CY1109655T1 - Συνδεση των παραγωγων κινουκλιδινης στους μουσκαρινικους υποδοχεις μ3 - Google Patents

Συνδεση των παραγωγων κινουκλιδινης στους μουσκαρινικους υποδοχεις μ3

Info

Publication number
CY1109655T1
CY1109655T1 CY20091101230T CY091101230T CY1109655T1 CY 1109655 T1 CY1109655 T1 CY 1109655T1 CY 20091101230 T CY20091101230 T CY 20091101230T CY 091101230 T CY091101230 T CY 091101230T CY 1109655 T1 CY1109655 T1 CY 1109655T1
Authority
CY
Cyprus
Prior art keywords
kinoclidin
muscaric
producers
receptors
connection
Prior art date
Application number
CY20091101230T
Other languages
English (en)
Inventor
Stephen Paul Collingwood
Brian Cox
Urs Boettig
Gurdip Bhalay
Nicholas James Devereux
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33420896&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1109655(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0324887A external-priority patent/GB0324887D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CY1109655T1 publication Critical patent/CY1109655T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Οι ενώσεις του χημικού τύπου (Ι), σε μορφή άλατος ή διιοντική μορφή στις οποίες οι R1, R2, R3 και R4 έχουν τις ερμηνείες που ορίστηκαν στην περιγραφή, είναι χρήσιμες στη θεραπεία καταστάσεων οι οποίες μεσολαβούνται από τον μουσκαρινικό υποδοχέα Μ3. Περιγράφονται επίσης τα φαρμακευτικά σκευάσματα τα οποία περιέχουν τις ενώσεις αυτές και μια διαδικασία για την παρασκευή των ενώσεων αυτών.
CY20091101230T 2003-05-02 2009-11-25 Συνδεση των παραγωγων κινουκλιδινης στους μουσκαρινικους υποδοχεις μ3 CY1109655T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0310232 2003-05-02
GB0324887A GB0324887D0 (en) 2003-10-24 2003-10-24 Organic compounds
EP04730519A EP1631569B1 (en) 2003-05-02 2004-04-30 Quinuclidine derivatives binding to mucarinic m3 receptors

Publications (1)

Publication Number Publication Date
CY1109655T1 true CY1109655T1 (el) 2014-08-13

Family

ID=33420896

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20091101230T CY1109655T1 (el) 2003-05-02 2009-11-25 Συνδεση των παραγωγων κινουκλιδινης στους μουσκαρινικους υποδοχεις μ3

Country Status (32)

Country Link
US (2) US20070060563A1 (el)
EP (1) EP1631569B1 (el)
JP (1) JP4416786B2 (el)
KR (1) KR100896544B1 (el)
AR (1) AR044134A1 (el)
AT (1) ATE440840T1 (el)
AU (1) AU2004234069B2 (el)
BR (1) BRPI0410238A (el)
CA (1) CA2523436C (el)
CL (1) CL2004000918A1 (el)
CO (1) CO5700782A2 (el)
CY (1) CY1109655T1 (el)
DE (1) DE602004022805D1 (el)
DK (1) DK1631569T3 (el)
EC (1) ECSP056134A (el)
ES (1) ES2331185T3 (el)
HK (1) HK1087704A1 (el)
HR (1) HRP20050933A2 (el)
IL (1) IL171591A (el)
IS (1) IS2746B (el)
MA (1) MA27775A1 (el)
MX (1) MXPA05011739A (el)
MY (1) MY142652A (el)
NO (1) NO20055688L (el)
NZ (1) NZ542995A (el)
PE (1) PE20050465A1 (el)
PL (1) PL1631569T3 (el)
PT (1) PT1631569E (el)
RU (1) RU2363700C2 (el)
SI (1) SI1631569T1 (el)
TW (1) TWI340139B (el)
WO (1) WO2004096800A2 (el)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
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ES2239546B1 (es) * 2004-03-15 2006-12-01 Almirall Prodesfarma, S.A. Nuevos esteres de quinuclidina cuaternizados.
GB0410712D0 (en) 2004-05-13 2004-06-16 Novartis Ag Organic compounds
GB0424284D0 (en) 2004-11-02 2004-12-01 Novartis Ag Organic compounds
GB0428416D0 (en) 2004-12-24 2005-02-02 Novartis Ag Organic compounds
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
EP1900737A1 (en) * 2006-08-31 2008-03-19 Novartis AG Polymorph of (R)-3-(2-hydroxy-2,2-diphenyl-acetoxy)-1-(isoxazol-3-ylcarbamoyl-methyl)-1-azonia-bicyclo-[2.2.2]octane bromide
EP1894568A1 (en) * 2006-08-31 2008-03-05 Novartis AG Pharmaceutical compositions for the treatment of inflammatory or obstructive airway diseases
TW200825084A (en) 2006-11-14 2008-06-16 Astrazeneca Ab New compounds 521
ATE555111T1 (de) * 2006-12-19 2012-05-15 Astrazeneca Ab Chinuclidinol-derivate als muscarinrezeptor- antagonisten
EP1950196A1 (de) * 2007-01-29 2008-07-30 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Ammoniumhexafluorophosphaten
PL2197841T3 (pl) 2007-09-07 2012-04-30 Theravance Inc Związki zawierające guanidynę przydatne jako antagoniści receptorów
EP2222637A1 (en) 2007-12-14 2010-09-01 Theravance, Inc. Amidine-containing compounds useful as muscarinic receptor antagonists
PL2231642T3 (pl) 2008-01-11 2014-04-30 Novartis Ag Pirymidyny jako inhibitory kinazy
EP2300464A1 (en) 2008-05-13 2011-03-30 AstraZeneca AB Quinuclidine derivatives as muscarinic m3 receptor antagonists
CN102088976B (zh) * 2008-05-13 2012-12-26 阿斯利康(瑞典)有限公司 包含毒蕈碱性受体拮抗剂和β2-肾上腺素受体激动剂的药物产品
GB0808709D0 (en) * 2008-05-13 2008-06-18 Astrazeneca Ab New combination 295
US20090326004A1 (en) 2008-06-03 2009-12-31 Ranbaxy Laboratories Limited Muscarinic receptor antagonists
WO2009153536A1 (en) * 2008-06-17 2009-12-23 Argenta Discovery Limited 1-aza-bicyclo [2.2.2] octane derivatives useful as muscarinic receptor antagonists
GB0811100D0 (en) * 2008-06-17 2008-07-23 Astrazeneca Ab New combination
RU2580835C2 (ru) * 2010-06-22 2016-04-10 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Алкалоидные производные на основе сложных аминоэфиров и композиции лекарственных средств, содержащие их
US8637516B2 (en) 2010-09-09 2014-01-28 Irm Llc Compounds and compositions as TRK inhibitors
WO2012034095A1 (en) 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
CA2828219A1 (en) 2011-02-25 2012-08-30 Irm Llc Pyrazolo [1,5-a] pyridines as trk inhibitors
JP2011195593A (ja) * 2011-06-30 2011-10-06 Astrazeneca Ab ムスカリンｍ３受容体アンタゴニストとしてのキヌクリジン誘導体
CA2862008A1 (en) * 2011-12-30 2013-07-04 Chiesi Farmaceutici S.P.A. Quinuclidine esters of 1-azaheterocyclylacetic acid as antimuscarinic agents, process for their preparation and medicinal compositions thereof
EP2844251B1 (en) * 2012-05-03 2018-08-01 Saint Louis College of Pharmacy Compositions and methods for increasing neurotrophic peptides
TWI647227B (zh) * 2013-02-28 2019-01-11 日商安斯泰來製藥股份有限公司 ２－醯胺噻唑衍生物或其鹽
CZ306791B6 (cs) 2013-10-29 2017-07-12 Zentiva, K.S. Průmyslově využitelný způsob přípravy aklidinium bromidu o vysoké čistotě
PT108370B (pt) * 2015-03-30 2018-10-25 Hovione Farm S A Processo de preparação de brometo de aclidínio
EP3111978B1 (en) 2015-07-03 2021-09-01 Novartis AG Inhaler adapted to read information stored in a data storage means of a container

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1219606A (en) * 1968-07-15 1971-01-20 Rech S Et D Applic Scient Soge Quinuclidinol derivatives and preparation thereof
DK534178A (da) * 1977-12-16 1979-06-17 Interx Research Corp Anticholinerge midler med sektrtionshaemmende virkning
ES2165768B1 (es) * 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
WO2002004402A1 (fr) * 2000-07-11 2002-01-17 Banyu Pharmaceutical Co., Ltd. Derives d'ester
CN1250545C (zh) * 2000-12-28 2006-04-12 阿尔米雷尔普罗迪斯制药有限公司 新的奎宁环衍生物类及含有这类衍生物的药物组合物
IL162596A0 (en) * 2001-12-20 2005-11-20 S A L V A T Lab Sa 1-Alkyl-1-azoniabicyclo Ä2.2.2Ü octane carbamate derivatives and their use as muscarinic receptor ntagonists
GB0424284D0 (en) * 2004-11-02 2004-12-01 Novartis Ag Organic compounds
EP1900737A1 (en) * 2006-08-31 2008-03-19 Novartis AG Polymorph of (R)-3-(2-hydroxy-2,2-diphenyl-acetoxy)-1-(isoxazol-3-ylcarbamoyl-methyl)-1-azonia-bicyclo-[2.2.2]octane bromide

Also Published As

Publication number Publication date
US8168654B2 (en) 2012-05-01
EP1631569B1 (en) 2009-08-26
DK1631569T3 (da) 2009-11-23
MA27775A1 (fr) 2006-02-01
PT1631569E (pt) 2009-11-26
BRPI0410238A (pt) 2006-05-16
AU2004234069A1 (en) 2004-11-11
HK1087704A1 (en) 2006-10-20
CO5700782A2 (es) 2006-11-30
HRP20050933A2 (en) 2006-12-31
PE20050465A1 (es) 2005-07-18
IS8158A (is) 2005-11-30
ES2331185T3 (es) 2009-12-23
KR100896544B1 (ko) 2009-05-07
CA2523436A1 (en) 2004-11-11
RU2363700C2 (ru) 2009-08-10
IS2746B (is) 2011-08-15
ATE440840T1 (de) 2009-09-15
MXPA05011739A (es) 2006-01-26
CA2523436C (en) 2011-11-01
CL2004000918A1 (es) 2005-02-11
NO20055688L (no) 2006-01-09
WO2004096800A2 (en) 2004-11-11
KR20060015572A (ko) 2006-02-17
US20070060563A1 (en) 2007-03-15
JP4416786B2 (ja) 2010-02-17
AR044134A1 (es) 2005-08-24
ECSP056134A (es) 2006-04-19
NZ542995A (en) 2009-02-28
TWI340139B (en) 2011-04-11
TW200505920A (en) 2005-02-16
PL1631569T3 (pl) 2010-02-26
SI1631569T1 (sl) 2010-01-29
AU2004234069B2 (en) 2008-02-21
EP1631569A2 (en) 2006-03-08
JP2006525267A (ja) 2006-11-09
DE602004022805D1 (de) 2009-10-08
MY142652A (en) 2010-12-15
NO20055688D0 (no) 2005-12-01
RU2005137360A (ru) 2006-07-27
WO2004096800A3 (en) 2005-01-06
US20100041887A1 (en) 2010-02-18
IL171591A (en) 2010-11-30

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