JPS5537136A - Preparation of cephalosporin antibiotic - Google Patents

Preparation of cephalosporin antibiotic

Info

Publication number
JPS5537136A
JPS5537136A JP10944178A JP10944178A JPS5537136A JP S5537136 A JPS5537136 A JP S5537136A JP 10944178 A JP10944178 A JP 10944178A JP 10944178 A JP10944178 A JP 10944178A JP S5537136 A JPS5537136 A JP S5537136A
Authority
JP
Japan
Prior art keywords
medium
preparation
sulfocysteine
fermentation
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10944178A
Other languages
Japanese (ja)
Other versions
JPS6225358B2 (en
Inventor
Yukio Fujisawa
Masaru Suzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to JP10944178A priority Critical patent/JPS5537136A/en
Publication of JPS5537136A publication Critical patent/JPS5537136A/en
Publication of JPS6225358B2 publication Critical patent/JPS6225358B2/ja
Granted legal-status Critical Current

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PURPOSE: To accelerate the production of cephalosporin antibiotics (C) remarkably, by adding a specific sulfur-containing compound to a medium as a component for preparing C through fermentation.
CONSTITUTION: S-sulfocysteine is added to a medium for preparing cephalosporin antibiotics (C) through fermentation by culturing microorganisms having the ability to produce C. The S-sulfocysteine can be readily synthesized by the Segel method [Analytical Biochemistry 5,330 (1963)]. The concentration is preferably about 0.01W3.0W/V%, and the aerobic culturing at 20W37°C for 4W14 days and pH 5.0W9.0 (the medium) maximizes the accumulation of C in the culture.
COPYRIGHT: (C)1980,JPO&Japio
JP10944178A 1978-09-05 1978-09-05 Preparation of cephalosporin antibiotic Granted JPS5537136A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10944178A JPS5537136A (en) 1978-09-05 1978-09-05 Preparation of cephalosporin antibiotic

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10944178A JPS5537136A (en) 1978-09-05 1978-09-05 Preparation of cephalosporin antibiotic

Publications (2)

Publication Number Publication Date
JPS5537136A true JPS5537136A (en) 1980-03-15
JPS6225358B2 JPS6225358B2 (en) 1987-06-02

Family

ID=14510316

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10944178A Granted JPS5537136A (en) 1978-09-05 1978-09-05 Preparation of cephalosporin antibiotic

Country Status (1)

Country Link
JP (1) JPS5537136A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63173901U (en) * 1987-05-06 1988-11-11
KR100446108B1 (en) * 1997-10-24 2004-10-26 씨제이 주식회사 Cephalosporin c-producing microorganism having improved lipase activity and method for producing cephalosporin c using the same
JP2008018484A (en) * 2006-07-12 2008-01-31 Hitachi Koki Co Ltd Driving machine
CN102702229A (en) * 2011-08-04 2012-10-03 重庆天地药业有限责任公司 Preparation of ceftizoxime sodium key intermediate and preparation of high-content ceftizoxime sodium

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63173901U (en) * 1987-05-06 1988-11-11
JPH0413841Y2 (en) * 1987-05-06 1992-03-30
KR100446108B1 (en) * 1997-10-24 2004-10-26 씨제이 주식회사 Cephalosporin c-producing microorganism having improved lipase activity and method for producing cephalosporin c using the same
JP2008018484A (en) * 2006-07-12 2008-01-31 Hitachi Koki Co Ltd Driving machine
CN102702229A (en) * 2011-08-04 2012-10-03 重庆天地药业有限责任公司 Preparation of ceftizoxime sodium key intermediate and preparation of high-content ceftizoxime sodium

Also Published As

Publication number Publication date
JPS6225358B2 (en) 1987-06-02

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