PE20020958A1 - Inhibidores de la rho-quinasa - Google Patents
Inhibidores de la rho-quinasaInfo
- Publication number
- PE20020958A1 PE20020958A1 PE2002000225A PE2002000225A PE20020958A1 PE 20020958 A1 PE20020958 A1 PE 20020958A1 PE 2002000225 A PE2002000225 A PE 2002000225A PE 2002000225 A PE2002000225 A PE 2002000225A PE 20020958 A1 PE20020958 A1 PE 20020958A1
- Authority
- PE
- Peru
- Prior art keywords
- rho
- indazol
- refers
- compounds
- kinase inhibitors
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
SE REFIERE A 2-N-5'-AMINOINDAZOL-4-CLORO-6,7-DIMETOXIQUINAZOLINA; N-[2-[2,4-DICLOROFENIL)-4-QUINAZOLINIL]-N-(1H-INDAZOL-5-IL)AMINA; N2-(3-FLUOROFENIL)-N4-(1H-INDAZOL-5-IL)-6,7-DIMETOXI-2,4-QUINAZOLINADIAMINA Y COMPUESTOS QUINAZOLIL AMINO INDAZOL DE FORMULA III, IV, VI.TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS SON INHIBIDORES DE RhO-QUINASA Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE HIPERTENSION, ATEROSCLEROSIS, RESTENOSIS, ISQUEMIA CEREBRAL, VASOESPASMO CEREBRAL, DEGENERACION NEURONAL, LESIONES DE LA MEDULA ESPINAL, CANCER DE MAMA, COLON, PROSTATA, OVARIOS, CEREBRO, PULMON AFECCIONES TROMBOTICAS, ASMA, GLAUCOMA, OSTEOPOROSIS, DISFUNCION ERECTIL
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27797401P | 2001-03-23 | 2001-03-23 | |
US31533801P | 2001-08-29 | 2001-08-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20020958A1 true PE20020958A1 (es) | 2002-11-14 |
Family
ID=26958818
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2002000225A PE20020958A1 (es) | 2001-03-23 | 2002-03-22 | Inhibidores de la rho-quinasa |
Country Status (19)
Country | Link |
---|---|
US (3) | US20030087919A1 (es) |
EP (1) | EP1370552B1 (es) |
JP (1) | JP4320705B2 (es) |
AR (1) | AR035792A1 (es) |
AT (1) | ATE353889T1 (es) |
AU (1) | AU2002245709A1 (es) |
CA (1) | CA2441501C (es) |
CY (1) | CY1108041T1 (es) |
DE (1) | DE60218138T2 (es) |
DK (1) | DK1370552T3 (es) |
ES (1) | ES2280517T3 (es) |
HK (1) | HK1061029A1 (es) |
MX (1) | MXPA03008659A (es) |
MY (1) | MY142915A (es) |
PE (1) | PE20020958A1 (es) |
PT (1) | PT1370552E (es) |
TW (1) | TWI336328B (es) |
UY (1) | UY27225A1 (es) |
WO (1) | WO2002076977A2 (es) |
Families Citing this family (81)
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KR20230165846A (ko) | 2021-04-07 | 2023-12-05 | 후지필름 셀룰러 다이내믹스, 인코포레이티드 | 도파민성 전구세포 및 사용 방법 |
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WO2022259721A1 (ja) | 2021-06-10 | 2022-12-15 | 味の素株式会社 | 間葉系幹細胞の製造方法 |
WO2023017848A1 (ja) | 2021-08-11 | 2023-02-16 | 国立大学法人京都大学 | 腎間質前駆細胞の製造方法並びにエリスロポエチン産生細胞、およびレニン産生細胞の製造方法 |
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WO2024073776A1 (en) | 2022-09-30 | 2024-04-04 | FUJIFILM Cellular Dynamics, Inc. | Methods for the production of cardiac fibroblasts |
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- 2002-03-22 AU AU2002245709A patent/AU2002245709A1/en not_active Abandoned
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- 2002-03-22 DK DK02713884T patent/DK1370552T3/da active
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ES2280517T3 (es) | 2007-09-16 |
WO2002076977A3 (en) | 2002-12-12 |
MY142915A (en) | 2011-01-31 |
DE60218138T2 (de) | 2007-09-20 |
CA2441501A1 (en) | 2002-10-03 |
EP1370552B1 (en) | 2007-02-14 |
TWI336328B (en) | 2011-01-21 |
CY1108041T1 (el) | 2013-09-04 |
CA2441501C (en) | 2010-09-14 |
DK1370552T3 (da) | 2007-05-07 |
UY27225A1 (es) | 2002-10-31 |
PT1370552E (pt) | 2007-04-30 |
AU2002245709A1 (en) | 2002-10-08 |
US20100249159A1 (en) | 2010-09-30 |
EP1370552A2 (en) | 2003-12-17 |
ATE353889T1 (de) | 2007-03-15 |
DE60218138D1 (de) | 2007-03-29 |
US20060142314A1 (en) | 2006-06-29 |
AR035792A1 (es) | 2004-07-14 |
WO2002076977A2 (en) | 2002-10-03 |
JP2004528314A (ja) | 2004-09-16 |
HK1061029A1 (en) | 2004-09-03 |
MXPA03008659A (es) | 2005-04-08 |
JP4320705B2 (ja) | 2009-08-26 |
US20030087919A1 (en) | 2003-05-08 |
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