BR112017024732A2 - combinação farmacêutica de everolimus com dactolisibe - Google Patents
combinação farmacêutica de everolimus com dactolisibeInfo
- Publication number
- BR112017024732A2 BR112017024732A2 BR112017024732A BR112017024732A BR112017024732A2 BR 112017024732 A2 BR112017024732 A2 BR 112017024732A2 BR 112017024732 A BR112017024732 A BR 112017024732A BR 112017024732 A BR112017024732 A BR 112017024732A BR 112017024732 A2 BR112017024732 A2 BR 112017024732A2
- Authority
- BR
- Brazil
- Prior art keywords
- combination
- dactolisib
- everolimus
- enhancing
- immune response
- Prior art date
Links
Classifications
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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Abstract
a presente invenção refere-se a uma combinação compreendendo (a) rad001, ou um sal farmaceuticamente aceitável do mesmo, e (b) bez235, ou sal farmaceuticamente aceitável do mesmo, para uso simultâneo, separado ou sequencial para aperfeiçoamento de uma resposta imune; uma composição farmacêutica compreendendo tal combinação; um método de aperfeiçoamento de resposta imune em um sujeito compreendendo administração de dita combinação de um sujeito em sua necessidade; uso de tal combinação para preparação de um medicamento para o aperfeiçoamento de uma resposta imune; e uma embalagem comercial para a mesma.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562164354P | 2015-05-20 | 2015-05-20 | |
PCT/IB2016/052980 WO2016185443A1 (en) | 2015-05-20 | 2016-05-20 | Pharmaceutical combination of everolimus with dactolisib |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112017024732A2 true BR112017024732A2 (pt) | 2018-07-31 |
Family
ID=57319542
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017024732A BR112017024732A2 (pt) | 2015-05-20 | 2016-05-20 | combinação farmacêutica de everolimus com dactolisibe |
Country Status (13)
Country | Link |
---|---|
US (2) | US10576076B2 (pt) |
EP (1) | EP3297629A1 (pt) |
JP (1) | JP6857141B2 (pt) |
KR (1) | KR20180058659A (pt) |
CN (1) | CN107847491A (pt) |
AU (1) | AU2016263176A1 (pt) |
BR (1) | BR112017024732A2 (pt) |
CA (1) | CA2986359A1 (pt) |
EA (1) | EA201792314A1 (pt) |
HK (1) | HK1245095A1 (pt) |
IL (1) | IL255728A (pt) |
MX (1) | MX2017014776A (pt) |
WO (1) | WO2016185443A1 (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11083725B2 (en) | 2014-10-24 | 2021-08-10 | St. Jude Children's Research Hospital | Coordinated metabolic reprogramming in response to productive viral infections |
JP6857141B2 (ja) | 2015-05-20 | 2021-04-14 | ノバルティス アーゲー | エベロリムスとダクトリシブとの薬学的組合せ |
MX2019006090A (es) | 2016-11-23 | 2019-08-21 | Novartis Ag | Metodos para mejorar la respuesta inmune con everolimus, dactolisib o ambos. |
US11260078B2 (en) * | 2017-07-25 | 2022-03-01 | Insilico Medicine Ip Limited | Method of treating senescence with multi-stage longevity therapeutics |
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2016
- 2016-05-20 JP JP2017560254A patent/JP6857141B2/ja active Active
- 2016-05-20 WO PCT/IB2016/052980 patent/WO2016185443A1/en active Application Filing
- 2016-05-20 KR KR1020177036823A patent/KR20180058659A/ko not_active Application Discontinuation
- 2016-05-20 AU AU2016263176A patent/AU2016263176A1/en not_active Abandoned
- 2016-05-20 CA CA2986359A patent/CA2986359A1/en not_active Abandoned
- 2016-05-20 CN CN201680039501.8A patent/CN107847491A/zh active Pending
- 2016-05-20 EP EP16725601.5A patent/EP3297629A1/en not_active Ceased
- 2016-05-20 MX MX2017014776A patent/MX2017014776A/es unknown
- 2016-05-20 BR BR112017024732A patent/BR112017024732A2/pt not_active Application Discontinuation
- 2016-05-20 US US15/575,703 patent/US10576076B2/en not_active Expired - Fee Related
- 2016-05-20 EA EA201792314A patent/EA201792314A1/ru unknown
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2017
- 2017-11-16 IL IL255728A patent/IL255728A/en unknown
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2018
- 2018-04-04 HK HK18104516.7A patent/HK1245095A1/zh unknown
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2019
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US20210030741A1 (en) | 2021-02-04 |
JP6857141B2 (ja) | 2021-04-14 |
EP3297629A1 (en) | 2018-03-28 |
AU2016263176A1 (en) | 2017-12-07 |
EA201792314A1 (ru) | 2018-05-31 |
US10576076B2 (en) | 2020-03-03 |
CA2986359A1 (en) | 2016-11-24 |
KR20180058659A (ko) | 2018-06-01 |
MX2017014776A (es) | 2018-02-15 |
US20180289694A1 (en) | 2018-10-11 |
WO2016185443A1 (en) | 2016-11-24 |
HK1245095A1 (zh) | 2018-08-24 |
JP2018520102A (ja) | 2018-07-26 |
CN107847491A (zh) | 2018-03-27 |
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