TW201713630A - Substituted quinazoline compounds and methods of use thereof - Google Patents
Substituted quinazoline compounds and methods of use thereofInfo
- Publication number
- TW201713630A TW201713630A TW105123325A TW105123325A TW201713630A TW 201713630 A TW201713630 A TW 201713630A TW 105123325 A TW105123325 A TW 105123325A TW 105123325 A TW105123325 A TW 105123325A TW 201713630 A TW201713630 A TW 201713630A
- Authority
- TW
- Taiwan
- Prior art keywords
- methods
- compounds
- quinazoline compounds
- substituted quinazoline
- activity
- Prior art date
Links
Abstract
Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): or a pharmaceutically acceptable salt, stereoisomer or prodrug thereof, wherein R, R1, R<SP>2a</SP>, R<SP>2b</SP>, R<SP>2c</SP>, A, B, L1 and E are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also provided.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562195636P | 2015-07-22 | 2015-07-22 | |
US201662342078P | 2016-05-26 | 2016-05-26 | |
JOP/2016/0150A JOP20160150B1 (en) | 2015-07-22 | 2016-07-21 | Substituted quinazoline compounds and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
TW201713630A true TW201713630A (en) | 2017-04-16 |
Family
ID=59298009
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW105123325A TW201713630A (en) | 2015-07-22 | 2016-07-22 | Substituted quinazoline compounds and methods of use thereof |
Country Status (1)
Country | Link |
---|---|
TW (1) | TW201713630A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112225734A (en) * | 2019-10-25 | 2021-01-15 | 南京瑞捷医药科技有限公司 | KRAS G12C inhibitors and uses thereof |
CN113015724A (en) * | 2018-11-16 | 2021-06-22 | 美国安进公司 | Improved synthesis of key intermediates of KRAS G12C inhibitor compounds |
-
2016
- 2016-07-22 TW TW105123325A patent/TW201713630A/en unknown
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113015724A (en) * | 2018-11-16 | 2021-06-22 | 美国安进公司 | Improved synthesis of key intermediates of KRAS G12C inhibitor compounds |
CN112225734A (en) * | 2019-10-25 | 2021-01-15 | 南京瑞捷医药科技有限公司 | KRAS G12C inhibitors and uses thereof |
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