AU2001268154A1 - Indolinone derivatives as protein kinase/phosphatase inhibitors - Google Patents
Indolinone derivatives as protein kinase/phosphatase inhibitorsInfo
- Publication number
- AU2001268154A1 AU2001268154A1 AU2001268154A AU6815401A AU2001268154A1 AU 2001268154 A1 AU2001268154 A1 AU 2001268154A1 AU 2001268154 A AU2001268154 A AU 2001268154A AU 6815401 A AU6815401 A AU 6815401A AU 2001268154 A1 AU2001268154 A1 AU 2001268154A1
- Authority
- AU
- Australia
- Prior art keywords
- protein kinase
- phosphatase inhibitors
- indolinone derivatives
- indolinone
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 102000045595 Phosphoprotein Phosphatases Human genes 0.000 title 1
- 108700019535 Phosphoprotein Phosphatases Proteins 0.000 title 1
- 102000001253 Protein Kinase Human genes 0.000 title 1
- JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical class C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 108060006633 protein kinase Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20916200P | 2000-06-02 | 2000-06-02 | |
US60/209,162 | 2000-06-02 | ||
PCT/US2001/017961 WO2001094312A2 (en) | 2000-06-02 | 2001-06-04 | Indolinone derivatives as protein kinase/phosphatase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001268154A1 true AU2001268154A1 (en) | 2001-12-17 |
Family
ID=22777614
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001268154A Abandoned AU2001268154A1 (en) | 2000-06-02 | 2001-06-04 | Indolinone derivatives as protein kinase/phosphatase inhibitors |
Country Status (6)
Country | Link |
---|---|
US (2) | US6706709B2 (en) |
EP (1) | EP1294688A2 (en) |
JP (1) | JP2003535847A (en) |
AU (1) | AU2001268154A1 (en) |
CA (1) | CA2410509A1 (en) |
WO (1) | WO2001094312A2 (en) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2432114A1 (en) | 2000-12-20 | 2002-07-18 | Sugen, Inc. | 4-(hetero)aryl substituted indolinones |
US20030187026A1 (en) | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
US6797825B2 (en) | 2001-12-13 | 2004-09-28 | Abbott Laboratories | Protein kinase inhibitors |
JP2006510727A (en) | 2002-11-15 | 2006-03-30 | エクセリクシス, インク. | Kinase modulator |
AU2003284572A1 (en) * | 2002-11-22 | 2004-06-18 | Yamanouchi Pharmaceutical Co., Ltd. | 2-oxoindoline derivatives |
US7157577B2 (en) * | 2003-03-07 | 2007-01-02 | Sugen Inc. | 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors |
US20040266843A1 (en) * | 2003-03-07 | 2004-12-30 | Sugen, Inc. | Sulfonamide substituted indolinones as inhibitors of DNA dependent protein kinase (DNA-PK) |
US7640052B2 (en) | 2004-05-28 | 2009-12-29 | Ippp, Llc | Method of integrated proton beam and therapeutic magnetic resonance therapy |
US7801585B1 (en) * | 2003-06-02 | 2010-09-21 | Newlife Sciences Llc | System for analyzing and treating abnormality of human and animal tissues |
CA2534990A1 (en) * | 2003-07-25 | 2005-02-10 | Novartis Ag | P-38 kinase inhibitors |
GT200500321A (en) * | 2004-11-09 | 2006-09-04 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF PROTEIN KINASE. | |
US8108047B2 (en) * | 2005-11-08 | 2012-01-31 | Newlife Sciences Llc | Device and method for the treatment of pain with electrical energy |
CN101007815B (en) * | 2006-01-27 | 2010-06-23 | 江苏恒瑞医药股份有限公司 | Pyrrolehexa-heterocyclic compound and pharmaceutical use thereof |
CA2636701C (en) | 2006-01-27 | 2014-08-05 | Shanghai Hengrui Pharmaceutical Co. Ltd. | Pyrrolo [3,2-c] pyridine-4-one 2-indolinone protein kinase inhibitors |
WO2007093616A1 (en) * | 2006-02-15 | 2007-08-23 | France Telecom | Method and device for managing at least one group of users, corresponding computer program product |
US8080252B2 (en) * | 2006-07-19 | 2011-12-20 | The Cleveland Clinic Foundation | Compounds and methods of modulating angiogenesis |
WO2008011513A2 (en) * | 2006-07-19 | 2008-01-24 | The Cleveland Clinic Foundation | Compounds and methods of modulating angiogenesis |
US8329686B2 (en) * | 2006-08-29 | 2012-12-11 | Washington University | Isatin analogues and uses therefor |
US20080109049A1 (en) * | 2006-11-08 | 2008-05-08 | Schumann Daniel H | Device & method for relieving pain |
WO2008138232A1 (en) * | 2007-05-14 | 2008-11-20 | Shanghai Hengrui Pharmaceutical Co., Ltd. | Pyrrolo-nitrogenous heterocyclic derivatives, the preparation and the pharmaceutical use thereof |
WO2008138184A1 (en) | 2007-05-14 | 2008-11-20 | Shanghai Hengrui Pharmaceutical Co.Ltd. | Derivatives of pyrroloazacycles, the method of making them and the use thereof as inhibitors of protein kinases |
CN101367801B (en) | 2007-08-15 | 2011-01-12 | 上海恒瑞医药有限公司 | Preparation method for pyrrol-hexahydric N heterocycle hydroxyl morpholine derivants, and medical uses thereof |
ES2759347T3 (en) | 2007-09-06 | 2020-05-08 | Boston Biomedical Inc | Compositions of kinase inhibitors and their use for the treatment of cancer and other kinase related diseases |
US20090149732A1 (en) * | 2007-12-08 | 2009-06-11 | Weinstock Ronald J | System for use of electrical resonant frequencies in analyzing and treating abnormality of human and animal tissues |
US20100324627A1 (en) * | 2008-07-28 | 2010-12-23 | Newlife Sciences, Llc | Method and apparatus for resistivity measurement, detection and treatment in living tissue |
CA2756568C (en) | 2009-04-06 | 2018-02-13 | University Health Network | Kinase inhibitors and method of treating cancer with same |
EP2377850A1 (en) * | 2010-03-30 | 2011-10-19 | Pharmeste S.r.l. | TRPV1 vanilloid receptor antagonists with a bicyclic portion |
PL2556071T3 (en) | 2010-04-06 | 2017-02-28 | University Health Network | Kinase inhibitors and their use in treating cancer |
WO2011137089A1 (en) | 2010-04-29 | 2011-11-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Activators of human pyruvate kinase |
WO2012074794A2 (en) | 2010-11-30 | 2012-06-07 | Newlife Sciences Llc | Apparatus and method for treatment of pain with body impedance analyzer |
EP3012248B1 (en) * | 2013-06-20 | 2019-09-11 | Institute of Radiation Medicine, Academy of Military Medical Sciences, People's Liberation Army of China | Substance having tyrosine kinase inhibitory activity and preparation method and use thereof |
MX357763B (en) | 2013-10-18 | 2018-07-23 | Univ Health Network | Treatment for pancreatic cancer. |
FR3030516B1 (en) * | 2014-12-19 | 2019-12-27 | Galderma Research & Development | BICYCLE SULFONAMIDE DERIVATIVES AS INVERTED AGONISTS OF THE ORPHAN GAMMA RECEPTOR ASSOCIATED WITH ROR GAMMA (T) RETINOIDS |
US20170057948A1 (en) * | 2015-08-27 | 2017-03-02 | Tallinn University Of Technology | Indole-like trk receptor antagonists |
CA3141259A1 (en) | 2019-06-12 | 2020-12-17 | John Crosson | System and method for delivering pulsed electric current to living tissue |
WO2021260722A1 (en) * | 2020-06-21 | 2021-12-30 | Translational Health Science And Technology Institute | Design, synthesis of novel oxyindole inhibitors of denv rna dependent rna polymerase |
US11911605B2 (en) | 2021-03-05 | 2024-02-27 | Truerelief Llc | Method and apparatus for injury treatment |
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US6635640B2 (en) * | 2000-06-30 | 2003-10-21 | Sugen, Inc. | 4-heteroaryl-3-heteroarylidenyl-2-indolinones and their use as protein kinase inhibitors |
CA2432114A1 (en) * | 2000-12-20 | 2002-07-18 | Sugen, Inc. | 4-(hetero)aryl substituted indolinones |
US6797825B2 (en) * | 2001-12-13 | 2004-09-28 | Abbott Laboratories | Protein kinase inhibitors |
US7157577B2 (en) * | 2003-03-07 | 2007-01-02 | Sugen Inc. | 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors |
-
2001
- 2001-06-04 EP EP01946059A patent/EP1294688A2/en not_active Withdrawn
- 2001-06-04 CA CA002410509A patent/CA2410509A1/en not_active Abandoned
- 2001-06-04 JP JP2002501862A patent/JP2003535847A/en not_active Withdrawn
- 2001-06-04 WO PCT/US2001/017961 patent/WO2001094312A2/en not_active Application Discontinuation
- 2001-06-04 AU AU2001268154A patent/AU2001268154A1/en not_active Abandoned
- 2001-06-04 US US09/871,700 patent/US6706709B2/en not_active Expired - Fee Related
-
2003
- 2003-12-02 US US10/725,277 patent/US7071332B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20040147586A1 (en) | 2004-07-29 |
JP2003535847A (en) | 2003-12-02 |
US7071332B2 (en) | 2006-07-04 |
US6706709B2 (en) | 2004-03-16 |
US20020052369A1 (en) | 2002-05-02 |
EP1294688A2 (en) | 2003-03-26 |
WO2001094312A3 (en) | 2002-08-08 |
CA2410509A1 (en) | 2001-12-13 |
WO2001094312A2 (en) | 2001-12-13 |
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