UA104849C2 - 4-піразоліл-n-арилпіримідин-2-аміни і 4-піразоліл-n-гетероарилпіримідин-2-аміни як інгібітори кіназ janus - Google Patents
4-піразоліл-n-арилпіримідин-2-аміни і 4-піразоліл-n-гетероарилпіримідин-2-аміни як інгібітори кіназ janusInfo
- Publication number
- UA104849C2 UA104849C2 UAA201007505A UAA201007505A UA104849C2 UA 104849 C2 UA104849 C2 UA 104849C2 UA A201007505 A UAA201007505 A UA A201007505A UA A201007505 A UAA201007505 A UA A201007505A UA 104849 C2 UA104849 C2 UA 104849C2
- Authority
- UA
- Ukraine
- Prior art keywords
- pyrazolyl
- amines
- heteroarylpyrimidin
- arylpyrimidin
- inhibitors
- Prior art date
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- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- C07D498/10—Spiro-condensed systems
Abstract
Даний винахід стосується заміщених біциклічних гетероарильних сполук формули (І), включаючи, наприклад, 4-піразоліл-N-арилпіримідин-2-аміни і 4-піразоліл-N-гетероарилпіримідин-2-аміни, які модулюють активність кіназ і застосовні при лікуванні захворювань, пов'язаних з активністю кіназ, включаючи, наприклад, хвороби, пов'язані з імунітетом, шкірні розлади, мієлоїднопроліферативні розлади, рак і інші захворювання.I
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US98860607P | 2007-11-16 | 2007-11-16 | |
PCT/US2008/083319 WO2009064835A1 (en) | 2007-11-16 | 2008-11-13 | 4-pyrazolyl-n-arylpyrimidin-2-amines and 4-pyrazolyl-n-heteroarylpyrimidin-2-amines as janus kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
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UA104849C2 true UA104849C2 (uk) | 2014-03-25 |
Family
ID=40380038
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA201007505A UA104849C2 (uk) | 2007-11-16 | 2008-11-13 | 4-піразоліл-n-арилпіримідин-2-аміни і 4-піразоліл-n-гетероарилпіримідин-2-аміни як інгібітори кіназ janus |
Country Status (21)
Country | Link |
---|---|
US (1) | US8309718B2 (uk) |
EP (1) | EP2220068B1 (uk) |
JP (1) | JP5480813B2 (uk) |
KR (1) | KR101580482B1 (uk) |
CN (1) | CN101910152B (uk) |
AU (1) | AU2008321046B2 (uk) |
BR (1) | BRPI0820544A2 (uk) |
CA (1) | CA2704599C (uk) |
CO (1) | CO6280420A2 (uk) |
CR (1) | CR11430A (uk) |
EA (1) | EA020777B1 (uk) |
EC (1) | ECSP10010263A (uk) |
ES (1) | ES2569528T3 (uk) |
HK (1) | HK1147476A1 (uk) |
IL (1) | IL205571A (uk) |
MX (1) | MX2010005300A (uk) |
MY (1) | MY152948A (uk) |
NZ (1) | NZ585139A (uk) |
UA (1) | UA104849C2 (uk) |
WO (1) | WO2009064835A1 (uk) |
ZA (1) | ZA201004055B (uk) |
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WO2005105814A1 (en) * | 2004-04-28 | 2005-11-10 | Incyte Corporation | Tetracyclic inhibitors of janus kinases |
DK2343299T3 (en) | 2005-12-13 | 2016-01-18 | Incyte Holdings Corp | Heteroberl-substituted pyrrolo [2,3-b] pyridines and pyrrolo [2,3-b] pyrimidines as Janus kinase inhibitors |
ES2415863T3 (es) | 2006-12-22 | 2013-07-29 | Incyte Corporation | Heterociclos sustituidos como inhibidores de Janus Quinasas |
CL2008001709A1 (es) | 2007-06-13 | 2008-11-03 | Incyte Corp | Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras. |
ES2575797T3 (es) * | 2007-06-13 | 2016-07-01 | Incyte Holdings Corporation | Sales del inhibidor de cinasas Janus (R)-3-(4-(7H-pirrolo[2,3-d]pirimidin-4-il)-1H-pirazol-1-il)-3-ciclopentilpropanonitrilo |
FR2938537B1 (fr) | 2008-11-14 | 2012-10-26 | Sanofi Aventis | Derives de carbamates d'alkyl-heterocycles, leur preparation et leur application en therapeutique. |
JOP20190230A1 (ar) | 2009-01-15 | 2017-06-16 | Incyte Corp | طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به |
EP2432555B1 (en) | 2009-05-22 | 2014-04-30 | Incyte Corporation | N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
DK2432472T3 (da) | 2009-05-22 | 2019-11-18 | Incyte Holdings Corp | 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octan- eller heptan-nitril som jak-inhibitorer |
US9249145B2 (en) | 2009-09-01 | 2016-02-02 | Incyte Holdings Corporation | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
US20110207736A1 (en) * | 2009-12-23 | 2011-08-25 | Gatekeeper Pharmaceuticals, Inc. | Compounds that modulate egfr activity and methods for treating or preventing conditions therewith |
WO2011098673A1 (en) * | 2010-02-10 | 2011-08-18 | Genon Biotechnologies Oy | Dual activity kinase domains and uses thereof |
MX2012009541A (es) * | 2010-02-18 | 2012-10-01 | Incyte Corp | Derivados de ciclobutano y metilciclobutano como inhibidores de janus cinasa. |
MX364636B (es) | 2010-03-10 | 2019-05-03 | Incyte Corp | Derivados de piperidin-4-il azetidina como inhibidores de janus cinasa 1 (jak1). |
GB201007286D0 (en) | 2010-04-30 | 2010-06-16 | Astex Therapeutics Ltd | New compounds |
EP3087972A1 (en) | 2010-05-21 | 2016-11-02 | Incyte Holdings Corporation | Topical formulation for a jak inhibitor |
JP5713367B2 (ja) | 2010-06-04 | 2015-05-07 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Lrrk2モジュレーターとしてのアミノピリミジン誘導体 |
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US8309718B2 (en) | 2012-11-13 |
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JP2011503194A (ja) | 2011-01-27 |
AU2008321046A1 (en) | 2009-05-22 |
JP5480813B2 (ja) | 2014-04-23 |
IL205571A0 (en) | 2010-12-30 |
ECSP10010263A (es) | 2010-07-30 |
HK1147476A1 (zh) | 2011-08-12 |
EP2220068A1 (en) | 2010-08-25 |
US20090318405A1 (en) | 2009-12-24 |
CN101910152A (zh) | 2010-12-08 |
ES2569528T3 (es) | 2016-05-11 |
KR20100095582A (ko) | 2010-08-31 |
AU2008321046B2 (en) | 2013-10-24 |
CR11430A (es) | 2010-07-01 |
CN101910152B (zh) | 2014-08-06 |
NZ585139A (en) | 2012-05-25 |
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