ATE312926T1 - Mikroorganismen mit erhöhter herstellung von clavulansäure - Google Patents

Mikroorganismen mit erhöhter herstellung von clavulansäure

Info

Publication number
ATE312926T1
ATE312926T1 AT98906924T AT98906924T ATE312926T1 AT E312926 T1 ATE312926 T1 AT E312926T1 AT 98906924 T AT98906924 T AT 98906924T AT 98906924 T AT98906924 T AT 98906924T AT E312926 T1 ATE312926 T1 AT E312926T1
Authority
AT
Austria
Prior art keywords
microorganisms
increased production
clavulanic acid
clavulanic
acid
Prior art date
Application number
AT98906924T
Other languages
English (en)
Inventor
Barry Barton
John Patrick Griffin
Roy Henry Mosher
Ashish Sudhakar Paradkar
Susan Jensen
Cecilia Anders
Original Assignee
Smithkline Beecham Plc
Univ Alberta
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc, Univ Alberta filed Critical Smithkline Beecham Plc
Application granted granted Critical
Publication of ATE312926T1 publication Critical patent/ATE312926T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT98906924T 1997-02-04 1998-02-02 Mikroorganismen mit erhöhter herstellung von clavulansäure ATE312926T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9702218.0A GB9702218D0 (en) 1997-02-04 1997-02-04 Novel product
PCT/EP1998/000644 WO1998033896A2 (en) 1997-02-04 1998-02-02 Microorganisms with increased production of clavulanic acid

Publications (1)

Publication Number Publication Date
ATE312926T1 true ATE312926T1 (de) 2005-12-15

Family

ID=10807030

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98906924T ATE312926T1 (de) 1997-02-04 1998-02-02 Mikroorganismen mit erhöhter herstellung von clavulansäure

Country Status (32)

Country Link
US (5) US6936458B1 (de)
EP (2) EP0970198B1 (de)
JP (2) JP4227199B2 (de)
KR (2) KR100514964B1 (de)
CN (2) CN1192107C (de)
AP (1) AP1320A (de)
AR (2) AR011100A1 (de)
AT (1) ATE312926T1 (de)
AU (1) AU735782B2 (de)
BG (1) BG103704A (de)
BR (1) BR9807144A (de)
CA (1) CA2279207A1 (de)
DE (1) DE69832783T2 (de)
DZ (1) DZ2413A1 (de)
EA (1) EA003773B1 (de)
ES (1) ES2255149T3 (de)
GB (1) GB9702218D0 (de)
HU (1) HUP0001048A3 (de)
ID (1) ID22144A (de)
IL (1) IL131043A0 (de)
MA (1) MA24464A1 (de)
MY (1) MY140928A (de)
NO (1) NO993758D0 (de)
NZ (1) NZ336894A (de)
OA (1) OA11082A (de)
PL (1) PL334961A1 (de)
SK (1) SK105499A3 (de)
TR (1) TR199901862T2 (de)
TW (2) TW589377B (de)
UY (2) UY24874A1 (de)
WO (1) WO1998033896A2 (de)
ZA (1) ZA98868B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7983400A (en) * 1999-09-16 2001-04-17 Johns Hopkins University, The Improvement of clavulanic acid production
JP2003512832A (ja) * 1999-10-22 2003-04-08 スミスクライン ビーチャム パブリック リミテッド カンパニー Latおよびcvm遺伝子の欠失した5rクラバム産生微生物
GB0308696D0 (en) 2003-04-15 2003-05-21 Glaxo Group Ltd New process
EP2589663A1 (de) 2011-11-04 2013-05-08 LEK Pharmaceuticals d.d. Verfahren zur Herstellung von Clavulansäure
CN107964522B (zh) * 2018-01-04 2020-12-08 上海交通大学 海洋链霉菌dut11及其抗补体活性应用
EP3994154A1 (de) 2019-07-05 2022-05-11 GlaxoSmithKline Intellectual Property (No.2) Limited Streptomyces clavuligerus

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110165A (en) * 1974-04-20 1978-08-29 Beecham Group Limited Process for the production of clavulanic acid
YU40452B (en) * 1975-02-07 1986-02-28 Beecham Group Plc Process for the elimination of contaminating impurities from clavulinic acid
GB1585661A (en) 1976-06-08 1981-03-11 Glaxo Lab Ltd Clavam derivatives
JPS589679B2 (ja) 1977-02-24 1983-02-22 武田薬品工業株式会社 抗生物質の製造法
US4202819A (en) 1979-05-04 1980-05-13 Hoffman-La Roche Inc. 2-(3-Alanyl)clavam antibiotic
GB8521516D0 (en) * 1985-08-29 1985-10-02 Beecham Group Plc Compounds
GB9020683D0 (en) 1990-09-22 1990-11-07 Univ Strathclyde Isolation of dna
CA2108113C (en) * 1993-10-08 2006-12-05 Susan E. Jensen Dna sequence encoding enzymes of clavulanic acid biosynthesis

Also Published As

Publication number Publication date
CN1696301A (zh) 2005-11-16
CN1251612A (zh) 2000-04-26
WO1998033896A3 (en) 1998-11-19
DZ2413A1 (fr) 2003-01-04
JP2001511001A (ja) 2001-08-07
AR011100A1 (es) 2000-08-02
EP0970198B1 (de) 2005-12-14
EA003773B1 (ru) 2003-08-28
US20030124690A1 (en) 2003-07-03
AP1320A (en) 2004-10-29
EA199900718A1 (ru) 2000-02-28
CA2279207A1 (en) 1998-08-06
US20030166175A1 (en) 2003-09-04
EP1405913A3 (de) 2004-08-04
KR100514964B1 (ko) 2005-09-15
BR9807144A (pt) 2000-01-25
UY24874A1 (es) 2001-07-31
WO1998033896A2 (en) 1998-08-06
JP4227199B2 (ja) 2009-02-18
US6936458B1 (en) 2005-08-30
CN1192107C (zh) 2005-03-09
MA24464A1 (fr) 1998-10-01
TR199901862T2 (xx) 2000-12-21
TW200307041A (en) 2003-12-01
JP5042186B2 (ja) 2012-10-03
KR20000070723A (ko) 2000-11-25
KR20050053794A (ko) 2005-06-08
SK105499A3 (en) 2000-05-16
ZA98868B (en) 1999-08-03
HUP0001048A3 (en) 2001-09-28
BG103704A (en) 2000-05-31
HUP0001048A2 (hu) 2000-08-28
NO993758L (no) 1999-08-03
AU735782B2 (en) 2001-07-12
EP1405913A2 (de) 2004-04-07
US20030022321A1 (en) 2003-01-30
US7344869B2 (en) 2008-03-18
ES2255149T3 (es) 2006-06-16
GB9702218D0 (en) 1997-03-26
US20070298470A1 (en) 2007-12-27
AP9901614A0 (en) 1999-09-30
IL131043A0 (en) 2001-01-28
PL334961A1 (en) 2000-03-27
JP2009022298A (ja) 2009-02-05
NZ336894A (en) 2001-08-31
MY140928A (en) 2010-02-12
EP0970198A2 (de) 2000-01-12
AU6295398A (en) 1998-08-25
ID22144A (id) 1999-09-09
DE69832783T2 (de) 2006-07-20
AR018304A2 (es) 2001-11-14
DE69832783D1 (de) 2006-01-19
UY25197A1 (es) 1998-11-27
NO993758D0 (no) 1999-08-03
OA11082A (en) 2003-03-13
TW589377B (en) 2004-06-01

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