PE75199A1 - Derivado de quinolina util como antagonista de neuroquinina - Google Patents
Derivado de quinolina util como antagonista de neuroquininaInfo
- Publication number
- PE75199A1 PE75199A1 PE1998000398A PE00039898A PE75199A1 PE 75199 A1 PE75199 A1 PE 75199A1 PE 1998000398 A PE1998000398 A PE 1998000398A PE 00039898 A PE00039898 A PE 00039898A PE 75199 A1 PE75199 A1 PE 75199A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- neuroquinine
- compound
- antagonist
- rent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
- C07D251/52—Two nitrogen atoms with an oxygen or sulfur atom attached to the third ring carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA (I), SU SAL O SOLVATO; DONDE Ar ES ARILO, CICLOALCADIENILO C5-C7, CICLOALQUILO C5-C7, HETEROCICLO AROMATICO UNICO O CONDENSADO OPCIONALMENTE SUSTITUIDO; R ES ALQUILO C1-C6, CICLOALQUILO C3-C7, CICLOALQUIL C3-C7-ALQUILO, ENTRE OTROS; R1 ES H, HASTA 4 ALQUILO C1-C6, ALQUENILO C1-C6, ENTRE OTROS; R2 ES -(CH2)n-NY1Y2; n ES 1-9; Y1 E Y2 SON H, ALQUILO C1-C6 OPCIONALMENTE SUSTITUIDO CON HIDROXI, (ALQUIL C1-C6)-AMINO, ENTRE OTROS; O Y1 E Y2 JUNTO A N FORMAN UN HETEROCICLO SIMPLE O CONDENSADO, OPCIONALMENTE SUSTITUIDO; R3 ES ALQUILO C1-C6, CICLOALQUILO C3-C7, CICLOALQUILALQUILO C4-C7, ENTRE OTROS; R4 ES H o ALQUILO C1-C6. UN COMPUESTO PREFERIDO ES HIDROCLORURO DE (S)-N-(O-ETIL-BENCIL)-3-[(S)-2-(METOXICARBONIL)PIRROLIDIN-1-IL]-2-FENILQUINOLINA-4-CARBOXAMIDA. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO (I) PUEDE SER UTIL PARA EL TRATAMIENTO DE CONDICIONES PRIMARIAS O SECUNDARIAS COMO ENFERMEDADES RESPIRATORIAS, INFLAMATORIAS, CUTANEAS AL SER ANTAGONISTAS DE NEUROQUININA A NIVEL DE LOS RECEPTORES NK2 Y NK3
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9710750.2A GB9710750D0 (en) | 1997-05-23 | 1997-05-23 | Novel compounds |
IT002354 IT1295358B1 (it) | 1997-10-17 | 1997-10-17 | Derivati chinolinici procedimento per la loro preparazione e uso come antagonisti del recettore nk3 |
ITMI972775 IT1296976B1 (it) | 1997-12-16 | 1997-12-16 | Derivati chinolinici procedimento per la loro preparazione e uso come antagonisti del recettore nk3 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE75199A1 true PE75199A1 (es) | 1999-10-22 |
Family
ID=27268859
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1998000398A PE75199A1 (es) | 1997-05-23 | 1998-05-20 | Derivado de quinolina util como antagonista de neuroquinina |
Country Status (26)
Country | Link |
---|---|
EP (1) | EP0983262B1 (es) |
JP (1) | JP2002500645A (es) |
CN (1) | CN1264378A (es) |
AP (1) | AP9901695A0 (es) |
AR (1) | AR012732A1 (es) |
AT (1) | ATE244711T1 (es) |
AU (1) | AU8209898A (es) |
BG (1) | BG104009A (es) |
BR (1) | BR9809652A (es) |
CA (1) | CA2291111A1 (es) |
CO (1) | CO4950515A1 (es) |
DE (1) | DE69816290T2 (es) |
DZ (1) | DZ2498A1 (es) |
EA (1) | EA199901062A1 (es) |
ES (1) | ES2201509T3 (es) |
HU (1) | HUP0002300A3 (es) |
ID (1) | ID22876A (es) |
IL (1) | IL133036A0 (es) |
MA (1) | MA26501A1 (es) |
NO (1) | NO995711L (es) |
OA (1) | OA11515A (es) |
PE (1) | PE75199A1 (es) |
PL (1) | PL336942A1 (es) |
SK (1) | SK159299A3 (es) |
TR (1) | TR199902883T2 (es) |
WO (1) | WO1998052942A1 (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6780875B2 (en) * | 1998-11-20 | 2004-08-24 | Smithkline Beecham S.P.A. | Quinoline-4-carboxamide derivatives as NK-3 and NK-2 receptor antagonists |
GB9825554D0 (en) * | 1998-11-20 | 1999-01-13 | Smithkline Beecham Spa | Novel Compounds |
MXPA01005095A (es) * | 1998-11-20 | 2002-04-24 | Smithkline Beecham Spa | Derivados de quinolin-4-carboxamida como antagonistas de receptor de neurocinina-3 y neurocinina-2. |
ATE247652T1 (de) | 1999-03-29 | 2003-09-15 | Neurogen Corp | 4-substituierte chinolinderivate als nk-3 und/oder gaba(a) rezeptor liganden |
AU4802500A (en) | 1999-04-26 | 2000-11-10 | Neurogen Corporation | 2-aminoquinolinecarboxamides: neurokinin receptor ligands |
WO2002013825A1 (en) * | 2000-08-11 | 2002-02-21 | Smithkline Beecham P.L.C. | Novel pharmaceutical use of quinnoline derivatives |
AU2002220702A1 (en) * | 2000-11-13 | 2002-05-21 | Glaxosmithkline S.P.A. | Quinoline derivatives as nk-3 and nk-2 antagonists |
GB0028964D0 (en) * | 2000-11-28 | 2001-01-10 | Smithkline Beecham Spa | Novel compounds |
WO2002044165A1 (en) * | 2000-11-28 | 2002-06-06 | Glaxosmithkline Spa | Quinoline derivatives as nk-3 antagonists |
US6540733B2 (en) | 2000-12-29 | 2003-04-01 | Corazon Technologies, Inc. | Proton generating catheters and methods for their use in enhancing fluid flow through a vascular site occupied by a calcified vascular occlusion |
GB0109122D0 (en) * | 2001-04-11 | 2001-05-30 | Smithkline Beecham Spa | Novel compounds |
ES2259096T3 (es) * | 2001-04-11 | 2006-09-16 | Glaxosmithkline S.P.A. | Derivados de quinolina-4-carboxamida 3-sustituida como antagonistas de los receptores nk-3 y nk-2. |
MY134211A (en) * | 2001-05-18 | 2007-11-30 | Smithkline Beecham Corp | Novel use |
GB0425076D0 (en) * | 2004-11-12 | 2004-12-15 | Smithkline Beecham Corp | Novel compounds |
GB0425075D0 (en) * | 2004-11-12 | 2004-12-15 | Smithkline Beecham Corp | Novel compounds |
GB0425077D0 (en) * | 2004-11-12 | 2004-12-15 | Smithkline Beecham Corp | Novel compounds |
KR20080016591A (ko) * | 2005-06-03 | 2008-02-21 | 아스트라제네카 아베 | Nk3 길항제로서의 퀴놀린 유도체 |
GB0515580D0 (en) | 2005-07-29 | 2005-09-07 | Merck Sharp & Dohme | Therapeutic compounds |
AR057130A1 (es) | 2005-09-21 | 2007-11-14 | Astrazeneca Ab | Quinolinas de alquilsulfoxido y una composicion farmaceutica |
DE202007017299U1 (de) * | 2007-12-12 | 2009-04-23 | Drebo Werkzeugfabrik Gmbh | Bohrer |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL186665B1 (pl) * | 1994-05-27 | 2004-02-27 | Smithkline Beecham Spa | Pochodne chinoliny jako antagoniści receptorów NKtachykininy, sposób ich wytwarzania, kompozycja farmaceutyczna zawierająca pochodne chinoliny oraz ich zastosowanie |
AR004735A1 (es) * | 1995-11-24 | 1999-03-10 | Smithkline Beecham Spa | Quinoleina 4-amido sustituida, un procedimiento para su preparacion, una composicion farmaceutica que los contiene y el uso de los mismos para lapreparacion de un medicamento. |
-
1998
- 1998-05-18 DE DE69816290T patent/DE69816290T2/de not_active Expired - Fee Related
- 1998-05-18 BR BR9809652-4A patent/BR9809652A/pt not_active IP Right Cessation
- 1998-05-18 EP EP98932069A patent/EP0983262B1/en not_active Expired - Lifetime
- 1998-05-18 CA CA002291111A patent/CA2291111A1/en not_active Abandoned
- 1998-05-18 ES ES98932069T patent/ES2201509T3/es not_active Expired - Lifetime
- 1998-05-18 EA EA199901062A patent/EA199901062A1/ru unknown
- 1998-05-18 TR TR1999/02883T patent/TR199902883T2/xx unknown
- 1998-05-18 WO PCT/EP1998/003014 patent/WO1998052942A1/en not_active Application Discontinuation
- 1998-05-18 IL IL13303698A patent/IL133036A0/xx unknown
- 1998-05-18 ID IDW991432A patent/ID22876A/id unknown
- 1998-05-18 AU AU82098/98A patent/AU8209898A/en not_active Abandoned
- 1998-05-18 AT AT98932069T patent/ATE244711T1/de not_active IP Right Cessation
- 1998-05-18 SK SK1592-99A patent/SK159299A3/sk unknown
- 1998-05-18 HU HU0002300A patent/HUP0002300A3/hu unknown
- 1998-05-18 PL PL98336942A patent/PL336942A1/xx unknown
- 1998-05-18 CN CN98807356A patent/CN1264378A/zh active Pending
- 1998-05-18 AP APAP/P/1999/001695A patent/AP9901695A0/en unknown
- 1998-05-18 JP JP54996798A patent/JP2002500645A/ja not_active Ceased
- 1998-05-19 DZ DZ980108A patent/DZ2498A1/xx active
- 1998-05-20 PE PE1998000398A patent/PE75199A1/es not_active Application Discontinuation
- 1998-05-21 MA MA25086A patent/MA26501A1/fr unknown
- 1998-05-21 AR ARP980102363A patent/AR012732A1/es not_active Application Discontinuation
- 1998-05-22 CO CO98029024A patent/CO4950515A1/es unknown
-
1999
- 1999-11-22 NO NO995711A patent/NO995711L/no not_active Application Discontinuation
- 1999-11-23 OA OA9900253A patent/OA11515A/en unknown
- 1999-12-14 BG BG104009A patent/BG104009A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
ID22876A (id) | 1999-12-16 |
DZ2498A1 (fr) | 2003-01-25 |
EP0983262A1 (en) | 2000-03-08 |
PL336942A1 (en) | 2000-07-17 |
DE69816290D1 (de) | 2003-08-14 |
CA2291111A1 (en) | 1998-11-26 |
EP0983262B1 (en) | 2003-07-09 |
AU8209898A (en) | 1998-12-11 |
JP2002500645A (ja) | 2002-01-08 |
ATE244711T1 (de) | 2003-07-15 |
CN1264378A (zh) | 2000-08-23 |
AP9901695A0 (en) | 1999-12-31 |
SK159299A3 (en) | 2000-06-12 |
OA11515A (en) | 2004-02-04 |
CO4950515A1 (es) | 2000-09-01 |
HUP0002300A3 (en) | 2002-01-28 |
BG104009A (en) | 2000-07-31 |
WO1998052942A1 (en) | 1998-11-26 |
MA26501A1 (fr) | 2004-12-20 |
HUP0002300A2 (hu) | 2001-06-28 |
NO995711L (no) | 2000-01-19 |
NO995711D0 (no) | 1999-11-22 |
DE69816290T2 (de) | 2004-05-27 |
ES2201509T3 (es) | 2004-03-16 |
EA199901062A1 (ru) | 2000-08-28 |
IL133036A0 (en) | 2001-03-19 |
BR9809652A (pt) | 2001-09-11 |
AR012732A1 (es) | 2000-11-08 |
TR199902883T2 (xx) | 2000-05-22 |
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Legal Events
Date | Code | Title | Description |
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FC | Refusal |