AR056786A1 - Compuesto de 1h- imidazo ( 4,5-c) piridin-2-ilo, composicion farmaceutica que lo comprende, procedimiento para preparar dicha composicion, su uso para preparar unmedicamento, uso de una combinacion que omprende al compuesto y al menos un agente antineoplasico para preparar un medicamento y dicha com - Google Patents

Compuesto de 1h- imidazo ( 4,5-c) piridin-2-ilo, composicion farmaceutica que lo comprende, procedimiento para preparar dicha composicion, su uso para preparar unmedicamento, uso de una combinacion que omprende al compuesto y al menos un agente antineoplasico para preparar un medicamento y dicha com

Info

Publication number
AR056786A1
AR056786A1 ARP060104898A ARP060104898A AR056786A1 AR 056786 A1 AR056786 A1 AR 056786A1 AR P060104898 A ARP060104898 A AR P060104898A AR P060104898 A ARP060104898 A AR P060104898A AR 056786 A1 AR056786 A1 AR 056786A1
Authority
AR
Argentina
Prior art keywords
prepare
imidazo
pharmaceutically acceptable
composite
pyridin
Prior art date
Application number
ARP060104898A
Other languages
English (en)
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of AR056786A1 publication Critical patent/AR056786A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Un compuesto de 1H-imidazo[4,5-c]piridin-2-ilo que es seleccionado de: 4-(2-(4-amino-1,2,5-oxadiazol-3-il)-1-etil-7-{[(3S)-3-piperidinilmetil]oxi}-1H-imidazo[4,5-c]piridin-4-il)-2-metil-3-butin-2-ol; 4-(2-(4-amino-1,2,5-oxadiazol-3-il)-1-etil-7- {[(2S)-2-tiomorfolinilmetil]oxi}-1H-imidazo[4,5-c]piridin-4-il)-2-metil-3-butin-2-ol; 4-(2-(4-amino-1,2,5-oxadiazol-3-il)-1-etil-7-{[(2S)-2-morfolinilmetil]oxi}-1H-imidazo[4,5-c]piridin-4-il)-2-metil-3-butin-2-ol; y 4-[2-(4-amino-1,2,5-oxadiazol-3- il)-1-etil-7-{[(2R)-6metil-2-morfolinil]metil}oxi)-1H-imidazo[4,5-c]piridin-4-il)-2-metil-3-butin-2-ol; y/o sus sales, hidratos, solvatos y profármacos farmacéuticamente aceptables. Composicion farmacéutica que lo comprende y un vehículo farmacéuticamente aceptable, y procedimiento para preparar dicha composicion que comprende poner el compuesto de formula (1) y/o una de sus sales, hidratos, solvatos o profármacos farmacéuticamente aceptables en asociacion con un vehículo farmacéuticamente aceptable. Uso de una cantidad terapéuticamente eficaz de un compuesto de formula (1) y/o una de sus sales, hidratos, solvatos o profármacos farmacéuticamente aceptables, para preparar un medicamento util para tratar o reducir la gravedad de una enfermedad o estado patologico seleccionado de cáncer y artritis en un mamífero que lo necesita, mediante la administracion a dicho mamífero de dicho compuesto. Uso de una combinacion que comprende una cantidad terapéuticamente eficaz de: a) un compuesto de la formula (1) y/o una de sus sales, hidratos, solvatos o profármacos farmacéuticamente aceptables; y b) al menos un agente antineoplásico, para preparar un medicamento para tratar cáncer en un mamífero que lo necesita, mediante la administracion de la combinacion a dicho mamífero, y dicha combinacion farmacéutica.
ARP060104898A 2005-11-10 2006-11-08 Compuesto de 1h- imidazo ( 4,5-c) piridin-2-ilo, composicion farmaceutica que lo comprende, procedimiento para preparar dicha composicion, su uso para preparar unmedicamento, uso de una combinacion que omprende al compuesto y al menos un agente antineoplasico para preparar un medicamento y dicha com AR056786A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73595505P 2005-11-10 2005-11-10
US77228906P 2006-02-10 2006-02-10
US82692806P 2006-09-26 2006-09-26

Publications (1)

Publication Number Publication Date
AR056786A1 true AR056786A1 (es) 2007-10-24

Family

ID=38049129

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060104898A AR056786A1 (es) 2005-11-10 2006-11-08 Compuesto de 1h- imidazo ( 4,5-c) piridin-2-ilo, composicion farmaceutica que lo comprende, procedimiento para preparar dicha composicion, su uso para preparar unmedicamento, uso de una combinacion que omprende al compuesto y al menos un agente antineoplasico para preparar un medicamento y dicha com

Country Status (16)

Country Link
US (1) US20100056523A1 (es)
EP (1) EP1948188A4 (es)
JP (1) JP2009516653A (es)
KR (1) KR20080067646A (es)
AP (1) AP2008004442A0 (es)
AR (1) AR056786A1 (es)
AU (1) AU2006315805A1 (es)
BR (1) BRPI0618309A2 (es)
CA (1) CA2629429A1 (es)
EA (1) EA200801301A1 (es)
EC (1) ECSP088425A (es)
IL (1) IL190968A0 (es)
MA (1) MA29935B1 (es)
NO (1) NO20082414L (es)
TW (1) TW200736260A (es)
WO (1) WO2007058850A2 (es)

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Also Published As

Publication number Publication date
EP1948188A4 (en) 2011-02-16
EP1948188A2 (en) 2008-07-30
US20100056523A1 (en) 2010-03-04
EA200801301A1 (ru) 2009-02-27
TW200736260A (en) 2007-10-01
NO20082414L (no) 2008-08-05
BRPI0618309A2 (pt) 2011-08-23
JP2009516653A (ja) 2009-04-23
KR20080067646A (ko) 2008-07-21
MA29935B1 (fr) 2008-11-03
CA2629429A1 (en) 2007-05-24
WO2007058850A3 (en) 2009-04-30
AU2006315805A1 (en) 2007-05-24
AP2008004442A0 (en) 2008-04-30
IL190968A0 (en) 2009-02-11
ECSP088425A (es) 2008-06-30
WO2007058850A2 (en) 2007-05-24

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