Myers Squibb Company | Peptide inhibitors of the p33cdk2 and p34cdc2 cell cycle regulatory kinases and human papillomavirus E7 oncoprotein |
| US5631156A (en) | 1994-06-21 | 1997-05-20 | The University Of Michigan | DNA encoding and 18 KD CDK6 inhibiting protein |
| AU700964B2 (en) * | 1994-11-10 | 1999-01-14 | Cor Therapeutics, Inc. | Pharmaceutical pyrazole compositions useful as inhibitors of protein kinases |
| CA2212061A1 (en) | 1995-02-02 | 1996-08-08 | Laramie Mary Gaster | Indole derivatives as 5-ht receptor antagonist |
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| US5733920A (en) | 1995-10-31 | 1998-03-31 | Mitotix, Inc. | Inhibitors of cyclin dependent kinases |
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| US5821243A (en) | 1996-07-22 | 1998-10-13 | Viropharma Incorporated | Compounds compositions and methods for treating influenza |
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| GB9716324D0 (en) | 1997-08-01 | 1997-10-08 | Mead Corp | Packaging machine and method of carton set up |
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| GB9718913D0 (en) | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
| DE69818083T2 (en) | 1997-10-06 | 2004-07-08 | Abbott Gmbh & Co. Kg | INDENO [1,2-c] -, NAPHTHO [1,2-C] AND BENZO [6,7] CYCLOHEPTA [1,2-c] PYRAZOLE DERIVATIVES |
| ID24372A (en) | 1997-10-27 | 2000-07-13 | Agouron Pharma | COMPOUNDS OF 4-AMINO-TIAZOL-2-IL COMPOUNDS AS CDKERS |
| TR200001256T2 (en) | 1997-11-04 | 2000-11-21 | Pfizer Products Inc. | Therapeutically active compositions. |
| US6391872B1 (en) | 1997-11-04 | 2002-05-21 | Pfizer Inc | Indazole bioisostere replacement of catechol in therapeutically active compounds |
| US6040321A (en) | 1997-11-12 | 2000-03-21 | Bristol-Myers Squibb Company | Aminothiazole inhibitors of cyclin dependent kinases |
| US6479487B1 (en) | 1998-02-26 | 2002-11-12 | Aventis Pharmaceuticals Inc. | 6, 9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines |
| TR200002482T2 (en) | 1998-02-26 | 2002-10-21 | Aventis Pharmaceuticals Inc. | 6,9-Diikameli 2- (Trans- (4-Aminocyclohexyl) Amino) Purines |
| EA003603B1 (en) | 1998-02-27 | 2003-06-26 | Пфайзер Продактс Инк. | N-[(substituted five-membered di- or triaza diunsaturated ring)carbonyl] guanidine derivatives for the treatment of ischemia |
| NZ507567A (en) | 1998-04-21 | 2003-08-29 | Du Pont Pharm Co | 5-aminoindeno(1,2-c)pyrazol-4-ones as anti-cancer and anti-proliferative agents |
| CA2332325A1 (en) | 1998-06-18 | 1999-12-23 | Bristol-Myers Squibb Company | Carbon substituted aminothiazole inhibitors of cyclin dependent kinases |
| CN1165532C (en) | 1998-09-29 | 2004-09-08 | 惠氏控股有限公司 | Substituted 3-cyanoquinolines as protein tyrosine kinases inhibitors |
| WO2000066112A1 (en) * | 1999-05-03 | 2000-11-09 | Smithkline Beecham Corporation | Cxcr-4 receptor antagonists - thrombopoietin mimetics |
-
2001
- 2001-04-05 EP EP01923144A patent/EP1274706A1/en not_active Withdrawn
- 2001-04-05 JP JP2001576797A patent/JP2004501083A/en not_active Withdrawn
- 2001-04-05 BR BR0110302-4A patent/BR0110302A/en not_active IP Right Cessation
- 2001-04-05 AU AU2001249865A patent/AU2001249865A1/en not_active Abandoned
- 2001-04-05 MX MXPA02010222A patent/MXPA02010222A/en active IP Right Grant
- 2001-04-05 CA CA002398446A patent/CA2398446A1/en not_active Abandoned
- 2001-04-05 WO PCT/US2001/010997 patent/WO2001079198A1/en active Application Filing
- 2001-04-06 SV SV2001000376A patent/SV2002000376A/en unknown
- 2001-04-11 PE PE2001000337A patent/PE20020226A1/en not_active Application Discontinuation
- 2001-04-17 GT GT200100061A patent/GT200100061A/en unknown
- 2001-04-17 US US09/835,566 patent/US6462069B2/en not_active Expired - Fee Related
- 2001-04-17 PA PA20018515701A patent/PA8515701A1/en unknown
- 2001-04-18 AR ARP010101823A patent/AR030211A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001079198B1 (en) | 2002-06-13 |
| WO2001079198A1 (en) | 2001-10-25 |
| BR0110302A (en) | 2003-01-14 |
| PA8515701A1 (en) | 2002-02-21 |
| PE20020226A1 (en) | 2002-04-02 |
| EP1274706A1 (en) | 2003-01-15 |
| JP2004501083A (en) | 2004-01-15 |
| SV2002000376A (en) | 2002-12-02 |
| GT200100061A (en) | 2002-03-14 |
| WO2001079198A9 (en) | 2002-05-16 |
| MXPA02010222A (en) | 2003-05-23 |
| AR030211A1 (en) | 2003-08-13 |
| US6462069B2 (en) | 2002-10-08 |
| US20020006952A1 (en) | 2002-01-17 |
| CA2398446A1 (en) | 2001-10-25 |
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