SG11202104927QA - Improved synthesis of key intermediate of kras g12c inhibitor compound - Google Patents

Improved synthesis of key intermediate of kras g12c inhibitor compound

Info

Publication number
SG11202104927QA
SG11202104927QA SG11202104927QA SG11202104927QA SG11202104927QA SG 11202104927Q A SG11202104927Q A SG 11202104927QA SG 11202104927Q A SG11202104927Q A SG 11202104927QA SG 11202104927Q A SG11202104927Q A SG 11202104927QA SG 11202104927Q A SG11202104927Q A SG 11202104927QA
Authority
SG
Singapore
Prior art keywords
kras
inhibitor compound
key intermediate
improved synthesis
synthesis
Prior art date
Application number
SG11202104927QA
Other languages
English (en)
Inventor
Andrew Thomas Parsons
Brian Mcneil Cochran
Powazinik, Iv
Marc Anthony Caporini
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of SG11202104927QA publication Critical patent/SG11202104927QA/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/24—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/06—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
SG11202104927QA 2018-11-16 2019-11-15 Improved synthesis of key intermediate of kras g12c inhibitor compound SG11202104927QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862768802P 2018-11-16 2018-11-16
PCT/US2019/061815 WO2020102730A1 (en) 2018-11-16 2019-11-15 Improved synthesis of key intermediate of kras g12c inhibitor compound

Publications (1)

Publication Number Publication Date
SG11202104927QA true SG11202104927QA (en) 2021-06-29

Family

ID=68887130

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202104927QA SG11202104927QA (en) 2018-11-16 2019-11-15 Improved synthesis of key intermediate of kras g12c inhibitor compound

Country Status (25)

Country Link
US (2) US11299491B2 (da)
EP (2) EP3880670B1 (da)
JP (1) JP2020090482A (da)
KR (1) KR20210093276A (da)
CN (1) CN113015724A (da)
AR (1) AR117101A1 (da)
AU (1) AU2019381817A1 (da)
BR (1) BR112021009384A2 (da)
CA (1) CA3117221A1 (da)
CL (1) CL2021001266A1 (da)
DK (1) DK3880670T3 (da)
EA (1) EA202191381A1 (da)
ES (1) ES2953752T3 (da)
FI (1) FI3880670T3 (da)
HU (1) HUE062656T2 (da)
IL (1) IL282682A (da)
LT (1) LT3880670T (da)
MA (1) MA54233A (da)
MX (2) MX2021005598A (da)
PL (1) PL3880670T3 (da)
PT (1) PT3880670T (da)
SG (1) SG11202104927QA (da)
SI (1) SI3880670T1 (da)
TW (1) TW202035354A (da)
WO (1) WO2020102730A1 (da)

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JOP20190272A1 (ar) 2017-05-22 2019-11-21 Amgen Inc مثبطات kras g12c وطرق لاستخدامها
SG11202001499WA (en) 2017-09-08 2020-03-30 Amgen Inc Inhibitors of kras g12c and methods of using the same
US11045484B2 (en) 2018-05-04 2021-06-29 Amgen Inc. KRAS G12C inhibitors and methods of using the same
US11090304B2 (en) 2018-05-04 2021-08-17 Amgen Inc. KRAS G12C inhibitors and methods of using the same
JP7361720B2 (ja) 2018-05-10 2023-10-16 アムジエン・インコーポレーテツド がんの治療のためのｋｒａｓ ｇ１２ｃ阻害剤
MX2020012731A (es) 2018-06-01 2021-02-22 Amgen Inc Inhibidores de kras g12c y metodos para su uso.
MX2020012261A (es) 2018-06-12 2021-03-31 Amgen Inc Inhibidores de kras g12c que comprenden un anillo de piperazina y uso de estos en el tratamiento del cancer.
JP2020090482A (ja) 2018-11-16 2020-06-11 アムジエン・インコーポレーテツド Ｋｒａｓ ｇ１２ｃ阻害剤化合物の重要な中間体の改良合成法
JP7377679B2 (ja) 2018-11-19 2023-11-10 アムジエン・インコーポレーテツド がん治療のためのｋｒａｓｇ１２ｃ阻害剤及び１種以上の薬学的に活性な追加の薬剤を含む併用療法
JP7454572B2 (ja) 2018-11-19 2024-03-22 アムジエン・インコーポレーテツド Ｋｒａｓ ｇ１２ｃ阻害剤及びその使用方法
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WO2021244555A1 (zh) * 2020-06-02 2021-12-09 上海喆邺生物科技有限公司 一种手性中间体及其制备方法
CN115916194A (zh) 2020-06-18 2023-04-04 锐新医药公司 用于延迟、预防和治疗针对ras抑制剂的获得性抗性的方法
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WO2022028346A1 (zh) 2020-08-02 2022-02-10 上海喆邺生物科技有限公司 一种芳香类化合物及其在抗肿瘤药物中的应用
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IL301517A (en) * 2020-10-07 2023-05-01 Amgen Inc A method for preparing the racemate and isolating atropisomers of 7-chloro-6-fluoro-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[3,2-D]pyrimidine-4,2(1H,3H)-dione
AR124105A1 (es) 2020-11-20 2023-02-15 Amgen Inc Procedimiento para preparar 7-cloro-6-fluoro-1-(2-isopropil-4-metilpiridin-3-il)pirido[2,3-d]pirimidino-2,4(1h,3h)-diona
CN117479942A (zh) 2021-04-09 2024-01-30 勃林格殷格翰国际有限公司 抗癌疗法
JP2024518845A (ja) 2021-05-19 2024-05-07 テバ・ファーマシューティカルズ・インターナショナル・ゲーエムベーハー ソトラシブ及びその固体状態形態の調製のためのプロセス
CN114605406B (zh) * 2021-09-18 2023-05-26 都创(上海)医药开发有限公司 Amg510化合物的晶型及其制备方法和用途
WO2023117681A1 (en) 2021-12-22 2023-06-29 Boehringer Ingelheim International Gmbh Heteroaromatic compounds for the treatment of cancer
TW202346267A (zh) 2022-03-07 2023-12-01 美商安進公司 用於製備４－甲基－２－丙－２－基－吡啶－３－甲腈之方法
CN115466259B (zh) * 2022-08-16 2023-12-05 山东大学 一种kras g12c抑制剂索托拉西布的制备方法

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