US4309430A
(en)
|
1980-06-27 |
1982-01-05 |
Merck & Co., Inc. |
Pyrazinyl-1,2,4-oxadiazole-5-ones, for treatment of edema, and processes for preparing same
|
US5329012A
(en)
|
1987-10-29 |
1994-07-12 |
The Research Foundation Of State University Of New York |
Bis(acyloxmethyl)imidazole compounds
|
JP2597917B2
(en)
|
1990-04-26 |
1997-04-09 |
富士写真フイルム株式会社 |
Novel dye-forming coupler and silver halide color photographic material using the same
|
JPH11506428A
(en)
|
1995-05-09 |
1999-06-08 |
ビーエーエスエフ アクチェンゲゼルシャフト |
Pyrazolo [1,5a] pyrimidine, production method thereof and use thereof
|
WO1997043267A1
(en)
|
1996-05-11 |
1997-11-20 |
Kings College London |
Pyrazines
|
US6191131B1
(en)
|
1997-07-23 |
2001-02-20 |
Dupont Pharmaceuticals Company |
Azolo triazines and pyrimidines
|
HU228962B1
(en)
|
1996-07-24 |
2013-07-29 |
Bristol Myers Squibb Pharma Co |
Azolo triazines, pharmaceutical compositions containing them and use of the compounds
|
US6060478A
(en)
|
1996-07-24 |
2000-05-09 |
Dupont Pharmaceuticals |
Azolo triazines and pyrimidines
|
JPH10218881A
(en)
|
1997-02-03 |
1998-08-18 |
Pola Chem Ind Inc |
New pyrrolopyrazolopyrimidine derivative
|
GB2323861B
(en)
|
1997-02-05 |
2001-06-20 |
Sector Exhibiting Systems |
Artificial wall structure
|
JP2002241379A
(en)
|
1997-03-21 |
2002-08-28 |
Dainippon Pharmaceut Co Ltd |
3-oxadiazolylquinoxaline derivative
|
US6235741B1
(en)
|
1997-05-30 |
2001-05-22 |
Merck & Co., Inc. |
Angiogenesis inhibitors
|
AU734009B2
(en)
|
1997-05-30 |
2001-05-31 |
Merck & Co., Inc. |
Novel angiogenesis inhibitors
|
US6420367B1
(en)
|
1998-07-16 |
2002-07-16 |
Shionogo & Co., Ltd. |
Pyrimidine derivatives exhibiting antitumor activity
|
US6245759B1
(en)
|
1999-03-11 |
2001-06-12 |
Merck & Co., Inc. |
Tyrosine kinase inhibitors
|
US6660753B2
(en)
|
1999-08-19 |
2003-12-09 |
Nps Pharmaceuticals, Inc. |
Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
|
JP2001302666A
(en)
|
1999-09-21 |
2001-10-31 |
Nissan Chem Ind Ltd |
Azole-condensed heterocyclic anilide compound and herbicide
|
MY125533A
(en)
|
1999-12-06 |
2006-08-30 |
Bristol Myers Squibb Co |
Heterocyclic dihydropyrimidine compounds
|
DE60037905T2
(en)
|
1999-12-17 |
2009-01-29 |
Novartis Vaccines and Diagnostics, Inc., Emeryville |
PYRAZIN-BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3
|
AU2001264932A1
(en)
|
2000-05-26 |
2001-12-11 |
Neurogen Corporation |
Oxo-imidazopyrimidine-carboxamides and their use as gaba brain receptor ligands
|
US20020041880A1
(en)
|
2000-07-05 |
2002-04-11 |
Defeo-Jones Deborah |
Method of treating cancer
|
US6849660B1
(en)
|
2000-08-01 |
2005-02-01 |
Isis Pharmaceuticals, Inc. |
Antimicrobial biaryl compounds
|
US7067520B2
(en)
|
2000-11-17 |
2006-06-27 |
Ishihara Sangyo Kaisha, Ltd. |
Preventive or therapeutic medicines for diabetes containing fused-heterocyclic compounds or their salts
|
EP1217000A1
(en)
|
2000-12-23 |
2002-06-26 |
Aventis Pharma Deutschland GmbH |
Inhibitors of factor Xa and factor VIIa
|
US6420637B1
(en)
|
2001-01-29 |
2002-07-16 |
Asgrow Seed Company L.L.C. |
Plants and seeds of corn variety I389972
|
GB0103926D0
(en)
|
2001-02-17 |
2001-04-04 |
Astrazeneca Ab |
Chemical compounds
|
CA2446380A1
(en)
|
2001-05-08 |
2002-11-14 |
Yale University |
Proteomimetic compounds and methods
|
EP1463742A4
(en)
|
2001-06-21 |
2006-05-10 |
Ariad Pharma Inc |
Novel pyrazolo-and pyrrolo-pyrimidines and uses thereof
|
SE0102439D0
(en)
|
2001-07-05 |
2001-07-05 |
Astrazeneca Ab |
New compounds
|
SE0102438D0
(en)
|
2001-07-05 |
2001-07-05 |
Astrazeneca Ab |
New compounds
|
CA2465326C
(en)
|
2001-11-01 |
2011-03-29 |
Icagen, Inc. |
Pyrazolopyrimidines for decreasing ion flow through a voltage-dependent sodium channel
|
US6992087B2
(en)
|
2001-11-21 |
2006-01-31 |
Pfizer Inc |
Substituted aryl 1,4-pyrazine derivatives
|
PT1446387E
(en)
|
2001-11-21 |
2009-12-21 |
Pharmacia & Upjohn Co Llc |
Substituted aryl 1,4-pyrazine derivatives
|
US20040034037A1
(en)
|
2002-02-06 |
2004-02-19 |
Harbeson Scott L. |
Heteroaryl compounds useful as inhibitors of GSK-3
|
ES2306859T3
(en)
|
2002-03-13 |
2008-11-16 |
Janssen Pharmaceutica Nv |
DERIVATIVES OF SULFONIL AS NEW INHIBITORS OF HISTONE DEACETILASE.
|
GB0206860D0
(en)
|
2002-03-22 |
2002-05-01 |
Glaxo Group Ltd |
Compounds
|
TWI319387B
(en)
|
2002-04-05 |
2010-01-11 |
Astrazeneca Ab |
Benzamide derivatives
|
CN100343255C
(en)
*
|
2002-04-23 |
2007-10-17 |
盐野义制药株式会社 |
Pyrazolo (1,5-a) pyrimidine derivative and nad(p)h oxidase inhibitor containing the same
|
GB0209715D0
(en)
|
2002-04-27 |
2002-06-05 |
Astrazeneca Ab |
Chemical compounds
|
US7704995B2
(en)
|
2002-05-03 |
2010-04-27 |
Exelixis, Inc. |
Protein kinase modulators and methods of use
|
AU2003234464B2
(en)
|
2002-05-03 |
2009-06-04 |
Exelixis, Inc. |
Protein kinase modulators and methods of use
|
JP4414881B2
(en)
|
2002-05-31 |
2010-02-10 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
Pyrazole compound and pharmaceutical composition comprising the same
|
WO2003101993A1
(en)
|
2002-06-04 |
2003-12-11 |
Neogenesis Pharmaceuticals, Inc. |
Pyrazolo` 1,5a! pyrimidine compounds as antiviral agents
|
US7449488B2
(en)
|
2002-06-04 |
2008-11-11 |
Schering Corporation |
Pyrazolopyrimidines as protein kinase inhibitors
|
AU2003249369A1
(en)
|
2002-06-21 |
2004-01-06 |
Cellular Genomics, Inc. |
Certain amino-substituted monocycles as kinase modulators
|
US8673924B2
(en)
|
2002-09-04 |
2014-03-18 |
Merck Sharp & Dohme Corp. |
Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
|
US7601724B2
(en)
|
2002-09-04 |
2009-10-13 |
Schering Corporation |
Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
|
US7196092B2
(en)
|
2002-09-04 |
2007-03-27 |
Schering Corporation |
N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors
|
US7205308B2
(en)
|
2002-09-04 |
2007-04-17 |
Schering Corporation |
Trisubstituted 7-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors
|
US7119200B2
(en)
|
2002-09-04 |
2006-10-10 |
Schering Corporation |
Pyrazolopyrimidines as cyclin dependent kinase inhibitors
|
CA2497444C
(en)
|
2002-09-04 |
2010-11-30 |
Schering Corporation |
Pyrazolopyrimidines as cyclin dependent kinase inhibitors
|
US7196078B2
(en)
|
2002-09-04 |
2007-03-27 |
Schering Corpoartion |
Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors
|
BRPI0314001B8
(en)
|
2002-09-04 |
2021-05-25 |
Merck Sharp & Dohme |
pyrazolopyrimidines as cyclin-dependent kinase inhibitors and pharmaceutical composition comprising them
|
US8580782B2
(en)
|
2002-09-04 |
2013-11-12 |
Merck Sharp & Dohme Corp. |
Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
|
US7563798B2
(en)
|
2002-09-04 |
2009-07-21 |
Schering Corporation |
Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
|
WO2004026229A2
(en)
|
2002-09-04 |
2004-04-01 |
Schering Corporation |
Pyrazolo[1,5-a]pyrimidines compounds as cyclin dependent kinase inhibitors
|
EP1534710B1
(en)
|
2002-09-04 |
2007-10-24 |
Schering Corporation |
Pyrazolopyrimidines as cyclin dependent kinase inhibitors
|
AU2003282679A1
(en)
|
2002-10-04 |
2004-05-04 |
Arena Pharmaceuticals, Inc. |
Hydroxypyrazoles for use against metabolic-related disorders
|
AU2003299651A1
(en)
|
2002-12-11 |
2004-06-30 |
Merck And Co., Inc. |
Tyrosine kinase inhibitors
|
SE0203754D0
(en)
|
2002-12-17 |
2002-12-17 |
Astrazeneca Ab |
New compounds
|
SE0203752D0
(en)
|
2002-12-17 |
2002-12-17 |
Astrazeneca Ab |
New compounds
|
PT2476667E
(en)
|
2003-02-26 |
2014-09-18 |
Sugen Inc |
Aminoheteroaryl compounds as protein kinase inhibitors
|
EP1599482A4
(en)
|
2003-02-28 |
2008-10-01 |
Teijin Pharma Ltd |
Pyrazolo 1,5-a pyrimidine derivatives
|
CA2517720A1
(en)
|
2003-03-11 |
2004-09-23 |
Pfizer Products Inc. |
Pyrazine compounds as transforming growth factor (tgf) inhibitors
|
WO2004084813A2
(en)
|
2003-03-21 |
2004-10-07 |
Smithkline Beecham Corporation |
Chemical compounds
|
US20060293339A1
(en)
|
2003-03-24 |
2006-12-28 |
Chakravarty Prasun K |
Biaryl substituted 6-membered heterocycles as sodium channel blockers
|
GB2400101A
(en)
|
2003-03-28 |
2004-10-06 |
Biofocus Discovery Ltd |
Compounds capable of binding to the active site of protein kinases
|
JP2006528980A
(en)
|
2003-05-15 |
2006-12-28 |
メルク エンド カムパニー インコーポレーテッド |
3- (2-Amino-1-azacyclo) -5-aryl-1,2,4-oxadiazoles as S1P receptor agonists
|
TWI339206B
(en)
|
2003-09-04 |
2011-03-21 |
Vertex Pharma |
Compositions useful as inhibitors of protein kinases
|
JP2007505933A
(en)
|
2003-09-18 |
2007-03-15 |
コンフォーマ・セラピューティクス・コーポレイション |
Novel heterocyclic compounds as HSP90 inhibitors
|
US7807696B2
(en)
|
2003-10-07 |
2010-10-05 |
The Feinstein Institute For Medical Research |
Isoxazole and isothiazole compounds useful in the treatment of inflammation
|
US7576072B2
(en)
|
2003-11-19 |
2009-08-18 |
Array Biopharma Inc. |
Heterocyclic inhibitors of MEK and methods of use thereof
|
DE10356579A1
(en)
|
2003-12-04 |
2005-07-07 |
Merck Patent Gmbh |
amine derivatives
|
AU2005215379A1
(en)
|
2004-02-12 |
2005-09-01 |
Merck & Co., Inc. |
Bipyridyl amides as modulators of metabotropic glutamate receptor-5
|
US20070197389A1
(en)
|
2004-02-25 |
2007-08-23 |
Anja Schwogler |
Azolopyrimidine compounds and use thereof for combating parasitic fungi
|
CA2563699C
(en)
|
2004-04-23 |
2014-03-25 |
Exelixis, Inc. |
Kinase modulators and method of use
|
JP2008502687A
(en)
|
2004-06-14 |
2008-01-31 |
タケダ サン ディエゴ インコーポレイテッド |
Kinase inhibitor
|
JP2008508304A
(en)
|
2004-07-27 |
2008-03-21 |
エスジーエックス ファーマシューティカルズ、インコーポレイテッド |
Fused ring heterocyclic kinase regulator
|
US7626021B2
(en)
|
2004-07-27 |
2009-12-01 |
Sgx Pharmaceuticals, Inc. |
Fused ring heterocycle kinase modulators
|
JP5030229B2
(en)
|
2004-11-04 |
2012-09-19 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Pyrazolo [1,5-a] pyrimidines useful as inhibitors of protein kinases
|
EP1828144A2
(en)
|
2004-11-12 |
2007-09-05 |
OSI Pharmaceuticals, Inc. |
Integrin antagonists useful as anticancer agents
|
ZA200704888B
(en)
|
2004-11-22 |
2009-02-25 |
Vertex Pharma |
Pyrrolopyrazines and pyrazolopyrazines useful as inhibitors of protein kinases
|
GB0428235D0
(en)
|
2004-12-23 |
2005-01-26 |
Glaxo Group Ltd |
Novel compounds
|
ES2368338T3
(en)
|
2004-12-27 |
2011-11-16 |
Novartis Ag |
AMINOPIRAZINE ANALOGS FOR THE TREATMENT OF GLAUCOMA AND OTHER DISEASES MEDIATED BY RHO CINASA.
|
US7635699B2
(en)
|
2004-12-29 |
2009-12-22 |
Bristol-Myers Squibb Company |
Azolopyrimidine-based inhibitors of dipeptidyl peptidase IV and methods
|
GB0500492D0
(en)
|
2005-01-11 |
2005-02-16 |
Cyclacel Ltd |
Compound
|
US7622583B2
(en)
|
2005-01-14 |
2009-11-24 |
Chemocentryx, Inc. |
Heteroaryl sulfonamides and CCR2
|
US20060156482A1
(en)
|
2005-01-14 |
2006-07-20 |
The Procter & Gamble Company |
Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof
|
GB0501999D0
(en)
|
2005-02-01 |
2005-03-09 |
Sentinel Oncology Ltd |
Pharmaceutical compounds
|
US7868006B2
(en)
|
2005-02-16 |
2011-01-11 |
Schering Corporation |
Heterocyclic substituted piperazines with CXCR3 antagonist activity
|
DE102005007534A1
(en)
|
2005-02-17 |
2006-08-31 |
Bayer Cropscience Ag |
pyrazolopyrimidine
|
JP5033119B2
(en)
|
2005-04-25 |
2012-09-26 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Novel azaheterocycles as kinase inhibitors
|
US20070155737A1
(en)
|
2005-05-20 |
2007-07-05 |
Alantos Pharmaceuticals, Inc. |
Heterobicyclic metalloprotease inhibitors
|
US20070155738A1
(en)
|
2005-05-20 |
2007-07-05 |
Alantos Pharmaceuticals, Inc. |
Heterobicyclic metalloprotease inhibitors
|
CN101238127A
(en)
|
2005-05-20 |
2008-08-06 |
艾伦托斯制药控股公司 |
Pyrimidine or triazine fused bicyclic metalloprotease inhibitors
|
WO2007015632A1
(en)
|
2005-08-04 |
2007-02-08 |
Cgk Co., Ltd. |
Atm and atr inhibitor
|
WO2007044407A2
(en)
|
2005-10-06 |
2007-04-19 |
Schering Corporation |
Pyrazolo (1 , 5a) pyrimidines as protein kinase inhibitors
|
CN101321759A
(en)
|
2005-10-06 |
2008-12-10 |
先灵公司 |
Pyrazolopyrimidines as protein kinase inhibitors
|
EP1931676B1
(en)
|
2005-10-06 |
2011-11-16 |
Schering Corporation |
Pyrazolopyrimidines as protein kinase inhibitors
|
WO2007044441A2
(en)
|
2005-10-06 |
2007-04-19 |
Schering Corporation |
Use of pyrazolo [1 , 5 -a] pyrimidine derivatives for inhibiting protein kinases methods for inhibiting protein kinases
|
EP1948617B1
(en)
|
2005-10-21 |
2011-07-27 |
Exelixis, Inc. |
Pyrimidinones as casein kinase ii (ck2) modulators
|
AU2006305104B2
(en)
|
2005-10-21 |
2009-10-22 |
Mitsubishi Tanabe Pharma Corporation |
Pyrazolo[1,5-a]pyrimidine compounds as cannabinoid receptor antagonists
|
TW200736260A
(en)
|
2005-11-10 |
2007-10-01 |
Smithkline Beecham Corp |
Inhibitors of Akt activity
|
RU2396269C2
(en)
|
2005-12-01 |
2010-08-10 |
Ф.Хоффманн-Ля Рош Аг |
Heteroaryl-substituted piperidine derivatives as hepatic carnitine palmitoyltransferase (l-cpt1) inhibitors
|
US7871982B2
(en)
|
2005-12-09 |
2011-01-18 |
Meiji Seika Kaisha, Ltd. |
Lincomycin derivatives and antimicrobial agents comprising the same as active ingredient
|
ZA200804497B
(en)
|
2005-12-22 |
2009-10-28 |
Alcon Res Ltd |
(Indazol-5-yl)-pyrazines and (1,3-dihydro-indol-2-one)-pyrazines for treating rho kinase-mediated diseases and conditions
|
ITMI20060311A1
(en)
|
2006-02-21 |
2007-08-22 |
Btsr Int Spa |
PERFECT DEVICE FOR WIRE OR FILATIO SUPPLY TO A TEXTILE MACHINE AND METHOD TO IMPLEMENT THIS POWER SUPPLY
|
GB0603684D0
(en)
|
2006-02-23 |
2006-04-05 |
Novartis Ag |
Organic compounds
|
WO2007096764A2
(en)
|
2006-02-27 |
2007-08-30 |
Glenmark Pharmaceuticals S.A. |
Bicyclic heteroaryl derivatives as cannabinoid receptor modulators
|
TW200800203A
(en)
|
2006-03-08 |
2008-01-01 |
Astrazeneca Ab |
New use
|
WO2007111904A2
(en)
|
2006-03-22 |
2007-10-04 |
Vertex Pharmaceuticals Incorporated |
C-met protein kinase inhibitors for the treatment of proliferative disorders
|
EA200870385A1
(en)
|
2006-03-29 |
2009-04-28 |
Фолдркс Фармасьютикалз, Инк. |
INHIBITION OF TOXICITY ALPHA-SINUCLEINE
|
CN101454314A
(en)
|
2006-03-31 |
2009-06-10 |
先灵公司 |
Kinase inhibitors
|
AU2007268083A1
(en)
|
2006-05-22 |
2007-12-06 |
Schering Corporation |
Pyrazolo [1, 5-A] pyrimidines as CDK inhibitors
|
CA2655857C
(en)
|
2006-06-22 |
2014-12-02 |
Mallinckrodt Inc. |
Pyrazine derivatives with extended conjugation and uses thereof
|
JP2009541268A
(en)
|
2006-06-22 |
2009-11-26 |
ビオヴィトルム・アクチボラゲット(プブリクト) |
Pyridine and pyrazine derivatives as MNK kinase inhibitors
|
AR061793A1
(en)
|
2006-07-05 |
2008-09-24 |
Mitsubishi Tanabe Pharma Corp |
PIRAZOLO COMPOUND [1,5-A] PYRIMIDINE AND PHARMACEUTICAL COMPOSITION
|
US8217177B2
(en)
|
2006-07-14 |
2012-07-10 |
Amgen Inc. |
Fused heterocyclic derivatives and methods of use
|
PE20121506A1
(en)
|
2006-07-14 |
2012-11-26 |
Amgen Inc |
TRIAZOLOPYRIDINE COMPOUNDS AS C-MET INHIBITORS
|
US8198448B2
(en)
|
2006-07-14 |
2012-06-12 |
Amgen Inc. |
Fused heterocyclic derivatives and methods of use
|
KR20090073121A
(en)
|
2006-09-29 |
2009-07-02 |
노파르티스 아게 |
Pyrazolopyrimidines as pi3k lipid kinase inhibitors
|
GB0619342D0
(en)
|
2006-09-30 |
2006-11-08 |
Vernalis R&D Ltd |
New chemical compounds
|
KR101107896B1
(en)
|
2006-10-04 |
2012-01-25 |
에프. 호프만-라 로슈 아게 |
3-pyridinecarboxamide and 2-pyrazinecarboxamide derivatives as hdl-cholesterol raising agents
|
US7981893B2
(en)
|
2006-10-19 |
2011-07-19 |
Signal Pharmaceuticals, Llc |
Heteroaryl compounds, compositions thereof, and methods of treatment therewith
|
US8148361B2
(en)
|
2006-11-10 |
2012-04-03 |
Bristol-Myers Squibb Company |
Kinase inhibitors
|
US20080176870A1
(en)
|
2006-11-20 |
2008-07-24 |
Bert Nolte |
Heterobicyclic metalloprotease inhibitors
|
TW200833690A
(en)
|
2006-12-15 |
2008-08-16 |
Bayer Schering Pharma Ag |
3-H-pyrazolopyridines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
|
CA2672438A1
(en)
|
2006-12-20 |
2008-07-03 |
Amgen Inc. |
Substituted heterocycles and methods of use
|
GB0625659D0
(en)
|
2006-12-21 |
2007-01-31 |
Cancer Rec Tech Ltd |
Therapeutic compounds and their use
|
PE20121126A1
(en)
|
2006-12-21 |
2012-08-24 |
Plexxikon Inc |
PIRROLO [2,3-B] PYRIDINES COMPOUNDS AS KINASE MODULATORS
|
JP2010519204A
(en)
|
2007-02-16 |
2010-06-03 |
アムジエン・インコーポレーテツド |
Nitrogen-containing heterocyclic ketones and their use as c-Met inhibitors
|
CA2679659C
(en)
|
2007-03-01 |
2016-01-19 |
Novartis Ag |
Pim kinase inhibitors and methods of their use
|
NZ580241A
(en)
|
2007-04-10 |
2011-02-25 |
Bayer Cropscience Ag |
Insecticidal aryl isoxazoline derivatives
|
CL2008001356A1
(en)
|
2007-05-10 |
2008-11-14 |
Smithkline Beecham Corp |
Compounds derived from quinoxaline, inhibitors of pi3 kinase _ (p13ka, pi3ko, pi3b and / or pi3ky); pharmaceutical composition; Use to treat an autoimmune disorder, inflammatory, cardiovascular, neurodegerative disease, allergy, asthma, kidney disease, cancer, transplant rejection, lung lesions.
|
PE20090717A1
(en)
|
2007-05-18 |
2009-07-18 |
Smithkline Beecham Corp |
QUINOLINE DERIVATIVES AS PI3 KINASE INHIBITORS
|
EP2014661A1
(en)
|
2007-06-13 |
2009-01-14 |
Bayer CropScience AG |
Hererocyclically substituted heterocyclic carboxylic acid derivates
|
UY31137A1
(en)
|
2007-06-14 |
2009-01-05 |
Smithkline Beecham Corp |
DERIVATIVES OF QUINAZOLINE AS INHIBITORS OF THE PI3 QUINASA
|
US20100190980A1
(en)
|
2007-06-21 |
2010-07-29 |
Taisho Pharmaceutical Co., Ltd |
Pyrazinamide compound
|
CA2691003A1
(en)
|
2007-06-26 |
2008-12-31 |
Lexicon Pharmaceuticals, Inc. |
Methods of treating serotonin-mediated diseases and disorders
|
WO2009006580A1
(en)
|
2007-07-05 |
2009-01-08 |
Cv Therapeutics, Inc. |
Optionally condensed dihydropyridine, dihydropyrimidine and dihydropyrane derivatives acting as late sodium channel blockers
|
US20090012103A1
(en)
|
2007-07-05 |
2009-01-08 |
Matthew Abelman |
Substituted heterocyclic compounds
|
GB0713259D0
(en)
|
2007-07-09 |
2007-08-15 |
Astrazeneca Ab |
Pyrazine derivatives 954
|
JP5241834B2
(en)
|
2007-07-19 |
2013-07-17 |
メルク・シャープ・アンド・ドーム・コーポレーション |
Heterocyclic amide compounds as protein kinase inhibitors
|
SG187396A1
(en)
|
2007-07-19 |
2013-02-28 |
Lundbeck & Co As H |
5-membered heterocyclic amides and related compounds
|
WO2009017954A1
(en)
|
2007-08-01 |
2009-02-05 |
Phenomix Corporation |
Inhibitors of jak2 kinase
|
BRPI0815042A2
(en)
|
2007-08-01 |
2015-02-10 |
Pfizer |
PIRAZOL COMPOUNDS
|
WO2009024825A1
(en)
|
2007-08-21 |
2009-02-26 |
Astrazeneca Ab |
2-pyrazinylbenzimidazole derivatives as receptor tyrosine kinase inhibitors
|
US8415358B2
(en)
|
2007-09-17 |
2013-04-09 |
Neurosearch A/S |
Pyrazine derivatives and their use as potassium channel modulators
|
CN101910158A
(en)
|
2007-10-25 |
2010-12-08 |
阿斯利康(瑞典)有限公司 |
Pyridine and pyrazine derivatives useful in the treatment of cell proliferative disorders
|
JP2011504931A
(en)
|
2007-11-28 |
2011-02-17 |
シェーリング コーポレイション |
2-Fluoropyrazolo [1,5-a] pyrimidine as a protein kinase inhibitor
|
WO2009075790A1
(en)
|
2007-12-07 |
2009-06-18 |
Alantos Pharmaceuticals Holding, Inc. |
Metalloprotease inhibitors for intra-articular application
|
JP5587206B2
(en)
*
|
2007-12-19 |
2014-09-10 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Pyrazolo [1,5-a] pyrimidines useful as JAK2 inhibitors
|
KR101653842B1
(en)
|
2008-01-04 |
2016-09-02 |
인텔리카인, 엘엘씨 |
Certain chemical entities, compositions and methods
|
EP2085398A1
(en)
|
2008-02-01 |
2009-08-05 |
Merz Pharma GmbH & Co. KGaA |
Pyrazolopyrimidines, a process for their preparation and their use as medicine
|
CA2716223A1
(en)
|
2008-02-25 |
2009-09-03 |
F. Hoffmann-La Roche Ag |
Pyrrolopyrazine kinase inhibitors
|
CA2713718A1
(en)
|
2008-02-25 |
2009-09-03 |
F. Hoffmann-La Roche Ag |
Pyrrolopyrazine kinase inhibitors
|
PL2247592T3
(en)
|
2008-02-25 |
2012-01-31 |
Hoffmann La Roche |
Pyrrolopyrazine kinase inhibitors
|
CA2712507A1
(en)
|
2008-02-25 |
2009-09-03 |
F. Hoffmann-La Roche Ag |
Pyrrolopyrazine kinase inhibitors
|
TW200940537A
(en)
|
2008-02-26 |
2009-10-01 |
Astrazeneca Ab |
Heterocyclic urea derivatives and methods of use thereof
|
ES2413806T3
(en)
|
2008-03-20 |
2013-07-17 |
Amgen Inc. |
Aurora kinase modulators and method of use
|
US8110576B2
(en)
|
2008-06-10 |
2012-02-07 |
Plexxikon Inc. |
Substituted pyrrolo[2,3b]pyrazines and methods for treatment of raf protein kinase-mediated indications
|
NZ590258A
(en)
|
2008-07-08 |
2013-10-25 |
Intellikine Llc |
Kinase inhibitors and methods of use
|
GB0814364D0
(en)
|
2008-08-05 |
2008-09-10 |
Eisai London Res Lab Ltd |
Diazaindole derivatives and their use in the inhibition of c-Jun N-terminal kinase
|
AU2009279936A1
(en)
|
2008-08-05 |
2010-02-11 |
Banyu Pharmaceutical Co., Ltd. |
Therapeutic compounds
|
WO2010034738A2
(en)
|
2008-09-24 |
2010-04-01 |
Basf Se |
Pyrazole compounds for controlling invertebrate pests
|
CN102317277A
(en)
|
2008-10-21 |
2012-01-11 |
沃泰克斯药物股份有限公司 |
C-met protein kinase inhibitors
|
WO2010051549A1
(en)
|
2008-10-31 |
2010-05-06 |
Genentech, Inc. |
Pyrazolopyrimidine jak inhibitor compounds and methods
|
KR101712576B1
(en)
|
2008-11-10 |
2017-03-06 |
버텍스 파마슈티칼스 인코포레이티드 |
Compounds useful as Inhibitors of ATR kinase
|
WO2010059836A1
(en)
|
2008-11-20 |
2010-05-27 |
Decode Genetics Ehf |
Substituted aza-bridged bicyclics for cardiovascular and cns disease
|
CN102264743B
(en)
|
2008-11-25 |
2015-02-11 |
罗彻斯特大学 |
MLK inhibitors and methods of use
|
CA2744507A1
(en)
|
2008-12-05 |
2010-06-10 |
F.Hoffmann-La Roche Ag |
Pyrrolopyrazinyl urea kinase inhibitors
|
RU2016141566A
(en)
*
|
2008-12-19 |
2018-12-20 |
Вертекс Фармасьютикалз Инкорпорейтед |
PYRASINE DERIVATIVES USED AS ATR KINASE INHIBITORS
|
CA2740193A1
(en)
|
2008-12-23 |
2010-07-01 |
Abbott Laboratories |
Anti-viral compounds
|
WO2010086040A1
(en)
|
2009-01-29 |
2010-08-05 |
Biomarin Iga, Ltd. |
Pyrazolo-pyrimidines for treatment of duchenne muscular dystrophy
|
WO2010087430A1
(en)
|
2009-01-30 |
2010-08-05 |
富山化学工業株式会社 |
N-acyl anthranilic acid derivative or salt thereof
|
US20100204265A1
(en)
|
2009-02-09 |
2010-08-12 |
Genelabs Technologies, Inc. |
Certain Nitrogen Containing Bicyclic Chemical Entities for Treating Viral Infections
|
BRPI1008020A2
(en)
|
2009-02-11 |
2016-03-15 |
Sunovion Pharmaceuticals Inc |
histamine h3 antagonists and inverse agonists and methods of using them
|
CN101537007A
(en)
|
2009-03-18 |
2009-09-23 |
中国医学科学院血液病医院(血液学研究所) |
Application of N-(thiofuran-2) pyrazolo (1, 5-a) pyridine-3-formanides compounds for preparing antineoplastic
|
WO2010111653A2
(en)
|
2009-03-27 |
2010-09-30 |
The Uab Research Foundation |
Modulating ires-mediated translation
|
UA110324C2
(en)
|
2009-07-02 |
2015-12-25 |
Genentech Inc |
Jak inhibitory compounds based on pyrazolo pyrimidine
|
AR077468A1
(en)
|
2009-07-09 |
2011-08-31 |
Array Biopharma Inc |
PIRAZOLO COMPOUNDS (1,5-A) PYRIMIDINE SUBSTITUTED AS TRK-QUINASA INHIBITORS
|
CN102471345A
(en)
|
2009-07-15 |
2012-05-23 |
雅培制药有限公司 |
Pyrrolopyrazine inhibitors of kinases
|
AU2010284254B2
(en)
|
2009-08-17 |
2015-09-17 |
Intellikine, Llc |
Heterocyclic compounds and uses thereof
|
EP2470183B1
(en)
|
2009-08-26 |
2015-09-16 |
Merck Sharp & Dohme Corp. |
Heterocyclic amide compounds as protein kinase inhibitors
|
CN101671336B
(en)
|
2009-09-23 |
2013-11-13 |
辽宁利锋科技开发有限公司 |
Aromatic heterocyclic pyridine derivatives and analogs and preparation method and application thereof
|
US8575177B2
(en)
|
2009-12-04 |
2013-11-05 |
Senhwa Biosciences, Inc. |
Pyrazolopyrimidines and related heterocycles as CK2 inhibitors
|
GB2481563B
(en)
|
2009-12-22 |
2017-07-19 |
Intel Corp |
Method and apparatus to provide secure application execution
|
ES2572387T3
(en)
|
2010-03-18 |
2016-05-31 |
Pasteur Institut Korea |
Anti-infectious compounds
|
US8518945B2
(en)
|
2010-03-22 |
2013-08-27 |
Hoffmann-La Roche Inc. |
Pyrrolopyrazine kinase inhibitors
|
WO2011121096A1
(en)
|
2010-03-31 |
2011-10-06 |
Dkfz Deutsches Krebsforschungszentrum |
PYRAZOL[1,5-a]PYRIMIDINE DERIVATIVES AS WNT PATHWAY ANTAGONISTS
|
MX2012011549A
(en)
|
2010-04-08 |
2013-01-29 |
Ah Usa 42 Llc |
Substituted 3,5- di phenyl - isoxazoline derivatives as insecticides and acaricides.
|
US20130030237A1
(en)
|
2010-04-15 |
2013-01-31 |
Charles Theuer |
Potentiation of anti-cancer activity through combination therapy with ber pathway inhibitors
|
EP2568984A1
(en)
|
2010-05-12 |
2013-03-20 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
US9334244B2
(en)
|
2010-05-12 |
2016-05-10 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
US9062008B2
(en)
|
2010-05-12 |
2015-06-23 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
AU2011253021A1
(en)
|
2010-05-12 |
2012-11-29 |
Vertex Pharmaceuticals Incorporated |
2 -aminopyridine derivatives useful as inhibitors of ATR kinase
|
JP2013526539A
(en)
|
2010-05-12 |
2013-06-24 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Pyrazines useful as ATR kinase inhibitors
|
JP5836367B2
(en)
|
2010-05-12 |
2015-12-24 |
バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated |
Compounds useful as ATR kinase inhibitors
|
BR112012029437A2
(en)
|
2010-05-20 |
2017-03-07 |
F Hoffmann - La Roche Ag |
pyrrolo [2,3-b] pyrazine-7-carboxamide derivatives and their use as jak and syk inhibitors
|
RU2012152354A
(en)
|
2010-05-20 |
2014-06-27 |
Ф. Хоффманн-Ля Рош Аг |
Pyrrolopyrazine derivatives as syk and jak inhibitors
|
MX2013000103A
(en)
|
2010-06-23 |
2013-06-13 |
Vertex Pharma |
Pyrrolo- pyrazine derivatives useful as inhibitors of atr kinase.
|
AU2011270798B2
(en)
|
2010-06-24 |
2015-03-19 |
Gilead Sciences, Inc. |
Pyrazolo [1, 5 -a] pyrimidines as antiviral agents
|
CN102311396B
(en)
|
2010-07-05 |
2015-01-07 |
暨南大学 |
Pyrazine derivative and preparation method as well as application thereof to pharmacy
|
KR101995013B1
(en)
|
2010-07-13 |
2019-07-02 |
에프. 호프만-라 로슈 아게 |
Pyrazolo[1,5a]pyrimidine and thieno[3,2b]pyrimidine derivatives as irak4 modulators
|
EP2407478A1
(en)
|
2010-07-14 |
2012-01-18 |
GENETADI Biotech, S.L. |
New cyclotetrapeptides with pro-angiogenic properties
|
WO2012022045A1
(en)
|
2010-08-20 |
2012-02-23 |
Hutchison Medipharma Limited |
Pyrrolopyrimidine compounds and uses thereof
|
EP2608669B1
(en)
|
2010-08-23 |
2016-06-22 |
Merck Sharp & Dohme Corp. |
NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
|
US8609669B2
(en)
|
2010-11-16 |
2013-12-17 |
Abbvie Inc. |
Potassium channel modulators
|
CA2817968C
(en)
|
2010-11-16 |
2019-03-12 |
Array Biopharma Inc. |
Combination of checkpoint kinase 1 inhibitors and wee 1 kinase inhibitors
|
RU2603637C2
(en)
|
2010-12-08 |
2016-11-27 |
Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретэри, Департмент Оф Хелс Энд Хьюмэн Сервисис |
Substituted pyrazolopyrimidines as glucocerebrosidase activators
|
CA2825098C
(en)
|
2011-01-27 |
2020-03-10 |
Universite De Montreal |
Pyrazolopyridine and pyrazolopyrimidine derivatives as melanocortin-4 receptor modulators
|
AU2012240030A1
(en)
*
|
2011-04-05 |
2013-10-24 |
Vertex Pharmaceuticals Incorporated |
Aminopyrazine compounds useful as inhibitors of TRA kinase
|
KR20140093610A
(en)
|
2011-04-21 |
2014-07-28 |
재단법인 한국파스퇴르연구소 |
Anti-inflammation compounds
|
US9090610B2
(en)
|
2011-04-21 |
2015-07-28 |
Bayer Intellectual Property Gmbh |
Fluoroalkyl-substituted pyrazolopyridines and use thereof
|
EP2710006A1
(en)
|
2011-05-17 |
2014-03-26 |
Principia Biopharma Inc. |
Azaindole derivatives as tyrosine kinase inhibitors
|
AU2012272815B2
(en)
|
2011-06-22 |
2017-09-07 |
The General Hospital Corporation |
Treatment of proteinopathies
|
JP2014517079A
(en)
|
2011-06-22 |
2014-07-17 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Compounds useful as ATR kinase inhibitors
|
US9096602B2
(en)
|
2011-06-22 |
2015-08-04 |
Vertex Pharmaceuticals Incorporated |
Substituted pyrrolo[2,3-B]pyrazines as ATR kinase inhibitors
|
EP2723745A1
(en)
|
2011-06-22 |
2014-04-30 |
Vertex Pharmaceuticals Inc. |
Compounds useful as inhibitors of atr kinase
|
EA201490265A1
(en)
|
2011-07-13 |
2014-12-30 |
Фармасайкликс, Инк. |
BLUTON TYROSINKINASE INHIBITORS
|
WO2013052263A2
(en)
|
2011-09-16 |
2013-04-11 |
Microbiotix, Inc. |
Antifungal compounds
|
KR102056586B1
(en)
|
2011-09-30 |
2019-12-18 |
버텍스 파마슈티칼스 인코포레이티드 |
Treating pancreatic cancer and non-small cell lung cancer with atr inhibitors
|
US8846686B2
(en)
|
2011-09-30 |
2014-09-30 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
US8853217B2
(en)
|
2011-09-30 |
2014-10-07 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
WO2013049719A1
(en)
|
2011-09-30 |
2013-04-04 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
RU2018147217A
(en)
|
2011-09-30 |
2019-01-18 |
Вертекс Фармасьютикалз Инкорпорейтед |
METHODS FOR PRODUCING COMPOUNDS THAT CAN BE USED AS ATR KINASE INHIBITORS
|
CN104394869A
(en)
|
2011-10-20 |
2015-03-04 |
葛兰素史密斯克莱有限责任公司 |
Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators
|
US8841337B2
(en)
|
2011-11-09 |
2014-09-23 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
WO2013071085A1
(en)
|
2011-11-09 |
2013-05-16 |
Vertex Pharmaceuticals Incorporated |
Pyrazine compounds useful as inhibitors of atr kinase
|
EP2776420A1
(en)
|
2011-11-09 |
2014-09-17 |
Vertex Pharmaceuticals Incorporated |
Pyrazine compounds useful as inhibitors of atr kinase
|
US8846917B2
(en)
|
2011-11-09 |
2014-09-30 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
WO2013071094A1
(en)
|
2011-11-09 |
2013-05-16 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
US9193725B2
(en)
|
2012-03-14 |
2015-11-24 |
Bristol-Meyers Squibb Company |
Cyclic hydrazine derivatives as HIV attachment inhibitors
|
AU2013243671B2
(en)
|
2012-04-02 |
2017-09-21 |
Cytokinetics, Inc. |
Methods for improving diaphragm function
|
AR090548A1
(en)
|
2012-04-02 |
2014-11-19 |
Incyte Corp |
BICYCLIC AZAHETEROCICLOBENCILAMINS AS PI3K INHIBITORS
|
NZ720511A
(en)
|
2012-04-05 |
2016-12-23 |
Vertex Pharma |
Compounds useful as inhibitors of atr kinase and combination therapies thereof
|
US8940742B2
(en)
|
2012-04-10 |
2015-01-27 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
CN103373996A
(en)
|
2012-04-20 |
2013-10-30 |
山东亨利医药科技有限责任公司 |
Bicyclic derivatives serving as CRTH2 receptor antagonist
|
CN106279142B
(en)
|
2012-05-15 |
2019-05-03 |
癌症研究技术有限公司 |
5- [[4- [[morpholine -2-yl] methylamino]-5- (trifluoromethyl)-2- pyridyl group] amino] pyrazine-2- nitrile and its treatment use
|
MX2014014109A
(en)
|
2012-05-23 |
2016-03-31 |
Savira Pharmaceuticals Gmbh |
7-oxo-4,7 -dihydro- pyrazolo [1, 5 -a] pyrimidine derivatives which are useful in the treatment, amelioration or prevention of a viral disease.
|
RU2014143250A
(en)
|
2012-05-23 |
2016-07-20 |
Савира Фармасьютикалз Гмбх |
7-OXO-THIAZOLOPYRIDINE CARBOXYLIC ACID DERIVATIVES AND THEIR APPLICATION FOR TREATMENT, TREATMENT OR PREVENTION OF A VIRAL DISEASE
|
US20140018361A1
(en)
|
2012-07-11 |
2014-01-16 |
Nimbus Iris, Inc. |
Irak inhibitors and uses thereof
|
WO2014015523A1
(en)
|
2012-07-27 |
2014-01-30 |
Hutchison Medipharma Limited |
Novel heteroaryl and heterocycle compounds, compositions and methods
|
MX2015001478A
(en)
|
2012-08-06 |
2015-08-12 |
Savira Pharmaceuticals Gmbh |
Dihydroxypyrimidine carbonic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease.
|
WO2014025850A1
(en)
|
2012-08-09 |
2014-02-13 |
Bristol-Myers Squibb Company |
Tricyclic amidine derivatives as hiv attachment inhibitors
|
WO2014025852A1
(en)
|
2012-08-09 |
2014-02-13 |
Bristol-Myers Squibb Company |
Tricyclic alkene derivatives as hiv attachment inhibitors
|
US9505752B2
(en)
|
2012-08-09 |
2016-11-29 |
Viiv Healthcare Uk (No. 5) Limited |
Piperidine amide derivatives as HIV attachment inhibitors
|
CA2881995A1
(en)
|
2012-08-17 |
2014-02-20 |
Bayer Cropscience Ag |
Azaindole carboxylic acid amides and azaindole thiocarboxylic acid amides for use as insecticides and acaricides
|
CA2873295A1
(en)
|
2012-08-24 |
2014-02-27 |
F. Hoffmann-La Roche Ag |
New bicyclicpyridine derivatives
|
WO2014035140A2
(en)
|
2012-08-30 |
2014-03-06 |
Kainos Medicine, Inc. |
Compounds and compositions for modulating histone methyltransferase activity
|
US9475816B2
(en)
|
2012-09-07 |
2016-10-25 |
Takeda Pharmaceutical Company Limited |
Substituted-1,4-dihydropyrazolo[4,3-b]indoles
|
WO2014042433A2
(en)
|
2012-09-14 |
2014-03-20 |
Kainos Medicine, Inc. |
Compounds and compositions for modulating adenosine a3 receptor activity
|
TW201412740A
(en)
|
2012-09-20 |
2014-04-01 |
Bayer Pharma AG |
Substituted pyrrolopyrimidinylamino-benzothiazolones
|
WO2014047648A1
(en)
|
2012-09-24 |
2014-03-27 |
Neupharma, Inc. |
Certain chemical entities, compositions, and methods
|
EP2904406B1
(en)
|
2012-10-04 |
2018-03-21 |
Vertex Pharmaceuticals Incorporated |
Method for measuring atr inhibition mediated increases in dna damage
|
CA2900335C
(en)
|
2012-10-22 |
2021-10-26 |
City Of Hope |
Synthetic analogs of epipolythiodioxopiperazines and uses thereof
|
EP2912464B1
(en)
|
2012-10-24 |
2017-04-26 |
Becton Dickinson and Company |
Hydroxamate substituted azaindoline-cyanine dyes and bioconjugates of the same
|
TR201807740T4
(en)
|
2012-12-07 |
2018-06-21 |
Vertex Pharma |
2-amino-6-fluoro-n- (5-fluoro-4- (4- (4- (oxetan-3-yl) piperazine-1-carbonyl) piperidin-1-yl) pyridine-3- as an ATR kinase inhibitor yl) pyrazolo [1,5alf a] pyrimidine-3-carboxamide.
|
US8969360B2
(en)
|
2013-03-15 |
2015-03-03 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
US9663519B2
(en)
|
2013-03-15 |
2017-05-30 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
US8957078B2
(en)
|
2013-03-15 |
2015-02-17 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
SG11201604519PA
(en)
|
2013-12-06 |
2016-07-28 |
Vertex Pharma |
2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, its preparation, different solid forms and radiolabelled derivatives thereof
|
US20150158868A1
(en)
|
2013-12-06 |
2015-06-11 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
WO2015187451A1
(en)
|
2014-06-05 |
2015-12-10 |
Vertex Pharmacetucals Incorporated |
Radiolabelled derivatives of a 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]- pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, the preparation of said compound and different solid forms thereof
|
LT3157566T
(en)
|
2014-06-17 |
2019-08-12 |
Vertex Pharmaceuticals Incorporated |
Method for treating cancer using a combination of chk1 and atr inhibitors
|