AR012634A1 - Compuesto basado en quinazolina, composicion famaceutica que lo comprende, metodo para sintetizarlo, su uso, metodos de modulacion de la funcion deserina/treonina proteinaquinasa con dicho compuesto y metodo in vitro para identificar compuestos que modulan dicha funcion - Google Patents
Compuesto basado en quinazolina, composicion famaceutica que lo comprende, metodo para sintetizarlo, su uso, metodos de modulacion de la funcion deserina/treonina proteinaquinasa con dicho compuesto y metodo in vitro para identificar compuestos que modulan dicha funcionInfo
- Publication number
- AR012634A1 AR012634A1 ARP980102020A ARP980102020A AR012634A1 AR 012634 A1 AR012634 A1 AR 012634A1 AR P980102020 A ARP980102020 A AR P980102020A AR P980102020 A ARP980102020 A AR P980102020A AR 012634 A1 AR012634 A1 AR 012634A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- hydrogen
- independently selected
- saturated
- formula
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/84—Nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- G01N2333/91205—Phosphotransferases in general
- G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
- G01N2333/91215—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases with a definite EC number (2.7.1.-)
Abstract
Un compuesto basado en quinazolina que tiene una estructura que se muestra en la formula I, II, o III, donde: (i) Z es oxígeno, NX1 o azufre, den X seselecciona del grupo formado por hidrogeno, alquilo saturado o insaturado, y grupos de anillos heteroarilo o arilo de cinco o seis miembros; (ii) n es 0, 1,2, 3 o 4; (iii) A1, A2, A3, A4, A5, y A6 se seleccionan independientemente del grupo formado por carbono, nitrogeno, oxígeno y azufre; (iv) R1 y R2 seseleccionan independientemente del grupo formado por: (a) hidrogeno; (b) alquilo saturado o insaturado; (c) NX2X3, donde X2 y X3 se seleccionanindependientemente del grupo formado por hidrogeno y alquilo saturado o insaturado; y (d) halogeno o trihalometilo; (e) anillo heteroarilo o arilo decinco a seis miembros; (v) R3, R4, R5, R6, R7, R8, R9 y R10 se seleccionan independientemente del grupo formado por: (a) hidrogeno, con la condicion deque por lo menos uno entre R3, R4, R5, R6, R7, R8, R9 y R10 es un grupodistinto de hidrogeno si R2 es -NH2; (b) alquilo saturado o insaturado, dondedicho R8 no es metilo cuando R2 es -NH2 y cuando n=1; (c) NX2X3 donde X2 y X3 se seleccionan independientemente del grupo formado por hidrogeno, alquilosaturado o insaturado, y anillos heteroarilo o arilo de cinco o seis miembros; (d) halogeno o trihalometilo, donde dicho R8 no es cloro ni fluor cuando R2 es-NH2 y cuando n=1; (e) una cetona de formula -CO-X4, donde X4 se seleccina del grupo formado por hidrogeno, alquilo, y grupos heteroarilo o arilo de cinco oseis miembros; (f) un ácido carboxílico de formula -(X5)n-COOH o ester de formula -(X6)n-COO-S7, donde X5, X6; y X7 y se seleccionan independientementedel grupo formado por alquilo y grupos heteroarilo o arilo de cinco o seis miembros y donde n es 0 o 1; (g) un alcohol de formula (X8)n -OH o un grupo
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4535197P | 1997-05-02 | 1997-05-02 | |
US6015297P | 1997-09-26 | 1997-09-26 |
Publications (1)
Publication Number | Publication Date |
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AR012634A1 true AR012634A1 (es) | 2000-11-08 |
Family
ID=26722670
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP980102020A AR012634A1 (es) | 1997-05-02 | 1998-04-30 | Compuesto basado en quinazolina, composicion famaceutica que lo comprende, metodo para sintetizarlo, su uso, metodos de modulacion de la funcion deserina/treonina proteinaquinasa con dicho compuesto y metodo in vitro para identificar compuestos que modulan dicha funcion |
Country Status (8)
Country | Link |
---|---|
US (2) | US6204267B1 (es) |
EP (1) | EP0981519A1 (es) |
JP (1) | JP2001524128A (es) |
AR (1) | AR012634A1 (es) |
AU (1) | AU7282998A (es) |
CA (1) | CA2288778A1 (es) |
CO (1) | CO4950533A1 (es) |
WO (1) | WO1998050370A1 (es) |
Families Citing this family (102)
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MY179503A (en) | 2013-07-30 | 2020-11-09 | Janssen Sciences Ireland Uc | Thieno[3,2-d]pyrimidines derivatives for the treatment of viral infections |
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-
1998
- 1998-04-30 AR ARP980102020A patent/AR012634A1/es unknown
- 1998-05-01 JP JP54833698A patent/JP2001524128A/ja not_active Withdrawn
- 1998-05-01 US US09/071,682 patent/US6204267B1/en not_active Expired - Fee Related
- 1998-05-01 WO PCT/US1998/009060 patent/WO1998050370A1/en not_active Application Discontinuation
- 1998-05-01 CA CA002288778A patent/CA2288778A1/en not_active Abandoned
- 1998-05-01 AU AU72829/98A patent/AU7282998A/en not_active Abandoned
- 1998-05-01 EP EP98920203A patent/EP0981519A1/en not_active Withdrawn
- 1998-05-04 CO CO98024266A patent/CO4950533A1/es unknown
-
2001
- 2001-01-26 US US09/769,360 patent/US6911446B2/en not_active Expired - Fee Related
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US6911446B2 (en) | 2005-06-28 |
CO4950533A1 (es) | 2000-09-01 |
WO1998050370A1 (en) | 1998-11-12 |
US20010014679A1 (en) | 2001-08-16 |
JP2001524128A (ja) | 2001-11-27 |
CA2288778A1 (en) | 1998-11-12 |
EP0981519A1 (en) | 2000-03-01 |
US6204267B1 (en) | 2001-03-20 |
AU7282998A (en) | 1998-11-27 |
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