WO2008105058A1 - スルホンアミド化合物 - Google Patents

スルホンアミド化合物 Download PDF

Info

Publication number
WO2008105058A1
WO2008105058A1 PCT/JP2007/053567 JP2007053567W WO2008105058A1 WO 2008105058 A1 WO2008105058 A1 WO 2008105058A1 JP 2007053567 W JP2007053567 W JP 2007053567W WO 2008105058 A1 WO2008105058 A1 WO 2008105058A1
Authority
WO
WIPO (PCT)
Prior art keywords
hydroxy
alkyl
hydrogen
alkenyl
halogeno
Prior art date
Application number
PCT/JP2007/053567
Other languages
English (en)
French (fr)
Inventor
Rintaro Yamada
Minoru Seto
Original Assignee
Asahi Kasei Pharma Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Kasei Pharma Corporation filed Critical Asahi Kasei Pharma Corporation
Priority to PCT/JP2007/053567 priority Critical patent/WO2008105058A1/ja
Priority to US12/526,000 priority patent/US8415372B2/en
Publication of WO2008105058A1 publication Critical patent/WO2008105058A1/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

　Rhoキナーゼを強力に阻害する式（１）［Ａは含窒素飽和環を示し；ｍは０～２の整数を示し；ｎは１～４の整数を示し；Ｇ1は水素原子、塩素原子、水酸基、アルコキシ基、又はアミノ基を示し；Ｇ2はハロゲン原子、水酸基、シアノ基、カルボキシ基、アルキル基、アルケニル基などを示し；Ｇ3は水素原子、ハロゲン原子、水酸基、シアノ基、カルボキシ基、アルキル基、アルケニル基などを示し；Ｇ4は水酸基、又は－Ｎ(Ｒ1)(Ｒ2)（Ｒ1及びＲ2は水素原子、アルキル基、アラルキル基、アルケニル基、アルキニル基、又は飽和ヘテロ環基を示す）を示し；Ｇ5はＡの環構成炭素原子における置換基であり、水素原子、フッ素原子、又はアルキル基を示す］で表される化合物又はその塩、あるいはプロドラッグであるそれらの誘導体。
PCT/JP2007/053567 2007-02-27 2007-02-27 スルホンアミド化合物 WO2008105058A1 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/JP2007/053567 WO2008105058A1 (ja) 2007-02-27 2007-02-27 スルホンアミド化合物
US12/526,000 US8415372B2 (en) 2007-02-27 2007-02-27 Sulfonamide compound

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2007/053567 WO2008105058A1 (ja) 2007-02-27 2007-02-27 スルホンアミド化合物

Publications (1)

Publication Number Publication Date
WO2008105058A1 true WO2008105058A1 (ja) 2008-09-04

Family

ID=39720904

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/053567 WO2008105058A1 (ja) 2007-02-27 2007-02-27 スルホンアミド化合物

Country Status (2)

Country Link
US (1) US8415372B2 (ja)
WO (1) WO2008105058A1 (ja)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7618984B2 (en) 2005-08-30 2009-11-17 Asahi Kasei Pharma Corporation Sulfonamide compound
US7964613B2 (en) 2007-02-28 2011-06-21 Asahi Kasei Pharma Corporation Sulfonamide compound
US8232292B2 (en) 2007-07-02 2012-07-31 Asahi Kasei Pharma Corporation Sulfonamide compound and crystal thereof
WO2012105674A1 (ja) 2011-02-04 2012-08-09 興和株式会社 緑内障予防又は治療のための薬物療法
WO2014192915A1 (ja) * 2013-05-30 2014-12-04 国立大学法人 千葉大学 抗ミオシン調節軽鎖ポリペプチド抗体を含む炎症疾患治療用組成物
WO2017122666A1 (ja) * 2016-01-12 2017-07-20 国立大学法人 千葉大学 抗Ｍｙｌ９抗体
EP3461484B1 (en) 2013-03-15 2020-11-18 Aerie Pharmaceuticals, Inc. Dimesylate salts of 4-(3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl, their combinations with prostaglandins and the use thereof in the treatment of ocular disorders

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2760562C (en) 2009-05-01 2016-07-19 Aerie Pharmaceuticals, Inc. Dual mechanism inhibitors for the treatment of disease
WO2014199131A1 (en) * 2013-06-13 2014-12-18 Cipla Limited Fixed Dose Pharmaceutical Composition
ES2774923T3 (es) 2014-04-28 2020-07-23 China Resources Pharmaceutical Holdings Company Ltd Derivados de isoquinolinsulfonilo como inhibidores de RHO quinasa
BR112019003945A2 (pt) 2016-08-31 2019-05-21 Aerie Pharmaceuticals, Inc. composições oftálmicas
WO2020056345A1 (en) 2018-09-14 2020-03-19 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05208973A (ja) * 1991-07-31 1993-08-20 Adir 新規なｎ−（イソキノリン−５−イルスルホニル）アザシクロアルカン化合物
JPH06100540A (ja) * 1992-09-24 1994-04-12 Asahi Chem Ind Co Ltd ５−イソキノリンスルホン酸アミド誘導体
JPH1087491A (ja) * 1996-07-26 1998-04-07 Asahi Chem Ind Co Ltd 転写調節因子阻害剤
WO1999064011A1 (fr) * 1998-06-11 1999-12-16 Hiroyoshi Hidaka Medicaments
JP2001509780A (ja) * 1995-12-21 2001-07-24 アルコン ラボラトリーズ，インコーポレイテッド 緑内障および眼虚血の治療のための特定のイソキノリンスルホニル化合物の使用
JP2004107335A (ja) * 2002-08-29 2004-04-08 Santen Pharmaceut Co Ltd Ｒｈｏキナーゼ阻害剤とプロスタグランジン類からなる緑内障治療剤
JP2004182723A (ja) * 2002-11-18 2004-07-02 Santen Pharmaceut Co Ltd Ｒｈｏキナーゼ阻害剤とβ遮断薬からなる緑内障治療剤
WO2005080394A1 (en) * 2004-02-24 2005-09-01 Bioaxone Therapeutique Inc. 4-substituted piperidine derivatives

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57156463A (en) 1981-03-20 1982-09-27 Asahi Chem Ind Co Ltd Isoquinoline derivative
JPS57200366A (en) 1981-06-01 1982-12-08 Asahi Chem Ind Co Ltd Isoquinoline compound
US4456757A (en) 1981-03-20 1984-06-26 Asahi Kasei Kogyo Kabushiki Kaisha Isoquinolinesulfonyl derivatives and process for the preparation thereof
JPH0667926B2 (ja) 1985-11-12 1994-08-31 旭化成工業株式会社 環状のイソキノリンスルホンアミド誘導体
US5245034A (en) 1988-12-26 1993-09-14 Kiroyoshi Hidaka Compound having vessel smooth muscle relaxation activity
JP2886225B2 (ja) 1988-12-26 1999-04-26 弘義 日高 アルキレンジアミン誘導体及びその製造方法
CA2005741C (en) 1988-12-26 1998-06-02 Hiroyoshi Hidaka Quinoline sulfonoamino compounds having vessel smooth muscle relaxation activity
US5216150A (en) 1988-12-26 1993-06-01 Hiroyoshi Hidaka Derivatives of isoquinoline (and naphthalene) sulfonamides
JP3408546B2 (ja) 1991-02-19 2003-05-19 旭化成株式会社 抗喘息剤
JP3176619B2 (ja) 1991-09-05 2001-06-18 ファルノ−ヴェトロファルム ゲゼルシャフト ミット ベシュレンクテル ハフツング 芳香族スルホンアミド化合物、阻害剤及びそれを含有する医薬組成物
CA2240271C (en) 1995-12-21 2005-12-13 Alcon Laboratories, Inc. Use of certain isoquinolinesulfonyl compounds for the treatment of glaucoma and ocular ischemia
DE69724108T2 (de) 1996-02-02 2004-06-09 D.Western Therapeutics Institute, Nagoya Isochinolinderivate und arzneimittel
EP0956865B2 (en) 1996-08-12 2010-08-18 Mitsubishi Tanabe Pharma Corporation MEDICINES COMPRISING Rho KINASE INHIBITOR
JP4316794B2 (ja) 1997-10-22 2009-08-19 株式会社デ・ウエスタン・セラピテクス研究所 イソキノリン誘導体及び医薬
CA2327276A1 (en) 1998-04-23 1999-10-28 Hiroshi Muramatsu Isoquinolinesulfonamide derivatives and drugs containing the same as the active ingredient
US7217722B2 (en) 2000-02-01 2007-05-15 Kirin Beer Kabushiki Kaisha Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same
MXPA03008659A (es) 2001-03-23 2005-04-08 Bayer Ag Inhibidores de rho-cinasa.
HN2002000067A (es) 2001-03-23 2003-10-24 Bayer Healthcare Llc Inhibidores de la rho - quinasa.
US7199147B2 (en) 2001-06-12 2007-04-03 Dainippon Sumitomo Pharma Co., Ltd. Rho kinase inhibitors
WO2004009555A1 (ja) 2002-07-22 2004-01-29 Asahi Kasei Pharma Corporation ５−置換イソキノリン誘導体
US7094789B2 (en) 2002-07-22 2006-08-22 Asahi Kasei Pharma Corporation 5-substituted isoquinoline derivatives
ES2382733T3 (es) 2002-08-29 2012-06-13 Santen Pharmaceutical Co., Ltd. Remedio para el glaucoma que comprende un inhibidor de la Rho quinasa y prostaglandinas
EP1550660A1 (en) 2002-09-12 2005-07-06 Kirin Beer Kabushiki Kaisha Isoquinoline derivatives having kinasae inhibitory activity and drugs containing the same
MY140618A (en) 2003-02-28 2009-12-31 Kowa Co Method for preparing acid addition salts of polyacidic basic compounds
US7160894B2 (en) 2003-06-06 2007-01-09 Asahi Kasei Pharma Corporation Tricyclic compound
GB0317315D0 (en) 2003-07-24 2003-08-27 Astex Technology Ltd Pharmaceutical compounds
TWI344961B (en) 2003-10-15 2011-07-11 Ube Industries Novel indazole derivative
JP2007015928A (ja) 2003-10-15 2007-01-25 Ube Ind Ltd 新規オレフィン誘導体
JP2007008816A (ja) 2003-10-15 2007-01-18 Ube Ind Ltd 新規イソキノリン誘導体
JP2005232175A (ja) 2004-01-21 2005-09-02 Asahi Kasei Pharma Kk ５−置換イソキノリン医薬
US20060247266A1 (en) 2004-11-26 2006-11-02 Asahi Kasei Pharma Corporation Nitrogen-containing tricyclic compounds
MY139797A (en) 2004-11-29 2009-10-30 Kowa Co (s)-(-)-1-(4-fluoroisoquinolin-5-yl)sulfonyl-2-methyl-1, 4-homopiperazine hydrochloride dihydrate
EP1866298A2 (en) 2005-03-31 2007-12-19 Takeda San Diego, Inc. Hydroxysteroid dehydrogenase inhibitors
WO2006115245A1 (ja) 2005-04-25 2006-11-02 D. Western Therapeutics Institute, Inc. ４－エチニルイソキノリン誘導体及びこれを含有する医薬
ATE423779T1 (de) 2005-04-25 2009-03-15 Western Therapeutics Inst Inc Hochselektiver rho-kinase-inhibitor
WO2006115244A1 (ja) 2005-04-25 2006-11-02 D. Western Therapeutics Institute, Inc. ４－ブロモイソキノリン誘導体及びこれを含有する医薬
JP2006348028A (ja) 2005-05-19 2006-12-28 Kowa Co 緑内障予防又は治療剤
WO2006137368A1 (ja) 2005-06-21 2006-12-28 Kowa Co., Ltd. 緑内障の予防又は治療剤
JP4972552B2 (ja) 2005-07-12 2012-07-11 興和株式会社 緑内障を予防又は治療する薬剤
RU2376300C1 (ru) 2005-08-30 2009-12-20 Асахи Касеи Фарма Корпорэйшн Сульфонамидное соединение
JP2007238458A (ja) 2006-03-06 2007-09-20 D Western Therapeutics Institute Inc 新規なイソキノリン誘導体及びこれを含有する医薬
EP2130828A4 (en) 2007-02-28 2010-12-29 Asahi Kasei Pharma Corp sulfonamide
WO2009004792A1 (ja) 2007-07-02 2009-01-08 Asahi Kasei Pharma Corporation スルホンアミド化合物及びその結晶

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05208973A (ja) * 1991-07-31 1993-08-20 Adir 新規なｎ−（イソキノリン−５−イルスルホニル）アザシクロアルカン化合物
JPH06100540A (ja) * 1992-09-24 1994-04-12 Asahi Chem Ind Co Ltd ５−イソキノリンスルホン酸アミド誘導体
JP2001509780A (ja) * 1995-12-21 2001-07-24 アルコン ラボラトリーズ，インコーポレイテッド 緑内障および眼虚血の治療のための特定のイソキノリンスルホニル化合物の使用
JPH1087491A (ja) * 1996-07-26 1998-04-07 Asahi Chem Ind Co Ltd 転写調節因子阻害剤
WO1999064011A1 (fr) * 1998-06-11 1999-12-16 Hiroyoshi Hidaka Medicaments
JP2004107335A (ja) * 2002-08-29 2004-04-08 Santen Pharmaceut Co Ltd Ｒｈｏキナーゼ阻害剤とプロスタグランジン類からなる緑内障治療剤
JP2004182723A (ja) * 2002-11-18 2004-07-02 Santen Pharmaceut Co Ltd Ｒｈｏキナーゼ阻害剤とβ遮断薬からなる緑内障治療剤
WO2005080394A1 (en) * 2004-02-24 2005-09-01 Bioaxone Therapeutique Inc. 4-substituted piperidine derivatives

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7618984B2 (en) 2005-08-30 2009-11-17 Asahi Kasei Pharma Corporation Sulfonamide compound
US7964613B2 (en) 2007-02-28 2011-06-21 Asahi Kasei Pharma Corporation Sulfonamide compound
US8664243B2 (en) 2007-07-02 2014-03-04 Asahi Kasei Pharma Corporation Sulfonamide compound and crystal thereof
US8232292B2 (en) 2007-07-02 2012-07-31 Asahi Kasei Pharma Corporation Sulfonamide compound and crystal thereof
KR20180023041A (ko) 2011-02-04 2018-03-06 코와 가부시키가이샤 녹내장 예방 또는 치료를 위한 약물 요법
JPWO2012105674A1 (ja) * 2011-02-04 2014-07-03 興和株式会社 緑内障予防又は治療のための薬物療法
WO2012105674A1 (ja) 2011-02-04 2012-08-09 興和株式会社 緑内障予防又は治療のための薬物療法
EP3461484B1 (en) 2013-03-15 2020-11-18 Aerie Pharmaceuticals, Inc. Dimesylate salts of 4-(3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl, their combinations with prostaglandins and the use thereof in the treatment of ocular disorders
WO2014192915A1 (ja) * 2013-05-30 2014-12-04 国立大学法人 千葉大学 抗ミオシン調節軽鎖ポリペプチド抗体を含む炎症疾患治療用組成物
JPWO2014192915A1 (ja) * 2013-05-30 2017-02-23 国立大学法人 千葉大学 抗ミオシン調節軽鎖ポリペプチド抗体を含む炎症疾患治療用組成物
WO2017122666A1 (ja) * 2016-01-12 2017-07-20 国立大学法人 千葉大学 抗Ｍｙｌ９抗体
CN108431037A (zh) * 2016-01-12 2018-08-21 国立大学法人千叶大学 抗myl9抗体
JPWO2017122666A1 (ja) * 2016-01-12 2018-11-01 国立大学法人千葉大学 抗Ｍｙｌ９抗体
US10513561B2 (en) 2016-01-12 2019-12-24 National University Corporation Chiba University Anti-MYL9 antibody
CN108431037B (zh) * 2016-01-12 2021-12-17 国立大学法人千叶大学 抗myl9抗体

Also Published As

Publication number Publication date
US20100093789A1 (en) 2010-04-15
US8415372B2 (en) 2013-04-09

Similar Documents

Publication Publication Date Title
WO2008105058A1 (ja) スルホンアミド化合物
WO2008105442A1 (ja) スルホンアミド誘導体
TN2009000024A1 (en) Prodrug of cinnamide compound
RS54260B1 (en) AMINODIHYDROTIAZINE DERIVATIVES AS BACE INHIBITORS FOR ALZHEIMER DISEASE TREATMENT
TW200732306A (en) Pyrimidine derivatives
WO2008108378A3 (en) Bicyclic oxomorpholine derivative
WO2009001817A1 (ja) １１β－ＨＳＤ１阻害活性を有する化合物
WO2008005368A3 (en) Piperazines as p2x7 antagonists
WO2007084914A3 (en) Phenoxy-substituted pyrimidines as adenosine receptor antagonists
AU2008303600A8 (en) 1,1,1-trifluoro-2-hydroxy-3-phenylpropane derivatives
WO2005110410A3 (en) Kinase inhibitors as therapeutic agents
WO2009035150A3 (en) 4-phenyl-5-hydroxy-3(2h)-pyridazinone derivatives as herbicides
TNSN08407A1 (en) Organic compounds
MX2009004920A (es) Nuevos derivados de aminopirimidina como inhibidores de plk1.
WO2008096829A1 (ja) ３環系化合物
EA017861B9 (ru) Способ получения 4-оксохинолинового соединения
WO2009107850A3 (en) Fused heterocyclic derivative and use thereof
WO2009057079A3 (en) Novel pyrimidine derivatives
WO2007103839A3 (en) Pyrrolotriazine aniline prodrug compounds useful as kinase inhibitors
WO2006113509A3 (en) Quinobenzoxazine analogs and methods of using thereof
WO2007133352A3 (en) Macrocyclic kinase inhibitors
WO2008078725A1 (ja) チアゼピン誘導体
IN2014CN00532A (ja)
WO2008156094A1 (ja) ピリダジノン誘導体及びそれらを有効成分とするｐｄｅ阻害剤
WO2009038064A1 (ja) Ｉ型１１βヒドロキシステロイド脱水素酵素阻害活性を有する複素環誘導体

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07714960

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 12526000

Country of ref document: US

122 Ep: pct application non-entry in european phase

Ref document number: 07714960

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: JP