MX2020012731A - Inhibidores de kras g12c y metodos para su uso. - Google Patents

Inhibidores de kras g12c y metodos para su uso.

Info

Publication number
MX2020012731A
MX2020012731A MX2020012731A MX2020012731A MX2020012731A MX 2020012731 A MX2020012731 A MX 2020012731A MX 2020012731 A MX2020012731 A MX 2020012731A MX 2020012731 A MX2020012731 A MX 2020012731A MX 2020012731 A MX2020012731 A MX 2020012731A
Authority
MX
Mexico
Prior art keywords
inhibitors
same
kras
methods
colorectal
Prior art date
Application number
MX2020012731A
Other languages
English (en)
Inventor
Victor J Cee
Brian Alan Lanman
Michael D Bartberger
Ning Chen
Patricia Lopez
John Gordon Allen
Aaron C Siegmund
Shon Booker
Ryan Paul Wurz
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX2020012731A publication Critical patent/MX2020012731A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152

Abstract

En el presente documento, se proporcionan inhibidores de KRAS G12C, tales como (ver Fórmula) composiciones de los mismos y métodos de uso de los mismos. Dichos inhibidores son útiles para el tratamiento de múltiples trastornos, incluyendo cáncer pancreático, colorrectal y de pulmón.
MX2020012731A 2018-06-01 2019-05-31 Inhibidores de kras g12c y metodos para su uso. MX2020012731A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862679655P 2018-06-01 2018-06-01
PCT/US2019/034974 WO2019232419A1 (en) 2018-06-01 2019-05-31 Kras g12c inhibitors and methods of using the same

Publications (1)

Publication Number Publication Date
MX2020012731A true MX2020012731A (es) 2021-02-22

Family

ID=67138027

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020012731A MX2020012731A (es) 2018-06-01 2019-05-31 Inhibidores de kras g12c y metodos para su uso.

Country Status (9)

Country Link
US (1) US11096939B2 (es)
EP (1) EP3802535B1 (es)
JP (1) JP7360396B2 (es)
AU (1) AU2019278998B2 (es)
CA (1) CA3098885A1 (es)
ES (1) ES2938987T3 (es)
MA (1) MA52765A (es)
MX (1) MX2020012731A (es)
WO (1) WO2019232419A1 (es)

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