IL143920A0 - 3-heteroarylidenyl-2-indolinone derivatives and pharmaceutical compositions containing the same - Google Patents
3-heteroarylidenyl-2-indolinone derivatives and pharmaceutical compositions containing the sameInfo
- Publication number
- IL143920A0 IL143920A0 IL14392099A IL14392099A IL143920A0 IL 143920 A0 IL143920 A0 IL 143920A0 IL 14392099 A IL14392099 A IL 14392099A IL 14392099 A IL14392099 A IL 14392099A IL 143920 A0 IL143920 A0 IL 143920A0
- Authority
- IL
- Israel
- Prior art keywords
- heteroarylidenyl
- same
- pharmaceutical compositions
- compositions containing
- indolinone derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11431398P | 1998-12-31 | 1998-12-31 | |
| PCT/US1999/031232 WO2000038519A1 (en) | 1998-12-31 | 1999-12-30 | 3-heteroarylidenyl-2-indolinone compounds for modulating protein kinase activity and for use in cancer chemotherapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL143920A0 true IL143920A0 (en) | 2002-04-21 |
Family
ID=22354480
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL14392099A IL143920A0 (en) | 1998-12-31 | 1999-12-30 | 3-heteroarylidenyl-2-indolinone derivatives and pharmaceutical compositions containing the same |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1139754A4 (en) |
| JP (1) | JP2002533360A (en) |
| KR (1) | KR20010108063A (en) |
| CN (1) | CN1356872A (en) |
| AU (1) | AU760964B2 (en) |
| BR (1) | BR9916735A (en) |
| CA (1) | CA2357042A1 (en) |
| IL (1) | IL143920A0 (en) |
| MX (1) | MXPA01006742A (en) |
| WO (1) | WO2000038519A1 (en) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6569868B2 (en) | 1998-04-16 | 2003-05-27 | Sugen, Inc. | 2-indolinone derivatives as modulators of protein kinase activity |
| ES2367007T3 (en) * | 1999-11-24 | 2011-10-27 | Sugen, Inc. | INDONINABLE DERIVATIVES OF INDOLINONA AND ITS USE AS PTK BINDERS. |
| US6878733B1 (en) | 1999-11-24 | 2005-04-12 | Sugen, Inc. | Formulations for pharmaceutical agents ionizable as free acids or free bases |
| EP1255752B1 (en) * | 2000-02-15 | 2007-08-08 | Sugen, Inc. | Pyrrole substituted 2-indolinone protein kinase inhibitors |
| EP1278518B1 (en) * | 2000-02-28 | 2006-11-08 | Pfizer Enterprises SARL | Synergistic combination for the treatment of colorectal cancer |
| MY128449A (en) | 2000-05-24 | 2007-02-28 | Sugen Inc | Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives |
| US6706709B2 (en) | 2000-06-02 | 2004-03-16 | Sugen, Inc. | Indolinone derivatives as protein kinase/phosphatase inhibitors |
| US7312237B2 (en) | 2001-03-14 | 2007-12-25 | Bristol-Myers Squibb Co. | Combination of epothilone analogs and chemotherapeutic agents for the treatment of prolilferative diseases |
| US6599902B2 (en) | 2001-05-30 | 2003-07-29 | Sugen, Inc. | 5-aralkysufonyl-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives as kinase inhibitors |
| AR038957A1 (en) * | 2001-08-15 | 2005-02-02 | Pharmacia Corp | COMBINATION THERAPY FOR CANCER TREATMENT |
| WO2003035614A2 (en) * | 2001-10-25 | 2003-05-01 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| WO2003035616A2 (en) * | 2001-10-25 | 2003-05-01 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| WO2003035619A1 (en) * | 2001-10-25 | 2003-05-01 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| AU2002346457A1 (en) * | 2001-11-21 | 2003-06-10 | Pharmacia And Upjohn Company | Pharmaceutical formulations comprising indolinone derivatives |
| US20030187026A1 (en) | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
| US6797825B2 (en) | 2001-12-13 | 2004-09-28 | Abbott Laboratories | Protein kinase inhibitors |
| CA2470480C (en) | 2001-12-27 | 2010-12-14 | Theravance, Inc. | Indolinone derivatives useful as protein kinase inhibitors |
| TW200407124A (en) * | 2002-06-25 | 2004-05-16 | Wyeth Corp | Use of thio-oxindole derivatives in treatment of hormone-related conditions |
| US7115649B2 (en) | 2002-06-25 | 2006-10-03 | Wyeth | Methods of treating skin disorders using thio-oxindole derivatives |
| IL166528A0 (en) | 2002-08-02 | 2006-01-15 | Ab Science | 2-(3-aminoaryl)amino-4-aryl-thiazoles and their use as c-kit inhibitors |
| US8450302B2 (en) | 2002-08-02 | 2013-05-28 | Ab Science | 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors |
| MXPA05003431A (en) * | 2002-11-15 | 2005-07-05 | Warner Lambert Co | Combination chemotherapy comprising a mek inhibitor and capecitabine for treating cancer. |
| ATE465731T1 (en) | 2003-10-23 | 2010-05-15 | Ab Science | 2-AMINOARYLOXAZOLE COMPOUNDS AS TYROSINE KINASE INHIBITORS |
| CN100432071C (en) * | 2004-11-05 | 2008-11-12 | 中国科学院上海药物研究所 | Substituted 1H-indole-2-ketone compound and its preparation method and uses |
| MX2007012392A (en) | 2005-04-04 | 2007-12-05 | Ab Science | Substituted oxazole derivatives and their use as tyrosine kinase inhibitors. |
| US8246966B2 (en) | 2006-08-07 | 2012-08-21 | University Of Georgia Research Foundation, Inc. | Trypanosome microsome system and uses thereof |
| US8338433B2 (en) | 2006-11-22 | 2012-12-25 | University Of Georgia Research Foundation, Inc. | Tyrosine kinase inhibitors as anti-kinetoplastid agents |
| AP3881A (en) * | 2011-11-11 | 2016-10-31 | Lilly Co Eli | Combination therapy for ovarian cancer |
| EP3242934B1 (en) | 2015-01-08 | 2021-08-18 | The Board of Trustees of the Leland Stanford Junior University | Factors and cells that provide for induction of bone, bone marrow, and cartilage |
| AU2016255434C1 (en) | 2015-04-29 | 2021-09-23 | Rapport Therapeutics, Inc. | Azabenzimidazoles and their use as AMPA receptor modulators |
| CN105585558A (en) * | 2015-12-15 | 2016-05-18 | 贵州大学 | Double-alkoxy pyrimidine jointing 3-ethylenic-bond-oxoindole derivative and preparing method and application thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| ES2251741T3 (en) * | 1996-08-23 | 2006-05-01 | Sugen, Inc. | INDOLINONA COMBINATORY LIBRARIES AND RELATED PRODUCTS AND METHODS FOR THE TREATMENT OF DISEASES. |
-
1999
- 1999-12-30 EP EP99966725A patent/EP1139754A4/en not_active Withdrawn
- 1999-12-30 JP JP2000590484A patent/JP2002533360A/en not_active Withdrawn
- 1999-12-30 CN CN99816376A patent/CN1356872A/en active Pending
- 1999-12-30 IL IL14392099A patent/IL143920A0/en unknown
- 1999-12-30 CA CA002357042A patent/CA2357042A1/en not_active Abandoned
- 1999-12-30 MX MXPA01006742A patent/MXPA01006742A/en unknown
- 1999-12-30 KR KR1020017008453A patent/KR20010108063A/en not_active Application Discontinuation
- 1999-12-30 WO PCT/US1999/031232 patent/WO2000038519A1/en not_active Application Discontinuation
- 1999-12-30 AU AU22215/00A patent/AU760964B2/en not_active Ceased
- 1999-12-30 BR BR9916735-2A patent/BR9916735A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000038519A1 (en) | 2000-07-06 |
| JP2002533360A (en) | 2002-10-08 |
| AU760964B2 (en) | 2003-05-22 |
| EP1139754A4 (en) | 2002-12-18 |
| EP1139754A1 (en) | 2001-10-10 |
| KR20010108063A (en) | 2001-12-07 |
| MXPA01006742A (en) | 2004-04-21 |
| CA2357042A1 (en) | 2000-07-06 |
| AU2221500A (en) | 2000-07-31 |
| CN1356872A (en) | 2002-07-03 |
| BR9916735A (en) | 2001-09-25 |
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