|
CN101001857B
(zh)
|
2002-01-22 |
2011-06-22 |
沃尼尔·朗伯有限责任公司 |
2-(吡啶-2-基氨基)-吡啶并[2,3-d]嘧啶-7-酮
|
|
JP2007530654A
(ja)
*
|
2004-03-30 |
2007-11-01 |
ファイザー・プロダクツ・インク |
シグナル伝達阻害剤の組合せ
|
|
WO2007044813A1
(en)
*
|
2005-10-07 |
2007-04-19 |
Exelixis, Inc. |
PYRIDOPYRIMIDINONE INHIBITORS OF PI3Kα
|
|
WO2007044698A1
(en)
*
|
2005-10-07 |
2007-04-19 |
Exelixis, Inc. |
PYRIDOPYRIMIDINONE INHIBITORS OF PI3Kα
|
|
BRPI0716880A2
(pt)
|
2006-09-08 |
2013-10-15 |
Pfizer Prod Inc |
Síntese de 2-(piridin-2-ilamino)-pirido[2,3-d]pirimidin-7-onas
|
|
MX2009002927A
(es)
|
2006-09-15 |
2009-03-31 |
Pfizer Prod Inc |
Compuestos de pirido (2,3-d)pirimidinona y su uso como inhibidores de la enzima fosfoinositido 3.
|
|
WO2008063888A2
(en)
|
2006-11-22 |
2008-05-29 |
Plexxikon, Inc. |
Compounds modulating c-fms and/or c-kit activity and uses therefor
|
|
AU2007333791A1
(en)
*
|
2006-12-14 |
2008-06-26 |
Panacea Pharmaceuticals, Inc. |
Methods of neuroprotection by cyclin-dependent kinase inhibition
|
|
US9259399B2
(en)
*
|
2007-11-07 |
2016-02-16 |
Cornell University |
Targeting CDK4 and CDK6 in cancer therapy
|
|
KR20100095020A
(ko)
|
2007-12-19 |
2010-08-27 |
암젠 인크 |
세포 주기 억제제로서의 융합된 피리딘, 피리미딘 및 트리아진 화합물
|
|
ATE531372T1
(de)
*
|
2008-04-07 |
2011-11-15 |
Amgen Inc |
Gem-disubstituierte und spirocyclische aminopyridine/pyrimidine als zellcyclus- inhibitoren
|
|
US20110224221A1
(en)
*
|
2008-10-01 |
2011-09-15 |
Sharpless Norman E |
Hematopoietic protection against ionizing radiation using selective cyclin-dependent kinase 4/6 inhibitors
|
|
WO2010039997A2
(en)
*
|
2008-10-01 |
2010-04-08 |
The University Of North Carolina At Chapel Hill |
Hematopoietic protection against chemotherapeutic compounds using selective cyclin-dependent kinase 4/6 inhibitors
|
|
PA8852901A1
(es)
*
|
2008-12-22 |
2010-07-27 |
Lilly Co Eli |
Inhibidores de proteina cinasa
|
|
WO2010114928A2
(en)
|
2009-04-03 |
2010-10-07 |
F.Hoffmann-La Roche Ag |
Compositions and uses thereof
|
|
JP2012526850A
(ja)
|
2009-05-13 |
2012-11-01 |
ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル |
サイクリン依存性キナーゼ阻害剤及びその用法
|
|
ES2633317T3
(es)
|
2009-11-06 |
2017-09-20 |
Plexxikon, Inc. |
Compuestos y métodos para la modulación de quinasas, e indicaciones para ello
|
|
KR20120111739A
(ko)
|
2009-12-31 |
2012-10-10 |
센트로 내셔널 드 인베스티가시오네스 온콜로지카스 (씨엔아이오) |
키나제 억제제로서의 사용을 위한 삼환식 화합물
|
|
TWI619713B
(zh)
|
2010-04-21 |
2018-04-01 |
普雷辛肯公司 |
用於激酶調節的化合物和方法及其適應症
|
|
US8691830B2
(en)
|
2010-10-25 |
2014-04-08 |
G1 Therapeutics, Inc. |
CDK inhibitors
|
|
EP2640394A4
(en)
*
|
2010-11-17 |
2015-02-25 |
Univ North Carolina |
PROTECTION OF RENAL TISSUES AGAINST ISCHEMIA THROUGH INHIBITION OF CDK4 AND CDK6 PROLIFERATIVE KINASES
|
|
WO2012098387A1
(en)
|
2011-01-18 |
2012-07-26 |
Centro Nacional De Investigaciones Oncológicas (Cnio) |
6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors
|
|
AU2012214762B2
(en)
|
2011-02-07 |
2015-08-13 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
PT2688887E
(pt)
|
2011-03-23 |
2015-07-06 |
Amgen Inc |
Inibidores duais tricíclicos fusionados de cdk 4/6 e flt3
|
|
ES2702487T3
(es)
*
|
2011-06-17 |
2019-03-01 |
Nantenergy Inc |
Líquido iónico que contiene iones sulfonato
|
|
CA2868966C
(en)
|
2012-03-29 |
2021-01-26 |
Francis Xavier Tavares |
Lactam kinase inhibitors
|
|
US9150570B2
(en)
|
2012-05-31 |
2015-10-06 |
Plexxikon Inc. |
Synthesis of heterocyclic compounds
|
|
PL2958916T3
(pl)
|
2013-02-21 |
2019-01-31 |
Pfizer Inc. |
Stałe postacie selektywnego inhibitora CDK4/6
|
|
WO2014150925A2
(en)
*
|
2013-03-15 |
2014-09-25 |
Concert Pharmaceuticals, Inc. |
Deuterated palbociclib
|
|
JP6435315B2
(ja)
|
2013-03-15 |
2018-12-05 |
ジー１、セラピューティクス、インコーポレイテッドＧ１ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． |
高活性抗新生物薬及び抗増殖剤
|
|
CN108283644B
(zh)
|
2013-03-15 |
2022-03-18 |
G1治疗公司 |
在化学疗法期间对正常细胞的瞬时保护
|
|
WO2014203129A1
(en)
|
2013-06-19 |
2014-12-24 |
Olema Pharmaceuticals, Inc. |
Combinations of benzopyran compounds, compositions and uses thereof
|
|
WO2015161287A1
(en)
|
2014-04-17 |
2015-10-22 |
G1 Therapeutics, Inc. |
Tricyclic lactams for use in the protection of normal cells during chemotherapy
|
|
EP3172214B1
(en)
*
|
2014-07-26 |
2020-05-13 |
Sunshine Lake Pharma Co., Ltd. |
2-amino-pyrido[2,3-d]pyrimidin-7(8h)-one derivatives as cdk inhibitors and uses thereof
|
|
WO2016016769A1
(en)
*
|
2014-07-31 |
2016-02-04 |
Sun Pharmaceutical Industries Limited |
A process for the preparation of palbociclib
|
|
US20170240543A1
(en)
*
|
2014-08-14 |
2017-08-24 |
Sun Pharmaceutical Industries Limited |
Crystalline forms of palbociclib
|
|
EP3191098A4
(en)
|
2014-09-12 |
2018-04-25 |
G1 Therapeutics, Inc. |
Combinations and dosing regimes to treat rb-positive tumors
|
|
WO2016040848A1
(en)
|
2014-09-12 |
2016-03-17 |
G1 Therapeutics, Inc. |
Treatment of rb-negative tumors using topoisomerase inhibitors in combination with cyclin dependent kinase 4/6 inhibitors
|
|
CN105622638B
(zh)
*
|
2014-10-29 |
2018-10-02 |
广州必贝特医药技术有限公司 |
嘧啶或吡啶并吡啶酮类化合物及其制备方法和应用
|
|
WO2016066420A1
(en)
*
|
2014-10-29 |
2016-05-06 |
Sandoz Ag |
Crystalline forms of palbociclib monohydrochloride
|
|
CN105616419A
(zh)
*
|
2014-11-07 |
2016-06-01 |
江苏豪森药业集团有限公司 |
含有细胞周期蛋白抑制剂固体分散体的药物组合物及其制备方法
|
|
CN105616418A
(zh)
*
|
2014-11-07 |
2016-06-01 |
江苏豪森药业集团有限公司 |
含有细胞周期蛋白抑制剂的药物制剂及其制备方法
|
|
PT3218005T
(pt)
|
2014-11-12 |
2023-04-11 |
Seagen Inc |
Compostos que interagem com glicano e métodos de uso
|
|
WO2016090257A1
(en)
*
|
2014-12-05 |
2016-06-09 |
Crystal Pharmatech Inc. |
Salts and crystalline forms of 6-acetyl-8-cyclopentyl-5-methyl-2((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d] pyrimidin-7(8h)-one (palbociclib)
|
|
WO2016092442A1
(en)
*
|
2014-12-08 |
2016-06-16 |
Sun Pharmaceutical Industries Limited |
Processes for the preparation of crystalline forms of palbociclib acetate
|
|
CN105732615B
(zh)
*
|
2014-12-31 |
2018-05-01 |
山东轩竹医药科技有限公司 |
Cdk激酶抑制剂
|
|
RS59782B1
(sr)
*
|
2015-02-03 |
2020-02-28 |
Jiangsu hengrui medicine co ltd |
Hidroksietil sulfonat od ciklina zavisnog inhibitora kinaze proteina, njegov kristalni oblik, i postupak za njegovo dobijanje
|
|
CZ201589A3
(cs)
|
2015-02-11 |
2016-08-24 |
Zentiva, K.S. |
Pevné formy soli Palbociclibu
|
|
AR104068A1
(es)
|
2015-03-26 |
2017-06-21 |
Hoffmann La Roche |
Combinaciones de un compuesto inhibidor de fosfoinosítido 3-cinasa y un compuesto inhibidor de cdk4/6 para el tratamiento del cáncer
|
|
EP3078663A1
(en)
|
2015-04-09 |
2016-10-12 |
Sandoz Ag |
Modified particles of palbociclib
|
|
WO2016156070A1
(en)
|
2015-04-02 |
2016-10-06 |
Sandoz Ag |
Modified particles of palbociclib
|
|
CN104910149A
(zh)
*
|
2015-04-28 |
2015-09-16 |
上海百奇医药科技有限公司 |
一种Palbociclib制备方法
|
|
CN106117199A
(zh)
*
|
2015-05-04 |
2016-11-16 |
江苏恒瑞医药股份有限公司 |
一种细胞周期蛋白依赖性激酶抑制剂的二羟乙基磺酸盐、其结晶形式及其制备方法
|
|
TWI714590B
(zh)
*
|
2015-05-29 |
2021-01-01 |
日商帝人製藥股份有限公司 |
吡啶並［３，４－ｄ］嘧啶衍生物及其藥學上可被許可的鹽
|
|
HUE047477T2
(hu)
|
2015-06-04 |
2020-04-28 |
Pfizer |
Palbociclib szilárd dózisformái
|
|
CN106317053A
(zh)
*
|
2015-06-29 |
2017-01-11 |
北大方正集团有限公司 |
一种帕博昔布晶型a的制备方法
|
|
WO2017021111A1
(en)
*
|
2015-08-05 |
2017-02-09 |
Ratiopharm Gmbh |
New crystalline form and acetic acid adducts of palbociclib
|
|
CN105085517B
(zh)
*
|
2015-08-06 |
2016-11-23 |
天津华洛康生物科技有限公司 |
一种结晶型帕博西尼游离碱水合物及其制备方法
|
|
CN106474129A
(zh)
*
|
2015-09-01 |
2017-03-08 |
上海方楠生物科技有限公司 |
一种帕博西林或其药学上可接受的盐与药用辅料的组合物及其制备方法
|
|
HU230962B1
(hu)
*
|
2015-10-28 |
2019-06-28 |
Egis Gyógyszergyár Zrt. |
Palbociclib sók
|
|
SG11201803213XA
(en)
|
2015-11-12 |
2018-05-30 |
Siamab Therapeutics Inc |
Glycan-interacting compounds and methods of use
|
|
CN105418603A
(zh)
*
|
2015-11-17 |
2016-03-23 |
重庆莱美药业股份有限公司 |
一种高纯度帕布昔利布及其反应中间体的制备方法
|
|
CN106800553A
(zh)
*
|
2015-11-26 |
2017-06-06 |
上海科胜药物研发有限公司 |
一种帕博西尼二羟乙基磺酸盐的晶型
|
|
CN106800554A
(zh)
*
|
2015-11-26 |
2017-06-06 |
上海科胜药物研发有限公司 |
一种帕博西尼二盐酸盐的晶型及其制备方法
|
|
CN105541832A
(zh)
*
|
2015-12-15 |
2016-05-04 |
南京艾德凯腾生物医药有限责任公司 |
一种羟乙基磺酸盐帕布昔利布的制备方法
|
|
WO2017130219A1
(en)
|
2016-01-25 |
2017-08-03 |
Mylan Laboratories Limited |
Amorphous solid dispersion of palbociclib
|
|
WO2017145054A1
(en)
|
2016-02-24 |
2017-08-31 |
Lupin Limited |
Modified particles of crystalline palbociclib free base and process for the preparation thereof
|
|
CN107137408A
(zh)
*
|
2016-03-01 |
2017-09-08 |
江苏恒瑞医药股份有限公司 |
一种cdk4/6抑制剂与芳香化酶抑制剂联合在制备治疗乳腺癌的药物中的用途
|
|
CN107137409A
(zh)
*
|
2016-03-01 |
2017-09-08 |
江苏恒瑞医药股份有限公司 |
一种cdk4/6抑制剂与***受体拮抗剂联合在制备治疗乳腺癌的药物中的用途
|
|
WO2017172734A1
(en)
*
|
2016-03-29 |
2017-10-05 |
Mayo Foundation For Medical Education And Research |
Treating cancer metastasis
|
|
US10449195B2
(en)
|
2016-03-29 |
2019-10-22 |
Shenzhen Pharmacin Co., Ltd. |
Pharmaceutical formulation of palbociclib and a preparation method thereof
|
|
WO2018001270A1
(en)
*
|
2016-06-30 |
2018-01-04 |
Noratech Pharmaceuticals, Inc. |
Palbociclib prodrugs and composition thereof
|
|
WO2018005863A1
(en)
|
2016-07-01 |
2018-01-04 |
G1 Therapeutics, Inc. |
Pyrimidine-based compounds for the treatment of cancer
|
|
JP6870082B2
(ja)
|
2016-07-07 |
2021-05-12 |
プランテックス・リミテッド |
二メシル酸パルボシクリブの固体形態
|
|
JP6563623B1
(ja)
|
2016-08-15 |
2019-08-21 |
ファイザー・インク |
ピリドピリミジノンｃｄｋ２／４／６阻害剤
|
|
WO2018065999A1
(en)
|
2016-10-07 |
2018-04-12 |
Mylan Laboratories Limited |
Novel polymorph of an intermediate for palbociclib synthesis
|
|
SG11201902523UA
(en)
|
2016-10-20 |
2019-05-30 |
Pfizer |
Anti-proliferative agents for treating pah
|
|
WO2018073574A1
(en)
|
2016-10-20 |
2018-04-26 |
Cipla Limited |
Polymorphic forms of palbociclib
|
|
US20190275049A1
(en)
|
2016-11-16 |
2019-09-12 |
Pfizer Inc. |
Combination of an EGFR T790M Inhibitor and a CDK Inhibitor for the Treatment of Non-Small Cell Lung Cancer
|
|
US11401330B2
(en)
|
2016-11-17 |
2022-08-02 |
Seagen Inc. |
Glycan-interacting compounds and methods of use
|
|
HUE057706T2
(hu)
*
|
2016-11-28 |
2022-05-28 |
Teijin Pharma Ltd |
Pirido[3,4-d]pirimiden-származék vagy szolvátja kristálya
|
|
CN110177554B
(zh)
|
2017-01-06 |
2023-06-02 |
G1治疗公司 |
用于治疗癌症的组合疗法
|
|
AU2018226824A1
(en)
|
2017-03-03 |
2019-09-19 |
Seagen Inc. |
Glycan-interacting compounds and methods of use
|
|
US20200054560A1
(en)
*
|
2017-04-21 |
2020-02-20 |
Alnova Pharmaceuticals, Ltd. |
Palbociclib compositions and methods thereof
|
|
CA3067873A1
(en)
|
2017-06-29 |
2019-01-03 |
G1 Therapeutics, Inc. |
Morphic forms of g1t38 and methods of manufacture thereof
|
|
EP3658119A1
(en)
|
2017-07-28 |
2020-06-03 |
Synthon B.V. |
Pharmaceutical composition comprising palbociclib
|
|
CN111989099A
(zh)
*
|
2018-01-29 |
2020-11-24 |
贝塔制药有限公司 |
作为cdk4和cdk6抑制剂的2h-吲唑衍生物及其治疗用途
|
|
JP2021514975A
(ja)
|
2018-02-27 |
2021-06-17 |
ファイザー・インク |
サイクリン依存性キナーゼ阻害剤およびｂｅｔ−ブロモドメイン阻害剤の組合せ
|
|
PL3793609T3
(pl)
|
2018-05-14 |
2024-05-13 |
Pfizer Inc. |
Preparat w postaci doustnego roztworu
|
|
CA3106273A1
(en)
|
2018-07-23 |
2020-01-30 |
F. Hoffmann-La Roche Ag |
Methods of treating cancer with pi3k inhibitor, gdc-0077
|
|
EP3840756A4
(en)
|
2018-08-24 |
2022-04-27 |
G1 Therapeutics, Inc. |
IMPROVED SYNTHESIS OF 1,4-DIAZASPIRO[5.5]UNDECAN-3-ONE
|
|
JP6952747B2
(ja)
|
2018-09-18 |
2021-10-20 |
ファイザー・インク |
がん処置のためのＴＧＦβ阻害剤およびＣＤＫ阻害剤の組合せ
|
|
EP3863618A1
(en)
|
2018-10-08 |
2021-08-18 |
F. Hoffmann-La Roche AG |
Methods of treating cancer with pi3k alpha inhibitors and metformin
|
|
US11424484B2
(en)
|
2019-01-24 |
2022-08-23 |
Octet Scientific, Inc. |
Zinc battery electrolyte additive
|
|
WO2020157709A1
(en)
|
2019-02-01 |
2020-08-06 |
Pfizer Inc. |
Combination of a cdk inhibitor and a pim inhibitor
|
|
CA3141452A1
(en)
|
2019-05-24 |
2020-12-03 |
Pfizer Inc. |
Combination therapies using cdk inhibitors
|
|
JP2022534889A
(ja)
|
2019-05-24 |
2022-08-04 |
ファイザー・インコーポレイテッド |
Ｃｄｋ阻害剤を使用した組合せ療法
|
|
CN112094272A
(zh)
|
2019-06-18 |
2020-12-18 |
北京睿熙生物科技有限公司 |
Cdk激酶抑制剂
|
|
CN110143948B
(zh)
*
|
2019-06-21 |
2021-05-14 |
上海博悦生物科技有限公司 |
Cdk4/6抑制剂、其药物组合物、制备方法及应用
|
|
IL293347A
(en)
|
2019-12-03 |
2022-07-01 |
Genentech Inc |
Combined therapies for the treatment of breast cancer
|
|
WO2021176349A1
(en)
|
2020-03-05 |
2021-09-10 |
Pfizer Inc. |
Combination of an anaplastic lymphoma kinase inhibitor and a cyclin dependent kinase inhibitor
|
|
US10988479B1
(en)
|
2020-06-15 |
2021-04-27 |
G1 Therapeutics, Inc. |
Morphic forms of trilaciclib and methods of manufacture thereof
|
|
IL299871A
(en)
|
2020-07-15 |
2023-03-01 |
Pfizer |
Methods and combinations of KAT6 inhibitors for the treatment of cancer
|
|
WO2022018596A1
(en)
|
2020-07-20 |
2022-01-27 |
Pfizer Inc. |
Combination therapy
|
|
CN114246841B
(zh)
*
|
2020-09-24 |
2024-02-02 |
南京济群医药科技股份有限公司 |
一种羟乙磺酸哌柏西利的组合物及药物
|
|
CN114306245A
(zh)
|
2020-09-29 |
2022-04-12 |
深圳市药欣生物科技有限公司 |
无定形固体分散体的药物组合物及其制备方法
|
|
WO2022091001A1
(en)
|
2020-10-29 |
2022-05-05 |
Pfizer Ireland Pharmaceuticals |
Process for preparation of palbociclib
|
|
WO2022123419A1
(en)
|
2020-12-08 |
2022-06-16 |
Pfizer Inc. |
Treatment of luminal subtypes of hr-positive, her2-negative early breast cancer with palbociclib
|
|
CN113845520A
(zh)
*
|
2021-09-09 |
2021-12-28 |
安徽皓元药业有限公司 |
一种帕布昔利布乳清酸盐及其制备方法
|
|
WO2023107525A1
(en)
|
2021-12-10 |
2023-06-15 |
Eli Lilly And Company |
Cdk4 and 6 inhibitor in combination with fulvestrant for the treatment of hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced or metastatic breast cancer in patients previously treated with a cdk4 and 6 inhibitor
|
|
WO2023111810A1
(en)
|
2021-12-14 |
2023-06-22 |
Pfizer Inc. |
Combination therapies and uses for treating cancer
|
|
WO2023114264A1
(en)
|
2021-12-15 |
2023-06-22 |
Eli Lilly And Company |
Combination for treatment of high-risk metastatic hormone-sensitive prostate cancer
|
|
CN114195784A
(zh)
*
|
2021-12-29 |
2022-03-18 |
斯坦德标准技术研究(湖北)有限公司 |
帕博西尼有关物质及其制备方法和应用
|
|
EP4302832A1
(en)
|
2022-07-07 |
2024-01-10 |
Lotus Pharmaceutical Co., Ltd. |
Palbociclib formulation containing glucono delta lactone
|
|
EP4302755A1
(en)
|
2022-07-07 |
2024-01-10 |
Lotus Pharmaceutical Co., Ltd. |
Palbociclib formulation containing an amino acid
|
|
WO2024023703A1
(en)
|
2022-07-29 |
2024-02-01 |
Pfizer Inc. |
Dosing regimens comprising a kat6 inhibitor for the treatment of cancer
|
|
WO2024049926A1
(en)
|
2022-08-31 |
2024-03-07 |
Arvinas Operations, Inc. |
Dosage regimens of estrogen receptor degraders
|
|
JP2024067010A
(ja)
|
2022-11-02 |
2024-05-16 |
ペトラ・ファーマ・コーポレイション |
疾患の治療用のホスホイノシチド３－キナーゼ（ｐｉ３ｋ）のアロステリッククロメノン阻害剤
|