EA200501129A1 - Парентеральные композиции пептида для лечения системной красной волчанки - Google Patents
Парентеральные композиции пептида для лечения системной красной волчанкиInfo
- Publication number
- EA200501129A1 EA200501129A1 EA200501129A EA200501129A EA200501129A1 EA 200501129 A1 EA200501129 A1 EA 200501129A1 EA 200501129 A EA200501129 A EA 200501129A EA 200501129 A EA200501129 A EA 200501129A EA 200501129 A1 EA200501129 A1 EA 200501129A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- peptide
- composition
- lork
- treatment
- humans
- Prior art date
Links
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/724—Cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Abstract
Настоящее изобретение относится к фармацевтической композиции, содержащей водный носитель, от 0,1 до 20 мг/мл композиции фармацевтически приемлемой соли пептида, имеющего структурную формулу NH-Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Glu Glu Trp Ile Gly-COOH, и замещенный β-циклодекстрин в количестве, эффективном для растворения пептида в водном носителе, при этом композиция имеет pH от 4 до 9, к способу получения и способу ослабления симптомов системной красной волчанки (СКВ) у человека, включающему в себя введение человеку фармацевтической композиции.Отчет о международном поиске был опубликован 2005.03.24.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43995003P | 2003-01-14 | 2003-01-14 | |
PCT/US2004/000955 WO2004064788A2 (en) | 2003-01-14 | 2004-01-14 | Parenteral formulations of a peptide for the treatment of systemic lupus erythematosus |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200501129A1 true EA200501129A1 (ru) | 2006-02-24 |
EA008438B1 EA008438B1 (ru) | 2007-06-29 |
Family
ID=32771763
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200501129A EA008438B1 (ru) | 2003-01-14 | 2004-01-14 | Парентеральные композиции пептида для лечения системной красной волчанки |
Country Status (18)
Country | Link |
---|---|
US (2) | US7294687B2 (ru) |
EP (1) | EP1587525A4 (ru) |
JP (1) | JP2006516034A (ru) |
KR (1) | KR20050100616A (ru) |
CN (1) | CN1761477A (ru) |
AU (1) | AU2004206844A1 (ru) |
BR (1) | BRPI0406737A (ru) |
CA (1) | CA2513331A1 (ru) |
CO (1) | CO5640149A2 (ru) |
CR (1) | CR7936A (ru) |
EA (1) | EA008438B1 (ru) |
EC (1) | ECSP055960A (ru) |
MX (1) | MXPA05007552A (ru) |
NO (1) | NO20053761L (ru) |
NZ (1) | NZ541659A (ru) |
UA (1) | UA83816C2 (ru) |
WO (1) | WO2004064788A2 (ru) |
ZA (1) | ZA200506205B (ru) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL141647A0 (en) * | 2001-02-26 | 2002-03-10 | Yeda Res & Dev | Synthetic human peptides and pharmaceutical compositions comprising them for the treatment of systemic lupus erythematosus |
CN1761477A (zh) * | 2003-01-14 | 2006-04-19 | 特瓦制药工业有限公司 | 治疗***性红斑狼疮的肽的胃肠道外制剂 |
DK1594434T3 (da) * | 2003-01-14 | 2017-01-02 | Yeda Res & Dev Company Ltd At The Weizmann Inst Of Science | Parenterale formuleringer af peptide til behandling af systemisk lupus erythematosus |
DE102004043750A1 (de) * | 2004-09-10 | 2006-03-30 | Sanofi-Aventis Deutschland Gmbh | Formulierungen des Peptids p277 oder dessen Varianten mit optimierter Stabilität |
US20100160442A1 (en) * | 2006-07-18 | 2010-06-24 | Ossovskaya Valeria S | Formulations for cancer treatment |
US20100168011A1 (en) * | 2006-12-12 | 2010-07-01 | Amylin Pharmaceuticals, Inc. | Pharmaceutical Formulations and Methods for Making the Same |
CN101668561A (zh) * | 2007-01-16 | 2010-03-10 | 彼帕科学公司 | 癌症治疗制剂 |
US7635773B2 (en) | 2008-04-28 | 2009-12-22 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions |
KR20110039348A (ko) | 2008-08-06 | 2011-04-15 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | 연장된 생체내 효능을 가지는 콘쥬게이트된 단백질 |
DK2814849T3 (da) | 2012-02-15 | 2020-03-09 | Cydex Pharmaceuticals Inc | Fremgangsmåde til fremstilling af cyclodextrin-derivater |
WO2014066274A1 (en) | 2012-10-22 | 2014-05-01 | Cydex Pharmaceuticals, Inc. | Alkylated cyclodextrin compositions and processes for preparing and using the same |
JP6914188B2 (ja) | 2014-08-22 | 2021-08-04 | サイデックス・ファーマシューティカルズ・インコーポレイテッド | 分画アルキル化シクロデキストリン組成物ならびにその調製方法および使用方法 |
AU2018205885A1 (en) | 2017-01-05 | 2019-06-27 | Yeda Research And Development Co. Ltd. | Peptides for treating Sjogren's syndrome |
CN110960442B (zh) * | 2019-12-17 | 2023-03-31 | 珠海冀百康生物科技有限公司 | 一种多肽包封物的制备方法 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60184098A (ja) | 1984-03-02 | 1985-09-19 | Suntory Ltd | 新規なペプチド及びこれを有効成分とする利尿剤 |
US6407079B1 (en) * | 1985-07-03 | 2002-06-18 | Janssen Pharmaceutica N.V. | Pharmaceutical compositions containing drugs which are instable or sparingly soluble in water and methods for their preparation |
US5997856A (en) * | 1988-10-05 | 1999-12-07 | Chiron Corporation | Method and compositions for solubilization and stabilization of polypeptides, especially proteins |
US5126249A (en) | 1989-05-09 | 1992-06-30 | Eli Lilly And Company | Enzymatic removal of a protein amino-terminal sequence |
US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
KR0166088B1 (ko) * | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
GB9017008D0 (en) | 1990-08-02 | 1990-09-19 | Erba Carlo Spa | Process for the enzymatic preparation of basic fibroblast growth factor |
US5646131A (en) * | 1994-02-22 | 1997-07-08 | The Arab Company For Drug Industries And Medical Applicances (Acdima) | Method for solubilizing drugs using cyclodextrins and carboxylic acids |
IL113159A0 (en) * | 1995-03-28 | 1995-06-29 | Yeda Res & Dev | Synthetic peptides and pharmaceutical compositions comprising them |
US6613536B1 (en) | 1995-03-28 | 2003-09-02 | Yeda Research And Development Co. Ltd. | Synthetic peptides and pharmaceutical compositions comprising them for the treatment of systemic lupus erythematosus |
IL120503A0 (en) | 1997-03-20 | 1997-07-13 | Hadasit Med Res Service | Peptides for the treatment of systemic lupus erythematosis and pharmaceutical compositions containing them |
US20020054872A1 (en) | 1997-03-20 | 2002-05-09 | Yaakov Naparstek | Peptides for the treatment of systemic lupus erythematosus and methods of treating systemic lupus erythematosus |
DE69839221T2 (de) | 1997-12-18 | 2009-04-30 | Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield | Pyridone als hemmer der sh2-domäne der src-familie |
IL141647A0 (en) * | 2001-02-26 | 2002-03-10 | Yeda Res & Dev | Synthetic human peptides and pharmaceutical compositions comprising them for the treatment of systemic lupus erythematosus |
US7114005B2 (en) | 2002-02-05 | 2006-09-26 | Cisco Technology, Inc. | Address hopping of packet-based communications |
DK1594434T3 (da) * | 2003-01-14 | 2017-01-02 | Yeda Res & Dev Company Ltd At The Weizmann Inst Of Science | Parenterale formuleringer af peptide til behandling af systemisk lupus erythematosus |
CN1761477A (zh) * | 2003-01-14 | 2006-04-19 | 特瓦制药工业有限公司 | 治疗***性红斑狼疮的肽的胃肠道外制剂 |
-
2004
- 2004-01-14 CN CNA2004800069919A patent/CN1761477A/zh active Pending
- 2004-01-14 MX MXPA05007552A patent/MXPA05007552A/es active IP Right Grant
- 2004-01-14 EP EP04702214A patent/EP1587525A4/en not_active Withdrawn
- 2004-01-14 WO PCT/US2004/000955 patent/WO2004064788A2/en not_active Application Discontinuation
- 2004-01-14 UA UAA200507998A patent/UA83816C2/ru unknown
- 2004-01-14 CA CA002513331A patent/CA2513331A1/en not_active Abandoned
- 2004-01-14 KR KR1020057013097A patent/KR20050100616A/ko not_active Application Discontinuation
- 2004-01-14 US US10/758,572 patent/US7294687B2/en not_active Expired - Lifetime
- 2004-01-14 AU AU2004206844A patent/AU2004206844A1/en not_active Abandoned
- 2004-01-14 BR BR0406737-1A patent/BRPI0406737A/pt not_active IP Right Cessation
- 2004-01-14 JP JP2006500958A patent/JP2006516034A/ja not_active Withdrawn
- 2004-01-14 EA EA200501129A patent/EA008438B1/ru not_active IP Right Cessation
- 2004-01-14 NZ NZ541659A patent/NZ541659A/en unknown
-
2005
- 2005-08-03 ZA ZA200506205A patent/ZA200506205B/en unknown
- 2005-08-08 NO NO20053761A patent/NO20053761L/no not_active Application Discontinuation
- 2005-08-09 CR CR7936A patent/CR7936A/es unknown
- 2005-08-10 CO CO05079319A patent/CO5640149A2/es not_active Application Discontinuation
- 2005-08-11 EC EC2005005960A patent/ECSP055960A/es unknown
-
2007
- 2007-11-12 US US11/985,068 patent/US20080287366A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ECSP055960A (es) | 2006-04-19 |
CA2513331A1 (en) | 2004-08-05 |
UA83816C2 (ru) | 2008-08-26 |
CN1761477A (zh) | 2006-04-19 |
NO20053761D0 (no) | 2005-08-08 |
CO5640149A2 (es) | 2006-05-31 |
US7294687B2 (en) | 2007-11-13 |
ZA200506205B (en) | 2006-12-27 |
WO2004064788A2 (en) | 2004-08-05 |
EP1587525A4 (en) | 2008-09-10 |
MXPA05007552A (es) | 2006-05-19 |
CR7936A (es) | 2006-05-31 |
BRPI0406737A (pt) | 2005-12-20 |
US20080287366A1 (en) | 2008-11-20 |
KR20050100616A (ko) | 2005-10-19 |
WO2004064788A3 (en) | 2005-03-24 |
EP1587525A2 (en) | 2005-10-26 |
AU2004206844A1 (en) | 2004-08-05 |
NO20053761L (no) | 2005-10-12 |
EA008438B1 (ru) | 2007-06-29 |
NZ541659A (en) | 2007-05-31 |
US20040180059A1 (en) | 2004-09-16 |
JP2006516034A (ja) | 2006-06-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |