PE20050465A1 - Compuestos derivados de quinuclidina como antagonistas del receptor muscarinico m3 - Google Patents

Compuestos derivados de quinuclidina como antagonistas del receptor muscarinico m3

Info

Publication number
PE20050465A1
PE20050465A1 PE2004000435A PE2004000435A PE20050465A1 PE 20050465 A1 PE20050465 A1 PE 20050465A1 PE 2004000435 A PE2004000435 A PE 2004000435A PE 2004000435 A PE2004000435 A PE 2004000435A PE 20050465 A1 PE20050465 A1 PE 20050465A1
Authority
PE
Peru
Prior art keywords
azonia
acetoxy
octane
bicycle
diphenyl
Prior art date
Application number
PE2004000435A
Other languages
English (en)
Inventor
Stephen Paul Collingwood
Brian Cox
Urs Baettig
Gurdip Bhalay
Nicholas James Devereux
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33420896&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20050465(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0324887A external-priority patent/GB0324887D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20050465A1 publication Critical patent/PE20050465A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE QUINUCLIDINA DE FORMULA (I), DONDE R1 Y R3 SON INDEPENDIENTEMENTE, CARBOCICLICO (C3-C15), O UN HETEROCICLO DE 4 A 12 MIEMBROS Y POR LO MENOS CON UN ANILLO HETEROGENEO SELECCIONADO DE N, O Y S; O -CR1R2R3 JUNTOS FORMAN UN GRUPO DE FORMULA (i) DONDE R ES -O-, -S-, -CH2-, -CH=CH-, -CH2-CH2-, AMINO O -N(CH3)-; R2 ES H, HALOGENO, -OH, ALCOXI O ALQUILO(C1-C8); R4 ES ALQUILO(C1-C8) SUSTITUIDO POR -NR5, -NR5-CO-R6, -NR5-CO-NH-R7-, ENTRE OTROS, O ES ALQUINILO(C3-C10), OPCIONALMENTE SUSTITUIDO. SON COMPUESTOS PREFERIDOS: TRIFLUOROACETATO DE (R)-3-(2-HIDROXI-2,2-DIFENIL-ACETOXI)-1-[3-(3-FENIL-UREIDO)-PROPIL]1-AZONIA-BICICLO[2,2,2]-OCTANO, (R)-3-(2-HIDROXI-2,2-DIFENIL-ACETOXI)-1-FENILCARBAMOILMETIL-1-AZONIA-BICICLO[2,2,2]-OCTANO, BROMURO DE (R)-3-(2-FLUORO-2,2-DIFENIL-ACETOXI)-1-FENOXICARBONILMETIL-1-AZONIA-BICICLO[2,2,2]-OCTANO, ENTRE OTROS. TAMBIEN SE REFIERE A PROCEDIMIENTO DE OBTENCION. ESTOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR MUSCARINICO M3 Y PUEDEN PRESENTARSE EN COMBINACION CON UN ANTIINFLAMATORIO, BRONCODILATADOR, ANTIHISTAMINICO, ENTRE OTROS, Y SON UTILES PARA ELTRATAMIENTO DE ENFERMEDADES INFLAMATORIAS U OBSTRUCTIVAS DE LAS VIAS RESPIRATORIAS
PE2004000435A 2003-05-02 2004-04-30 Compuestos derivados de quinuclidina como antagonistas del receptor muscarinico m3 PE20050465A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0310232 2003-05-02
GB0324887A GB0324887D0 (en) 2003-10-24 2003-10-24 Organic compounds

Publications (1)

Publication Number Publication Date
PE20050465A1 true PE20050465A1 (es) 2005-07-18

Family

ID=33420896

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2004000435A PE20050465A1 (es) 2003-05-02 2004-04-30 Compuestos derivados de quinuclidina como antagonistas del receptor muscarinico m3

Country Status (32)

Country Link
US (2) US20070060563A1 (es)
EP (1) EP1631569B1 (es)
JP (1) JP4416786B2 (es)
KR (1) KR100896544B1 (es)
AR (1) AR044134A1 (es)
AT (1) ATE440840T1 (es)
AU (1) AU2004234069B2 (es)
BR (1) BRPI0410238A (es)
CA (1) CA2523436C (es)
CL (1) CL2004000918A1 (es)
CO (1) CO5700782A2 (es)
CY (1) CY1109655T1 (es)
DE (1) DE602004022805D1 (es)
DK (1) DK1631569T3 (es)
EC (1) ECSP056134A (es)
ES (1) ES2331185T3 (es)
HK (1) HK1087704A1 (es)
HR (1) HRP20050933A2 (es)
IL (1) IL171591A (es)
IS (1) IS2746B (es)
MA (1) MA27775A1 (es)
MX (1) MXPA05011739A (es)
MY (1) MY142652A (es)
NO (1) NO20055688L (es)
NZ (1) NZ542995A (es)
PE (1) PE20050465A1 (es)
PL (1) PL1631569T3 (es)
PT (1) PT1631569E (es)
RU (1) RU2363700C2 (es)
SI (1) SI1631569T1 (es)
TW (1) TWI340139B (es)
WO (1) WO2004096800A2 (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2239546B1 (es) * 2004-03-15 2006-12-01 Almirall Prodesfarma, S.A. Nuevos esteres de quinuclidina cuaternizados.
GB0410712D0 (en) 2004-05-13 2004-06-16 Novartis Ag Organic compounds
GB0424284D0 (en) 2004-11-02 2004-12-01 Novartis Ag Organic compounds
GB0428416D0 (en) 2004-12-24 2005-02-02 Novartis Ag Organic compounds
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
EP1900737A1 (en) * 2006-08-31 2008-03-19 Novartis AG Polymorph of (R)-3-(2-hydroxy-2,2-diphenyl-acetoxy)-1-(isoxazol-3-ylcarbamoyl-methyl)-1-azonia-bicyclo-[2.2.2]octane bromide
EP1894568A1 (en) * 2006-08-31 2008-03-05 Novartis AG Pharmaceutical compositions for the treatment of inflammatory or obstructive airway diseases
TW200825084A (en) 2006-11-14 2008-06-16 Astrazeneca Ab New compounds 521
ATE555111T1 (de) * 2006-12-19 2012-05-15 Astrazeneca Ab Chinuclidinol-derivate als muscarinrezeptor- antagonisten
EP1950196A1 (de) * 2007-01-29 2008-07-30 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Ammoniumhexafluorophosphaten
PL2197841T3 (pl) 2007-09-07 2012-04-30 Theravance Inc Związki zawierające guanidynę przydatne jako antagoniści receptorów
EP2222637A1 (en) 2007-12-14 2010-09-01 Theravance, Inc. Amidine-containing compounds useful as muscarinic receptor antagonists
PL2231642T3 (pl) 2008-01-11 2014-04-30 Novartis Ag Pirymidyny jako inhibitory kinazy
EP2300464A1 (en) 2008-05-13 2011-03-30 AstraZeneca AB Quinuclidine derivatives as muscarinic m3 receptor antagonists
CN102088976B (zh) * 2008-05-13 2012-12-26 阿斯利康(瑞典)有限公司 包含毒蕈碱性受体拮抗剂和β2-肾上腺素受体激动剂的药物产品
GB0808709D0 (en) * 2008-05-13 2008-06-18 Astrazeneca Ab New combination 295
US20090326004A1 (en) 2008-06-03 2009-12-31 Ranbaxy Laboratories Limited Muscarinic receptor antagonists
WO2009153536A1 (en) * 2008-06-17 2009-12-23 Argenta Discovery Limited 1-aza-bicyclo [2.2.2] octane derivatives useful as muscarinic receptor antagonists
GB0811100D0 (en) * 2008-06-17 2008-07-23 Astrazeneca Ab New combination
RU2580835C2 (ru) * 2010-06-22 2016-04-10 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Алкалоидные производные на основе сложных аминоэфиров и композиции лекарственных средств, содержащие их
US8637516B2 (en) 2010-09-09 2014-01-28 Irm Llc Compounds and compositions as TRK inhibitors
WO2012034095A1 (en) 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
CA2828219A1 (en) 2011-02-25 2012-08-30 Irm Llc Pyrazolo [1,5-a] pyridines as trk inhibitors
JP2011195593A (ja) * 2011-06-30 2011-10-06 Astrazeneca Ab ムスカリンｍ３受容体アンタゴニストとしてのキヌクリジン誘導体
CA2862008A1 (en) * 2011-12-30 2013-07-04 Chiesi Farmaceutici S.P.A. Quinuclidine esters of 1-azaheterocyclylacetic acid as antimuscarinic agents, process for their preparation and medicinal compositions thereof
EP2844251B1 (en) * 2012-05-03 2018-08-01 Saint Louis College of Pharmacy Compositions and methods for increasing neurotrophic peptides
TWI647227B (zh) * 2013-02-28 2019-01-11 日商安斯泰來製藥股份有限公司 ２－醯胺噻唑衍生物或其鹽
CZ306791B6 (cs) 2013-10-29 2017-07-12 Zentiva, K.S. Průmyslově využitelný způsob přípravy aklidinium bromidu o vysoké čistotě
PT108370B (pt) * 2015-03-30 2018-10-25 Hovione Farm S A Processo de preparação de brometo de aclidínio
EP3111978B1 (en) 2015-07-03 2021-09-01 Novartis AG Inhaler adapted to read information stored in a data storage means of a container

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1219606A (en) * 1968-07-15 1971-01-20 Rech S Et D Applic Scient Soge Quinuclidinol derivatives and preparation thereof
DK534178A (da) * 1977-12-16 1979-06-17 Interx Research Corp Anticholinerge midler med sektrtionshaemmende virkning
ES2165768B1 (es) * 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
WO2002004402A1 (fr) * 2000-07-11 2002-01-17 Banyu Pharmaceutical Co., Ltd. Derives d'ester
CN1250545C (zh) * 2000-12-28 2006-04-12 阿尔米雷尔普罗迪斯制药有限公司 新的奎宁环衍生物类及含有这类衍生物的药物组合物
IL162596A0 (en) * 2001-12-20 2005-11-20 S A L V A T Lab Sa 1-Alkyl-1-azoniabicyclo Ä2.2.2Ü octane carbamate derivatives and their use as muscarinic receptor ntagonists
GB0424284D0 (en) * 2004-11-02 2004-12-01 Novartis Ag Organic compounds
EP1900737A1 (en) * 2006-08-31 2008-03-19 Novartis AG Polymorph of (R)-3-(2-hydroxy-2,2-diphenyl-acetoxy)-1-(isoxazol-3-ylcarbamoyl-methyl)-1-azonia-bicyclo-[2.2.2]octane bromide

Also Published As

Publication number Publication date
US8168654B2 (en) 2012-05-01
EP1631569B1 (en) 2009-08-26
DK1631569T3 (da) 2009-11-23
CY1109655T1 (el) 2014-08-13
MA27775A1 (fr) 2006-02-01
PT1631569E (pt) 2009-11-26
BRPI0410238A (pt) 2006-05-16
AU2004234069A1 (en) 2004-11-11
HK1087704A1 (en) 2006-10-20
CO5700782A2 (es) 2006-11-30
HRP20050933A2 (en) 2006-12-31
IS8158A (is) 2005-11-30
ES2331185T3 (es) 2009-12-23
KR100896544B1 (ko) 2009-05-07
CA2523436A1 (en) 2004-11-11
RU2363700C2 (ru) 2009-08-10
IS2746B (is) 2011-08-15
ATE440840T1 (de) 2009-09-15
MXPA05011739A (es) 2006-01-26
CA2523436C (en) 2011-11-01
CL2004000918A1 (es) 2005-02-11
NO20055688L (no) 2006-01-09
WO2004096800A2 (en) 2004-11-11
KR20060015572A (ko) 2006-02-17
US20070060563A1 (en) 2007-03-15
JP4416786B2 (ja) 2010-02-17
AR044134A1 (es) 2005-08-24
ECSP056134A (es) 2006-04-19
NZ542995A (en) 2009-02-28
TWI340139B (en) 2011-04-11
TW200505920A (en) 2005-02-16
PL1631569T3 (pl) 2010-02-26
SI1631569T1 (sl) 2010-01-29
AU2004234069B2 (en) 2008-02-21
EP1631569A2 (en) 2006-03-08
JP2006525267A (ja) 2006-11-09
DE602004022805D1 (de) 2009-10-08
MY142652A (en) 2010-12-15
NO20055688D0 (no) 2005-12-01
RU2005137360A (ru) 2006-07-27
WO2004096800A3 (en) 2005-01-06
US20100041887A1 (en) 2010-02-18
IL171591A (en) 2010-11-30

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