US4309430A
(en)
|
1980-06-27 |
1982-01-05 |
Merck & Co., Inc. |
Pyrazinyl-1,2,4-oxadiazole-5-ones, for treatment of edema, and processes for preparing same
|
US5329012A
(en)
|
1987-10-29 |
1994-07-12 |
The Research Foundation Of State University Of New York |
Bis(acyloxmethyl)imidazole compounds
|
JP2597917B2
(ja)
|
1990-04-26 |
1997-04-09 |
富士写真フイルム株式会社 |
新規な色素形成カプラー及びそれを用いたハロゲン化銀カラー写真感光材料
|
CA2217778A1
(en)
|
1995-05-09 |
1996-11-14 |
Basf Aktiengesellschaft |
Pyrazolo(1,5a)pyrimidines, their preparation and their use
|
WO1997043267A1
(en)
|
1996-05-11 |
1997-11-20 |
Kings College London |
Pyrazines
|
US6191131B1
(en)
|
1997-07-23 |
2001-02-20 |
Dupont Pharmaceuticals Company |
Azolo triazines and pyrimidines
|
EP1908764A1
(en)
|
1996-07-24 |
2008-04-09 |
Bristol-Myers Squibb Pharma Company |
Azolo triazines and pyrimidines
|
US6060478A
(en)
|
1996-07-24 |
2000-05-09 |
Dupont Pharmaceuticals |
Azolo triazines and pyrimidines
|
JPH10218881A
(ja)
|
1997-02-03 |
1998-08-18 |
Pola Chem Ind Inc |
新規なピロロピラゾロピリミジン誘導体
|
GB2323861B
(en)
|
1997-02-05 |
2001-06-20 |
Sector Exhibiting Systems |
Artificial wall structure
|
JP2002241379A
(ja)
|
1997-03-21 |
2002-08-28 |
Dainippon Pharmaceut Co Ltd |
3−オキサジアゾリルキノキサリン誘導体
|
WO1998054093A1
(en)
|
1997-05-30 |
1998-12-03 |
Merck & Co., Inc. |
Novel angiogenesis inhibitors
|
US6235741B1
(en)
|
1997-05-30 |
2001-05-22 |
Merck & Co., Inc. |
Angiogenesis inhibitors
|
CA2336832A1
(en)
|
1998-07-16 |
2000-01-27 |
Shionogi & Co., Ltd. |
Pyrimidine derivatives exhibiting antitumor activity
|
US6245759B1
(en)
|
1999-03-11 |
2001-06-12 |
Merck & Co., Inc. |
Tyrosine kinase inhibitors
|
US6660753B2
(en)
|
1999-08-19 |
2003-12-09 |
Nps Pharmaceuticals, Inc. |
Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
|
JP2001302666A
(ja)
|
1999-09-21 |
2001-10-31 |
Nissan Chem Ind Ltd |
アゾール縮合ヘテロ環アニライド化合物及び除草剤
|
MY125533A
(en)
|
1999-12-06 |
2006-08-30 |
Bristol Myers Squibb Co |
Heterocyclic dihydropyrimidine compounds
|
US6608063B2
(en)
|
1999-12-17 |
2003-08-19 |
Chiron Corporation |
Pyrazine based inhibitors of glycogen synthase kinase 3
|
US6723332B2
(en)
|
2000-05-26 |
2004-04-20 |
Neurogen Corporation |
Oxomidazopyridine-carboxamides
|
US20020041880A1
(en)
|
2000-07-05 |
2002-04-11 |
Defeo-Jones Deborah |
Method of treating cancer
|
US6849660B1
(en)
|
2000-08-01 |
2005-02-01 |
Isis Pharmaceuticals, Inc. |
Antimicrobial biaryl compounds
|
US7067520B2
(en)
|
2000-11-17 |
2006-06-27 |
Ishihara Sangyo Kaisha, Ltd. |
Preventive or therapeutic medicines for diabetes containing fused-heterocyclic compounds or their salts
|
EP1217000A1
(en)
|
2000-12-23 |
2002-06-26 |
Aventis Pharma Deutschland GmbH |
Inhibitors of factor Xa and factor VIIa
|
US6420637B1
(en)
|
2001-01-29 |
2002-07-16 |
Asgrow Seed Company L.L.C. |
Plants and seeds of corn variety I389972
|
GB0103926D0
(en)
|
2001-02-17 |
2001-04-04 |
Astrazeneca Ab |
Chemical compounds
|
DE60229059D1
(de)
|
2001-05-08 |
2008-11-06 |
Univ Yale |
Proteomimetische verbindungen und verfahren
|
AU2002315389A1
(en)
|
2001-06-21 |
2003-01-08 |
Ariad Pharmaceuticals, Inc. |
Novel pyrazolo-and pyrrolo-pyrimidines and uses thereof
|
SE0102439D0
(sv)
|
2001-07-05 |
2001-07-05 |
Astrazeneca Ab |
New compounds
|
SE0102438D0
(sv)
|
2001-07-05 |
2001-07-05 |
Astrazeneca Ab |
New compounds
|
US6833371B2
(en)
|
2001-11-01 |
2004-12-21 |
Icagen, Inc. |
Pyrazolopyrimidines
|
US6992087B2
(en)
|
2001-11-21 |
2006-01-31 |
Pfizer Inc |
Substituted aryl 1,4-pyrazine derivatives
|
EP1446387B1
(en)
|
2001-11-21 |
2009-11-04 |
Pharmacia & Upjohn Company LLC |
Substituted aryl 1,4-pyrazine derivatives
|
AU2003215087B2
(en)
|
2002-02-06 |
2009-07-16 |
Vertex Pharmaceuticals Incorporated |
Heteroaryl compounds useful as inhibitors of GSK-3
|
OA12792A
(en)
|
2002-03-13 |
2006-07-10 |
Janssen Pharmaceutica Nv |
Sulfonyl-derivatives as novel inhibitors of histone deacetylase.
|
GB0206860D0
(en)
|
2002-03-22 |
2002-05-01 |
Glaxo Group Ltd |
Compounds
|
TWI319387B
(en)
|
2002-04-05 |
2010-01-11 |
Astrazeneca Ab |
Benzamide derivatives
|
MXPA04010441A
(es)
*
|
2002-04-23 |
2005-02-14 |
Shionogi & Co |
Derivado de pirazolo[1,5-a]pirimidina e inhibidor de nad(p)h oxidasa que contiene el mismo.
|
GB0209715D0
(en)
|
2002-04-27 |
2002-06-05 |
Astrazeneca Ab |
Chemical compounds
|
US7704995B2
(en)
|
2002-05-03 |
2010-04-27 |
Exelixis, Inc. |
Protein kinase modulators and methods of use
|
EP1501514B1
(en)
|
2002-05-03 |
2012-12-19 |
Exelixis, Inc. |
Protein kinase modulators and methods of use
|
KR20050004214A
(ko)
|
2002-05-31 |
2005-01-12 |
에자이 가부시키가이샤 |
피라졸 화합물 및 이것을 포함하여 이루어지는 의약 조성물
|
AU2003240488A1
(en)
|
2002-06-04 |
2003-12-19 |
Neogenesis Pharmaceuticals, Inc. |
Pyrazolo` 1,5a! pyrimidine compounds as antiviral agents
|
US7449488B2
(en)
|
2002-06-04 |
2008-11-11 |
Schering Corporation |
Pyrazolopyrimidines as protein kinase inhibitors
|
AU2003249369A1
(en)
|
2002-06-21 |
2004-01-06 |
Cellular Genomics, Inc. |
Certain amino-substituted monocycles as kinase modulators
|
KR20050058507A
(ko)
|
2002-09-04 |
2005-06-16 |
쉐링 코포레이션 |
사이클린 의존성 키나제 억제제로서의 피라졸로피리미딘
|
US8580782B2
(en)
|
2002-09-04 |
2013-11-12 |
Merck Sharp & Dohme Corp. |
Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
|
US7563798B2
(en)
|
2002-09-04 |
2009-07-21 |
Schering Corporation |
Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
|
US8673924B2
(en)
|
2002-09-04 |
2014-03-18 |
Merck Sharp & Dohme Corp. |
Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
|
ES2291665T3
(es)
|
2002-09-04 |
2008-03-01 |
Schering Corporation |
Pirazolopirimidinas como inhibidores de quinasas dependientes de ciclinas.
|
US7119200B2
(en)
|
2002-09-04 |
2006-10-10 |
Schering Corporation |
Pyrazolopyrimidines as cyclin dependent kinase inhibitors
|
AU2003298571B2
(en)
|
2002-09-04 |
2006-10-19 |
Merck Sharp & Dohme Corp. |
Pyrazolo[1,5-a]pyrimidines compounds as cyclin dependent kinase inhibitors
|
EP1537116B1
(en)
|
2002-09-04 |
2010-06-02 |
Schering Corporation |
Pyrazolopyrimidines suitable for the treatment of cancer diseases
|
US7601724B2
(en)
|
2002-09-04 |
2009-10-13 |
Schering Corporation |
Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
|
US7196078B2
(en)
|
2002-09-04 |
2007-03-27 |
Schering Corpoartion |
Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors
|
US7205308B2
(en)
|
2002-09-04 |
2007-04-17 |
Schering Corporation |
Trisubstituted 7-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors
|
US7196092B2
(en)
|
2002-09-04 |
2007-03-27 |
Schering Corporation |
N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors
|
AU2003282679A1
(en)
|
2002-10-04 |
2004-05-04 |
Arena Pharmaceuticals, Inc. |
Hydroxypyrazoles for use against metabolic-related disorders
|
AU2003299651A1
(en)
|
2002-12-11 |
2004-06-30 |
Merck And Co., Inc. |
Tyrosine kinase inhibitors
|
SE0203752D0
(sv)
|
2002-12-17 |
2002-12-17 |
Astrazeneca Ab |
New compounds
|
SE0203754D0
(sv)
|
2002-12-17 |
2002-12-17 |
Astrazeneca Ab |
New compounds
|
DK2476667T3
(da)
|
2003-02-26 |
2014-09-15 |
Sugen Inc |
Aminoheteroaryl-forbindelser som proteinkinase-inhibitorer
|
KR20050115252A
(ko)
|
2003-02-28 |
2005-12-07 |
데이진 화-마 가부시키가이샤 |
피라졸로[1,5-a]피리미딘 유도체
|
CA2517720A1
(en)
|
2003-03-11 |
2004-09-23 |
Pfizer Products Inc. |
Pyrazine compounds as transforming growth factor (tgf) inhibitors
|
US7459454B2
(en)
|
2003-03-21 |
2008-12-02 |
Smithkline Beecham Corporation |
Aminopyrazine derivatives and compositions
|
US20060293339A1
(en)
|
2003-03-24 |
2006-12-28 |
Chakravarty Prasun K |
Biaryl substituted 6-membered heterocycles as sodium channel blockers
|
GB2400101A
(en)
|
2003-03-28 |
2004-10-06 |
Biofocus Discovery Ltd |
Compounds capable of binding to the active site of protein kinases
|
JP2006528980A
(ja)
|
2003-05-15 |
2006-12-28 |
メルク エンド カムパニー インコーポレーテッド |
S1p受容体作働薬としての3−(2−アミノ−1−アザシクロ)−5−アリール−1,2,4−オキサジアゾール類
|
AR045595A1
(es)
|
2003-09-04 |
2005-11-02 |
Vertex Pharma |
Composiciones utiles como inhibidores de proteinas quinasas
|
WO2005028434A2
(en)
|
2003-09-18 |
2005-03-31 |
Conforma Therapeutics Corporation |
Novel heterocyclic compounds as hsp90-inhibitors
|
WO2005034952A2
(en)
|
2003-10-07 |
2005-04-21 |
The Feinstein Institute For Medical Research |
Isoxazole and isothiazole compounds useful in the treatment of inflammation
|
US7772234B2
(en)
|
2003-11-19 |
2010-08-10 |
Array Biopharma Inc. |
Bicyclic inhibitors of MEK and methods of use thereof
|
DE10356579A1
(de)
|
2003-12-04 |
2005-07-07 |
Merck Patent Gmbh |
Aminderivate
|
US20070149547A1
(en)
|
2004-02-12 |
2007-06-28 |
Celine Bonnefous |
Bipyridyl amides as modulators of metabotropic glutamate receptor-5
|
JP2007523939A
(ja)
|
2004-02-25 |
2007-08-23 |
ビーエーエスエフ アクチェンゲゼルシャフト |
アゾロピリミジン化合物及び寄生性菌類を駆除するためのその使用
|
CA2563699C
(en)
|
2004-04-23 |
2014-03-25 |
Exelixis, Inc. |
Kinase modulators and method of use
|
WO2005123672A2
(en)
|
2004-06-14 |
2005-12-29 |
Takeda San Diego, Inc. |
Kinase inhibitors
|
MX2007001126A
(es)
|
2004-07-27 |
2007-09-25 |
Sgx Pharmaceuticals Inc |
Moduladores de heterociclo cinasa de anillo fusionado.
|
US7626021B2
(en)
|
2004-07-27 |
2009-12-01 |
Sgx Pharmaceuticals, Inc. |
Fused ring heterocycle kinase modulators
|
AU2005304784B2
(en)
|
2004-11-04 |
2011-03-24 |
Vertex Pharmaceuticals Incorporated |
Pyrazolo[1,5-a]pyrimidines useful as inhibitors of protein kinases
|
WO2006053342A2
(en)
|
2004-11-12 |
2006-05-18 |
Osi Pharmaceuticals, Inc. |
Integrin antagonists useful as anticancer agents
|
JP2008520738A
(ja)
|
2004-11-22 |
2008-06-19 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
プロテインキナーゼの阻害剤として有用なピロロピラジンおよびピラゾロピラジン
|
GB0428235D0
(en)
|
2004-12-23 |
2005-01-26 |
Glaxo Group Ltd |
Novel compounds
|
US20080269249A2
(en)
|
2004-12-27 |
2008-10-30 |
Alcon, Inc. |
Aminopyrazine analogs for treating glaucoma and other rho kinase-mediated diseases and conditions
|
US7635699B2
(en)
|
2004-12-29 |
2009-12-22 |
Bristol-Myers Squibb Company |
Azolopyrimidine-based inhibitors of dipeptidyl peptidase IV and methods
|
GB0500492D0
(en)
|
2005-01-11 |
2005-02-16 |
Cyclacel Ltd |
Compound
|
US7622583B2
(en)
|
2005-01-14 |
2009-11-24 |
Chemocentryx, Inc. |
Heteroaryl sulfonamides and CCR2
|
US20060156482A1
(en)
|
2005-01-14 |
2006-07-20 |
The Procter & Gamble Company |
Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof
|
GB0501999D0
(en)
|
2005-02-01 |
2005-03-09 |
Sentinel Oncology Ltd |
Pharmaceutical compounds
|
MX2007009945A
(es)
|
2005-02-16 |
2007-09-26 |
Schering Corp |
Piperazinas sustituidas con heterociclicos con actividad antagonista de cxcr3.
|
DE102005007534A1
(de)
|
2005-02-17 |
2006-08-31 |
Bayer Cropscience Ag |
Pyrazolopyrimidine
|
CA2605738C
(en)
|
2005-04-25 |
2013-10-01 |
Merck Patent Gesellschaft Mit Beschraenkter Haftung |
Novel azaheterocyclic compounds as kinase inhibitors
|
US20070155738A1
(en)
|
2005-05-20 |
2007-07-05 |
Alantos Pharmaceuticals, Inc. |
Heterobicyclic metalloprotease inhibitors
|
WO2006128184A2
(en)
|
2005-05-20 |
2006-11-30 |
Alantos-Pharmaceuticals, Inc. |
Pyrimidine or triazine fused bicyclic metalloprotease inhibitors
|
US20070155737A1
(en)
|
2005-05-20 |
2007-07-05 |
Alantos Pharmaceuticals, Inc. |
Heterobicyclic metalloprotease inhibitors
|
WO2007015632A1
(en)
|
2005-08-04 |
2007-02-08 |
Cgk Co., Ltd. |
Atm and atr inhibitor
|
AR057979A1
(es)
|
2005-10-06 |
2008-01-09 |
Schering Corp |
PIRAZOLPIRIMIDINAS COMO INHIBIDORAS DE PROTEíNA QUINASA. COMPOSICIONES FARMACEUTICAS.
|
PE20070543A1
(es)
|
2005-10-06 |
2007-06-14 |
Schering Corp |
Pirazolopirimidinas como inhibidores de protein quinasas
|
US20070082900A1
(en)
|
2005-10-06 |
2007-04-12 |
Schering Corporation |
Methods for inhibiting protein kinases
|
WO2007044426A2
(en)
|
2005-10-06 |
2007-04-19 |
Schering Corporation |
Pyrazolopyrimidines as protein kinase inhibitors
|
AR056876A1
(es)
|
2005-10-21 |
2007-10-31 |
Tanabe Seiyaku Co |
Compuestos de pirazolo[1-5-a]pirimidina, antagonistas de receptores canabinoides cb1, composiciones farmaceuticas que los contienen y usos en el tratamiento de enfermedades del sistema nervioso central, tales como trastornos psicoticos, neurologicos y similares
|
AU2006304875B2
(en)
|
2005-10-21 |
2013-01-17 |
Exelixis, Inc. |
Pyrazolo-pyrimidines as casein kinase II (CK2) modulators
|
AR056786A1
(es)
|
2005-11-10 |
2007-10-24 |
Smithkline Beecham Corp |
Compuesto de 1h- imidazo ( 4,5-c) piridin-2-ilo, composicion farmaceutica que lo comprende, procedimiento para preparar dicha composicion, su uso para preparar unmedicamento, uso de una combinacion que omprende al compuesto y al menos un agente antineoplasico para preparar un medicamento y dicha com
|
KR101135310B1
(ko)
|
2005-12-01 |
2012-04-12 |
에프. 호프만-라 로슈 아게 |
L-cpt1 억제제로서의 헤테로아릴 치환된 피페리딘유도체
|
JP5064237B2
(ja)
|
2005-12-09 |
2012-10-31 |
Meiji Seikaファルマ株式会社 |
リンコマイシン誘導体およびこれを有効成分とする抗菌剤
|
CN101340912A
(zh)
|
2005-12-22 |
2009-01-07 |
爱尔康研究有限公司 |
用于治疗rho激酶介导的疾病和病状的(吲唑-5-基)-吡嗪和(1,3-二氢-吲哚-2-酮)-吡嗪
|
ITMI20060311A1
(it)
|
2006-02-21 |
2007-08-22 |
Btsr Int Spa |
Dispositivo perfezionato di alimentazione di filo o filatio ad una macchina tessile e metodo per attuare tale alimentazione
|
GB0603684D0
(en)
|
2006-02-23 |
2006-04-05 |
Novartis Ag |
Organic compounds
|
WO2007096764A2
(en)
|
2006-02-27 |
2007-08-30 |
Glenmark Pharmaceuticals S.A. |
Bicyclic heteroaryl derivatives as cannabinoid receptor modulators
|
TW200800203A
(en)
|
2006-03-08 |
2008-01-01 |
Astrazeneca Ab |
New use
|
NZ571933A
(en)
|
2006-03-22 |
2011-06-30 |
Vertex Pharma |
C-Met protein kinase inhibitors for the treatment of proliferative disorders
|
BRPI0709699A2
(pt)
|
2006-03-29 |
2011-07-26 |
Foldrx Pharmaceuticals Inc |
inibiÇço da toxidez da alfa-sinucleina
|
WO2007126964A2
(en)
|
2006-03-31 |
2007-11-08 |
Schering Corporation |
Kinase inhibitors
|
CN101495481A
(zh)
|
2006-05-22 |
2009-07-29 |
先灵公司 |
作为CDK抑制剂的吡唑并[1,5-α]嘧啶
|
JP2009541323A
(ja)
|
2006-06-22 |
2009-11-26 |
マリンクロット インコーポレイテッド |
拡張された共役を有するピラジン誘導体およびその使用
|
WO2007147874A1
(en)
|
2006-06-22 |
2007-12-27 |
Biovitrum Ab (Publ) |
Pyridine and pyrazine derivatives as mnk kinase inhibitors
|
AR061793A1
(es)
|
2006-07-05 |
2008-09-24 |
Mitsubishi Tanabe Pharma Corp |
Compuesto de pirazolo[1,5-a] pirimidina y composicion farmaceutica
|
US8198448B2
(en)
|
2006-07-14 |
2012-06-12 |
Amgen Inc. |
Fused heterocyclic derivatives and methods of use
|
PE20121506A1
(es)
|
2006-07-14 |
2012-11-26 |
Amgen Inc |
Compuestos triazolopiridinas como inhibidores de c-met
|
US8217177B2
(en)
|
2006-07-14 |
2012-07-10 |
Amgen Inc. |
Fused heterocyclic derivatives and methods of use
|
CA2664378A1
(en)
|
2006-09-29 |
2008-04-03 |
Novartis Ag |
Pyrazolopyrimidines as pi3k lipid kinase inhibitors
|
GB0619342D0
(en)
|
2006-09-30 |
2006-11-08 |
Vernalis R&D Ltd |
New chemical compounds
|
EP2450350A1
(en)
|
2006-10-04 |
2012-05-09 |
F. Hoffmann-La Roche AG |
3-Pyridinecarboxamide and 2-pyrazinecarboxamide derivatives as HDL-cholesterol raising agents
|
WO2008051493A2
(en)
|
2006-10-19 |
2008-05-02 |
Signal Pharmaceuticals, Llc |
Heteroaryl compounds, compositions thereof, and their use as protein kinase inhibitors
|
JP5244118B2
(ja)
|
2006-11-10 |
2013-07-24 |
ブリストル−マイヤーズ スクイブ カンパニー |
新規キナーゼ阻害剤
|
AU2007321924A1
(en)
|
2006-11-20 |
2008-05-29 |
Alantos Pharmaceuticals Holding, Inc. |
Heterobicyclic metalloprotease inhibitors
|
CA2672367A1
(en)
|
2006-12-15 |
2008-06-19 |
Bayer Schering Pharma Aktiengesellschaft |
3-h-pyrazolopyridines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
|
CA2672438A1
(en)
|
2006-12-20 |
2008-07-03 |
Amgen Inc. |
Substituted heterocycles and methods of use
|
PE20121126A1
(es)
|
2006-12-21 |
2012-08-24 |
Plexxikon Inc |
Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa
|
GB0625659D0
(en)
|
2006-12-21 |
2007-01-31 |
Cancer Rec Tech Ltd |
Therapeutic compounds and their use
|
EP2114898A2
(en)
|
2007-02-16 |
2009-11-11 |
Amgen Inc. |
Nitrogen-containing heterocyclyl ketones and their use as c-met inhibitors
|
MX2009009304A
(es)
|
2007-03-01 |
2009-11-18 |
Novartis Ag |
Inhibidores de cinasa pim y metodos para su uso.
|
RU2009141185A
(ru)
|
2007-04-10 |
2011-05-20 |
Байер КропСайенс АГ (DE) |
Инсектицидные производные арилизоксазолина
|
US20100234386A1
(en)
|
2007-05-10 |
2010-09-16 |
Chaudhari Amita |
Quinoxaline derivatives as pi3 kinase inhibitors
|
PE20090717A1
(es)
|
2007-05-18 |
2009-07-18 |
Smithkline Beecham Corp |
Derivados de quinolina como inhibidores de la pi3 quinasa
|
EP2014661A1
(de)
|
2007-06-13 |
2009-01-14 |
Bayer CropScience AG |
Heterocyclisch substituierte Heterocyclyl-carbonsäurederivate
|
UY31137A1
(es)
|
2007-06-14 |
2009-01-05 |
Smithkline Beecham Corp |
Derivados de quinazolina como inhibidores de la pi3 quinasa
|
JPWO2008156174A1
(ja)
|
2007-06-21 |
2010-08-26 |
大正製薬株式会社 |
ピラジンアミド化合物
|
CA2691003A1
(en)
|
2007-06-26 |
2008-12-31 |
Lexicon Pharmaceuticals, Inc. |
Methods of treating serotonin-mediated diseases and disorders
|
WO2009006580A1
(en)
|
2007-07-05 |
2009-01-08 |
Cv Therapeutics, Inc. |
Optionally condensed dihydropyridine, dihydropyrimidine and dihydropyrane derivatives acting as late sodium channel blockers
|
US20090012103A1
(en)
|
2007-07-05 |
2009-01-08 |
Matthew Abelman |
Substituted heterocyclic compounds
|
GB0713259D0
(en)
|
2007-07-09 |
2007-08-15 |
Astrazeneca Ab |
Pyrazine derivatives 954
|
EP2178861B1
(en)
|
2007-07-19 |
2014-08-20 |
Merck Sharp & Dohme Corp. |
Heterocyclic amide compounds as protein kinase inhibitors
|
CA2691507C
(en)
|
2007-07-19 |
2016-06-21 |
H. Lundbeck A/S |
5-membered heterocyclic amides and related compounds
|
EA201000113A1
(ru)
|
2007-08-01 |
2010-08-30 |
Пфайзер Инк. |
Пиразольные соединения
|
WO2009017954A1
(en)
|
2007-08-01 |
2009-02-05 |
Phenomix Corporation |
Inhibitors of jak2 kinase
|
WO2009024825A1
(en)
|
2007-08-21 |
2009-02-26 |
Astrazeneca Ab |
2-pyrazinylbenzimidazole derivatives as receptor tyrosine kinase inhibitors
|
EP2203436A1
(en)
|
2007-09-17 |
2010-07-07 |
Neurosearch A/S |
Pyrazine derivatives and their use as potassium channel modulators
|
CA2703653A1
(en)
|
2007-10-25 |
2009-04-30 |
Astrazeneca Ab |
Pyridine and pyrazine derivatives -083
|
CN101970440A
(zh)
|
2007-11-28 |
2011-02-09 |
先灵公司 |
作为蛋白激酶抑制剂的2-氟吡唑并[1,5-a]嘧啶类
|
WO2009075790A1
(en)
|
2007-12-07 |
2009-06-18 |
Alantos Pharmaceuticals Holding, Inc. |
Metalloprotease inhibitors for intra-articular application
|
EP2252618A1
(en)
*
|
2007-12-19 |
2010-11-24 |
Vertex Pharmaceuticals Incorporated |
PYRAZOLO [1,5-a] PYRIMIDINES USEFUL AS JAK2 INHIBITORS
|
CN101965336B
(zh)
|
2008-01-04 |
2015-06-17 |
英特利凯恩有限责任公司 |
某些化学实体、组合物和方法
|
EP2085398A1
(en)
|
2008-02-01 |
2009-08-05 |
Merz Pharma GmbH & Co. KGaA |
Pyrazolopyrimidines, a process for their preparation and their use as medicine
|
CN101952294B
(zh)
|
2008-02-25 |
2014-11-26 |
霍夫曼-拉罗奇有限公司 |
吡咯并吡嗪激酶抑制剂
|
WO2009106445A1
(en)
|
2008-02-25 |
2009-09-03 |
F. Hoffmann-La Roche Ag |
Pyrrolopyrazine kinase inhibitors
|
EP2247592B1
(en)
|
2008-02-25 |
2011-08-31 |
F. Hoffmann-La Roche AG |
Pyrrolopyrazine kinase inhibitors
|
BRPI0907928A2
(pt)
|
2008-02-25 |
2015-07-28 |
Hoffmann La Roche |
Inibidores de pirrolopirazina quinase.
|
TW200940537A
(en)
|
2008-02-26 |
2009-10-01 |
Astrazeneca Ab |
Heterocyclic urea derivatives and methods of use thereof
|
CA2716856C
(en)
|
2008-03-20 |
2013-02-19 |
Amgen Inc. |
Aurora kinase modulators and method of use
|
US8110576B2
(en)
|
2008-06-10 |
2012-02-07 |
Plexxikon Inc. |
Substituted pyrrolo[2,3b]pyrazines and methods for treatment of raf protein kinase-mediated indications
|
CA2730106A1
(en)
|
2008-07-08 |
2010-01-14 |
Intellikine, Inc. |
Kinase inhibitors and methods of use
|
US8455477B2
(en)
|
2008-08-05 |
2013-06-04 |
Merck Sharp & Dohme Corp. |
Therapeutic compounds
|
GB0814364D0
(en)
|
2008-08-05 |
2008-09-10 |
Eisai London Res Lab Ltd |
Diazaindole derivatives and their use in the inhibition of c-Jun N-terminal kinase
|
CN102223798A
(zh)
|
2008-09-24 |
2011-10-19 |
巴斯夫欧洲公司 |
用于防治无脊椎动物害虫的吡唑化合物
|
WO2010048131A1
(en)
|
2008-10-21 |
2010-04-29 |
Vertex Pharmaceuticals Incorporated |
C-met protein kinase inhibitors
|
PE20131197A1
(es)
|
2008-10-31 |
2013-11-06 |
Genentech Inc |
Compuestos de pirazolopirimidina como inhibidores de jak y composiciones farmaceuticas que los contienen
|
CN102264721B
(zh)
|
2008-11-10 |
2015-12-09 |
沃泰克斯药物股份有限公司 |
用作atr激酶抑制剂的化合物
|
WO2010059836A1
(en)
|
2008-11-20 |
2010-05-27 |
Decode Genetics Ehf |
Substituted aza-bridged bicyclics for cardiovascular and cns disease
|
EP2379561B1
(en)
|
2008-11-25 |
2015-11-04 |
University Of Rochester |
Mlk inhibitors and methods of use
|
AU2009324210A1
(en)
|
2008-12-05 |
2010-06-10 |
F. Hoffmann-La Roche Ag |
Pyrrolopyrazinyl urea kinase inhibitors
|
RS56995B1
(sr)
*
|
2008-12-19 |
2018-05-31 |
Vertex Pharma |
Derivati pirazina korisni kao inhibitori atr kinaze
|
ES2567047T3
(es)
|
2008-12-23 |
2016-04-19 |
Abbvie Inc. |
Derivados de pirimidina anti-virales
|
WO2010086040A1
(en)
|
2009-01-29 |
2010-08-05 |
Biomarin Iga, Ltd. |
Pyrazolo-pyrimidines for treatment of duchenne muscular dystrophy
|
SG173027A1
(en)
|
2009-01-30 |
2011-08-29 |
Toyama Chemical Co Ltd |
N-acyl anthranilic acid derivative or salt thereof
|
US20100204265A1
(en)
|
2009-02-09 |
2010-08-12 |
Genelabs Technologies, Inc. |
Certain Nitrogen Containing Bicyclic Chemical Entities for Treating Viral Infections
|
CN102388043A
(zh)
|
2009-02-11 |
2012-03-21 |
桑诺维恩药品公司 |
组胺h3反相激动剂和拮抗剂及其使用方法
|
CN101537007A
(zh)
|
2009-03-18 |
2009-09-23 |
中国医学科学院血液病医院(血液学研究所) |
N-(噻吩-2)吡唑并[1,5-a]嘧啶-3-甲酰胺类化合物在制备抗恶性肿瘤药物方面的应用
|
EP2411007A4
(en)
|
2009-03-27 |
2012-12-05 |
Uab Research Foundation |
MODULATION OF IRES-MEDIATED TRANSLATION
|
UA110324C2
(en)
|
2009-07-02 |
2015-12-25 |
Genentech Inc |
Jak inhibitory compounds based on pyrazolo pyrimidine
|
AR077468A1
(es)
|
2009-07-09 |
2011-08-31 |
Array Biopharma Inc |
Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
|
CN102471345A
(zh)
|
2009-07-15 |
2012-05-23 |
雅培制药有限公司 |
激酶的吡咯并吡嗪抑制剂
|
MX2012002066A
(es)
|
2009-08-17 |
2012-03-29 |
Intellikine Inc |
Compuestos heterociclicos y usos de los mismos.
|
WO2011025706A2
(en)
|
2009-08-26 |
2011-03-03 |
Schering Corporation |
Heterocyclic amide compounds as protein kinase inhibitors
|
CN101671336B
(zh)
|
2009-09-23 |
2013-11-13 |
辽宁利锋科技开发有限公司 |
芳杂环并嘧啶衍生物和类似物及其制备方法和用途
|
CN102762208A
(zh)
|
2009-12-04 |
2012-10-31 |
赛林药物股份有限公司 |
作为ck2抑制剂的吡唑嘧啶和相关杂环
|
DE112009005466T5
(de)
|
2009-12-22 |
2012-10-31 |
Intel Corporation |
Verfahren und Vorrichtung zum Bereitstellen einer sicheren Anwendungsausführung
|
CN102869661B
(zh)
|
2010-03-18 |
2015-08-05 |
韩国巴斯德研究所 |
抗感染化合物
|
US8518945B2
(en)
|
2010-03-22 |
2013-08-27 |
Hoffmann-La Roche Inc. |
Pyrrolopyrazine kinase inhibitors
|
WO2011121096A1
(en)
|
2010-03-31 |
2011-10-06 |
Dkfz Deutsches Krebsforschungszentrum |
PYRAZOL[1,5-a]PYRIMIDINE DERIVATIVES AS WNT PATHWAY ANTAGONISTS
|
EP2556060A1
(en)
|
2010-04-08 |
2013-02-13 |
Ah Usa 42 Llc |
Substituted 3,5- diphenyl-isoxazoline derivatives as insecticides and acaricides
|
US20130030237A1
(en)
|
2010-04-15 |
2013-01-31 |
Charles Theuer |
Potentiation of anti-cancer activity through combination therapy with ber pathway inhibitors
|
US9334244B2
(en)
|
2010-05-12 |
2016-05-10 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
US8969356B2
(en)
|
2010-05-12 |
2015-03-03 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
WO2011143423A2
(en)
|
2010-05-12 |
2011-11-17 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
WO2011143419A1
(en)
|
2010-05-12 |
2011-11-17 |
Vertex Pharmaceuticals Incorporated |
Pyrazines useful as inhibitors of atr kinase
|
SG185524A1
(en)
|
2010-05-12 |
2012-12-28 |
Vertex Pharma |
Compounds useful as inhibitors of atr kinase
|
CN102947272A
(zh)
|
2010-05-12 |
2013-02-27 |
沃泰克斯药物股份有限公司 |
用作atr激酶抑制剂的2-氨基吡啶衍生物
|
CA2798970A1
(en)
|
2010-05-20 |
2011-11-24 |
F. Hoffmann-La Roche Ag |
Pyrrolopyrazine derivatives as syk and jak inhibitors
|
BR112012029437A2
(pt)
|
2010-05-20 |
2017-03-07 |
F Hoffmann - La Roche Ag |
derivados de pirrolo[2,3-b]pirazina-7-carboxamida e seu uso como inibidores de jak e syk
|
MX2013000103A
(es)
|
2010-06-23 |
2013-06-13 |
Vertex Pharma |
Derivados de pirrolo-pirazina utiles como inhibidores de cinasa art.
|
EP2585467B1
(en)
|
2010-06-24 |
2016-03-02 |
Gilead Sciences, Inc. |
Pyrazolo[1,5-a]pyrimidines and -triazines as antiviral agents
|
CN102311396B
(zh)
|
2010-07-05 |
2015-01-07 |
暨南大学 |
一种吡嗪类衍生物和其制备方法及在制药中的应用
|
CN105367577B
(zh)
|
2010-07-13 |
2019-04-23 |
弗·哈夫曼-拉罗切有限公司 |
作为irak4调节剂的吡唑并[1,5a]嘧啶和噻吩并[3,2b]嘧啶衍生物
|
EP2407478A1
(en)
|
2010-07-14 |
2012-01-18 |
GENETADI Biotech, S.L. |
New cyclotetrapeptides with pro-angiogenic properties
|
WO2012022045A1
(en)
|
2010-08-20 |
2012-02-23 |
Hutchison Medipharma Limited |
Pyrrolopyrimidine compounds and uses thereof
|
EP2608669B1
(en)
|
2010-08-23 |
2016-06-22 |
Merck Sharp & Dohme Corp. |
NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
|
ES2621857T3
(es)
|
2010-11-16 |
2017-07-05 |
Array Biopharma, Inc. |
Combinación de inhibidores de la cinasa 1 de punto de control e inhibidores de la cinasa WEE1
|
US8609669B2
(en)
|
2010-11-16 |
2013-12-17 |
Abbvie Inc. |
Potassium channel modulators
|
PL3366688T3
(pl)
|
2010-12-08 |
2022-05-23 |
The U.S.A. As Represented By The Secretary, Department Of Health And Human Services |
Podstawione pirazolopirymidyny jako aktywatory glukocerebrozydazy
|
CA2825098C
(en)
|
2011-01-27 |
2020-03-10 |
Universite De Montreal |
Pyrazolopyridine and pyrazolopyrimidine derivatives as melanocortin-4 receptor modulators
|
EP2694498B1
(en)
|
2011-04-05 |
2016-03-30 |
Vertex Pharmaceuticals Incorporated |
Aminopyrazine compounds useful as inhibitors of tra kinase
|
KR20140093610A
(ko)
|
2011-04-21 |
2014-07-28 |
재단법인 한국파스퇴르연구소 |
소염 화합물
|
CA2833698A1
(en)
|
2011-04-21 |
2012-10-26 |
Bayer Intellectual Property Gmbh |
Fluoroalkyl-substituted pyrazolopyridines and use thereof
|
WO2012158785A1
(en)
|
2011-05-17 |
2012-11-22 |
Principia Biopharma Inc. |
Azaindole derivatives as tyrosine kinase inhibitors
|
WO2012178124A1
(en)
|
2011-06-22 |
2012-12-27 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
EP2723746A1
(en)
|
2011-06-22 |
2014-04-30 |
Vertex Pharmaceuticals Inc. |
Compounds useful as inhibitors of atr kinase
|
CA2840224C
(en)
|
2011-06-22 |
2019-08-13 |
The General Hospital Corporation |
Treatment of proteinopathies
|
WO2012178123A1
(en)
|
2011-06-22 |
2012-12-27 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
EA201490265A1
(ru)
|
2011-07-13 |
2014-12-30 |
Фармасайкликс, Инк. |
Ингибиторы тирозинкиназы брутона
|
WO2013052263A2
(en)
|
2011-09-16 |
2013-04-11 |
Microbiotix, Inc. |
Antifungal compounds
|
CN108464983A
(zh)
|
2011-09-30 |
2018-08-31 |
沃泰克斯药物股份有限公司 |
用atr抑制剂治疗胰腺癌和非小细胞肺癌
|
PT2940017T
(pt)
|
2011-09-30 |
2019-10-31 |
Vertex Pharma |
Processos para a produção de compostos úteis como inibidores de atr quinase
|
US8853217B2
(en)
|
2011-09-30 |
2014-10-07 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
WO2013049719A1
(en)
|
2011-09-30 |
2013-04-04 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
WO2013049722A1
(en)
|
2011-09-30 |
2013-04-04 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
WO2013059587A1
(en)
|
2011-10-20 |
2013-04-25 |
Sirtris Pharmaceuticals, Inc. |
Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators
|
EP2776419B1
(en)
|
2011-11-09 |
2016-05-11 |
Vertex Pharmaceuticals Incorporated |
Pyrazine compounds useful as inhibitors of atr kinase
|
US8841450B2
(en)
|
2011-11-09 |
2014-09-23 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
US8846918B2
(en)
|
2011-11-09 |
2014-09-30 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
WO2013071088A1
(en)
|
2011-11-09 |
2013-05-16 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
US8841337B2
(en)
|
2011-11-09 |
2014-09-23 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
US9193725B2
(en)
|
2012-03-14 |
2015-11-24 |
Bristol-Meyers Squibb Company |
Cyclic hydrazine derivatives as HIV attachment inhibitors
|
AR090548A1
(es)
|
2012-04-02 |
2014-11-19 |
Incyte Corp |
Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
|
CA2868507A1
(en)
|
2012-04-02 |
2013-10-10 |
Cytokinetics, Inc. |
Methods for improving diaphragm function
|
NZ700580A
(en)
|
2012-04-05 |
2016-07-29 |
Vertex Pharma |
Compounds useful as inhibitors of atr kinase and combination therapies thereof
|
US8940742B2
(en)
|
2012-04-10 |
2015-01-27 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
CN103373996A
(zh)
|
2012-04-20 |
2013-10-30 |
山东亨利医药科技有限责任公司 |
作为crth2受体拮抗剂的二并环衍生物
|
EP2855448B1
(en)
|
2012-05-15 |
2017-02-08 |
Cancer Research Technology Ltd |
5-[[4-[[morpholin-2-yl]methylamino]-5-(trifluoromethyl)-2-pyridyl]amino]pyrazine-2-carbonitrile and therapeutic uses thereof
|
BR112014029006A2
(pt)
|
2012-05-23 |
2017-06-27 |
European Molecular Biology Laboratory |
derivados de 7-oxo-4,7-di-hidro-pirazolo[1,5-a]pirimidina que são úteis no tratamento, melhora ou prevenção de uma doença viral
|
US9434745B2
(en)
|
2012-05-23 |
2016-09-06 |
Savira Pharmaceuticals Gmbh |
7-oxo-thiazolopyridine carbonic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease
|
US20140018361A1
(en)
|
2012-07-11 |
2014-01-16 |
Nimbus Iris, Inc. |
Irak inhibitors and uses thereof
|
WO2014015523A1
(en)
|
2012-07-27 |
2014-01-30 |
Hutchison Medipharma Limited |
Novel heteroaryl and heterocycle compounds, compositions and methods
|
JP2015524457A
(ja)
|
2012-08-06 |
2015-08-24 |
ザヴィラ ファーマシューティカルズ ゲーエムベーハー |
ジヒドロキシピリミジン炭酸誘導体及びウイルス性疾患の治療、改善又は予防における使用
|
US9655888B2
(en)
|
2012-08-09 |
2017-05-23 |
VIIV Healthcare UK (No.5) Limited |
Tricyclic alkene derivatives as HIV attachment inhibitors
|
ES2616492T3
(es)
|
2012-08-09 |
2017-06-13 |
VIIV Healthcare UK (No.5) Limited |
Derivados de piperidina amida como inhibidores de la fijación del VIH
|
WO2014025850A1
(en)
|
2012-08-09 |
2014-02-13 |
Bristol-Myers Squibb Company |
Tricyclic amidine derivatives as hiv attachment inhibitors
|
AU2013304133B2
(en)
|
2012-08-17 |
2017-02-23 |
Bayer Cropscience Ag |
Azaindole carboxylic acid amides and azaindole thiocarboxylic acid amides for use as insecticides and acaricides
|
CA2873295A1
(en)
|
2012-08-24 |
2014-02-27 |
F. Hoffmann-La Roche Ag |
New bicyclicpyridine derivatives
|
WO2014035140A2
(en)
|
2012-08-30 |
2014-03-06 |
Kainos Medicine, Inc. |
Compounds and compositions for modulating histone methyltransferase activity
|
US9475816B2
(en)
|
2012-09-07 |
2016-10-25 |
Takeda Pharmaceutical Company Limited |
Substituted-1,4-dihydropyrazolo[4,3-b]indoles
|
WO2014042433A2
(en)
|
2012-09-14 |
2014-03-20 |
Kainos Medicine, Inc. |
Compounds and compositions for modulating adenosine a3 receptor activity
|
TW201412740A
(zh)
|
2012-09-20 |
2014-04-01 |
Bayer Pharma AG |
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|
US9688635B2
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|
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2017-06-27 |
Neupharma, Inc. |
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|
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|
2012-10-04 |
2018-06-18 |
Vertex Pharma |
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|
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|
2012-10-22 |
2019-02-06 |
シティ・オブ・ホープCity of Hope |
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|
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(en)
|
2012-10-24 |
2014-05-01 |
Becton, Dickinson And Company |
Hydroxamate substituted azaindoline-cyanine dyes and bioconjugates of the same
|
US9340546B2
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|
2012-12-07 |
2016-05-17 |
Vertex Pharmaceuticals Incorporated |
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|
EP2970289A1
(en)
|
2013-03-15 |
2016-01-20 |
Vertex Pharmaceuticals Inc. |
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|
WO2014143240A1
(en)
|
2013-03-15 |
2014-09-18 |
Vertex Pharmaceuticals Incorporated |
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|
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|
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Vertex Pharmaceuticals Incorporated |
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|
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(hu)
|
2013-12-06 |
2020-03-30 |
Vertex Pharma |
Az ATR-kináz inhibitoraként használható vegyület, 2-amino-6-fluoro-N-[5-fluoro-piridin-3-IL]-pirazolo-[1,5-A]-pirimidin-3-karboxamid, ennek elõállítása, különbözõ szilárd formái és ezek radioaktív nyomjelzett származékai
|
US20150158868A1
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|
2013-12-06 |
2015-06-11 |
Vertex Pharmaceuticals Incorporated |
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|
AU2015271030B2
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|
2014-06-05 |
2019-05-16 |
Vertex Pharmaceuticals Incorporated |
Radiolabelled derivatives of a 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]- pyrazolo [1,5-a] pyrimidin-3-carboxamide compound useful as ATR kinase inhibitor, the preparation of said compound and different solid forms thereof
|
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|
2014-06-17 |
2019-10-31 |
Vertex Pharma |
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|