RU2004113205A - Фармацевтические композиции, включающие коллоидную двуокись кремния - Google Patents

Фармацевтические композиции, включающие коллоидную двуокись кремния Download PDF

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RU2004113205A
RU2004113205A RU2004113205/15A RU2004113205A RU2004113205A RU 2004113205 A RU2004113205 A RU 2004113205A RU 2004113205/15 A RU2004113205/15 A RU 2004113205/15A RU 2004113205 A RU2004113205 A RU 2004113205A RU 2004113205 A RU2004113205 A RU 2004113205A
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silicon dioxide
pharmaceutical composition
composition
macrolide
colloidal silicon
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RU2004113205/15A
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RU2322970C2 (ru
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Барбара ХЭБЕРЛИН (CH)
Барбара ХЭБЕРЛИН
Андреа КРАМЕР (DE)
Андреа КРАМЕР
Сильвиа ХЕЮРДИНГ (CH)
Сильвиа ХЕЮРДИНГ
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Новартис АГ (CH)
Новартис Аг
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Claims (10)

1. Фармацевтическая композиция, включающая твердую дисперсию макролида, дезинтегрирующее средство и коллоидную двуокись кремния, где композиция содержит от 1 до 5% по массе коллоидной двуокиси кремния.
2. Фармацевтическая композиция по п.1, где 250 мг композиции, будучи подвергнутыми сжатию с применением силы от 8 до 11 кН при использовании пресс-формы в 9 мм и стандартных плоских штампов, образуют таблетку с твердостью от 35 до 80 Н и временем дезинтеграции в 3 мин или менее.
3. Композиция по п.1, где композиция находится в форме диспергируемой таблетки.
4. Композиция по п.3, где время дезинтеграции таблетки составляет 90 с или менее.
5. Композиция по любому из предшествующих пунктов, где макролид является рапамицином, аскомицином или их производным.
6. Композиция по любому из пп.1-4, где производным рапамицина является 40-O-(2-гидроксиэтил)рапамицин.
7. Лекарственное средство, обладающее иммунодепрессивным действием, содержащее фармацевтическую композицию по любому из пп.1-6.
8. Способ введения фармацевтической композиции по одному из предшествующих пунктов субъекту при необходимости такого лечения, который включает (i) взаимодействие композиции с водным раствором, (ii) предоставление возможности композиции диспергироваться в водном растворе с образованием диспергированной смеси и (ii) проглатывание диспергированной смеси.
9. Применение коллоидной двуокиси кремния в качестве кодезинтегрирующего средства, где коллоидная двуокись кремния входит в состав фармацевтической композиции, также содержащей твердую дисперсию макролида и дезинтегрирующее средство, и коллоидная двуокись кремния применяется для увеличения скорости дезинтеграции фармацевтической композиции в водном растворе.
10. Способ приготовления содержащей макролид диспергируемой таблетки, включающий приготовление твердой дисперсии макролида, смешение твердой диспепсии макролида с дезинтегрирующим средством и коллоидной двуокисью кремния для образования фармацевтической композиции и прессование фармацевтической композиции для образования диспергируемой таблетки.
RU2004113205/15A 2001-09-28 2002-09-27 Фармацевтические композиции, включающие коллоидную двуокись кремния RU2322970C2 (ru)

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GB0123400.4 2001-09-28
GBGB0123400.4A GB0123400D0 (en) 2001-09-28 2001-09-28 Organic compounds

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RU2004113205A true RU2004113205A (ru) 2005-04-20
RU2322970C2 RU2322970C2 (ru) 2008-04-27

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US (4) US20040254210A1 (ru)
EP (2) EP1432408B8 (ru)
JP (2) JP2005507897A (ru)
KR (1) KR100626785B1 (ru)
CN (3) CN101912392A (ru)
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NZ (2) NZ542273A (ru)
PE (1) PE20030602A1 (ru)
PL (1) PL209704B1 (ru)
PT (2) PT1432408E (ru)
RU (1) RU2322970C2 (ru)
SI (1) SI1432408T1 (ru)
TW (1) TWI242449B (ru)
WO (1) WO2003028705A1 (ru)
ZA (1) ZA200401300B (ru)

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