UY25197A1 - Un procedimiento para mejorar la producción de 5r clavams - Google Patents
Un procedimiento para mejorar la producción de 5r clavamsInfo
- Publication number
- UY25197A1 UY25197A1 UY25197A UY25197A UY25197A1 UY 25197 A1 UY25197 A1 UY 25197A1 UY 25197 A UY25197 A UY 25197A UY 25197 A UY25197 A UY 25197A UY 25197 A1 UY25197 A1 UY 25197A1
- Authority
- UY
- Uruguay
- Prior art keywords
- clavam
- production
- clavulanic acid
- clavams
- amoxicillin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente invención se refiere a nuevos genes bacterianos y procedimiento para mejorar la fabricación de clavams, por ejemplo, ácido clavulánico útil como antibiótico. También proporciona nuevos organismos capaces de producir cantidades incrementadas de ácido clavulánico. Un proceso para mejorar la producción de 5R clavam en un microorganismo adecuado que comprende la manipulación de ADN que comprende uno o más genes específicos para la biosíntesis de 5R clavam en S. Clavuligerus que no es esencial para la biosíntesis de 5R clavam, y su inclusión en dicho microorganismo. Dicho proceso comprende la disrupción u otra manera de hacer defectuosas las regiones de ADN que flanquean a cas1. Se presenta un proceso en el que el 5S clavam es clavam-2-carboxilato y/o 2-hidroximetilclavam. Y un proceso para la preparación de una composición que comprende clavulnato de potasio y amoxicilina, comprendiendo dicho proceso la producción de ácido clavulánico y en adelante convertirlo en sal de potasio y la sal de potasio con amoxicilina.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9702218.0A GB9702218D0 (en) | 1997-02-04 | 1997-02-04 | Novel product |
UY24874A UY24874A1 (es) | 1997-02-04 | 1998-02-03 | Nuevos compuestos |
Publications (1)
Publication Number | Publication Date |
---|---|
UY25197A1 true UY25197A1 (es) | 1998-11-27 |
Family
ID=10807030
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY24874A UY24874A1 (es) | 1997-02-04 | 1998-02-03 | Nuevos compuestos |
UY25197A UY25197A1 (es) | 1997-02-04 | 1998-09-30 | Un procedimiento para mejorar la producción de 5r clavams |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY24874A UY24874A1 (es) | 1997-02-04 | 1998-02-03 | Nuevos compuestos |
Country Status (32)
Country | Link |
---|---|
US (5) | US6936458B1 (es) |
EP (2) | EP0970198B1 (es) |
JP (2) | JP4227199B2 (es) |
KR (2) | KR100514964B1 (es) |
CN (2) | CN1192107C (es) |
AP (1) | AP1320A (es) |
AR (2) | AR011100A1 (es) |
AT (1) | ATE312926T1 (es) |
AU (1) | AU735782B2 (es) |
BG (1) | BG103704A (es) |
BR (1) | BR9807144A (es) |
CA (1) | CA2279207A1 (es) |
DE (1) | DE69832783T2 (es) |
DZ (1) | DZ2413A1 (es) |
EA (1) | EA003773B1 (es) |
ES (1) | ES2255149T3 (es) |
GB (1) | GB9702218D0 (es) |
HU (1) | HUP0001048A3 (es) |
ID (1) | ID22144A (es) |
IL (1) | IL131043A0 (es) |
MA (1) | MA24464A1 (es) |
MY (1) | MY140928A (es) |
NO (1) | NO993758D0 (es) |
NZ (1) | NZ336894A (es) |
OA (1) | OA11082A (es) |
PL (1) | PL334961A1 (es) |
SK (1) | SK105499A3 (es) |
TR (1) | TR199901862T2 (es) |
TW (2) | TW589377B (es) |
UY (2) | UY24874A1 (es) |
WO (1) | WO1998033896A2 (es) |
ZA (1) | ZA98868B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU7983400A (en) * | 1999-09-16 | 2001-04-17 | Johns Hopkins University, The | Improvement of clavulanic acid production |
JP2003512832A (ja) * | 1999-10-22 | 2003-04-08 | スミスクライン ビーチャム パブリック リミテッド カンパニー | Latおよびcvm遺伝子の欠失した5rクラバム産生微生物 |
GB0308696D0 (en) | 2003-04-15 | 2003-05-21 | Glaxo Group Ltd | New process |
EP2589663A1 (en) | 2011-11-04 | 2013-05-08 | LEK Pharmaceuticals d.d. | Process for production of clavulanic acid |
CN107964522B (zh) * | 2018-01-04 | 2020-12-08 | 上海交通大学 | 海洋链霉菌dut11及其抗补体活性应用 |
EP3994154A1 (en) | 2019-07-05 | 2022-05-11 | GlaxoSmithKline Intellectual Property (No.2) Limited | Streptomyces clavuligerus |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4110165A (en) * | 1974-04-20 | 1978-08-29 | Beecham Group Limited | Process for the production of clavulanic acid |
YU40452B (en) * | 1975-02-07 | 1986-02-28 | Beecham Group Plc | Process for the elimination of contaminating impurities from clavulinic acid |
GB1585661A (en) | 1976-06-08 | 1981-03-11 | Glaxo Lab Ltd | Clavam derivatives |
JPS589679B2 (ja) | 1977-02-24 | 1983-02-22 | 武田薬品工業株式会社 | 抗生物質の製造法 |
US4202819A (en) | 1979-05-04 | 1980-05-13 | Hoffman-La Roche Inc. | 2-(3-Alanyl)clavam antibiotic |
GB8521516D0 (en) * | 1985-08-29 | 1985-10-02 | Beecham Group Plc | Compounds |
GB9020683D0 (en) | 1990-09-22 | 1990-11-07 | Univ Strathclyde | Isolation of dna |
CA2108113C (en) * | 1993-10-08 | 2006-12-05 | Susan E. Jensen | Dna sequence encoding enzymes of clavulanic acid biosynthesis |
-
1997
- 1997-02-04 GB GBGB9702218.0A patent/GB9702218D0/en active Pending
-
1998
- 1998-01-27 MY MYPI98000390A patent/MY140928A/en unknown
- 1998-02-02 HU HU0001048A patent/HUP0001048A3/hu unknown
- 1998-02-02 EA EA199900718A patent/EA003773B1/ru not_active IP Right Cessation
- 1998-02-02 CA CA002279207A patent/CA2279207A1/en not_active Abandoned
- 1998-02-02 PL PL98334961A patent/PL334961A1/xx unknown
- 1998-02-02 TR TR1999/01862T patent/TR199901862T2/xx unknown
- 1998-02-02 NZ NZ336894A patent/NZ336894A/en unknown
- 1998-02-02 ES ES98906924T patent/ES2255149T3/es not_active Expired - Lifetime
- 1998-02-02 JP JP53256398A patent/JP4227199B2/ja not_active Expired - Lifetime
- 1998-02-02 AT AT98906924T patent/ATE312926T1/de not_active IP Right Cessation
- 1998-02-02 MA MA24953A patent/MA24464A1/fr unknown
- 1998-02-02 WO PCT/EP1998/000644 patent/WO1998033896A2/en not_active Application Discontinuation
- 1998-02-02 CN CNB988037475A patent/CN1192107C/zh not_active Expired - Lifetime
- 1998-02-02 ID IDW990801A patent/ID22144A/id unknown
- 1998-02-02 IL IL13104398A patent/IL131043A0/xx unknown
- 1998-02-02 CN CNA2004100105601A patent/CN1696301A/zh active Pending
- 1998-02-02 KR KR10-1999-7006973A patent/KR100514964B1/ko not_active IP Right Cessation
- 1998-02-02 BR BR9807144-0A patent/BR9807144A/pt not_active IP Right Cessation
- 1998-02-02 SK SK1054-99A patent/SK105499A3/sk unknown
- 1998-02-02 DE DE69832783T patent/DE69832783T2/de not_active Expired - Lifetime
- 1998-02-02 EP EP98906924A patent/EP0970198B1/en not_active Expired - Lifetime
- 1998-02-02 AP APAP/P/1999/001614A patent/AP1320A/en active
- 1998-02-02 AU AU62953/98A patent/AU735782B2/en not_active Ceased
- 1998-02-02 KR KR1020057007954A patent/KR20050053794A/ko not_active Application Discontinuation
- 1998-02-02 EP EP03078351A patent/EP1405913A3/en not_active Withdrawn
- 1998-02-02 AR ARP980100451A patent/AR011100A1/es unknown
- 1998-02-03 ZA ZA9800868A patent/ZA98868B/xx unknown
- 1998-02-03 UY UY24874A patent/UY24874A1/es not_active Application Discontinuation
- 1998-02-04 DZ DZ980023A patent/DZ2413A1/xx active
- 1998-05-12 TW TW087107252A patent/TW589377B/zh not_active IP Right Cessation
- 1998-05-12 TW TW092119091A patent/TW200307041A/zh unknown
- 1998-09-30 UY UY25197A patent/UY25197A1/es not_active IP Right Cessation
-
1999
- 1999-03-04 AR ARP990100913A patent/AR018304A2/es unknown
- 1999-07-09 US US09/350,702 patent/US6936458B1/en not_active Expired - Lifetime
- 1999-08-03 NO NO993758A patent/NO993758D0/no not_active Application Discontinuation
- 1999-08-04 OA OA9900170A patent/OA11082A/en unknown
- 1999-09-01 BG BG103704A patent/BG103704A/xx unknown
-
2002
- 2002-02-08 US US10/071,338 patent/US20030022321A1/en not_active Abandoned
- 2002-11-07 US US10/214,519 patent/US20030166175A1/en not_active Abandoned
- 2002-11-07 US US10/289,980 patent/US20030124690A1/en not_active Abandoned
-
2004
- 2004-10-08 US US10/961,636 patent/US7344869B2/en not_active Expired - Fee Related
-
2008
- 2008-10-01 JP JP2008256485A patent/JP5042186B2/ja not_active Expired - Lifetime
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
VENC | Patent expired |
Effective date: 20180930 |